Cell type guides
Cell-type-specific RNA silencing guides
Discover how AUM BioTech's self-delivering ASO technology enables efficient gene silencing across diverse cell types without transfection reagents. Each guide provides cell-specific protocols, troubleshooting tips, and research applications tailored to your experimental needs.
Master gene knockdown in hard-to-transfect cells with self-delivering ASOs
T cells RNA silencing guide
- Knockdown Efficiency: 70-95% knockdown
- Cell Viability: Preserved; target-dependent
- Transfection Required: None
Overcome transfection challenges with self-delivering ASOs
Regulatory T cells (Tregs) RNA silencing guide
- Knockdown Efficiency: 70-95% knockdown
- Cell Viability: Preserved; target-dependent
Transfection-free self-delivering ASO solution for difficult Tregs
TILs RNA silencing guide
- TIL Viability: Preserved; target-dependent
- Knockdown Efficiency: 70-95% knockdown
Reverse exhaustion, enhance expansion, and optimize tumor-infiltrating lymphocytes: all without transfection
Dendritic cells RNA silencing guide
- Knockdown Efficiency: 70-95% knockdown
- Cell Viability: Preserved; target-dependent
Engineer DC vaccines and tolerogenic DCs without maturation artifacts
Macrophages RNA silencing guide
- Knockdown Efficiency: 70-95% knockdown
- Cell Viability: Preserved; target-dependent
Reprogram TAMs and study phagocytosis without phenotypic switching
iPSCs RNA silencing guide
- Knockdown Efficiency: 70-95% knockdown
- Cell Viability: Preserved; target-dependent
Preserve pluripotency and control differentiation without spontaneous maturation
Hepatocytes RNA silencing guide
- Knockdown Efficiency: 70-95% knockdown
- Cell Viability: Preserved; target-dependent
Study drug metabolism and NAFLD
Endothelial cells RNA silencing guide
- Knockdown Efficiency: 70-95% knockdown
- Cell Viability: Preserved; target-dependent
Study angiogenesis and barrier function with no transfection reagent
Hematopoietic stem cells RNA silencing guide
- Knockdown Efficiency: 70-95% knockdown
- Cell Viability: Preserved; target-dependent
- Engraftment: Target-dependent
Transfection-free knockdown in hematopoietic stem cells
B cells RNA silencing guide
- Knockdown Efficiency: 70-95% knockdown
- Cell Viability: Preserved; target-dependent
Study antibody production and B cell lymphomas without activation artifacts
CAR-T cells RNA silencing guide
- CAR-T Viability: Preserved; target-dependent
- Expansion Compatible: Yes
- Knockdown Efficiency: 70-95% knockdown
Enhance persistence, prevent exhaustion, and optimize manufacturing: all without transfection
Cardiomyocytes RNA silencing guide
- Knockdown Efficiency: 70-95% knockdown
- Cell Viability: Preserved; target-dependent
Study cardiac disease without electroporation-induced calcium overload
NK cells and CAR-NK cells RNA silencing guide
- Transfection-Free: Yes
- Cell Viability: Preserved; target-dependent
- CAR-NK Compatible: Yes
Engineer enhanced cytotoxicity and checkpoint resistance without transfection
Primary neurons RNA silencing guide
- Knockdown: 70-95% knockdown
- Cell Viability: Preserved; target-dependent
Transfection-free gene knockdown
Mesenchymal stem cells RNA silencing guide
- Knockdown Efficiency: 70-95% knockdown
- Cell Viability: Preserved; target-dependent
- Multipotency: Target-dependent
Preserve multipotency while achieving gene knockdown
What makes our guides unique
Each guide is developed with input from researchers working with challenging cell types
Cell-specific protocols
Optimized protocols for each cell type, including culture conditions, optimal ASO concentrations, and timing recommendations.
Performance data
Real-world efficiency metrics, viability data, and comparison with traditional transfection methods.
Troubleshooting support
Common challenges and solutions specific to each cell type, based on extensive testing and customer feedback.
Can't find your cell type?
Our scientific team can help you optimize RNA silencing protocols for your specific cell type. Contact us for personalized consultation and custom ASO design.
For research use only. Not for use in diagnostic or therapeutic procedures.