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overview

Some of the most important features desired for any gene-silencing or manipulation tool are:

Efficient knock down or regulation of the target RNA.
Ability to bind to the target RNA (mRNA, miRNA or lncRNA) in a high sequence specific manner.
No toxicity.
Most importantly – efficient delivery without an external source (e.g. without a transfection agent, formulation, conjugate or viral vector).

Oligos designed using next generation FANA technology can effectively and efficiently perform all these activities.

2’F-ANA oligomer

ANA oligomer

DNA oligomer

RNA oligomer

Structures of (a) 2’F-ANA and (b) ANA, in comparison with (c) DNA and (d) RNA oligomers.

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