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Pathway Human Homo sapiens

Post NMDA receptor activation events

R-HSA-438064 in Reactome release 97: under Activation of NMDA receptors and postsynaptic events, with 83 genes placed in it by the mapping files and 6 child pathways in the hierarchy.

The same number in the other species

Reactome writes the mouse and rat events it infers from a human pathway under the human number with the species token. A door opens only where that species' own list in this release holds the id: R-MMU-438064 (mouse), R-RNO-438064 (rat). Whether the event was inferred from this one is what the record says.

01The record

Reactome's own record of this pathway

What this tells you

The pathway list, the hierarchy and the genes on this page are read from the files Reactome publishes for Reactome release 97, built into this site on 2026-09-09: the pathway list, the hierarchy relationship file and the two gene mapping files. The record card is the one live read, Reactome's own record of this pathway.

Reactome's download page describes the mapping files: Mapping files link the source database identifier to the lowest level pathway diagram or subset of the pathway, all levels of the pathway hierarchy or database identifier to all reactions. [R13] The gene list here is the all-levels mapping of NCBI Gene ids, filled from the all-levels mapping of Ensembl ids where the NCBI file has no row for a gene; each row names which file it came from by the shape of its source id. Each row carries the evidence codes the file writes for it, as written and unranked, and both where the file writes both; no page of Reactome's documentation the survey read defines the codes, so this page does not expand them. A gene id the identity files do not name is kept as the source's own id with no door rather than turned into a symbol.

On citing what a search finds, Reactome says: It should be remembered that while we strive to contain the most current and accurate data, Reactome should not be used in citations where other primary sources of information are available. [R12] The record card prints the literature Reactome attaches to a curated pathway for that reason. The data are public domain: All data in the Reactome database and files derived from that data are licensed under the Creative Commons Public Domain Dedication (CC0). User may copy, modify, and distribute these data, even for commercial purposes, without asking for permission. Attribution is encouraged but not required. [R10] The pathway illustrations are licensed apart, under CC BY 4.0, and none is shown here.

A gene on this list is one Reactome places in this pathway in this release, and that is all the row says: it does not say the gene is expressed in a tissue or associated with a disease, which are the other two explorers' questions, read from other sources. Reactome's papers of record are [R01] [R02].

  1. [R01] Ragueneau E, Gong C, Sinquin P, Sevilla C, Beavers D, Grentner A, et al. (2026). The Reactome Knowledgebase 2026. Nucleic Acids Research 54:D673-D681. PMID 41251150, doi 10.1093/nar/gkaf1223.
  2. [R02] Milacic M, Beavers D, Conley P, Gong C, Gillespie M, Griss J, et al. (2024). The Reactome Pathway Knowledgebase 2024. Nucleic Acids Research 52:D672-D678. PMID 37941124, doi 10.1093/nar/gkad1025.
  3. [R10] Reactome, reactome.org. License Agreement. https://reactome.org/license, read 2026-09-09.
  4. [R12] Reactome, reactome.org. Citing us. https://reactome.org/cite, read 2026-09-09.
  5. [R13] Reactome, reactome.org. Download. https://reactome.org/download-data, read 2026-09-09.
Reading this pathway's record from Reactome (the pathway record).Still reading. A first read of a pathway can take a while; this page waits up to 35 seconds for it, and its scripts then bring in the panel, or a line saying what did not arrive.

02The genes

Genes Reactome places in this human pathway

The mapping files place 83 genes in this human pathway; showing 1 to 83, in pages of 100, sorted by symbol for reading. The order carries no ranking.

