Pathway Human Homo sapiens

Endosomal Sorting Complex Required For Transport (ESCRT)

R-HSA-917729 in Reactome release 97: under Membrane Trafficking, with 32 genes placed in it by the mapping files and 0 child pathways in the hierarchy.

The same number in the other species

Reactome writes the mouse and rat events it infers from a human pathway under the human number with the species token. A door opens only where that species' own list in this release holds the id: R-MMU-917729 (mouse), R-RNO-917729 (rat). Whether the event was inferred from this one is what the record says.

The record
The genes
Parents and children

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This page reads the pathway's record from its source while you read the rest; with scripts off the card stays at its loading line. Reload with scripts on to see it, or open the source's own page from the link in the card.

01The record

Reactome's own record of this pathway

What this tells you

The pathway list, the hierarchy and the genes on this page are read from the files Reactome publishes for Reactome release 97, built into this site on 2026-09-09: the pathway list, the hierarchy relationship file and the two gene mapping files. The record card is the one live read, Reactome's own record of this pathway.

Reactome's download page describes the mapping files: Mapping files link the source database identifier to the lowest level pathway diagram or subset of the pathway, all levels of the pathway hierarchy or database identifier to all reactions. [R13] The gene list here is the all-levels mapping of NCBI Gene ids, filled from the all-levels mapping of Ensembl ids where the NCBI file has no row for a gene; each row names which file it came from by the shape of its source id. Each row carries the evidence codes the file writes for it, as written and unranked, and both where the file writes both; no page of Reactome's documentation the survey read defines the codes, so this page does not expand them. A gene id the identity files do not name is kept as the source's own id with no door rather than turned into a symbol.

On citing what a search finds, Reactome says: It should be remembered that while we strive to contain the most current and accurate data, Reactome should not be used in citations where other primary sources of information are available. [R12] The record card prints the literature Reactome attaches to a curated pathway for that reason. The data are public domain: All data in the Reactome database and files derived from that data are licensed under the Creative Commons Public Domain Dedication (CC0). User may copy, modify, and distribute these data, even for commercial purposes, without asking for permission. Attribution is encouraged but not required. [R10] The pathway illustrations are licensed apart, under CC BY 4.0, and none is shown here.

A gene on this list is one Reactome places in this pathway in this release, and that is all the row says: it does not say the gene is expressed in a tissue or associated with a disease, which are the other two explorers' questions, read from other sources. Reactome's papers of record are [R01] [R02].

[R01] Ragueneau E, Gong C, Sinquin P, Sevilla C, Beavers D, Grentner A, et al. (2026). The Reactome Knowledgebase 2026. Nucleic Acids Research 54:D673-D681. PMID 41251150, doi 10.1093/nar/gkaf1223.
[R02] Milacic M, Beavers D, Conley P, Gong C, Gillespie M, Griss J, et al. (2024). The Reactome Pathway Knowledgebase 2024. Nucleic Acids Research 52:D672-D678. PMID 37941124, doi 10.1093/nar/gkad1025.
[R10] Reactome, reactome.org. License Agreement. https://reactome.org/license, read 2026-09-09.
[R12] Reactome, reactome.org. Citing us. https://reactome.org/cite, read 2026-09-09.
[R13] Reactome, reactome.org. Download. https://reactome.org/download-data, read 2026-09-09.

Stable id: R-HSA-917729.3
Class: Pathway
Species: Homo sapiens (human)
Inferred: no: a curated human pathway
Disease pathway: no
Released: 2011-03-15
Last updated: 2017-04-20
Events inside: 4, counted from the record

Many plasma membrane proteins are in a constant flux throughout the internal trafficking pathways of the cell. Some receptors are continuously internalized into recycling endosomes and returned to the cell surface. Others are sorted into intralumenal vesicles of morphologically distinctive endosomes that are known as multivesicular bodies (MVBs). These MVBs fuse with lysosomes, resulting in degradation of their cargo by lysosomal acidic hydrolases.

Endosomes can be operationally defined as being either early or late, referring to the relative time it takes for endocytosed material to reach either stage. Ultrastructural studies indicate that early endosomes are predominantly tubulovesicular structures, which constitute a major sorting platform in the cell, whereas late endosomes show the characteristics of typical MVBs and are capable of fusing with lysosomes.

A well characterized signal for shunting membrane proteins into the degradative MVB pathway is the ubiquitylation of these cargoes. At the center of a vast protein:protein and protein:lipid interaction network that underpins ubiquitin mediated sorting to the lysosome are the endosomal sorting complexes required for transport (ESCRTs), which are conserved throughout all major eukaryotic taxa.

Literature Reactome attaches

ESCRTing proteins in the endocytic pathwayTrends Biochem Sci, 2007, vol. 32, p. 561-73PubMed 17988873
SnapShot: the ESCRT machineryCell, 2009, vol. 137, p. 182-182.e1PubMed 19345195
The emerging shape of the ESCRT machineryNat Rev Mol Cell Biol, 2007, vol. 8, p. 355-68PubMed 17450176

Reactome's record lists 13 orthologous events, R-RNO-917729 (Rattus norvegicus), R-MMU-917729 (Mus musculus) among the species this site serves, and 11 in species this site opens no page for.

Reactome ContentService, this pathway's record · Reactome v97 · read 2026-09-30 ET · Reactome pathway browser"Endosomal Sorting Complex Required For Transport (ESCRT)". Reactome, release 97, https://reactome.org/PathwayBrowser/#/R-HSA-917729 with StableID: R-HSA-917729.3 (accessed 2026-09-30 ET). Reactome version 97 (CC0).

