Reading the record for BRSK2 from HGNC, NCBI Gene and Ensembl.Still reading. A first read of a gene can take a while; this page waits up to 115 seconds for it, and its scripts then bring in the page, or a line saying what did not arrive.
The full name, the identifiers, the location and the notes from the sources arrive with the record. Nothing is filled in ahead of it.
Order door
The door to order for BRSK2 opens with the record, which decides which product it carries. The order page itself is open now.
Cytogenetic band 11p15.5NCBI: 11:1,389,934-1,462,689 on the plus strand, GRCh38.p14 (GCF_000001405.40), sequence NC_000011.10, annotation GCF_000001405.40-RS_2025_08 of 2025-08-01Ensembl: 11:1,389,899-1,462,689 on the plus strand, GRCh38.p14 (GCA_000001405.29), release 116Coordinates are one-based with both ends included, as each source reports them.
Enables several functions, including ATP binding activity; ATPase binding…
NCBI Gene summary
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Reading NCBI Gene and UniProt.Still reading. A first read of a gene can take a while; this page waits up to 30 seconds for it, and its scripts then bring in the panel, or a line saying what did not arrive.
02 / Transcripts and isoforms
The RNA a design targets
40 RefSeq and 32 Ensembl transcripts on GRCh38.p14; MANE Select NM_001256627.2.
NCBI Datasets · Ensembl
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Reading NCBI Datasets and Ensembl.Still reading. A first read of a gene can take a while; this page waits up to 80 seconds for it, and its scripts then bring in the panel, or a line saying what did not arrive.
03 / Expression by tissue
Where BRSK2 is expressed
54 GTEx tissues; the highest median in Brain - Cerebellum, 140 TPM.
GTEx
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04 / Protein
The protein BRSK2 encodes
Reading UniProt, InterPro, AlphaFold DB and PDBe.Still reading. A first read of a gene can take a while; this page waits up to 80 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.
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05 / Interactions
Proteins STRING associates with BRSK2
The 25 highest-scoring STRING partners at or above a combined score of 0.4, of up to 25 asked for; CDC25B, CDC25C, WEE1 lead.
STRING v12.0
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06 / Pathways
Where BRSK2 acts, as Reactome curates it
Reading UniProt and Reactome.Still reading. A first read of a gene can take a while; this page waits up to 60 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.
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07 / Disease associations
Diseases linked to BRSK2
135 Open Targets disease associations; autosomal dominant non-syndromic intellectual disability first, at 0.63.
Open Targets
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08 / Variants
Classified variants of BRSK2
ClinVar: 418 records for BRSK2, 65 pathogenic or likely pathogenic.
ClinVar
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09 / Constraint
How much variation BRSK2 tolerates
pLI above 0.9999 and LOEUF 0.335 in gnomAD v4 (GRCh38), on ENST00000528841.6.
gnomAD
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10 / Orthologs
The same gene in mouse, rat and human
Mouse Brsk2 by 3 of 3 votes; rat Brsk2 by 3 of 3 votes. RGD is not answering, so the ortholog list could not be shown. Try again later. Reference 86ae2325-84c.
Alliance · NCBI · Ensembl Compara
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11 /MicroRNAs
MicroRNAs hosted within BRSK2
No annotated microRNA lies within BRSK2 in Ensembl release 116, on GRCh38.p14.
Ensembl · miRBase
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12 / Long non-coding RNAs
Long non-coding RNAs at the BRSK2 locus
No annotated long non-coding RNA overlaps BRSK2 in Ensembl release 116, on GRCh38.p14.
Ensembl
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13 / Literature
Papers that mention BRSK2
Reading Europe PMC.Still reading. A first read of a gene can take a while; this page waits up to 55 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.
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14 / Silencing this gene
From BRSK2 to a sequence that silences it
The AUMsilence™ platform designs the sequences against the human transcripts on this page. Six decisions are yours before it does. What is written under each is AUM's guidance; the timings and the concentrations are in the usage guide below.
01
Choose the region
A knockdown oligonucleotide can sit in the 5' untranslated region, the coding sequence or the 3' untranslated region, and all three are used. The coding sequence and the 3' untranslated region are the usual first choices for an RNase H design; the 5' end near the start codon suits a steric block. The map above shows where each region sits on the isoforms it draws.
