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Why AUM<i>silence</i> oligos?

Why AUMsilence?

Guaranteed Knockdown For RNA Silencing Studies

Advantages of AUMsilence ASOs for RNA Silencing and Regulation Studies

  • Self-delivery (Gymnotic delivery): Uptake of the AUMsilence ASOs without a delivery agent. No formulation, conjugate or viral vector (like AAV) needed for delivery.

  • Ideal for primary cells or difficult to transfect cell lines (no formulation, conjugate or viral vector needed for delivery). Works very well with hard-to-transfect cells especially primary cells which depict true biology (T- cells, B-cells, neuronal cultures and others).

  • AUMsilence ASO Treatment Workflow
  • Ideal for in vivo studies (no formulation, conjugate or viral vector needed for delivery).

  • Can work with fish, insect, and amphibian models (no formulatio or conjugates needed for delivery).

  • Non-toxic and do no cause cell death. No need to grow excessive number of cells (typically there is a need to do grow excessive number of cells when we use transfection agents to compensate for high cell death caused by these toxic reagents).

  • Resistant to degradation by serum and cellular nucleases significantly improves duration of activity. AUMsilence oligos do not degrade (up to several weeks/months)

  • Long term sustained silencing (can be used as an alternative for stable cell lines).

  • Low non-specific protein binding decreases toxicity.

  • Does not alter the biology of cells and the experiment (as in case of transfection and delivery reagents).

  • Ability to bind to RNA target with high affinity and specificity.

  • No RISC associated off target effects (as in case of siRNAs).

  • Effective in low concentrations; high bioavailability.

  • Excellent reproducibility.

  • Saves significant time and resources.

  • Cost effective and efficient.

  • Super easy to use (very convenient protocol).

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