Door one Designed against your target
Self-delivering products, designed by the AUMsilence platform
Name the gene, the microRNA, the long non-coding RNA or the viral RNA. The platform designs the sequence, and AUMsilence
RNA silencing products
Self-delivering, transfection-optimized and siRNA products
Start with a target
- 01
Name it
A gene, a microRNA or a long non-coding RNA, or paste a sequence.
- 02
Choose
Purification, yield and controls; the price follows.
- 03
Order
Card, purchase order or a quotation.
Door two Synthesized to your sequence
Conventional oligos, made to the sequence you send
2'-MOE, locked nucleic acid and 2'-OMe, in desalt, RPC and HPLC purification, from 5 to 1000 nmol. Bulk synthesis from nanomoles to multiple grams, with custom modifications. No design step: the sequence is yours.
By target and delivery
Every product, by what it targets and how it gets in
Read down for the target and across for the delivery. Every entry is a product with its own page.
FigureHow the three product types differ
| Target | Self-delivering (sdASO) | Transfection-optimized (toASO) | Enhanced siRNA |
|---|---|---|---|
| mRNA knockdown | AUMsilence | AUMsilence | AUMsiRNAAUMsiRNA Pool |
| miRNA inhibition | AUMantagomir | AUMantagomir | No product listed |
| miRNA replacement | AUMmimic | No product listed | No product listed |
| lncRNA knockdown | AUMlnc | AUMlnc | No product listed |
| Viral RNA knockdown | AUMsilence V+ | No product listed | No product listed |
| Steric blocking | AUMblock | No product listed | No product listed |
| Splice modulation | AUMsplice | No product listed | No product listed |
The families
Choose the family, then the product
Self-delivering antisense oligonucleotides (sdASO)
AUMsilence
AUMsilence
sdASO 
mRNA knockdown
Self-delivering antisense oligonucleotides for mRNA knockdown in cell lines and difficult-to-transfect primary cells, without a transfection reagent.
AUMantagomir
sdASO 
miRNA inhibition
Self-delivering antisense oligonucleotides that bind a mature microRNA and inhibit it, in difficult-to-transfect cells.
AUMmimic
sdASO 
miRNA mimic
Self-delivering antisense oligonucleotides that supply a chosen mature microRNA: the replacement counterpart of AUMantagomir sdASO.
AUMlnc
sdASO 
lncRNA knockdown
Self-delivering antisense oligonucleotides for knockdown of long non-coding RNA, including nuclear-retained transcripts.
AUMsilence V+
sdASO 
Viral RNA knockdown
Self-delivering antisense oligonucleotides for knockdown of viral RNA genomes and transcripts, in virology research and antiviral target discovery.
AUMblock
sdASO 
Blocker
Steric-blocking self-delivering antisense oligonucleotides that bind target RNAs and modulate their function without recruiting RNase H.
AUMsplice
sdASO 
Exon skipping
Self-delivering antisense oligonucleotides that bind pre-mRNA and redirect splicing, for exon skipping or inclusion.
When to choose self-delivering ASOs (sdASO)
Delivery
No transfection reagent, electroporation, or viral vector needed
Difficult-to-transfect cells
Used in primary cells, neurons, and immune cells
In vivo studies
Can be used in animal models without special delivery formulations
Cellular stress
A transfection reagent can introduce toxicity or alter the cellular response
Transfection-optimized ASOs (toASO)
Transfection-optimized ASOs (toASO) are the same designs as AUMsilence
AUMsilence
toASO 
Cost-effective ASOs
Antisense oligonucleotides designed by the AUMsilence platform, at a lower price, delivered with a standard transfection reagent. Used for high-throughput screening, routine gene silencing in standard cell lines, and academic research where budget constraints exist.
When to choose transfection-optimized ASOs (toASO)
Budget considerations
For every yield both products are sold in, at a lower price than AUMsilence
sdASO Standard cell lines
For cell lines that are easy to transfect (HEK293, HeLa, etc.)
