Applications
Applications by research stage, cell type and RNA class
Self-delivering antisense oligonucleotides silence a target in cells that resist transfection, in 3D models and in vivo, with no transfection reagent. Each entry leads to the guide or the product page written for it.
By research stage
Three stages, one platform
The same designed sequence serves a gene function study, a target validation and a patient-derived model; what changes is the cell, the read-out and the scale.
- 01
Basic fundamental research
Start from a gene symbol. The reference pages carry the transcript, its isoforms and where it is expressed, and the design reads the same record.
- Gene function studies
- Pathway dissection
- RNA biology discovery
- Mechanism of action
- 02
Translational research
Knock the target down in primary cells and in vivo without a carrier, with the controls and read-outs each cell type guide names.
- Target validation
- Biomarker discovery
- Disease modeling
- Preclinical studies
- 03
Preclinical research
Test candidates in patient-derived models, with the material the program needs, from the catalog to bulk synthesis.
- Candidate development
- Patient-derived models
- Preclinical candidate testing
- Scale-up for preclinical work
By cell type
A guide for the cells you work with
Each guide covers what makes the cell type difficult, how self-delivering antisense oligonucleotides are used in it, and the controls and read-outs the experiment needs.
- T cells RNA silencing guideMaster RNA silencing in T cells
- Regulatory T cells (Tregs) RNA silencing guideMaster RNA silencing in regulatory T cells
- TILs RNA silencing guideTransfection-free gene silencing in TIL research
- Dendritic cells RNA silencing guideMaster RNA silencing in dendritic cells
- Macrophages RNA silencing guideMaster RNA silencing in macrophages
- iPSCs RNA silencing guideMaster RNA silencing in iPSCs
- Hepatocytes RNA silencing guideMaster RNA silencing in hepatocytes
- Endothelial cells RNA silencing guideMaster RNA silencing in endothelial cells
- Hematopoietic stem cells RNA silencing guideMaster HSC gene silencing
- B cells RNA silencing guideMaster RNA silencing in B cells
- CAR-T cells RNA silencing guideMaster RNA silencing in CAR-T cells
- Cardiomyocytes RNA silencing guideMaster RNA silencing in cardiomyocytes
- NK cells and CAR-NK cells RNA silencing guideMaster RNA silencing in NK and CAR-NK cells
- Primary neurons RNA silencing guideMaster RNA silencing in primary neurons
- Mesenchymal stem cells RNA silencing guideMaster RNA silencing in MSCs
By model system
From cell culture to in vivo studies
Compatible cell types
Cell lines, primary cells, immune cells, stem cells and neurons, with the in vitro workflow.
3D models, organoids and cancer cell types
Spheroids, organoids and the cancer lines the compatibility page lists.
In vivo delivery
The administration routes and sites, with no carrier required.
By RNA class