Pathway Human Homo sapiens

Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)

R-HSA-9934037 in Reactome release 97: under SWI/SNF chromatin remodelers, with 25 genes placed in it by the mapping files and 0 child pathways in the hierarchy.

The same number in the other species

Reactome writes the mouse and rat events it infers from a human pathway under the human number with the species token. A door opens only where that species' own list in this release holds the id: R-MMU-9934037 (mouse), R-RNO-9934037 (rat). Whether the event was inferred from this one is what the record says.

The record
The genes
Parents and children

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This page reads the pathway's record from its source while you read the rest; with scripts off the card stays at its loading line. Reload with scripts on to see it, or open the source's own page from the link in the card.

01The record

Reactome's own record of this pathway

What this tells you

The pathway list, the hierarchy and the genes on this page are read from the files Reactome publishes for Reactome release 97, built into this site on 2026-09-09: the pathway list, the hierarchy relationship file and the two gene mapping files. The record card is the one live read, Reactome's own record of this pathway.

Reactome's download page describes the mapping files: Mapping files link the source database identifier to the lowest level pathway diagram or subset of the pathway, all levels of the pathway hierarchy or database identifier to all reactions. [R13] The gene list here is the all-levels mapping of NCBI Gene ids, filled from the all-levels mapping of Ensembl ids where the NCBI file has no row for a gene; each row names which file it came from by the shape of its source id. Each row carries the evidence codes the file writes for it, as written and unranked, and both where the file writes both; no page of Reactome's documentation the survey read defines the codes, so this page does not expand them. A gene id the identity files do not name is kept as the source's own id with no door rather than turned into a symbol.

On citing what a search finds, Reactome says: It should be remembered that while we strive to contain the most current and accurate data, Reactome should not be used in citations where other primary sources of information are available. [R12] The record card prints the literature Reactome attaches to a curated pathway for that reason. The data are public domain: All data in the Reactome database and files derived from that data are licensed under the Creative Commons Public Domain Dedication (CC0). User may copy, modify, and distribute these data, even for commercial purposes, without asking for permission. Attribution is encouraged but not required. [R10] The pathway illustrations are licensed apart, under CC BY 4.0, and none is shown here.

A gene on this list is one Reactome places in this pathway in this release, and that is all the row says: it does not say the gene is expressed in a tissue or associated with a disease, which are the other two explorers' questions, read from other sources. Reactome's papers of record are [R01] [R02].

[R01] Ragueneau E, Gong C, Sinquin P, Sevilla C, Beavers D, Grentner A, et al. (2026). The Reactome Knowledgebase 2026. Nucleic Acids Research 54:D673-D681. PMID 41251150, doi 10.1093/nar/gkaf1223.
[R02] Milacic M, Beavers D, Conley P, Gong C, Gillespie M, Griss J, et al. (2024). The Reactome Pathway Knowledgebase 2024. Nucleic Acids Research 52:D672-D678. PMID 37941124, doi 10.1093/nar/gkad1025.
[R10] Reactome, reactome.org. License Agreement. https://reactome.org/license, read 2026-09-09.
[R12] Reactome, reactome.org. Citing us. https://reactome.org/cite, read 2026-09-09.
[R13] Reactome, reactome.org. Download. https://reactome.org/download-data, read 2026-09-09.

Stable id: R-HSA-9934037.1
Class: Pathway
Species: Homo sapiens (human)
Inferred: no: a curated human pathway
Disease pathway: no
Released: 2025-03-26
Events inside: 2, counted from the record

Studies in mice have identified two distinct BAF complexes that regulate neuronal differentiation, exemplifying the combinatorial control of BAF activity through changes to complex composition (reviewed in Staahl and Crabtree, 2013; Kadoch and Crabtree, 2015; Innis and Cabot, 2020; Cenik and Shilatifard, 2021. Neuronal progenitor and neural stem cells contain an npBAF complex that is required for multipotency and proliferation; this complex is characterized by the presence of ACTL6A, SS18 and BAF45 family members DPF2 or PHF10 (Lessard et al, 2007; Staahl et al, 2013). Mature neurons that have exited the cell cycle, in contrast, contain a nBAF complex characterized by ACTL6B, the SS18 family member SS18L1 and DPF45 family members DPF1 and DPF3 (Lessard et al, 2007; Staahl et al, 2013).

Literature Reactome attaches

An essential switch in subunit composition of a chromatin remodeling complex during neural developmentNeuron, 2007, vol. 55, p. 201-15PubMed 17640523
Kinetic analysis of npBAF to nBAF switching reveals exchange of SS18 with CREST and integration with neural developmental pathwaysJ Neurosci, 2013, vol. 33, p. 10348-61PubMed 23785148
Creating a neural specific chromatin landscape by npBAF and nBAF complexesCurr Opin Neurobiol, 2013, vol. 23, p. 903-13PubMed 24090879
Mammalian SWI/SNF chromatin remodeling complexes and cancer: Mechanistic insights gained from human genomicsSci Adv, 2015, vol. 1, p. e1500447PubMed 26601204
GBAF, a small BAF sub-complex with big implications: a systematic reviewEpigenetics Chromatin, 2020, vol. 13, p. 48PubMed 33143733
COMPASS and SWI/SNF complexes in development and diseaseNat Rev Genet, 2021, vol. 22, p. 38-58PubMed 32958894

Reactome's record lists 8 orthologous events, R-RNO-9934037 (Rattus norvegicus), R-MMU-9934037 (Mus musculus) among the species this site serves, and 6 in species this site opens no page for.

