Pathway Human Homo sapiens

MET activates PTK2 signaling

R-HSA-8874081 in Reactome release 97: under MET promotes cell motility, with 30 genes placed in it by the mapping files and 0 child pathways in the hierarchy.

The same number in the other species

Reactome writes the mouse and rat events it infers from a human pathway under the human number with the species token. A door opens only where that species' own list in this release holds the id: R-MMU-8874081 (mouse), R-RNO-8874081 (rat). Whether the event was inferred from this one is what the record says.

The record
The genes
Parents and children

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This page reads the pathway's record from its source while you read the rest; with scripts off the card stays at its loading line. Reload with scripts on to see it, or open the source's own page from the link in the card.

01The record

Reactome's own record of this pathway

What this tells you

The pathway list, the hierarchy and the genes on this page are read from the files Reactome publishes for Reactome release 97, built into this site on 2026-09-09: the pathway list, the hierarchy relationship file and the two gene mapping files. The record card is the one live read, Reactome's own record of this pathway.

Reactome's download page describes the mapping files: Mapping files link the source database identifier to the lowest level pathway diagram or subset of the pathway, all levels of the pathway hierarchy or database identifier to all reactions. [R13] The gene list here is the all-levels mapping of NCBI Gene ids, filled from the all-levels mapping of Ensembl ids where the NCBI file has no row for a gene; each row names which file it came from by the shape of its source id. Each row carries the evidence codes the file writes for it, as written and unranked, and both where the file writes both; no page of Reactome's documentation the survey read defines the codes, so this page does not expand them. A gene id the identity files do not name is kept as the source's own id with no door rather than turned into a symbol.

On citing what a search finds, Reactome says: It should be remembered that while we strive to contain the most current and accurate data, Reactome should not be used in citations where other primary sources of information are available. [R12] The record card prints the literature Reactome attaches to a curated pathway for that reason. The data are public domain: All data in the Reactome database and files derived from that data are licensed under the Creative Commons Public Domain Dedication (CC0). User may copy, modify, and distribute these data, even for commercial purposes, without asking for permission. Attribution is encouraged but not required. [R10] The pathway illustrations are licensed apart, under CC BY 4.0, and none is shown here.

A gene on this list is one Reactome places in this pathway in this release, and that is all the row says: it does not say the gene is expressed in a tissue or associated with a disease, which are the other two explorers' questions, read from other sources. Reactome's papers of record are [R01] [R02].

[R01] Ragueneau E, Gong C, Sinquin P, Sevilla C, Beavers D, Grentner A, et al. (2026). The Reactome Knowledgebase 2026. Nucleic Acids Research 54:D673-D681. PMID 41251150, doi 10.1093/nar/gkaf1223.
[R02] Milacic M, Beavers D, Conley P, Gong C, Gillespie M, Griss J, et al. (2024). The Reactome Pathway Knowledgebase 2024. Nucleic Acids Research 52:D672-D678. PMID 37941124, doi 10.1093/nar/gkad1025.
[R10] Reactome, reactome.org. License Agreement. https://reactome.org/license, read 2026-09-09.
[R12] Reactome, reactome.org. Citing us. https://reactome.org/cite, read 2026-09-09.
[R13] Reactome, reactome.org. Download. https://reactome.org/download-data, read 2026-09-09.

Stable id: R-HSA-8874081.3
Class: Pathway
Species: Homo sapiens (human)
Inferred: no: a curated human pathway
Disease pathway: no
Released: 2016-09-19
Last updated: 2016-12-21
Events inside: 5, counted from the record

MET receptor activates the focal adhesion kinase PTK2 (FAK1) in a process that depends on the simultaneous interaction of PTK2 with integrins and with MET. SRC is needed for PTK2 to become fully active. Activation of PTK2 is needed for HGF-induced cell motility (Beviglia et al. 1999, Parr et al. 2001, Chen and Chen 2006, Lietha et al. 2007, Chen et al. 2011, Brami-Cherrier et al. 2014).

Literature Reactome attaches

HGF induces FAK activation and integrin-mediated adhesion in MTLn3 breast carcinoma cellsInt. J. Cancer, 1999, vol. 83, p. 640-9PubMed 10521801
Direct interaction of focal adhesion kinase (FAK) with Met is required for FAK to promote hepatocyte growth factor-induced cell invasionMol. Cell. Biol., 2006, vol. 26, p. 5155-67PubMed 16782899
The HGF/SF-induced phosphorylation of paxillin, matrix adhesion, and invasion of prostate cancer cells were suppressed by NK4, an HGF/SF variantBiochem. Biophys. Res. Commun., 2001, vol. 285, p. 1330-7PubMed 11478803
FAK dimerization controls its kinase-dependent functions at focal adhesionsEMBO J., 2014, vol. 33, p. 356-70

Reading this pathway's record from Reactome (the pathway record).Still reading. A first read of a pathway can take a while; this page waits up to 35 seconds for it, and its scripts then bring in the panel, or a line saying what did not arrive.

02The genes

Genes Reactome places in this human pathway

The mapping files place 30 genes in this human pathway; showing 1 to 30, in pages of 100, sorted by symbol for reading. The order carries no ranking.

