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Pathway Human Homo sapiens

Mitochondrial protein import

R-HSA-1268020 in Reactome release 97: under Protein localization, with 65 genes placed in it by the mapping files and 0 child pathways in the hierarchy.

The same number in the other species

Reactome writes the mouse and rat events it infers from a human pathway under the human number with the species token. A door opens only where that species' own list in this release holds the id: R-MMU-1268020 (mouse), R-RNO-1268020 (rat). Whether the event was inferred from this one is what the record says.

01The record

Reactome's own record of this pathway

What this tells you

The pathway list, the hierarchy and the genes on this page are read from the files Reactome publishes for Reactome release 97, built into this site on 2026-09-09: the pathway list, the hierarchy relationship file and the two gene mapping files. The record card is the one live read, Reactome's own record of this pathway.

Reactome's download page describes the mapping files: Mapping files link the source database identifier to the lowest level pathway diagram or subset of the pathway, all levels of the pathway hierarchy or database identifier to all reactions. [R13] The gene list here is the all-levels mapping of NCBI Gene ids, filled from the all-levels mapping of Ensembl ids where the NCBI file has no row for a gene; each row names which file it came from by the shape of its source id. Each row carries the evidence codes the file writes for it, as written and unranked, and both where the file writes both; no page of Reactome's documentation the survey read defines the codes, so this page does not expand them. A gene id the identity files do not name is kept as the source's own id with no door rather than turned into a symbol.

On citing what a search finds, Reactome says: It should be remembered that while we strive to contain the most current and accurate data, Reactome should not be used in citations where other primary sources of information are available. [R12] The record card prints the literature Reactome attaches to a curated pathway for that reason. The data are public domain: All data in the Reactome database and files derived from that data are licensed under the Creative Commons Public Domain Dedication (CC0). User may copy, modify, and distribute these data, even for commercial purposes, without asking for permission. Attribution is encouraged but not required. [R10] The pathway illustrations are licensed apart, under CC BY 4.0, and none is shown here.

A gene on this list is one Reactome places in this pathway in this release, and that is all the row says: it does not say the gene is expressed in a tissue or associated with a disease, which are the other two explorers' questions, read from other sources. Reactome's papers of record are [R01] [R02].

  1. [R01] Ragueneau E, Gong C, Sinquin P, Sevilla C, Beavers D, Grentner A, et al. (2026). The Reactome Knowledgebase 2026. Nucleic Acids Research 54:D673-D681. PMID 41251150, doi 10.1093/nar/gkaf1223.
  2. [R02] Milacic M, Beavers D, Conley P, Gong C, Gillespie M, Griss J, et al. (2024). The Reactome Pathway Knowledgebase 2024. Nucleic Acids Research 52:D672-D678. PMID 37941124, doi 10.1093/nar/gkad1025.
  3. [R10] Reactome, reactome.org. License Agreement. https://reactome.org/license, read 2026-09-09.
  4. [R12] Reactome, reactome.org. Citing us. https://reactome.org/cite, read 2026-09-09.
  5. [R13] Reactome, reactome.org. Download. https://reactome.org/download-data, read 2026-09-09.
Reading this pathway's record from Reactome (the pathway record).Still reading. A first read of a pathway can take a while; this page waits up to 35 seconds for it, and its scripts then bring in the panel, or a line saying what did not arrive.

02The genes

Genes Reactome places in this human pathway

The mapping files place 65 genes in this human pathway; showing 1 to 65, in pages of 100, sorted by symbol for reading. The order carries no ranking.