Genes Reactome places in this human pathway, page 1 of 1
GeneACTN2AuthorityHGNC:164Mapping file id88 NCBI fileEvidenceIEA
GeneADCY1AuthorityHGNC:232Mapping file id107 NCBI fileEvidenceIEA
GeneADCY8AuthorityHGNC:239Mapping file id114 NCBI fileEvidenceIEA
GeneARHGEF7AuthorityHGNC:15607Mapping file id8874 NCBI fileEvidenceIEA
GeneCALM1AuthorityHGNC:1442Mapping file id801 NCBI fileEvidenceIEA, TAS
GeneCALM2AuthorityHGNC:1445Mapping file id805 NCBI fileEvidenceIEA, TAS
GeneCALM3AuthorityHGNC:1449Mapping file id808 NCBI fileEvidenceIEA, TAS
GeneCAMK1AuthorityHGNC:1459Mapping file id8536 NCBI fileEvidenceIEA, TAS
GeneCAMK2AAuthorityHGNC:1460Mapping file id815 NCBI fileEvidenceIEA
GeneCAMK2BAuthorityHGNC:1461Mapping file id816 NCBI fileEvidenceIEA
GeneCAMK2DAuthorityHGNC:1462Mapping file id817 NCBI fileEvidenceIEA
GeneCAMK2GAuthorityHGNC:1463Mapping file id818 NCBI fileEvidenceIEA
GeneCAMK4AuthorityHGNC:1464Mapping file id814 NCBI fileEvidenceIEA, TAS
GeneCAMKK1AuthorityHGNC:1469Mapping file id84254 NCBI fileEvidenceIEA, TAS
GeneCAMKK2AuthorityHGNC:1470Mapping file id10645 NCBI fileEvidenceIEA, TAS
GeneCREB1AuthorityHGNC:2345Mapping file id1385 NCBI fileEvidenceIEA, TAS
GeneDLG1AuthorityHGNC:2900Mapping file id1739 NCBI fileEvidenceIEA
GeneDLG2AuthorityHGNC:2901Mapping file id1740 NCBI fileEvidenceIEA
GeneDLG3AuthorityHGNC:2902Mapping file id1741 NCBI fileEvidenceIEA
GeneDLG4AuthorityHGNC:2903Mapping file id1742 NCBI fileEvidenceIEA
GeneERBB4AuthorityHGNC:3432Mapping file id2066 NCBI fileEvidenceIEA
GeneGIT1AuthorityHGNC:4272Mapping file id28964 NCBI fileEvidenceIEA
GeneGRIA1AuthorityHGNC:4571Mapping file id2890 NCBI fileEvidenceIEA
GeneGRIA2AuthorityHGNC:4572Mapping file id2891 NCBI fileEvidenceIEA
GeneGRIN1AuthorityHGNC:4584Mapping file id2902 NCBI fileEvidenceIEA
GeneGRIN2AAuthorityHGNC:4585Mapping file id2903 NCBI fileEvidenceIEA
GeneGRIN2BAuthorityHGNC:4586Mapping file id2904 NCBI fileEvidenceIEA
GeneGRIN2CAuthorityHGNC:4587Mapping file id2905 NCBI fileEvidenceIEA
GeneGRIN2DAuthorityHGNC:4588Mapping file id2906 NCBI fileEvidenceIEA
GeneHRASAuthorityHGNC:5173Mapping file id3265 NCBI fileEvidenceIEA
GeneKPNA2AuthorityHGNC:6395Mapping file id3838 NCBI fileEvidenceIEA
GeneKRASAuthorityHGNC:6407Mapping file id3845 NCBI fileEvidenceIEA
GeneLRRC7AuthorityHGNC:18531Mapping file id57554 NCBI fileEvidenceIEA
GeneMAPK1AuthorityHGNC:6871Mapping file id5594 NCBI fileEvidenceIEA
GeneMAPK3AuthorityHGNC:6877Mapping file id5595 NCBI fileEvidenceIEA
GeneMAPTAuthorityHGNC:6893Mapping file id4137 NCBI fileEvidenceIEA
GeneNEFLAuthorityHGNC:7739Mapping file id4747 NCBI fileEvidenceIEA
GeneNRASAuthorityHGNC:7989Mapping file id4893 NCBI fileEvidenceIEA
GeneNRG1AuthorityHGNC:7997Mapping file id3084 NCBI fileEvidenceIEA
GeneNRGNAuthorityHGNC:8000Mapping file id4900 NCBI fileEvidenceIEA, TAS
GenePDPK1AuthorityHGNC:8816Mapping file id5170 NCBI fileEvidenceIEA
GenePRKAA1AuthorityHGNC:9376Mapping file id5562 NCBI fileEvidenceIEA
GenePRKAA2AuthorityHGNC:9377Mapping file id5563 NCBI fileEvidenceIEA
GenePRKAB1AuthorityHGNC:9378Mapping file id5564 NCBI fileEvidenceIEA
GenePRKAB2AuthorityHGNC:9379Mapping file id5565 NCBI fileEvidenceIEA
GenePRKACAAuthorityHGNC:9380Mapping file id5566 NCBI fileEvidenceIEA, TAS
GenePRKACBAuthorityHGNC:9381Mapping file id5567 NCBI fileEvidenceIEA, TAS
GenePRKACGAuthorityHGNC:9382Mapping file id5568 NCBI fileEvidenceIEA, TAS
GenePRKAG1AuthorityHGNC:9385Mapping file id5571 NCBI fileEvidenceIEA
GenePRKAG2AuthorityHGNC:9386Mapping file id51422 NCBI fileEvidenceIEA
GenePRKAG3AuthorityHGNC:9387Mapping file id53632 NCBI fileEvidenceIEA
GenePRKAR1AAuthorityHGNC:9388Mapping file id5573 NCBI fileEvidenceTAS
GenePRKAR1BAuthorityHGNC:9390Mapping file id5575 NCBI fileEvidenceTAS
GenePRKAR2AAuthorityHGNC:9391Mapping file id5576 NCBI fileEvidenceTAS
GenePRKAR2BAuthorityHGNC:9392Mapping file id5577 NCBI fileEvidenceTAS
GenePRKXAuthorityHGNC:9441Mapping file id5613 NCBI fileEvidenceIEA
GeneRAC1AuthorityHGNC:9801Mapping file id5879 NCBI fileEvidenceIEA
GeneRASGRF1AuthorityHGNC:9875Mapping file id5923 NCBI fileEvidenceIEA
GeneRASGRF2AuthorityHGNC:9876Mapping file id5924 NCBI fileEvidenceIEA
GeneRPS6KA1AuthorityHGNC:10430Mapping file id6195 NCBI fileEvidenceIEA, TAS
GeneRPS6KA2AuthorityHGNC:10431Mapping file id6196 NCBI fileEvidenceIEA, TAS
GeneRPS6KA3AuthorityHGNC:10432Mapping file id6197 NCBI fileEvidenceIEA, TAS
GeneRPS6KA6AuthorityHGNC:10435Mapping file id27330 NCBI fileEvidenceIEA, TAS
GeneSRCAuthorityHGNC:11283Mapping file id6714 NCBI fileEvidenceIEA
GeneTUBA1AAuthorityHGNC:20766Mapping file id7846 NCBI fileEvidenceIEA
GeneTUBA1BAuthorityHGNC:18809Mapping file id10376 NCBI fileEvidenceIEA
GeneTUBA1CAuthorityHGNC:20768Mapping file id84790 NCBI fileEvidenceIEA
GeneTUBA3CAuthorityHGNC:12408Mapping file id7278 NCBI fileEvidenceIEA
GeneTUBA3DAuthorityHGNC:24071Mapping file id113457 NCBI fileEvidenceIEA
GeneTUBA3EAuthorityHGNC:20765Mapping file id112714 NCBI fileEvidenceIEA
GeneTUBA4AAuthorityHGNC:12407Mapping file id7277 NCBI fileEvidenceIEA
GeneTUBA4BAuthorityHGNC:18637Mapping file id80086 NCBI fileEvidenceIEA
GeneTUBA8AuthorityHGNC:12410Mapping file id51807 NCBI fileEvidenceIEA
GeneTUBAL3AuthorityHGNC:23534Mapping file id79861 NCBI fileEvidenceIEA
GeneTUBB1AuthorityHGNC:16257Mapping file id81027 NCBI fileEvidenceIEA
GeneTUBB2AAuthorityHGNC:12412Mapping file id7280 NCBI fileEvidenceIEA
GeneTUBB2BAuthorityHGNC:30829Mapping file id347733 NCBI fileEvidenceIEA
GeneTUBB3AuthorityHGNC:20772Mapping file id10381 NCBI fileEvidenceIEA
GeneTUBB4AAuthorityHGNC:20774Mapping file id10382 NCBI fileEvidenceIEA
GeneTUBB4BAuthorityHGNC:20771Mapping file id10383 NCBI fileEvidenceIEA
GeneTUBB6AuthorityHGNC:20776Mapping file id84617 NCBI fileEvidenceIEA
GeneTUBB8AuthorityHGNC:20773Mapping file id347688 NCBI fileEvidenceIEA
GeneTUBB8BAuthorityHGNC:24983Mapping file id260334 NCBI fileEvidenceIEA