Reading this pathway's record from Reactome (the pathway record).Still reading. A first read of a pathway can take a while; this page waits up to 35 seconds for it, and its scripts then bring in the panel, or a line saying what did not arrive.

02The genes

Genes Reactome places in this human pathway

The mapping files place 32 genes in this human pathway; showing 1 to 32, in pages of 100, sorted by symbol for reading. The order carries no ranking.

Genes Reactome places in this human pathway, page 1 of 1
Gene	Authority id	Mapping file id	Evidence codes
GeneCHMP2A	AuthorityHGNC:30216	Mapping file id27243 NCBI file	EvidenceTAS
GeneCHMP2B	AuthorityHGNC:24537	Mapping file id25978 NCBI file	EvidenceTAS
GeneCHMP3	AuthorityHGNC:29865	Mapping file id51652 NCBI file	EvidenceTAS
GeneCHMP4A	AuthorityHGNC:20274	Mapping file id29082 NCBI file	EvidenceTAS
GeneCHMP4B	AuthorityHGNC:16171	Mapping file id128866 NCBI file	EvidenceTAS
GeneCHMP4C	AuthorityHGNC:30599	Mapping file id92421 NCBI file	EvidenceTAS
GeneCHMP5	AuthorityHGNC:26942	Mapping file id51510 NCBI file	EvidenceTAS
GeneCHMP6	AuthorityHGNC:25675	Mapping file id79643 NCBI file	EvidenceTAS
GeneCHMP7	AuthorityHGNC:28439	Mapping file id91782 NCBI file	EvidenceTAS
GeneHGS	AuthorityHGNC:4897	Mapping file id9146 NCBI file	EvidenceTAS
GeneMVB12A	AuthorityHGNC:25153	Mapping file id93343 NCBI file	EvidenceTAS
GeneMVB12B	AuthorityHGNC:23368	Mapping file id89853 NCBI file	EvidenceTAS
GeneRNF103-CHMP3	AuthorityHGNC:38847	Mapping file id100526767 NCBI file	EvidenceTAS
GeneRPS27A	AuthorityHGNC:10417	Mapping file id6233 NCBI file	EvidenceTAS
GeneSNF8	AuthorityHGNC:17028	Mapping file id11267 NCBI file	EvidenceTAS
GeneSTAM	AuthorityHGNC:11357	Mapping file id8027 NCBI file	EvidenceTAS
GeneSTAM2	AuthorityHGNC:11358	Mapping file id10254 NCBI file	EvidenceTAS
GeneTSG101	AuthorityHGNC:15971	Mapping file id7251 NCBI file	EvidenceTAS
GeneUBA52	AuthorityHGNC:12458	Mapping file id7311 NCBI file	EvidenceTAS
GeneUBAP1	AuthorityHGNC:12461	Mapping file id51271 NCBI file	EvidenceTAS
GeneUBB	AuthorityHGNC:12463	Mapping file id7314 NCBI file	EvidenceTAS
GeneUBC	AuthorityHGNC:12468	Mapping file id7316 NCBI file	EvidenceTAS
GeneVPS25	AuthorityHGNC:28122	Mapping file id84313 NCBI file	EvidenceTAS
GeneVPS28	AuthorityHGNC:18178	Mapping file id51160 NCBI file	EvidenceTAS
GeneVPS36	AuthorityHGNC:20312	Mapping file id51028 NCBI file	EvidenceTAS
GeneVPS37A	AuthorityHGNC:24928	Mapping file id137492 NCBI file	EvidenceTAS
GeneVPS37B	AuthorityHGNC:25754	Mapping file id79720 NCBI file	EvidenceTAS
GeneVPS37C	AuthorityHGNC:26097	Mapping file id55048 NCBI file	EvidenceTAS
GeneVPS37D	AuthorityHGNC:18287	Mapping file id155382 NCBI file	EvidenceTAS
GeneVPS4A	AuthorityHGNC:13488	Mapping file id27183 NCBI file	EvidenceTAS
GeneVPS4B	AuthorityHGNC:10895	Mapping file id9525 NCBI file	EvidenceTAS
GeneVTA1	AuthorityHGNC:20954	Mapping file id51534 NCBI file	EvidenceTAS

Evidence codes on this page: TAS, as the mapping file writes them; a row carrying two was written twice by the file, once under each. The mapping file id says which file placed the gene: an NCBI Gene id from NCBI2Reactome_All_Levels.txt, an Ensembl gene id from Ensembl2Reactome_All_Levels.txt. The two files can disagree about a code, so a row's codes are the one file's view. Measured by this site's build over this release on 2026-09-09: of the 138,908 human pathway-gene pairs both files place, 207 (0.149 per cent, over 47 genes) carry TAS in the Ensembl file where the NCBI rows carry IEA alone.

Reactome mapping files, the human rows for this pathway · Reactome release 97 · read 2026-09-09 · Reactome downloads"NCBI2Reactome_All_Levels.txt" and "Ensembl2Reactome_All_Levels.txt", Reactome, release 97, https://reactome.org/download-data/ (date of access 2026-09-09). Data CC0; attribution encouraged.

03The hierarchy

Parents and children in this release's hierarchy

Parents

Membrane TraffickingR-HSA-199991636 genes

Children

None: no pathway of this release's list names this one as a parent.

Reactome's hierarchy is a graph rather than a tree: a pathway can sit under more than one parent, and the gene counts are each pathway's own placements at every level under it, so a parent's count is not the sum of its children's.

Reactome, the human pathway list and hierarchy relationship file · Reactome release 97 · read 2026-09-09 · Reactome downloads"ReactomePathways.txt" and "ReactomePathwaysRelation.txt", Reactome, release 97, https://reactome.org/download-data/ (date of access 2026-09-09). Data CC0; attribution encouraged.