02
Cover the isoforms you mean
An exon every isoform carries silences the whole gene; an exon only some isoforms carry silences those and spares the rest. Decide which you want before a sequence is chosen, and check the reference transcript (MANE Select in human; RefSeq Select and Ensembl canonical in mouse and rat) is the one your cells express.
03
Think across species early
The orthologs panel says whether mouse and rat carry the same gene. Whether one oligonucleotide can serve two species is a sequence question, settled at design by matching the candidate against each transcript, not by the protein identity shown there.
04
Check expression in your model
A transcript that is not expressed in your cells cannot show knockdown. Confirm the gene is expressed in the cell type and condition you will use, from your own data or a reference atlas, before the order. The expression panel above gives GTEx's median per tissue for a human gene; for mouse and rat it says that no atlas is on this page yet.
05
Run the controls
A scramble control of the same chemistry, a positive control against a gene known to knock down in your cells, untreated cells, and a mock condition where a transfection reagent is used. Read knockdown at the RNA level first, then at the protein; the usage guide gives the timing and the concentrations to start from.
06
Pick the product
AUMsilence sdASO needs no transfection reagent and works in the cells that resist one. AUMsilence toASO is the transfection-optimised version of the same design, and AUMsiRNA™ is the siRNA route. The selection guide compares them.
For research use only. Not for use in diagnostic or therapeutic procedures.
Gene summary
Enables several functions, including ATP binding activity; ATPase binding activity; and magnesium ion binding activity. Involved in several processes, including G2/M transition of mitotic cell cycle; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; and regulation of insulin secretion involved in cellular response to glucose stimulus. Located in centrosome and endoplasmic reticulum.
Provided by Alliance of Genome Resources, Jul 2025, through NCBI Gene. NCBI disclaimer
Serine/threonine-protein kinase that plays a key role in polarization of neurons and axonogenesis, cell cycle progress and insulin secretion. Phosphorylates CDK16, CDC25C, MAPT/TAU, PAK1 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at 'Thr-529' and 'Ser-579'. Also regulates neuron polarization by mediating phosphorylation of WEE1 at 'Ser-642' in postmitotic neurons, leading to down-regulate WEE1 activity in polarized neurons. Plays a role in the regulation of the mitotic cell cycle progress and the onset of mitosis. Plays a role in the regulation of insulin secretion in response to elevated glucose levels, probably via phosphorylation of CDK16 and PAK1. While BRSK2 phosphorylated at Thr-174 can inhibit insulin secretion (PubMed:22798068), BRSK2 phosphorylated at Thr-260 can promote insulin secretion (PubMed:22669945). Regulates reorganization of the actin cytoskeleton. May play a role in the apoptotic response triggered by endoplasmic reticulum (ER) stress
NCBI Gene summary · NCBI Gene annotation RS_2025_08 · read · NCBI Gene 9024Data from NCBI, provided as is; NCBI's policies and disclaimers apply.
UniProtKB function · 2026_03 · read · UniProt Q8IWQ3UniProt data are available under the Creative Commons Attribution 4.0 licence.
Placed on GRCh38.p14 (GCF_000001405.40). MANE Select marks the one transcript RefSeq and Ensembl agree is the reference for this gene.
RefSeq 40 transcripts
coding sequence, tall
untranslated region, thin
non-coding exon
intron, fixed width
Genomic strand: plus. Drawn 5' to 3', so exon 1 sits at the left here and at the lowest coordinate on the chromosome.
