Pathway Human Homo sapiens

TRP channels

R-HSA-3295583 in Reactome release 97: under Stimuli-sensing channels, with 28 genes placed in it by the mapping files and 0 child pathways in the hierarchy.

The same number in the other species

Reactome writes the mouse and rat events it infers from a human pathway under the human number with the species token. A door opens only where that species' own list in this release holds the id: R-MMU-3295583 (mouse), R-RNO-3295583 (rat). Whether the event was inferred from this one is what the record says.

The record
The genes
Parents and children

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This page reads the pathway's record from its source while you read the rest; with scripts off the card stays at its loading line. Reload with scripts on to see it, or open the source's own page from the link in the card.

01The record

Reactome's own record of this pathway

What this tells you

The pathway list, the hierarchy and the genes on this page are read from the files Reactome publishes for Reactome release 97, built into this site on 2026-09-09: the pathway list, the hierarchy relationship file and the two gene mapping files. The record card is the one live read, Reactome's own record of this pathway.

Reactome's download page describes the mapping files: Mapping files link the source database identifier to the lowest level pathway diagram or subset of the pathway, all levels of the pathway hierarchy or database identifier to all reactions. [R13] The gene list here is the all-levels mapping of NCBI Gene ids, filled from the all-levels mapping of Ensembl ids where the NCBI file has no row for a gene; each row names which file it came from by the shape of its source id. Each row carries the evidence codes the file writes for it, as written and unranked, and both where the file writes both; no page of Reactome's documentation the survey read defines the codes, so this page does not expand them. A gene id the identity files do not name is kept as the source's own id with no door rather than turned into a symbol.

On citing what a search finds, Reactome says: It should be remembered that while we strive to contain the most current and accurate data, Reactome should not be used in citations where other primary sources of information are available. [R12] The record card prints the literature Reactome attaches to a curated pathway for that reason. The data are public domain: All data in the Reactome database and files derived from that data are licensed under the Creative Commons Public Domain Dedication (CC0). User may copy, modify, and distribute these data, even for commercial purposes, without asking for permission. Attribution is encouraged but not required. [R10] The pathway illustrations are licensed apart, under CC BY 4.0, and none is shown here.

A gene on this list is one Reactome places in this pathway in this release, and that is all the row says: it does not say the gene is expressed in a tissue or associated with a disease, which are the other two explorers' questions, read from other sources. Reactome's papers of record are [R01] [R02].

[R01] Ragueneau E, Gong C, Sinquin P, Sevilla C, Beavers D, Grentner A, et al. (2026). The Reactome Knowledgebase 2026. Nucleic Acids Research 54:D673-D681. PMID 41251150, doi 10.1093/nar/gkaf1223.
[R02] Milacic M, Beavers D, Conley P, Gong C, Gillespie M, Griss J, et al. (2024). The Reactome Pathway Knowledgebase 2024. Nucleic Acids Research 52:D672-D678. PMID 37941124, doi 10.1093/nar/gkad1025.
[R10] Reactome, reactome.org. License Agreement. https://reactome.org/license, read 2026-09-09.
[R12] Reactome, reactome.org. Citing us. https://reactome.org/cite, read 2026-09-09.
[R13] Reactome, reactome.org. Download. https://reactome.org/download-data, read 2026-09-09.

Stable id: R-HSA-3295583.4
Class: Pathway
Species: Homo sapiens (human)
Inferred: no: a curated human pathway
Disease pathway: no
Released: 2013-09-18
Last updated: 2022-06-09
Events inside: 7, counted from the record

Transient receptor potential (TRP) channel proteins were first discovered in Drosophila melanogaster and have many homologues in other species including humans. TRPs form cationic channels that can detect sensory stimuli such as temperature, pH or oxidative stress and transduce that into either electrical (change in membrane potential) or chemical signals (change in intracellular Ca2+ concentration). In humans, there are 28 TRP genes arranged into 6 subfamilies; TRPA, TRPC, TRPM, TRPML, TRPP, and TRPV (Wu et al. 2010). Each TRP channel subunit consists of six putative transmembrane-spanning segments (S1-S6) with a pore-forming loop between S5 and S6. These subunits assemble into tetramers to form functional channels. All functionally characterized TRP channels are permeable to Ca2+ except TRMP4 and 5 which are only permeable to monovalent cations such as Na+ (Latorre et al. 2009). Most TRPs can cause channelopathies which are risk factors for many disease states (Nilius & Owsianik 2010).

Literature Reactome attaches

International Union of Basic and Clinical Pharmacology. LXXVI. Current progress in the mammalian TRP ion channel familyPharmacol. Rev., 2010, vol. 62, p. 381-404PubMed 20716668
Transient receptor proteins illuminated: current views on TRPs and diseaseVet. J., 2011, vol. 187, p. 153-64PubMed 20347603
Structure-functional intimacies of transient receptor potential channelsQ. Rev. Biophys., 2009, vol. 42, p. 201-46PubMed 20025796
Transient receptor potential channelopathiesPflugers Arch., 2010, vol. 460, p. 437-50PubMed 20127491

Reactome's record lists 12 orthologous events, R-RNO-3295583 (Rattus norvegicus), R-MMU-3295583 (Mus musculus) among the species this site serves, and 10 in species this site opens no page for.

Reactome ContentService, this pathway's record · Reactome v97 · read 2026-10-03 ET · Reactome pathway browser"TRP channels". Reactome, release 97, https://reactome.org/PathwayBrowser/#/R-HSA-3295583 with StableID: R-HSA-3295583.4 (accessed 2026-10-03 ET). Reactome version 97 (CC0).

