Pathway Human Homo sapiens

Vitamin B5 (pantothenate) metabolism

R-HSA-199220 in Reactome release 97: under Metabolism of water-soluble vitamins and cofactors, with 20 genes placed in it by the mapping files and 1 child pathway in the hierarchy.

The same number in the other species

Reactome writes the mouse and rat events it infers from a human pathway under the human number with the species token. A door opens only where that species' own list in this release holds the id: R-MMU-199220 (mouse), R-RNO-199220 (rat). Whether the event was inferred from this one is what the record says.

The record
The genes
Parents and children

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This page reads the pathway's record from its source while you read the rest; with scripts off the card stays at its loading line. Reload with scripts on to see it, or open the source's own page from the link in the card.

01The record

Reactome's own record of this pathway

What this tells you

The pathway list, the hierarchy and the genes on this page are read from the files Reactome publishes for Reactome release 97, built into this site on 2026-09-09: the pathway list, the hierarchy relationship file and the two gene mapping files. The record card is the one live read, Reactome's own record of this pathway.

Reactome's download page describes the mapping files: Mapping files link the source database identifier to the lowest level pathway diagram or subset of the pathway, all levels of the pathway hierarchy or database identifier to all reactions. [R13] The gene list here is the all-levels mapping of NCBI Gene ids, filled from the all-levels mapping of Ensembl ids where the NCBI file has no row for a gene; each row names which file it came from by the shape of its source id. Each row carries the evidence codes the file writes for it, as written and unranked, and both where the file writes both; no page of Reactome's documentation the survey read defines the codes, so this page does not expand them. A gene id the identity files do not name is kept as the source's own id with no door rather than turned into a symbol.

On citing what a search finds, Reactome says: It should be remembered that while we strive to contain the most current and accurate data, Reactome should not be used in citations where other primary sources of information are available. [R12] The record card prints the literature Reactome attaches to a curated pathway for that reason. The data are public domain: All data in the Reactome database and files derived from that data are licensed under the Creative Commons Public Domain Dedication (CC0). User may copy, modify, and distribute these data, even for commercial purposes, without asking for permission. Attribution is encouraged but not required. [R10] The pathway illustrations are licensed apart, under CC BY 4.0, and none is shown here.

A gene on this list is one Reactome places in this pathway in this release, and that is all the row says: it does not say the gene is expressed in a tissue or associated with a disease, which are the other two explorers' questions, read from other sources. Reactome's papers of record are [R01] [R02].

[R01] Ragueneau E, Gong C, Sinquin P, Sevilla C, Beavers D, Grentner A, et al. (2026). The Reactome Knowledgebase 2026. Nucleic Acids Research 54:D673-D681. PMID 41251150, doi 10.1093/nar/gkaf1223.
[R02] Milacic M, Beavers D, Conley P, Gong C, Gillespie M, Griss J, et al. (2024). The Reactome Pathway Knowledgebase 2024. Nucleic Acids Research 52:D672-D678. PMID 37941124, doi 10.1093/nar/gkad1025.
[R10] Reactome, reactome.org. License Agreement. https://reactome.org/license, read 2026-09-09.
[R12] Reactome, reactome.org. Citing us. https://reactome.org/cite, read 2026-09-09.
[R13] Reactome, reactome.org. Download. https://reactome.org/download-data, read 2026-09-09.

Stable id: R-HSA-199220.5
Class: Pathway
Species: Homo sapiens (human)
Inferred: no: a curated human pathway
Disease pathway: no
Released: 2007-08-21
Last updated: 2023-09-13
Events inside: 10, counted from the record

Vitamin B5 ((R)-pantothenate, PanK), is an essential precursor for the synthesis of the metabolic cofactor Coenzyme A (CoA-SH) (Robishaw and Neely 1985) and is the prosthetic group of acyl carrier protein (ACP) (Joshi et al. 2003). The name pantothenate is from the Greek “pantothen”, "from everywhere". Both pantothenate and CoA-SH are found in nearly every foodstuff and in the gut microbiome. CoA-SH itself is readily degraded in the gut and in extracellular fluids within the body. No processes are known to transport it across plasma membranes. Instead, individual cells take up PanK, which is stable in the extracellular environment, to synthesize CoA-SH for their own use. Within a cell, distinct groups of CoA-SH-requiring reactions occur in the cytosol, mitochondrial matrix, and peroxisomes, and controlling CoA pool size in each location plays a major role in regulating and integrating cellular metabolic processes. Control is achieved by selective degradation, synthesis, and transport of CoA within a cell (Cavestro et al. 2023, Naquet et al. 2020). The reactions annotated here provide an incomplete description of these processes, as key steps remain incompletely understood.

Literature Reactome attaches

Cloning, expression, and characterization of a human 4'-phosphopantetheinyl transferase with broad substrate specificityJ Biol Chem, 2003, vol. 278, p. 33142-9PubMed 12815048
Coenzyme A metabolismAm J Physiol, 1985, vol. 248, p. E1-9PubMed 2981478

Reactome's record lists 14 orthologous events, R-RNO-199220 (Rattus norvegicus), R-MMU-199220 (Mus musculus) among the species this site serves, and 12 in species this site opens no page for.