Evidence codes on this page: IEA, TAS, as the mapping file writes them; a row carrying two was written twice by the file, once under each. The mapping file id says which file placed the gene: an NCBI Gene id from NCBI2Reactome_All_Levels.txt, an Ensembl gene id from Ensembl2Reactome_All_Levels.txt. The two files can disagree about a code, so a row's codes are the one file's view. Measured by this site's build over this release on 2026-09-09: of the 138,908 human pathway-gene pairs both files place, 207 (0.149 per cent, over 47 genes) carry TAS in the Ensembl file where the NCBI rows carry IEA alone.

  • Reactome mapping files, the human rows for this pathway · Reactome release 97 · read · Reactome downloads"NCBI2Reactome_All_Levels.txt" and "Ensembl2Reactome_All_Levels.txt", Reactome, release 97, https://reactome.org/download-data/ (date of access 2026-09-09). Data CC0; attribution encouraged.

03The hierarchy

Parents and children in this release's hierarchy

Reactome's hierarchy is a graph rather than a tree: a pathway can sit under more than one parent, and the gene counts are each pathway's own placements at every level under it, so a parent's count is not the sum of its children's.

  • Reactome, the human pathway list and hierarchy relationship file · Reactome release 97 · read · Reactome downloads"ReactomePathways.txt" and "ReactomePathwaysRelation.txt", Reactome, release 97, https://reactome.org/download-data/ (date of access 2026-09-09). Data CC0; attribution encouraged.