Pathway Human Homo sapiens

RAB geranylgeranylation

R-HSA-8873719 in Reactome release 97: under Post-translational protein modification, with 65 genes placed in it by the mapping files and 0 child pathways in the hierarchy.

The same number in the other species

Reactome writes the mouse and rat events it infers from a human pathway under the human number with the species token. A door opens only where that species' own list in this release holds the id: R-MMU-8873719 (mouse), R-RNO-8873719 (rat). Whether the event was inferred from this one is what the record says.

The record
The genes
Parents and children

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This page reads the pathway's record from its source while you read the rest; with scripts off the card stays at its loading line. Reload with scripts on to see it, or open the source's own page from the link in the card.

01The record

Reactome's own record of this pathway

What this tells you

The pathway list, the hierarchy and the genes on this page are read from the files Reactome publishes for Reactome release 97, built into this site on 2026-09-09: the pathway list, the hierarchy relationship file and the two gene mapping files. The record card is the one live read, Reactome's own record of this pathway.

Reactome's download page describes the mapping files: Mapping files link the source database identifier to the lowest level pathway diagram or subset of the pathway, all levels of the pathway hierarchy or database identifier to all reactions. [R13] The gene list here is the all-levels mapping of NCBI Gene ids, filled from the all-levels mapping of Ensembl ids where the NCBI file has no row for a gene; each row names which file it came from by the shape of its source id. Each row carries the evidence codes the file writes for it, as written and unranked, and both where the file writes both; no page of Reactome's documentation the survey read defines the codes, so this page does not expand them. A gene id the identity files do not name is kept as the source's own id with no door rather than turned into a symbol.

On citing what a search finds, Reactome says: It should be remembered that while we strive to contain the most current and accurate data, Reactome should not be used in citations where other primary sources of information are available. [R12] The record card prints the literature Reactome attaches to a curated pathway for that reason. The data are public domain: All data in the Reactome database and files derived from that data are licensed under the Creative Commons Public Domain Dedication (CC0). User may copy, modify, and distribute these data, even for commercial purposes, without asking for permission. Attribution is encouraged but not required. [R10] The pathway illustrations are licensed apart, under CC BY 4.0, and none is shown here.

A gene on this list is one Reactome places in this pathway in this release, and that is all the row says: it does not say the gene is expressed in a tissue or associated with a disease, which are the other two explorers' questions, read from other sources. Reactome's papers of record are [R01] [R02].

[R01] Ragueneau E, Gong C, Sinquin P, Sevilla C, Beavers D, Grentner A, et al. (2026). The Reactome Knowledgebase 2026. Nucleic Acids Research 54:D673-D681. PMID 41251150, doi 10.1093/nar/gkaf1223.
[R02] Milacic M, Beavers D, Conley P, Gong C, Gillespie M, Griss J, et al. (2024). The Reactome Pathway Knowledgebase 2024. Nucleic Acids Research 52:D672-D678. PMID 37941124, doi 10.1093/nar/gkad1025.
[R10] Reactome, reactome.org. License Agreement. https://reactome.org/license, read 2026-09-09.
[R12] Reactome, reactome.org. Citing us. https://reactome.org/cite, read 2026-09-09.
[R13] Reactome, reactome.org. Download. https://reactome.org/download-data, read 2026-09-09.

Stable id: R-HSA-8873719.4
Class: Pathway
Species: Homo sapiens (human)
Inferred: no: a curated human pathway
Disease pathway: no
Released: 2016-12-12
Last updated: 2021-09-15
Events inside: 5, counted from the record

Human cells have more than 60 RAB proteins that are involved in trafficking of proteins in the endolysosomal system. These small GTPases contribute to trafficking specificity by localizing to the membranes of different endocytic compartments and interacting with effectors such as sorting adaptors, tethering factors, kinases, phosphatases and tubular-vesicular cargo (reviewed in Stenmark et al, 2009; Wandinger-Ness and Zerial, 2014). RAB localization depends on a number of factors including C-terminal prenylation, the sequence of an upstream hypervariable regions and what nucleotide is bound (Chavrier et al, 1991; Ullrich et al, 1993; Soldati et al, 1994; Farnsworth et al, 1994; Seabra, 1996; Wu et al, 2010; reviewed in Stenmark, 2009; Wandinger-Ness and Zerial, 2014). In the active, GTP-bound form, prenylated RAB proteins are membrane associated, while in the inactive GDP-bound form, RABs are extracted from the target membrane and exist in a soluble form in complex with GDP dissociation inhibitors (GDIs) (Ullrich et al, 1993; Soldati et al, 1994; Gavriljuk et al, 2103). Conversion between the inactive and active form relies on the activities of RAB guanine nucleotide exchange factors (GEFs) and GTPase activating proteins (GAPs) (Yoshimura et al, 2010; Wu et al, 2011; Pan et al, 2006; Frasa et al, 2012; reviewed in Stenmark, 2009; Wandinger-Ness and Zerial, 2014).