Reactome ContentService, this pathway's record · Reactome v97 · read 2026-09-30 ET · Reactome pathway browser"Vitamin B5 (pantothenate) metabolism". Reactome, release 97, https://reactome.org/PathwayBrowser/#/R-HSA-199220 with StableID: R-HSA-199220.5 (accessed 2026-09-30 ET). Reactome version 97 (CC0).

Reading this pathway's record from Reactome (the pathway record).Still reading. A first read of a pathway can take a while; this page waits up to 35 seconds for it, and its scripts then bring in the panel, or a line saying what did not arrive.

02The genes

Genes Reactome places in this human pathway

The mapping files place 20 genes in this human pathway; showing 1 to 20, in pages of 100, sorted by symbol for reading. The order carries no ranking.

Genes Reactome places in this human pathway, page 1 of 1
Gene	Authority id	Mapping file id	Evidence codes
GeneAASDHPPT	AuthorityHGNC:14235	Mapping file id60496 NCBI file	EvidenceTAS
GeneCOASY	AuthorityHGNC:29932	Mapping file id80347 NCBI file	EvidenceTAS
GeneDCAKD	AuthorityHGNC:26238	Mapping file id79877 NCBI file	EvidenceTAS
GeneENPP1	AuthorityHGNC:3356	Mapping file id5167 NCBI file	EvidenceTAS
GeneENPP2	AuthorityHGNC:3357	Mapping file id5168 NCBI file	EvidenceTAS
GeneENPP3	AuthorityHGNC:3358	Mapping file id5169 NCBI file	EvidenceTAS
GeneFASN	AuthorityHGNC:3594	Mapping file id2194 NCBI file	EvidenceTAS
GeneNUDT8	AuthorityHGNC:8055	Mapping file id254552 NCBI file	EvidenceIEA
GenePANK1	AuthorityHGNC:8598	Mapping file id53354 NCBI file	EvidenceTAS
GenePANK2	AuthorityHGNC:15894	Mapping file id80025 NCBI file	EvidenceTAS
GenePANK3	AuthorityHGNC:19365	Mapping file id79646 NCBI file	EvidenceTAS
GenePANK4	AuthorityHGNC:19366	Mapping file id55229 NCBI file	EvidenceTAS
GenePDZD11	AuthorityHGNC:28034	Mapping file id51248 NCBI file	EvidenceTAS
GenePPCDC	AuthorityHGNC:28107	Mapping file id60490 NCBI file	EvidenceTAS
GenePPCS	AuthorityHGNC:25686	Mapping file id79717 NCBI file	EvidenceTAS
GeneSLC25A16	AuthorityHGNC:10986	Mapping file id8034 NCBI file	EvidenceTAS
GeneSLC25A42	AuthorityHGNC:28380	Mapping file id284439 NCBI file	EvidenceTAS
GeneSLC5A6	AuthorityHGNC:11041	Mapping file id8884 NCBI file	EvidenceTAS
GeneVNN1	AuthorityHGNC:12705	Mapping file id8876 NCBI file	EvidenceTAS
GeneVNN2	AuthorityHGNC:12706	Mapping file id8875 NCBI file	EvidenceTAS

Evidence codes on this page: IEA, TAS, as the mapping file writes them; a row carrying two was written twice by the file, once under each. The mapping file id says which file placed the gene: an NCBI Gene id from NCBI2Reactome_All_Levels.txt, an Ensembl gene id from Ensembl2Reactome_All_Levels.txt. The two files can disagree about a code, so a row's codes are the one file's view. Measured by this site's build over this release on 2026-09-09: of the 138,908 human pathway-gene pairs both files place, 207 (0.149 per cent, over 47 genes) carry TAS in the Ensembl file where the NCBI rows carry IEA alone.

Reactome mapping files, the human rows for this pathway · Reactome release 97 · read 2026-09-09 · Reactome downloads"NCBI2Reactome_All_Levels.txt" and "Ensembl2Reactome_All_Levels.txt", Reactome, release 97, https://reactome.org/download-data/ (date of access 2026-09-09). Data CC0; attribution encouraged.

03The hierarchy

Parents and children in this release's hierarchy

Parents

Metabolism of water-soluble vitamins and cofactorsR-HSA-196849125 genes

Children

Coenzyme A biosynthesisR-HSA-1967837 genes

Reactome's hierarchy is a graph rather than a tree: a pathway can sit under more than one parent, and the gene counts are each pathway's own placements at every level under it, so a parent's count is not the sum of its children's.

Reactome, the human pathway list and hierarchy relationship file · Reactome release 97 · read 2026-09-09 · Reactome downloads"ReactomePathways.txt" and "ReactomePathwaysRelation.txt", Reactome, release 97, https://reactome.org/download-data/ (date of access 2026-09-09). Data CC0; attribution encouraged.