High-throughput screening
For large gene panels and screening applications where cost per target matters
Academic teaching
For educational labs and training where budget constraints exist
Enhanced siRNA technology
Chemically enhanced AUMsiRNA duplexes leverage the proven RNA interference (RNAi) pathway, with chemical modifications the AUMsilence platform selects and positions. The mechanism is the familiar RNAi pathway, and the standard transfection protocols apply.
AUMsiRNA
Enhanced siRNA
Chemically enhanced small interfering RNA for mRNA knockdown through the RISC pathway.
AUMsiRNA Pool
siRNA pool technology
Several siRNAs against different regions of the same mRNA, because which sequence works in a given cell type is not predictable in advance.
What to know about enhanced siRNA technology
Proven RNAi pathway
The well-characterized RISC complex cleaves the target mRNA catalytically, and the protocols are established
Nuclease resistance
Chemical modification is what makes a duplex resist serum nucleases
Off-targeting comes from the seed
Positions 2 to 8 of either strand pair with unintended transcripts, and where a modification sits changes how much of that is avoided
Duration depends on the cells
Silencing is diluted by cell division, so it lasts longer in cells that divide slowly or not at all
Custom bulk ASO synthesis
Research and preclinical synthesis, from nanomoles to multiple grams, with a choice of modifications (2'-MOE, locked nucleic acid, 2'-F, 2'-OMe, PS, PO). Custom pricing for research and preclinical work.
Custom bulk synthesis
Nanomoles to multiple grams
A choice of modifications and purification tiers, for research and preclinical work.
Choosing between the products
The selection guide asks what the target is and where it has to work, then names the product for that pairing. The comparison table sets the three delivery classes side by side.
Self-delivering
Self-delivering antisense oligonucleotides (sdASO)
Antisense oligonucleotides that need no transfection reagent
AUMsilence
AUMsilence
sdASO Self-delivering antisense oligonucleotides for mRNA knockdown in cell lines and difficult-to-transfect primary cells, without a transfection reagent.
AUMantagomir
sdASO Self-delivering antisense oligonucleotides that bind a mature microRNA and inhibit it, in difficult-to-transfect cells.
AUMmimic
sdASO Self-delivering antisense oligonucleotides that supply a chosen mature microRNA: the replacement counterpart of AUMantagomir sdASO.
AUMlnc
sdASO Self-delivering antisense oligonucleotides for knockdown of long non-coding RNA, including nuclear-retained transcripts.
AUMsilence V+
sdASO Self-delivering antisense oligonucleotides for knockdown of viral RNA genomes and transcripts, in virology research and antiviral target discovery.
AUMblock
sdASO Steric-blocking self-delivering antisense oligonucleotides that bind target RNAs and modulate their function without recruiting RNase H.
AUMsplice
sdASO Self-delivering antisense oligonucleotides that bind pre-mRNA and redirect splicing, for exon skipping or inclusion.
Transfection-optimized
Transfection-optimized ASOs (toASO)
The same designs at a lower price
Transfection-optimized ASOs (toASO) are the same designs as AUMsilence
AUMsilence
toASO Antisense oligonucleotides designed by the AUMsilence platform, at a lower price, delivered with a standard transfection reagent. Used for high-throughput screening, routine gene silencing in standard cell lines, and academic research where budget constraints exist.
Enhanced siRNA
Enhanced siRNA technology
The proven RNAi pathway, with chemically modified duplexes
AUMsiRNA is chemically enhanced small interfering RNA, for researchers who prefer the familiar RNAi pathway for gene silencing. The duplexes are 21-23 nucleotides and carry chemical modifications that the AUMsilence platform both selects and positions along the sequence, and they keep compatibility with the standard transfection protocols already used in the lab.
AUMsiRNA
Chemically enhanced small interfering RNA for mRNA knockdown through the RISC pathway.
AUMsiRNA Pool
Several siRNAs against different regions of the same mRNA, because which sequence works in a given cell type is not predictable in advance.
Custom siRNA
siRNA for targets the order page does not cover, including genes that are difficult to silence. A scientist takes the request directly.
Ordering by target or by sequence
Either door leads to the same order page, with the price ladder for every yield and purification.
For research use only. Not for use in diagnostic or therapeutic procedures.