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Pathway Human Homo sapiens

Mitotic G2-G2/M phases

R-HSA-453274 in Reactome release 97: under Cell Cycle, Mitotic, with 193 genes placed in it by the mapping files and 2 child pathways in the hierarchy.

The same number in the other species

Reactome writes the mouse and rat events it infers from a human pathway under the human number with the species token. A door opens only where that species' own list in this release holds the id: R-MMU-453274 (mouse), R-RNO-453274 (rat). Whether the event was inferred from this one is what the record says.

01The record

Reactome's own record of this pathway

What this tells you

The pathway list, the hierarchy and the genes on this page are read from the files Reactome publishes for Reactome release 97, built into this site on 2026-09-09: the pathway list, the hierarchy relationship file and the two gene mapping files. The record card is the one live read, Reactome's own record of this pathway.

Reactome's download page describes the mapping files: Mapping files link the source database identifier to the lowest level pathway diagram or subset of the pathway, all levels of the pathway hierarchy or database identifier to all reactions. [R13] The gene list here is the all-levels mapping of NCBI Gene ids, filled from the all-levels mapping of Ensembl ids where the NCBI file has no row for a gene; each row names which file it came from by the shape of its source id. Each row carries the evidence codes the file writes for it, as written and unranked, and both where the file writes both; no page of Reactome's documentation the survey read defines the codes, so this page does not expand them. A gene id the identity files do not name is kept as the source's own id with no door rather than turned into a symbol.

On citing what a search finds, Reactome says: It should be remembered that while we strive to contain the most current and accurate data, Reactome should not be used in citations where other primary sources of information are available. [R12] The record card prints the literature Reactome attaches to a curated pathway for that reason. The data are public domain: All data in the Reactome database and files derived from that data are licensed under the Creative Commons Public Domain Dedication (CC0). User may copy, modify, and distribute these data, even for commercial purposes, without asking for permission. Attribution is encouraged but not required. [R10] The pathway illustrations are licensed apart, under CC BY 4.0, and none is shown here.

A gene on this list is one Reactome places in this pathway in this release, and that is all the row says: it does not say the gene is expressed in a tissue or associated with a disease, which are the other two explorers' questions, read from other sources. Reactome's papers of record are [R01] [R02].

  1. [R01] Ragueneau E, Gong C, Sinquin P, Sevilla C, Beavers D, Grentner A, et al. (2026). The Reactome Knowledgebase 2026. Nucleic Acids Research 54:D673-D681. PMID 41251150, doi 10.1093/nar/gkaf1223.
  2. [R02] Milacic M, Beavers D, Conley P, Gong C, Gillespie M, Griss J, et al. (2024). The Reactome Pathway Knowledgebase 2024. Nucleic Acids Research 52:D672-D678. PMID 37941124, doi 10.1093/nar/gkad1025.
  3. [R10] Reactome, reactome.org. License Agreement. https://reactome.org/license, read 2026-09-09.
  4. [R12] Reactome, reactome.org. Citing us. https://reactome.org/cite, read 2026-09-09.
  5. [R13] Reactome, reactome.org. Download. https://reactome.org/download-data, read 2026-09-09.
Reading this pathway's record from Reactome (the pathway record).Still reading. A first read of a pathway can take a while; this page waits up to 35 seconds for it, and its scripts then bring in the panel, or a line saying what did not arrive.

02The genes

Genes Reactome places in this human pathway

The mapping files place 193 genes in this human pathway; showing 101 to 193, in pages of 100, sorted by symbol for reading. The order carries no ranking.