Reactome ContentService, this pathway's record · Reactome v97 · read 2026-10-01 ET · Reactome pathway browser"Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)". Reactome, release 97, https://reactome.org/PathwayBrowser/#/R-HSA-9934037 with StableID: R-HSA-9934037.1 (accessed 2026-10-01 ET). Reactome version 97 (CC0).

Reading this pathway's record from Reactome (the pathway record).Still reading. A first read of a pathway can take a while; this page waits up to 35 seconds for it, and its scripts then bring in the panel, or a line saying what did not arrive.

02The genes

Genes Reactome places in this human pathway

The mapping files place 25 genes in this human pathway; showing 1 to 25, in pages of 100, sorted by symbol for reading. The order carries no ranking.

Genes Reactome places in this human pathway, page 1 of 1
Gene	Authority id	Mapping file id	Evidence codes
GeneACTB	AuthorityHGNC:132	Mapping file id60 NCBI file	EvidenceIEA, TAS
GeneACTL6A	AuthorityHGNC:24124	Mapping file id86 NCBI file	EvidenceIEA, TAS
GeneACTL6B	AuthorityHGNC:160	Mapping file id51412 NCBI file	EvidenceIEA
GeneARID1A	AuthorityHGNC:11110	Mapping file id8289 NCBI file	EvidenceIEA, TAS
GeneARID1B	AuthorityHGNC:18040	Mapping file id57492 NCBI file	EvidenceIEA, TAS
GeneBCL11A	AuthorityHGNC:13221	Mapping file id53335 NCBI file	EvidenceIEA, TAS
GeneBCL11B	AuthorityHGNC:13222	Mapping file id64919 NCBI file	EvidenceIEA, TAS
GeneBCL7A	AuthorityHGNC:1004	Mapping file id605 NCBI file	EvidenceIEA, TAS
GeneBCL7B	AuthorityHGNC:1005	Mapping file id9275 NCBI file	EvidenceIEA, TAS
GeneBCL7C	AuthorityHGNC:1006	Mapping file id9274 NCBI file	EvidenceIEA, TAS
GeneDPF1	AuthorityHGNC:20225	Mapping file id8193 NCBI file	EvidenceIEA
GeneDPF2	AuthorityHGNC:9964	Mapping file id5977 NCBI file	EvidenceIEA, TAS
GeneDPF3	AuthorityHGNC:17427	Mapping file id8110 NCBI file	EvidenceIEA
GenePHF10	AuthorityHGNC:18250	Mapping file id55274 NCBI file	EvidenceIEA, TAS
GeneSMARCA2	AuthorityHGNC:11098	Mapping file id6595 NCBI file	EvidenceIEA, TAS
GeneSMARCA4	AuthorityHGNC:11100	Mapping file id6597 NCBI file	EvidenceIEA, TAS
GeneSMARCB1	AuthorityHGNC:11103	Mapping file id6598 NCBI file	EvidenceIEA, TAS
GeneSMARCC1	AuthorityHGNC:11104	Mapping file id6599 NCBI file	EvidenceIEA, TAS
GeneSMARCC2	AuthorityHGNC:11105	Mapping file id6601 NCBI file	EvidenceIEA, TAS
GeneSMARCD1	AuthorityHGNC:11106	Mapping file id6602 NCBI file	EvidenceIEA, TAS
GeneSMARCD2	AuthorityHGNC:11107	Mapping file id6603 NCBI file	EvidenceTAS
GeneSMARCD3	AuthorityHGNC:11108	Mapping file id6604 NCBI file	EvidenceIEA, TAS
GeneSMARCE1	AuthorityHGNC:11109	Mapping file id6605 NCBI file	EvidenceIEA, TAS
GeneSS18	AuthorityHGNC:11340	Mapping file id6760 NCBI file	EvidenceIEA, TAS
GeneSS18L1	AuthorityHGNC:15592	Mapping file id26039 NCBI file	EvidenceIEA

Evidence codes on this page: IEA, TAS, as the mapping file writes them; a row carrying two was written twice by the file, once under each. The mapping file id says which file placed the gene: an NCBI Gene id from NCBI2Reactome_All_Levels.txt, an Ensembl gene id from Ensembl2Reactome_All_Levels.txt. The two files can disagree about a code, so a row's codes are the one file's view. Measured by this site's build over this release on 2026-09-09: of the 138,908 human pathway-gene pairs both files place, 207 (0.149 per cent, over 47 genes) carry TAS in the Ensembl file where the NCBI rows carry IEA alone.

Reactome mapping files, the human rows for this pathway · Reactome release 97 · read 2026-09-09 · Reactome downloads"NCBI2Reactome_All_Levels.txt" and "Ensembl2Reactome_All_Levels.txt", Reactome, release 97, https://reactome.org/download-data/ (date of access 2026-09-09). Data CC0; attribution encouraged.

03The hierarchy

Parents and children in this release's hierarchy

Parents

SWI/SNF chromatin remodelersR-HSA-993245132 genes

Children

None: no pathway of this release's list names this one as a parent.

Reactome's hierarchy is a graph rather than a tree: a pathway can sit under more than one parent, and the gene counts are each pathway's own placements at every level under it, so a parent's count is not the sum of its children's.

Reactome, the human pathway list and hierarchy relationship file · Reactome release 97 · read 2026-09-09 · Reactome downloads"ReactomePathways.txt" and "ReactomePathwaysRelation.txt", Reactome, release 97, https://reactome.org/download-data/ (date of access 2026-09-09). Data CC0; attribution encouraged.