Genes Reactome places in this human pathway, page 1 of 1
GeneACO2AuthorityHGNC:118Mapping file id50 NCBI fileEvidenceIEA
GeneATP5F1AAuthorityHGNC:823Mapping file id498 NCBI fileEvidenceIEA
GeneATP5F1BAuthorityHGNC:830Mapping file id506 NCBI fileEvidenceIEA, TAS
GeneATP5MC1AuthorityHGNC:841Mapping file id516 NCBI fileEvidenceIEA, TAS
GeneBCS1LAuthorityHGNC:1020Mapping file id617 NCBI fileEvidenceIEA
GeneCHCHD10AuthorityHGNC:15559Mapping file id400916 NCBI fileEvidenceIEA
GeneCHCHD2AuthorityHGNC:21645Mapping file id51142 NCBI fileEvidenceIEA
GeneCHCHD3AuthorityHGNC:21906Mapping file id54927 NCBI fileEvidenceIEA
GeneCHCHD4AuthorityHGNC:26467Mapping file id131474 NCBI fileEvidenceIEA
GeneCHCHD5AuthorityHGNC:17840Mapping file id84269 NCBI fileEvidenceIEA
GeneCHCHD7AuthorityHGNC:28314Mapping file id79145 NCBI fileEvidenceIEA
GeneCMC2AuthorityHGNC:24447Mapping file id56942 NCBI fileEvidenceIEA
GeneCMC4AuthorityHGNC:35428Mapping file id100272147 NCBI fileEvidenceIEA
GeneCOA4AuthorityHGNC:24604Mapping file id51287 NCBI fileEvidenceIEA
GeneCOA6AuthorityHGNC:18025Mapping file id388753 NCBI fileEvidenceIEA
GeneCOQ2AuthorityHGNC:25223Mapping file id27235 NCBI fileEvidenceIEA, TAS
GeneCOX17AuthorityHGNC:2264Mapping file id10063 NCBI fileEvidenceIEA
GeneCOX19AuthorityHGNC:28074Mapping file id90639 NCBI fileEvidenceIEA
GeneCSAuthorityHGNC:2422Mapping file id1431 NCBI fileEvidenceIEA
GeneCYC1AuthorityHGNC:2579Mapping file id1537 NCBI fileEvidenceIEA
GeneDNAJC19AuthorityHGNC:30528Mapping file id131118 NCBI fileEvidenceIEA
GeneFXNAuthorityHGNC:3951Mapping file id2395 NCBI fileEvidenceIEA, TAS
GeneGFERAuthorityHGNC:4236Mapping file id2671 NCBI fileEvidenceIEA
GeneGRPEL1AuthorityHGNC:19696Mapping file id80273 NCBI fileEvidenceIEA
GeneGRPEL2AuthorityHGNC:21060Mapping file id134266 NCBI fileEvidenceIEA
GeneHSCBAuthorityHGNC:28913Mapping file id150274 NCBI fileEvidenceIEA, TAS
GeneHSPA9AuthorityHGNC:5244Mapping file id3313 NCBI fileEvidenceIEA
GeneHSPD1AuthorityHGNC:5261Mapping file id3329 NCBI fileEvidenceIEA, TAS
GeneIDH3GAuthorityHGNC:5386Mapping file id3421 NCBI fileEvidenceIEA
GeneLDHDAuthorityHGNC:19708Mapping file id197257 NCBI fileEvidenceIEA, TAS
GeneMTX1AuthorityHGNC:7504Mapping file id4580 NCBI fileEvidenceIEA
GeneMTX2AuthorityHGNC:7506Mapping file id10651 NCBI fileEvidenceIEA
GeneNDUFB8AuthorityHGNC:7703Mapping file id4714 NCBI fileEvidenceIEA, TAS
GeneOTCAuthorityHGNC:8512Mapping file id5009 NCBI fileEvidenceIEA, TAS
GenePAM16AuthorityHGNC:29679Mapping file id51025 NCBI fileEvidenceIEA
GenePITRM1AuthorityHGNC:17663Mapping file id10531 NCBI fileEvidenceTAS
GenePMPCAAuthorityHGNC:18667Mapping file id23203 NCBI fileEvidenceIEA
GenePMPCBAuthorityHGNC:9119Mapping file id9512 NCBI fileEvidenceIEA
GeneSAMM50AuthorityHGNC:24276Mapping file id25813 NCBI fileEvidenceIEA
GeneSLC25A12AuthorityHGNC:10982Mapping file id8604 NCBI fileEvidenceIEA
GeneSLC25A13AuthorityHGNC:10983Mapping file id10165 NCBI fileEvidenceIEA
GeneSLC25A4AuthorityHGNC:10990Mapping file id291 NCBI fileEvidenceIEA, TAS
GeneSLC25A6AuthorityHGNC:10992Mapping file id293 NCBI fileEvidenceIEA, TAS
GeneTAFAZZINAuthorityHGNC:11577Mapping file id6901 NCBI fileEvidenceIEA, TAS
GeneTIMM10AuthorityHGNC:11814Mapping file id26519 NCBI fileEvidenceIEA, TAS
GeneTIMM10BAuthorityHGNC:4022Mapping file id26515 NCBI fileEvidenceTAS
GeneTIMM13AuthorityHGNC:11816Mapping file id26517 NCBI fileEvidenceIEA
GeneTIMM17AAuthorityHGNC:17315Mapping file id10440 NCBI fileEvidenceIEA, TAS
GeneTIMM17BAuthorityHGNC:17310Mapping file id10245 NCBI fileEvidenceIEA, TAS
GeneTIMM21AuthorityHGNC:25010Mapping file id29090 NCBI fileEvidenceIEA
GeneTIMM22AuthorityHGNC:17317Mapping file id29928 NCBI fileEvidenceIEA, TAS
GeneTIMM23AuthorityHGNC:17312Mapping file id100287932 NCBI fileEvidenceIEA, TAS
GeneTIMM44AuthorityHGNC:17316Mapping file id10469 NCBI fileEvidenceIEA
GeneTIMM50AuthorityHGNC:23656Mapping file id92609 NCBI fileEvidenceIEA
GeneTIMM8AAuthorityHGNC:11817Mapping file id1678 NCBI fileEvidenceIEA
GeneTIMM8BAuthorityHGNC:11818Mapping file id26521 NCBI fileEvidenceIEA
GeneTIMM9AuthorityHGNC:11819Mapping file id26520 NCBI fileEvidenceIEA, TAS
GeneTOMM20AuthorityHGNC:20947Mapping file id9804 NCBI fileEvidenceIEA
GeneTOMM22AuthorityHGNC:18002Mapping file id56993 NCBI fileEvidenceIEA
GeneTOMM40AuthorityHGNC:18001Mapping file id10452 NCBI fileEvidenceIEA
GeneTOMM5AuthorityHGNC:31369Mapping file id401505 NCBI fileEvidenceIEA
GeneTOMM6AuthorityHGNC:34528Mapping file id100188893 NCBI fileEvidenceIEA
GeneTOMM7AuthorityHGNC:21648Mapping file id54543 NCBI fileEvidenceIEA
GeneTOMM70AuthorityHGNC:11985Mapping file id9868 NCBI fileEvidenceIEA
GeneVDAC1AuthorityHGNC:12669Mapping file id7416 NCBI fileEvidenceIEA