Genes Reactome places in this human pathway, page 2 of 2
GenePHLDA1AuthorityHGNC:8933Mapping file id22822 NCBI fileEvidenceTAS
GenePKMYT1AuthorityHGNC:29650Mapping file id9088 NCBI fileEvidenceTAS
GenePLK1AuthorityHGNC:9077Mapping file id5347 NCBI fileEvidenceTAS
GenePLK4AuthorityHGNC:11397Mapping file id10733 NCBI fileEvidenceTAS
GenePPME1AuthorityHGNC:30178Mapping file id51400 NCBI fileEvidenceTAS
GenePPP1CBAuthorityHGNC:9282Mapping file id5500 NCBI fileEvidenceTAS
GenePPP1R12AAuthorityHGNC:7618Mapping file id4659 NCBI fileEvidenceTAS
GenePPP1R12BAuthorityHGNC:7619Mapping file id4660 NCBI fileEvidenceTAS
GenePPP2CAAuthorityHGNC:9299Mapping file id5515 NCBI fileEvidenceTAS
GenePPP2CBAuthorityHGNC:9300Mapping file id5516 NCBI fileEvidenceTAS
GenePPP2R1AAuthorityHGNC:9302Mapping file id5518 NCBI fileEvidenceTAS
GenePPP2R1BAuthorityHGNC:9303Mapping file id5519 NCBI fileEvidenceTAS
GenePPP2R2AAuthorityHGNC:9304Mapping file id5520 NCBI fileEvidenceTAS
GenePPP2R3BAuthorityHGNC:13417Mapping file id28227 NCBI fileEvidenceTAS
GenePRKACAAuthorityHGNC:9380Mapping file id5566 NCBI fileEvidenceTAS
GenePRKAR2BAuthorityHGNC:9392Mapping file id5577 NCBI fileEvidenceTAS
GenePSMA1AuthorityHGNC:9530Mapping file id5682 NCBI fileEvidenceTAS
GenePSMA2AuthorityHGNC:9531Mapping file id5683 NCBI fileEvidenceTAS
GenePSMA3AuthorityHGNC:9532Mapping file id5684 NCBI fileEvidenceTAS
GenePSMA4AuthorityHGNC:9533Mapping file id5685 NCBI fileEvidenceTAS
GenePSMA5AuthorityHGNC:9534Mapping file id5686 NCBI fileEvidenceTAS
GenePSMA6AuthorityHGNC:9535Mapping file id5687 NCBI fileEvidenceTAS
GenePSMA7AuthorityHGNC:9536Mapping file id5688 NCBI fileEvidenceTAS
GenePSMB1AuthorityHGNC:9537Mapping file id5689 NCBI fileEvidenceTAS
GenePSMB2AuthorityHGNC:9539Mapping file id5690 NCBI fileEvidenceTAS
GenePSMB3AuthorityHGNC:9540Mapping file id5691 NCBI fileEvidenceTAS
GenePSMB4AuthorityHGNC:9541Mapping file id5692 NCBI fileEvidenceTAS
GenePSMB5AuthorityHGNC:9542Mapping file id5693 NCBI fileEvidenceTAS
GenePSMB6AuthorityHGNC:9543Mapping file id5694 NCBI fileEvidenceTAS
GenePSMB7AuthorityHGNC:9544Mapping file id5695 NCBI fileEvidenceTAS
GenePSMC1AuthorityHGNC:9547Mapping file id5700 NCBI fileEvidenceTAS
GenePSMC2AuthorityHGNC:9548Mapping file id5701 NCBI fileEvidenceTAS
GenePSMC3AuthorityHGNC:9549Mapping file id5702 NCBI fileEvidenceTAS
GenePSMC4AuthorityHGNC:9551Mapping file id5704 NCBI fileEvidenceTAS
GenePSMC5AuthorityHGNC:9552Mapping file id5705 NCBI fileEvidenceTAS
GenePSMC6AuthorityHGNC:9553Mapping file id5706 NCBI fileEvidenceTAS
GenePSMD1AuthorityHGNC:9554Mapping file id5707 NCBI fileEvidenceTAS
GenePSMD11AuthorityHGNC:9556Mapping file id5717 NCBI fileEvidenceTAS
GenePSMD12AuthorityHGNC:9557Mapping file id5718 NCBI fileEvidenceTAS
GenePSMD13AuthorityHGNC:9558Mapping file id5719 NCBI fileEvidenceTAS
GenePSMD14AuthorityHGNC:16889Mapping file id10213 NCBI fileEvidenceTAS
GenePSMD2AuthorityHGNC:9559Mapping file id5708 NCBI fileEvidenceTAS
GenePSMD3AuthorityHGNC:9560Mapping file id5709 NCBI fileEvidenceTAS
GenePSMD6AuthorityHGNC:9564Mapping file id9861 NCBI fileEvidenceTAS
GenePSMD7AuthorityHGNC:9565Mapping file id5713 NCBI fileEvidenceTAS
GenePSMD8AuthorityHGNC:9566Mapping file id5714 NCBI fileEvidenceTAS
GeneRAB8AAuthorityHGNC:7007Mapping file id4218 NCBI fileEvidenceTAS
GeneRBBP4AuthorityHGNC:9887Mapping file id5928 NCBI fileEvidenceTAS
GeneRBX1AuthorityHGNC:9928Mapping file id9978 NCBI fileEvidenceTAS
GeneRPS27AAuthorityHGNC:10417Mapping file id6233 NCBI fileEvidenceTAS
GeneSDCCAG8AuthorityHGNC:10671Mapping file id10806 NCBI fileEvidenceTAS
GeneSEM1AuthorityHGNC:10845Mapping file id7979 NCBI fileEvidenceTAS
GeneSFI1AuthorityHGNC:29064Mapping file id9814 NCBI fileEvidenceTAS
GeneSGO1AuthorityHGNC:25088Mapping file id151648 NCBI fileEvidenceTAS
GeneSKP1AuthorityHGNC:10899Mapping file id6500 NCBI fileEvidenceTAS
GeneSSNA1AuthorityHGNC:11321Mapping file id8636 NCBI fileEvidenceTAS
GeneTICRRAuthorityHGNC:28704Mapping file id90381 NCBI fileEvidenceTAS
GeneTP53AuthorityHGNC:11998Mapping file id7157 NCBI fileEvidenceTAS
GeneTPX2AuthorityHGNC:1249Mapping file id22974 NCBI fileEvidenceTAS
GeneTUBA1AAuthorityHGNC:20766Mapping file id7846 NCBI fileEvidenceTAS
GeneTUBA1BAuthorityHGNC:18809Mapping file id10376 NCBI fileEvidenceTAS
GeneTUBA1CAuthorityHGNC:20768Mapping file id84790 NCBI fileEvidenceTAS
GeneTUBA3CAuthorityHGNC:12408Mapping file id7278 NCBI fileEvidenceTAS
GeneTUBA3DAuthorityHGNC:24071Mapping file id113457 NCBI fileEvidenceTAS
GeneTUBA3EAuthorityHGNC:20765Mapping file id112714 NCBI fileEvidenceTAS
GeneTUBA4AAuthorityHGNC:12407Mapping file id7277 NCBI fileEvidenceTAS
GeneTUBA4BAuthorityHGNC:18637Mapping file id80086 NCBI fileEvidenceTAS
GeneTUBA8AuthorityHGNC:12410Mapping file id51807 NCBI fileEvidenceTAS
GeneTUBAL3AuthorityHGNC:23534Mapping file id79861 NCBI fileEvidenceTAS
GeneTUBBAuthorityHGNC:20778Mapping file id203068 NCBI fileEvidenceTAS
GeneTUBB1AuthorityHGNC:16257Mapping file id81027 NCBI fileEvidenceTAS
GeneTUBB2AAuthorityHGNC:12412Mapping file id7280 NCBI fileEvidenceTAS
GeneTUBB2BAuthorityHGNC:30829Mapping file id347733 NCBI fileEvidenceTAS
GeneTUBB3AuthorityHGNC:20772Mapping file id10381 NCBI fileEvidenceTAS
GeneTUBB4AAuthorityHGNC:20774Mapping file id10382 NCBI fileEvidenceTAS
GeneTUBB4BAuthorityHGNC:20771Mapping file id10383 NCBI fileEvidenceTAS
GeneTUBB6AuthorityHGNC:20776Mapping file id84617 NCBI fileEvidenceTAS
GeneTUBB8AuthorityHGNC:20773Mapping file id347688 NCBI fileEvidenceTAS
GeneTUBB8BAuthorityHGNC:24983Mapping file id260334 NCBI fileEvidenceTAS
GeneTUBG1AuthorityHGNC:12417Mapping file id7283 NCBI fileEvidenceTAS
GeneTUBG2AuthorityHGNC:12419Mapping file id27175 NCBI fileEvidenceTAS
GeneTUBGCP2AuthorityHGNC:18599Mapping file id10844 NCBI fileEvidenceTAS
GeneTUBGCP3AuthorityHGNC:18598Mapping file id10426 NCBI fileEvidenceTAS
GeneTUBGCP4AuthorityHGNC:16691Mapping file id27229 NCBI fileEvidenceTAS
GeneTUBGCP5AuthorityHGNC:18600Mapping file id114791 NCBI fileEvidenceTAS
GeneTUBGCP6AuthorityHGNC:18127Mapping file id85378 NCBI fileEvidenceTAS
GeneUBA52AuthorityHGNC:12458Mapping file id7311 NCBI fileEvidenceTAS
GeneUBBAuthorityHGNC:12463Mapping file id7314 NCBI fileEvidenceTAS
GeneUBCAuthorityHGNC:12468Mapping file id7316 NCBI fileEvidenceTAS
GeneWEE1AuthorityHGNC:12761Mapping file id7465 NCBI fileEvidenceTAS
GeneXPO1AuthorityHGNC:12825Mapping file id7514 NCBI fileEvidenceTAS
GeneYWHAEAuthorityHGNC:12851Mapping file id7531 NCBI fileEvidenceTAS
GeneYWHAGAuthorityHGNC:12852Mapping file id7532 NCBI fileEvidenceTAS

