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AUMantagomir oligos

FANA antisense oligos (FANA ASOs) for miRNA inhibition and regulation

AUMantagomir oligos provide potent miRNA inhibition by using FANA ASO technology which is a third generation chemical modification platform. FANA technology allows simple and efficient delivery into difficult-to-transfect cells and animals without the need of transfection reagents or formulations.

AUMantagomir : Key features

  • Easy self-delivery without the need of transfection regents

  • Excellent uptake in difficult-totransfect cells and primary cultures

  • No toxicity

  • High specificity and affinity for target miRNA

  • High stability and resistance to endonucleases

AUMantagomir vs. Conventional antagomir
Not Required Transfection Reagents Required
High Efficiency in difficult-to-transfet cells Low-Moderate
Non-toxic Toxicity Can be toxic due to the use of transfection reagents
Easy and convenient one-step process Transition from cell culture to in vivo models Require extensie optimization use of delivery reagents
High: Resistant to nucleases Stability Moderate
FANAs have high binding affinity and specificity to the target RNA Specificity Low binding affinity and specificity

Lipid-based transfection and electroporation are widely utilized, conventional methods to deliver conventional antagomirs into the cells. However, in many primary cells, particularly immune cells, hematopoietic cells and neurons, lipid reagents and electroporation are associated with high toxicity and poor transfection efficiency. Alternative delivery methods, such as viral vectors, require laborious optimization and viral production steps, and carry associated risk of genome integration.

FANA Antisense Oligonucleotides (FANA ASOs) are uniquely modified with 2'-deoxy-2'-fluoro-arabinoguanosine (FANA) that enhances the intracellular stability of the oligos, as well as their binding to the target miRNA. The FANA modifications also allow for the oligos to be self-delivered into cells without any transfection reagents, as well as in animals, without the need of special delivery formulations.

Efficient knockdown of miR-134 by AUMantagomir in treated rat hippocampal slices

QRT-qPCR analysis showed a decrease in miR-134 expression in slices treated with FANA-miR-134 compared to scrambled control in Alzheimer's disease model. Adapted from Baby, N. et al. 2019. Aging Cell.

Ordering information:

Product Name Purification Application Study model
AUMantagomir RPC miRNA inhibition Cells lines and primary cells
AUMantagomir HPLC miRNA inhibition Sensitive primary cells and animal models
AUMantagomir In-vivo ready miRNA inhibition Animal models
  • Labeled FANAs: FANA ASOs can be labeled with any fluorescent label or tag (eg. biotin).

  • Size: FANAs are available in 10, 25, 50, 100, 250, 500 and 1000 nmoles. Higher amounts are also available.

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