Reading this pathway's record from Reactome (the pathway record).Still reading. A first read of a pathway can take a while; this page waits up to 35 seconds for it, and its scripts then bring in the panel, or a line saying what did not arrive.

02The genes

Genes Reactome places in this human pathway

The mapping files place 28 genes in this human pathway; showing 1 to 28, in pages of 100, sorted by symbol for reading. The order carries no ranking.

Genes Reactome places in this human pathway, page 1 of 1
Gene	Authority id	Mapping file id	Evidence codes
GeneMCOLN1	AuthorityHGNC:13356	Mapping file id57192 NCBI file	EvidenceTAS
GeneMCOLN2	AuthorityHGNC:13357	Mapping file id255231 NCBI file	EvidenceTAS
GeneMCOLN3	AuthorityHGNC:13358	Mapping file id55283 NCBI file	EvidenceTAS
GeneMLKL	AuthorityHGNC:26617	Mapping file id197259 NCBI file	EvidenceTAS
GeneRIPK1	AuthorityHGNC:10019	Mapping file id8737 NCBI file	EvidenceTAS
GeneRIPK3	AuthorityHGNC:10021	Mapping file id11035 NCBI file	EvidenceTAS
GeneTRPA1	AuthorityHGNC:497	Mapping file id8989 NCBI file	EvidenceTAS
GeneTRPC1	AuthorityHGNC:12333	Mapping file id7220 NCBI file	EvidenceTAS
GeneTRPC3	AuthorityHGNC:12335	Mapping file id7222 NCBI file	EvidenceTAS
GeneTRPC4	AuthorityHGNC:12336	Mapping file id7223 NCBI file	EvidenceTAS
GeneTRPC4AP	AuthorityHGNC:16181	Mapping file id26133 NCBI file	EvidenceTAS
GeneTRPC5	AuthorityHGNC:12337	Mapping file id7224 NCBI file	EvidenceTAS
GeneTRPC6	AuthorityHGNC:12338	Mapping file id7225 NCBI file	EvidenceTAS
GeneTRPC7	AuthorityHGNC:20754	Mapping file id57113 NCBI file	EvidenceTAS
GeneTRPM1	AuthorityHGNC:7146	Mapping file id4308 NCBI file	EvidenceTAS
GeneTRPM2	AuthorityHGNC:12339	Mapping file id7226 NCBI file	EvidenceTAS
GeneTRPM3	AuthorityHGNC:17992	Mapping file id80036 NCBI file	EvidenceTAS
GeneTRPM4	AuthorityHGNC:17993	Mapping file id54795 NCBI file	EvidenceTAS
GeneTRPM5	AuthorityHGNC:14323	Mapping file id29850 NCBI file	EvidenceTAS
GeneTRPM6	AuthorityHGNC:17995	Mapping file id140803 NCBI file	EvidenceTAS
GeneTRPM7	AuthorityHGNC:17994	Mapping file id54822 NCBI file	EvidenceTAS
GeneTRPM8	AuthorityHGNC:17961	Mapping file id79054 NCBI file	EvidenceTAS
GeneTRPV1	AuthorityHGNC:12716	Mapping file id7442 NCBI file	EvidenceTAS
GeneTRPV2	AuthorityHGNC:18082	Mapping file id51393 NCBI file	EvidenceTAS
GeneTRPV3	AuthorityHGNC:18084	Mapping file id162514 NCBI file	EvidenceTAS
GeneTRPV4	AuthorityHGNC:18083	Mapping file id59341 NCBI file	EvidenceTAS
GeneTRPV5	AuthorityHGNC:3145	Mapping file id56302 NCBI file	EvidenceTAS
GeneTRPV6	AuthorityHGNC:14006	Mapping file id55503 NCBI file	EvidenceTAS

Evidence codes on this page: TAS, as the mapping file writes them; a row carrying two was written twice by the file, once under each. The mapping file id says which file placed the gene: an NCBI Gene id from NCBI2Reactome_All_Levels.txt, an Ensembl gene id from Ensembl2Reactome_All_Levels.txt. The two files can disagree about a code, so a row's codes are the one file's view. Measured by this site's build over this release on 2026-09-09: of the 138,908 human pathway-gene pairs both files place, 207 (0.149 per cent, over 47 genes) carry TAS in the Ensembl file where the NCBI rows carry IEA alone.

Reactome mapping files, the human rows for this pathway · Reactome release 97 · read 2026-09-09 · Reactome downloads"NCBI2Reactome_All_Levels.txt" and "Ensembl2Reactome_All_Levels.txt", Reactome, release 97, https://reactome.org/download-data/ (date of access 2026-09-09). Data CC0; attribution encouraged.

03The hierarchy

Parents and children in this release's hierarchy

Parents

Stimuli-sensing channelsR-HSA-2672351108 genes

Children

None: no pathway of this release's list names this one as a parent.

Reactome's hierarchy is a graph rather than a tree: a pathway can sit under more than one parent, and the gene counts are each pathway's own placements at every level under it, so a parent's count is not the sum of its children's.

Reactome, the human pathway list and hierarchy relationship file · Reactome release 97 · read 2026-09-09 · Reactome downloads"ReactomePathways.txt" and "ReactomePathwaysRelation.txt", Reactome, release 97, https://reactome.org/download-data/ (date of access 2026-09-09). Data CC0; attribution encouraged.