Evidence codes on this page: TAS, as the mapping file writes them; a row carrying two was written twice by the file, once under each. The mapping file id says which file placed the gene: an NCBI Gene id from NCBI2Reactome_All_Levels.txt, an Ensembl gene id from Ensembl2Reactome_All_Levels.txt. The two files can disagree about a code, so a row's codes are the one file's view. Measured by this site's build over this release on 2026-09-09: of the 138,908 human pathway-gene pairs both files place, 207 (0.149 per cent, over 47 genes) carry TAS in the Ensembl file where the NCBI rows carry IEA alone.

  • Reactome mapping files, the human rows for this pathway · Reactome release 97 · read · Reactome downloads"NCBI2Reactome_All_Levels.txt" and "Ensembl2Reactome_All_Levels.txt", Reactome, release 97, https://reactome.org/download-data/ (date of access 2026-09-09). Data CC0; attribution encouraged.

03The hierarchy

Parents and children in this release's hierarchy

Reactome's hierarchy is a graph rather than a tree: a pathway can sit under more than one parent, and the gene counts are each pathway's own placements at every level under it, so a parent's count is not the sum of its children's.

  • Reactome, the human pathway list and hierarchy relationship file · Reactome release 97 · read · Reactome downloads"ReactomePathways.txt" and "ReactomePathwaysRelation.txt", Reactome, release 97, https://reactome.org/download-data/ (date of access 2026-09-09). Data CC0; attribution encouraged.