Newly synthesized RABs are bound by a RAB escort protein, CHM (also known as REP1) or CHML (REP2) (Alexandrov et al, 1994; Shen and Seabra, 1996). CHM/REP proteins are the substrate-binding component of the trimeric RAB geranylgeranyltransferase enzyme (GGTaseII) along with the two catalytic subunits RABGGTA and RABGGTB (reviewed in Gutkowska and Swiezewska, 2012; Palsuledesai and Distefano, 2015). REP proteins recruit the unmodified RAB in its GDP-bound state to the GGTase for sequential geranylgeranylation at one or two C-terminal cysteine residues (Alexandrov et al, 1994; Seabra et al 1996; Shen and Seabra, 1996; Baron and Seabra, 2008). After geranylgeranylation, CHM/REP proteins remain in complex with the geranylgeranylated RAB and escort it to its target membrane, where its activity is regulated by GAPs, GEFs, GDIs and membrane-bound GDI displacement factors (GDFs) (Sivars et al, 2003; reviewed in Stenmark, 2009; Wandinger-Ness and Zerial, 2014).

Literature Reactome attaches

Rab GTPases as coordinators of vesicle trafficNat. Rev. Mol. Cell Biol., 2009, vol. 10, p. 513-25PubMed 19603039
Rab proteins and the compartmentalization of the endosomal systemCold Spring Harb Perspect Biol, 2014, vol. 6, p. a022616PubMed 25341920
Hypervariable C-terminal domain of rab proteins acts as a targeting signalNature, 1991, vol. 353, p. 769-72PubMed 1944536
Rab GDP dissociation inhibitor as a general regulator for the membrane association of rab proteinsJ. Biol. Chem., 1993, vol. 268, p. 18143-50PubMed 8349690
Membrane targeting of the small GTPase Rab9 is accompanied by nucleotide exchangeNature, 1994, vol. 369, p. 76-8PubMed 8164745
Rab geranylgeranyl transferase catalyzes the geranylgeranylation of adjacent cysteines in the small GTPases Rab1A, Rab3A, and Rab5AProc. Natl. Acad. Sci. U.S.A., 1994, vol. 91, p. 11963-7PubMed 7991565
Nucleotide dependence of Rab geranylgeranylation. Rab escort protein interacts preferentially with GDP-bound RabJ. Biol. Chem., 1996, vol. 271, p. 14398-404

Reactome's record lists 12 orthologous events, R-RNO-8873719 (Rattus norvegicus), R-MMU-8873719 (Mus musculus) among the species this site serves, and 10 in species this site opens no page for.

Reactome ContentService, this pathway's record · Reactome v97 · read 2026-10-05 ET · Reactome pathway browser"RAB geranylgeranylation". Reactome, release 97, https://reactome.org/PathwayBrowser/#/R-HSA-8873719 with StableID: R-HSA-8873719.4 (accessed 2026-10-05 ET). Reactome version 97 (CC0).

Reading this pathway's record from Reactome (the pathway record).Still reading. A first read of a pathway can take a while; this page waits up to 35 seconds for it, and its scripts then bring in the panel, or a line saying what did not arrive.

02The genes

Genes Reactome places in this human pathway

The mapping files place 65 genes in this human pathway; showing 1 to 65, in pages of 100, sorted by symbol for reading. The order carries no ranking.

