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Pathway Human Homo sapiens

Late Phase of HIV Life Cycle

R-HSA-162599 in Reactome release 97: under HIV Life Cycle, with 146 genes placed in it by the mapping files and 4 child pathways in the hierarchy.

The same number in the other species

Reactome writes the mouse and rat events it infers from a human pathway under the human number with the species token. A door opens only where that species' own list in this release holds the id; neither of the other two lists holds it. Whether the event was inferred from this one is what the record says.

01The record

Reactome's own record of this pathway

What this tells you

The pathway list, the hierarchy and the genes on this page are read from the files Reactome publishes for Reactome release 97, built into this site on 2026-09-09: the pathway list, the hierarchy relationship file and the two gene mapping files. The record card is the one live read, Reactome's own record of this pathway.

Reactome's download page describes the mapping files: Mapping files link the source database identifier to the lowest level pathway diagram or subset of the pathway, all levels of the pathway hierarchy or database identifier to all reactions. [R13] The gene list here is the all-levels mapping of NCBI Gene ids, filled from the all-levels mapping of Ensembl ids where the NCBI file has no row for a gene; each row names which file it came from by the shape of its source id. Each row carries the evidence codes the file writes for it, as written and unranked, and both where the file writes both; no page of Reactome's documentation the survey read defines the codes, so this page does not expand them. A gene id the identity files do not name is kept as the source's own id with no door rather than turned into a symbol.

On citing what a search finds, Reactome says: It should be remembered that while we strive to contain the most current and accurate data, Reactome should not be used in citations where other primary sources of information are available. [R12] The record card prints the literature Reactome attaches to a curated pathway for that reason. The data are public domain: All data in the Reactome database and files derived from that data are licensed under the Creative Commons Public Domain Dedication (CC0). User may copy, modify, and distribute these data, even for commercial purposes, without asking for permission. Attribution is encouraged but not required. [R10] The pathway illustrations are licensed apart, under CC BY 4.0, and none is shown here.

A gene on this list is one Reactome places in this pathway in this release, and that is all the row says: it does not say the gene is expressed in a tissue or associated with a disease, which are the other two explorers' questions, read from other sources. Reactome's papers of record are [R01] [R02].

  1. [R01] Ragueneau E, Gong C, Sinquin P, Sevilla C, Beavers D, Grentner A, et al. (2026). The Reactome Knowledgebase 2026. Nucleic Acids Research 54:D673-D681. PMID 41251150, doi 10.1093/nar/gkaf1223.
  2. [R02] Milacic M, Beavers D, Conley P, Gong C, Gillespie M, Griss J, et al. (2024). The Reactome Pathway Knowledgebase 2024. Nucleic Acids Research 52:D672-D678. PMID 37941124, doi 10.1093/nar/gkad1025.
  3. [R10] Reactome, reactome.org. License Agreement. https://reactome.org/license, read 2026-09-09.
  4. [R12] Reactome, reactome.org. Citing us. https://reactome.org/cite, read 2026-09-09.
  5. [R13] Reactome, reactome.org. Download. https://reactome.org/download-data, read 2026-09-09.
Reading this pathway's record from Reactome (the pathway record).Still reading. A first read of a pathway can take a while; this page waits up to 35 seconds for it, and its scripts then bring in the panel, or a line saying what did not arrive.

02The genes

Genes Reactome places in this human pathway

The mapping files place 146 genes in this human pathway; showing 101 to 146, in pages of 100, sorted by symbol for reading. The order carries no ranking. 8 of the rows shown carry an id the identity file does not name, kept as the source wrote it.