Evidence codes on this page: IEA, TAS, as the mapping file writes them; a row carrying two was written twice by the file, once under each. The mapping file id says which file placed the gene: an NCBI Gene id from NCBI2Reactome_All_Levels.txt, an Ensembl gene id from Ensembl2Reactome_All_Levels.txt. The two files can disagree about a code, so a row's codes are the one file's view. Measured by this site's build over this release on 2026-09-09: of the 138,908 human pathway-gene pairs both files place, 207 (0.149 per cent, over 47 genes) carry TAS in the Ensembl file where the NCBI rows carry IEA alone.

  • Reactome mapping files, the human rows for this pathway · Reactome release 97 · read · Reactome downloads"NCBI2Reactome_All_Levels.txt" and "Ensembl2Reactome_All_Levels.txt", Reactome, release 97, https://reactome.org/download-data/ (date of access 2026-09-09). Data CC0; attribution encouraged.

03The hierarchy

Parents and children in this release's hierarchy

Children

None: no pathway of this release's list names this one as a parent.

Reactome's hierarchy is a graph rather than a tree: a pathway can sit under more than one parent, and the gene counts are each pathway's own placements at every level under it, so a parent's count is not the sum of its children's.

  • Reactome, the human pathway list and hierarchy relationship file · Reactome release 97 · read · Reactome downloads"ReactomePathways.txt" and "ReactomePathwaysRelation.txt", Reactome, release 97, https://reactome.org/download-data/ (date of access 2026-09-09). Data CC0; attribution encouraged.