Genes Reactome places in this human pathway, page 1 of 1
Gene	Authority id	Mapping file id	Evidence codes
GeneCHM	AuthorityHGNC:1940	Mapping file id1121 NCBI file	EvidenceTAS
GeneCHML	AuthorityHGNC:1941	Mapping file id1122 NCBI file	EvidenceTAS
GenePTP4A2	AuthorityHGNC:9635	Mapping file id8073 NCBI file	EvidenceTAS
GeneRAB10	AuthorityHGNC:9759	Mapping file id10890 NCBI file	EvidenceTAS
GeneRAB11A	AuthorityHGNC:9760	Mapping file id8766 NCBI file	EvidenceTAS
GeneRAB11B	AuthorityHGNC:9761	Mapping file id9230 NCBI file	EvidenceTAS
GeneRAB12	AuthorityHGNC:31332	Mapping file id201475 NCBI file	EvidenceTAS
GeneRAB13	AuthorityHGNC:9762	Mapping file id5872 NCBI file	EvidenceTAS
GeneRAB14	AuthorityHGNC:16524	Mapping file id51552 NCBI file	EvidenceTAS
GeneRAB15	AuthorityHGNC:20150	Mapping file id376267 NCBI file	EvidenceTAS
GeneRAB17	AuthorityHGNC:16523	Mapping file id64284 NCBI file	EvidenceTAS
GeneRAB18	AuthorityHGNC:14244	Mapping file id22931 NCBI file	EvidenceTAS
GeneRAB19	AuthorityHGNC:19982	Mapping file id401409 NCBI file	EvidenceTAS
GeneRAB1A	AuthorityHGNC:9758	Mapping file id5861 NCBI file	EvidenceTAS
GeneRAB1B	AuthorityHGNC:18370	Mapping file id81876 NCBI file	EvidenceTAS
GeneRAB20	AuthorityHGNC:18260	Mapping file id55647 NCBI file	EvidenceTAS
GeneRAB21	AuthorityHGNC:18263	Mapping file id23011 NCBI file	EvidenceTAS
GeneRAB22A	AuthorityHGNC:9764	Mapping file id57403 NCBI file	EvidenceTAS
GeneRAB23	AuthorityHGNC:14263	Mapping file id51715 NCBI file	EvidenceTAS
GeneRAB24	AuthorityHGNC:9765	Mapping file id53917 NCBI file	EvidenceTAS
GeneRAB25	AuthorityHGNC:18238	Mapping file id57111 NCBI file	EvidenceTAS
GeneRAB26	AuthorityHGNC:14259	Mapping file id25837 NCBI file	EvidenceTAS
GeneRAB27A	AuthorityHGNC:9766	Mapping file id5873 NCBI file	EvidenceTAS
GeneRAB27B	AuthorityHGNC:9767	Mapping file id5874 NCBI file	EvidenceTAS
GeneRAB29	AuthorityHGNC:9789	Mapping file id8934 NCBI file	EvidenceTAS
GeneRAB2A	AuthorityHGNC:9763	Mapping file id5862 NCBI file	EvidenceTAS
GeneRAB2B	AuthorityHGNC:20246	Mapping file id84932 NCBI file	EvidenceTAS
GeneRAB30	AuthorityHGNC:9770	Mapping file id27314 NCBI file	EvidenceTAS
GeneRAB31	AuthorityHGNC:9771	Mapping file id11031 NCBI file	EvidenceTAS
GeneRAB32	AuthorityHGNC:9772	Mapping file id10981 NCBI file	EvidenceTAS
GeneRAB33A	AuthorityHGNC:9773	Mapping file id9363 NCBI file	EvidenceTAS
GeneRAB33B	AuthorityHGNC:16075	Mapping file id83452 NCBI file	EvidenceTAS
GeneRAB34	AuthorityHGNC:16519	Mapping file id83871 NCBI file	EvidenceTAS
GeneRAB35	AuthorityHGNC:9774	Mapping file id11021 NCBI file	EvidenceTAS
GeneRAB36	AuthorityHGNC:9775	Mapping file id9609 NCBI file	EvidenceTAS
GeneRAB37	AuthorityHGNC:30268	Mapping file id326624 NCBI file	EvidenceTAS
GeneRAB38	AuthorityHGNC:9776	Mapping file id23682 NCBI file	EvidenceTAS
GeneRAB39A	AuthorityHGNC:16521	Mapping file id54734 NCBI file	EvidenceTAS
GeneRAB39B	AuthorityHGNC:16499	Mapping file id116442 NCBI file	EvidenceTAS
GeneRAB3A	AuthorityHGNC:9777	Mapping file id5864 NCBI file	EvidenceTAS
GeneRAB3B	AuthorityHGNC:9778	Mapping file id5865 NCBI file	EvidenceTAS
GeneRAB3C	AuthorityHGNC:30269	Mapping file id115827 NCBI file	EvidenceTAS
GeneRAB3D	AuthorityHGNC:9779	Mapping file id9545 NCBI file	EvidenceTAS
GeneRAB40A	AuthorityHGNC:18283	Mapping file id142684 NCBI file	EvidenceTAS
GeneRAB40B	AuthorityHGNC:18284	Mapping file id10966 NCBI file	EvidenceTAS
GeneRAB40C	AuthorityHGNC:18285	Mapping file id57799 NCBI file	EvidenceTAS
GeneRAB41	AuthorityHGNC:18293	Mapping file id347517 NCBI file	EvidenceTAS
GeneRAB42	AuthorityHGNC:28702	Mapping file id115273 NCBI file	EvidenceTAS
GeneRAB43	AuthorityHGNC:19983	Mapping file id339122 NCBI file	EvidenceTAS
GeneRAB44	AuthorityHGNC:21068	Mapping file id401258 NCBI file	EvidenceTAS
GeneRAB4A	AuthorityHGNC:9781	Mapping file id5867 NCBI file	EvidenceTAS
GeneRAB4B	AuthorityHGNC:9782	Mapping file id53916 NCBI file	EvidenceTAS
GeneRAB5A	AuthorityHGNC:9783	Mapping file id5868 NCBI file	EvidenceTAS
GeneRAB5B	AuthorityHGNC:9784	Mapping file id5869 NCBI file	EvidenceTAS
GeneRAB5C	AuthorityHGNC:9785	Mapping file id5878 NCBI file	EvidenceTAS
GeneRAB6A	AuthorityHGNC:9786	Mapping file id5870 NCBI file	EvidenceTAS
GeneRAB6B	AuthorityHGNC:14902	Mapping file id51560 NCBI file	EvidenceTAS
GeneRAB7A	AuthorityHGNC:9788	Mapping file id7879 NCBI file	EvidenceTAS
GeneRAB7B	AuthorityHGNC:30513	Mapping file id338382 NCBI file	EvidenceTAS
GeneRAB8A	AuthorityHGNC:7007	Mapping file id4218 NCBI file	EvidenceTAS
GeneRAB8B	AuthorityHGNC:30273	Mapping file id51762 NCBI file	EvidenceTAS
GeneRAB9A	AuthorityHGNC:9792	Mapping file id9367 NCBI file	EvidenceTAS
GeneRAB9B	AuthorityHGNC:14090	Mapping file id51209 NCBI file	EvidenceTAS
GeneRABGGTA	AuthorityHGNC:9795	Mapping file id5875 NCBI file	EvidenceTAS
GeneRABGGTB	AuthorityHGNC:9796	Mapping file id5876 NCBI file	EvidenceTAS