Genes Reactome places in this human pathway, page 1 of 1
Gene	Authority id	Mapping file id	Evidence codes
GeneCOL11A1	AuthorityHGNC:2186	Mapping file id1301 NCBI file	EvidenceTAS
GeneCOL11A2	AuthorityHGNC:2187	Mapping file id1302 NCBI file	EvidenceTAS
GeneCOL1A1	AuthorityHGNC:2197	Mapping file id1277 NCBI file	EvidenceTAS
GeneCOL1A2	AuthorityHGNC:2198	Mapping file id1278 NCBI file	EvidenceTAS
GeneCOL24A1	AuthorityHGNC:20821	Mapping file id255631 NCBI file	EvidenceTAS
GeneCOL27A1	AuthorityHGNC:22986	Mapping file id85301 NCBI file	EvidenceTAS
GeneCOL2A1	AuthorityHGNC:2200	Mapping file id1280 NCBI file	EvidenceTAS
GeneCOL3A1	AuthorityHGNC:2201	Mapping file id1281 NCBI file	EvidenceTAS
GeneCOL5A1	AuthorityHGNC:2209	Mapping file id1289 NCBI file	EvidenceTAS
GeneCOL5A2	AuthorityHGNC:2210	Mapping file id1290 NCBI file	EvidenceTAS
GeneCOL5A3	AuthorityHGNC:14864	Mapping file id50509 NCBI file	EvidenceTAS
GeneFN1	AuthorityHGNC:3778	Mapping file id2335 NCBI file	EvidenceTAS
GeneHGF	AuthorityHGNC:4893	Mapping file id3082 NCBI file	EvidenceTAS
GeneITGA2	AuthorityHGNC:6137	Mapping file id3673 NCBI file	EvidenceTAS
GeneITGA3	AuthorityHGNC:6139	Mapping file id3675 NCBI file	EvidenceTAS
GeneITGB1	AuthorityHGNC:6153	Mapping file id3688 NCBI file	EvidenceTAS
GeneLAMA1	AuthorityHGNC:6481	Mapping file id284217 NCBI file	EvidenceTAS
GeneLAMA2	AuthorityHGNC:6482	Mapping file id3908 NCBI file	EvidenceTAS
GeneLAMA3	AuthorityHGNC:6483	Mapping file id3909 NCBI file	EvidenceTAS
GeneLAMA4	AuthorityHGNC:6484	Mapping file id3910 NCBI file	EvidenceTAS
GeneLAMA5	AuthorityHGNC:6485	Mapping file id3911 NCBI file	EvidenceTAS
GeneLAMB1	AuthorityHGNC:6486	Mapping file id3912 NCBI file	EvidenceTAS
GeneLAMB2	AuthorityHGNC:6487	Mapping file id3913 NCBI file	EvidenceTAS
GeneLAMB3	AuthorityHGNC:6490	Mapping file id3914 NCBI file	EvidenceTAS
GeneLAMC1	AuthorityHGNC:6492	Mapping file id3915 NCBI file	EvidenceTAS
GeneLAMC2	AuthorityHGNC:6493	Mapping file id3918 NCBI file	EvidenceTAS
GeneLAMC3	AuthorityHGNC:6494	Mapping file id10319 NCBI file	EvidenceTAS
GeneMET	AuthorityHGNC:7029	Mapping file id4233 NCBI file	EvidenceTAS
GenePTK2	AuthorityHGNC:9611	Mapping file id5747 NCBI file	EvidenceTAS
GeneSRC	AuthorityHGNC:11283	Mapping file id6714 NCBI file	EvidenceTAS

Evidence codes on this page: TAS, as the mapping file writes them; a row carrying two was written twice by the file, once under each. The mapping file id says which file placed the gene: an NCBI Gene id from NCBI2Reactome_All_Levels.txt, an Ensembl gene id from Ensembl2Reactome_All_Levels.txt. The two files can disagree about a code, so a row's codes are the one file's view. Measured by this site's build over this release on 2026-09-09: of the 138,908 human pathway-gene pairs both files place, 207 (0.149 per cent, over 47 genes) carry TAS in the Ensembl file where the NCBI rows carry IEA alone.

Reactome mapping files, the human rows for this pathway · Reactome release 97 · read 2026-09-09 · Reactome downloads"NCBI2Reactome_All_Levels.txt" and "Ensembl2Reactome_All_Levels.txt", Reactome, release 97, https://reactome.org/download-data/ (date of access 2026-09-09). Data CC0; attribution encouraged.

03The hierarchy

Parents and children in this release's hierarchy

Parents

MET promotes cell motilityR-HSA-887587841 genes

Children

None: no pathway of this release's list names this one as a parent.

Reactome's hierarchy is a graph rather than a tree: a pathway can sit under more than one parent, and the gene counts are each pathway's own placements at every level under it, so a parent's count is not the sum of its children's.

Reactome, the human pathway list and hierarchy relationship file · Reactome release 97 · read 2026-09-09 · Reactome downloads"ReactomePathways.txt" and "ReactomePathwaysRelation.txt", Reactome, release 97, https://reactome.org/download-data/ (date of access 2026-09-09). Data CC0; attribution encouraged.