Genes Reactome places in this human pathway, page 2 of 2
GeneSUPT16HAuthorityHGNC:11465Mapping file id11198 NCBI fileEvidenceIEA
GeneSUPT4H1AuthorityHGNC:11467Mapping file id6827 NCBI fileEvidenceIEA, TAS
GeneSUPT5HAuthorityHGNC:11469Mapping file id6829 NCBI fileEvidenceIEA, TAS
GeneTAF1AuthorityHGNC:11535Mapping file id6872 NCBI fileEvidenceIEA
GeneTAF10AuthorityHGNC:11543Mapping file id6881 NCBI fileEvidenceIEA
GeneTAF11AuthorityHGNC:11544Mapping file id6882 NCBI fileEvidenceIEA
GeneTAF12AuthorityHGNC:11545Mapping file id6883 NCBI fileEvidenceIEA
GeneTAF13AuthorityHGNC:11546Mapping file id6884 NCBI fileEvidenceIEA
GeneTAF15AuthorityHGNC:11547Mapping file id8148 NCBI fileEvidenceIEA
GeneTAF1LAuthorityHGNC:18056Mapping file id138474 NCBI fileEvidenceIEA
GeneTAF2AuthorityHGNC:11536Mapping file id6873 NCBI fileEvidenceIEA
GeneTAF3AuthorityHGNC:17303Mapping file id83860 NCBI fileEvidenceIEA
GeneTAF4AuthorityHGNC:11537Mapping file id6874 NCBI fileEvidenceIEA
GeneTAF4BAuthorityHGNC:11538Mapping file id6875 NCBI fileEvidenceIEA
GeneTAF5AuthorityHGNC:11539Mapping file id6877 NCBI fileEvidenceIEA
GeneTAF6AuthorityHGNC:11540Mapping file id6878 NCBI fileEvidenceIEA
GeneTAF7AuthorityHGNC:11541Mapping file id6879 NCBI fileEvidenceIEA
GeneTAF7LAuthorityHGNC:11548Mapping file id54457 NCBI fileEvidenceIEA
GeneTAF8AuthorityHGNC:17300Mapping file id129685 NCBI fileEvidenceIEA
GeneTAF9AuthorityHGNC:11542Mapping file id6880 NCBI fileEvidenceIEA
GeneTAF9BAuthorityHGNC:17306Mapping file id51616 NCBI fileEvidenceIEA
GeneTBPAuthorityHGNC:11588Mapping file id6908 NCBI fileEvidenceIEA
GeneTCEA1AuthorityHGNC:11612Mapping file id6917 NCBI fileEvidenceIEA
GeneTPRAuthorityHGNC:12017Mapping file id7175 NCBI fileEvidenceTAS
GeneTSG101AuthorityHGNC:15971Mapping file id7251 NCBI fileEvidenceTAS
GeneUBA52AuthorityHGNC:12458Mapping file id7311 NCBI fileEvidenceTAS
GeneUBAP1AuthorityHGNC:12461Mapping file id51271 NCBI fileEvidenceTAS
GeneUBBAuthorityHGNC:12463Mapping file id7314 NCBI fileEvidenceTAS
GeneUBCAuthorityHGNC:12468Mapping file id7316 NCBI fileEvidenceTAS
GeneVPS28AuthorityHGNC:18178Mapping file id51160 NCBI fileEvidenceTAS
GeneVPS37AAuthorityHGNC:24928Mapping file id137492 NCBI fileEvidenceTAS
GeneVPS37BAuthorityHGNC:25754Mapping file id79720 NCBI fileEvidenceTAS
GeneVPS37CAuthorityHGNC:26097Mapping file id55048 NCBI fileEvidenceTAS
GeneVPS37DAuthorityHGNC:18287Mapping file id155382 NCBI fileEvidenceTAS
GeneVPS4AAuthorityHGNC:13488Mapping file id27183 NCBI fileEvidenceTAS
GeneVPS4BAuthorityHGNC:10895Mapping file id9525 NCBI fileEvidenceTAS
GeneVTA1AuthorityHGNC:20954Mapping file id51534 NCBI fileEvidenceTAS
GeneXPO1AuthorityHGNC:12825Mapping file id7514 NCBI fileEvidenceTAS
Geneno symbol in the identity fileAuthoritynoneMapping file id155030 NCBI fileEvidenceTAS
Geneno symbol in the identity fileAuthoritynoneMapping file id155348 NCBI fileEvidenceTAS
Geneno symbol in the identity fileAuthoritynoneMapping file id155459 NCBI fileEvidenceTAS
Geneno symbol in the identity fileAuthoritynoneMapping file id155871 NCBI fileEvidenceIEA, TAS
Geneno symbol in the identity fileAuthoritynoneMapping file id155908 NCBI fileEvidenceTAS
Geneno symbol in the identity fileAuthoritynoneMapping file id155945 NCBI fileEvidenceTAS
Geneno symbol in the identity fileAuthoritynoneMapping file id155971 NCBI fileEvidenceTAS
Geneno symbol in the identity fileAuthoritynoneMapping file id156110 NCBI fileEvidenceTAS

Evidence codes on this page: IEA, TAS, as the mapping file writes them; a row carrying two was written twice by the file, once under each. The mapping file id says which file placed the gene: an NCBI Gene id from NCBI2Reactome_All_Levels.txt, an Ensembl gene id from Ensembl2Reactome_All_Levels.txt. The two files can disagree about a code, so a row's codes are the one file's view. Measured by this site's build over this release on 2026-09-09: of the 138,908 human pathway-gene pairs both files place, 207 (0.149 per cent, over 47 genes) carry TAS in the Ensembl file where the NCBI rows carry IEA alone.

  • Reactome mapping files, the human rows for this pathway · Reactome release 97 · read · Reactome downloads"NCBI2Reactome_All_Levels.txt" and "Ensembl2Reactome_All_Levels.txt", Reactome, release 97, https://reactome.org/download-data/ (date of access 2026-09-09). Data CC0; attribution encouraged.

03The hierarchy

Parents and children in this release's hierarchy

Reactome's hierarchy is a graph rather than a tree: a pathway can sit under more than one parent, and the gene counts are each pathway's own placements at every level under it, so a parent's count is not the sum of its children's.

  • Reactome, the human pathway list and hierarchy relationship file · Reactome release 97 · read · Reactome downloads"ReactomePathways.txt" and "ReactomePathwaysRelation.txt", Reactome, release 97, https://reactome.org/download-data/ (date of access 2026-09-09). Data CC0; attribution encouraged.