Evidence codes on this page: TAS, as the mapping file writes them; a row carrying two was written twice by the file, once under each. The mapping file id says which file placed the gene: an NCBI Gene id from NCBI2Reactome_All_Levels.txt, an Ensembl gene id from Ensembl2Reactome_All_Levels.txt. The two files can disagree about a code, so a row's codes are the one file's view. Measured by this site's build over this release on 2026-09-09: of the 138,908 human pathway-gene pairs both files place, 207 (0.149 per cent, over 47 genes) carry TAS in the Ensembl file where the NCBI rows carry IEA alone.

Reactome mapping files, the human rows for this pathway · Reactome release 97 · read 2026-09-09 · Reactome downloads"NCBI2Reactome_All_Levels.txt" and "Ensembl2Reactome_All_Levels.txt", Reactome, release 97, https://reactome.org/download-data/ (date of access 2026-09-09). Data CC0; attribution encouraged.

03The hierarchy

Parents and children in this release's hierarchy

Parents

Post-translational protein modificationR-HSA-5975921,507 genes

Children

None: no pathway of this release's list names this one as a parent.

Reactome's hierarchy is a graph rather than a tree: a pathway can sit under more than one parent, and the gene counts are each pathway's own placements at every level under it, so a parent's count is not the sum of its children's.

Reactome, the human pathway list and hierarchy relationship file · Reactome release 97 · read 2026-09-09 · Reactome downloads"ReactomePathways.txt" and "ReactomePathwaysRelation.txt", Reactome, release 97, https://reactome.org/download-data/ (date of access 2026-09-09). Data CC0; attribution encouraged.