NM_001256627.2NM_001256627.2MANE Select
XM_017018533.2XM_017018533.2
XM_054333123.1XM_054333123.1
XM_017018536.2XM_017018536.2
XM_054333126.1XM_054333126.1
XM_054333122.1XM_054333122.1
XM_054333124.1XM_054333124.1
XM_054333125.1XM_054333125.1
XM_017018532.2XM_017018532.2
XM_006718374.3XM_006718374.3
XM_054333131.1XM_054333131.1
XM_017018534.2XM_017018534.2
XM_017018535.2XM_017018535.2
NM_001256630.1NM_001256630.1
NM_001440665.1NM_001440665.1
XM_005253218.4XM_005253218.4
XM_054333135.1XM_054333135.1
NM_001440666.1NM_001440666.1
XM_054333130.1XM_054333130.1
XM_054333132.1XM_054333132.1
XM_006718376.3XM_006718376.3
XM_054333127.1XM_054333127.1
XM_054333134.1XM_054333134.1
XM_047427852.1XM_047427852.1
NM_001440669.1NM_001440669.1
XM_017018537.2XM_017018537.2
XM_011520462.3XM_011520462.3
NM_001440668.1NM_001440668.1
NM_001256629.2NM_001256629.2
NM_001282218.2NM_001282218.2
NM_001440667.1NM_001440667.1
NM_001440670.1NM_001440670.1
NM_003957.4NM_003957.4
NM_001440675.1NM_001440675.1
NM_001440674.1NM_001440674.1
NM_001440671.1NM_001440671.1
NM_001440672.1NM_001440672.1
NM_001440673.1NM_001440673.1
NM_001440676.1NM_001440676.1
NR_046331.2NR_046331.2
scale
Drawn 5' to 3' from each transcript's exons as placed on the reference assembly; exon 1 is the 5' exon on the transcript's own strand. Exon blocks are to scale with each other, except 39 blocks too short to see, widened to a fixed few pixels; introns are drawn at one fixed width whatever their length, so the map is not to scale along the chromosome. Numbers are exon ranks along the strand; a rank is omitted where the exon is too narrow to carry it.
A window on one transcript
One pixel of the map above stands for several bases, and a block too short to see is drawn wider than its own scale, so the map chooses a region and the sequence here chooses the window. Click an exon on a row of the map, or drag across a row; then set the exact start and end below.
These controls are ready in a moment.
No transcript is chosen.
Once a window is chosen this panel shows its length, its G and C count as a percentage of that length, the letters it is made of, the exons it falls in, whether it crosses a junction, and its antisense strand.
NCBI also places this transcript on 11 NW_025791792.1 in this annotation, with 21 exons; only the 11 placement is drawn
transcript variant 5
non coding
none
21
4,153 nt
none
Ready in a moment
Not listed, because the source places them on another assembly only: XM_054370433.1 (not placed on GRCh38.p14); XM_054370434.1 (not placed on GRCh38.p14); XM_054370435.1 (not placed on GRCh38.p14); XM_054370436.1 (not placed on GRCh38.p14); XM_054370437.1 (not placed on GRCh38.p14); XM_054370438.1 (not placed on GRCh38.p14); XM_054370441.1 (not placed on GRCh38.p14); XM_054370442.1 (not placed on GRCh38.p14); XM_054370443.1 (not placed on GRCh38.p14); XM_054370445.1 (not placed on GRCh38.p14); XM_054370446.1 (not placed on GRCh38.p14).
NCBI Datasets, RefSeq transcripts · NCBI Datasets 18.38.0; GCF_000001405.40-RS_2025_08 · read · NCBI Gene 9024Data from NCBI, provided as is; NCBI's policies and disclaimers apply.
Ensembl 32 transcripts
coding sequence, tall
untranslated region, thin
non-coding exon
intron, fixed width
Genomic strand: plus. Drawn 5' to 3', so exon 1 sits at the left here and at the lowest coordinate on the chromosome.
Drawn 5' to 3' from each transcript's exons as placed on the reference assembly; exon 1 is the 5' exon on the transcript's own strand. Exon blocks are to scale with each other, except 3 blocks too short to see, widened to a fixed few pixels; introns are drawn at one fixed width whatever their length, so the map is not to scale along the chromosome. Numbers are exon ranks along the strand; a rank is omitted where the exon is too narrow to carry it.
A window on one transcript
One pixel of the map above stands for several bases, and a block too short to see is drawn wider than its own scale, so the map chooses a region and the sequence here chooses the window. Click an exon on a row of the map, or drag across a row; then set the exact start and end below.
These controls are ready in a moment.
No transcript is chosen.
Once a window is chosen this panel shows its length, its G and C count as a percentage of that length, the letters it is made of, the exons it falls in, whether it crosses a junction, and its antisense strand.
Lengths are spliced lengths, as each source states them. Exon ranks follow the strand: on a minus-strand gene exon 1 has the highest genomic coordinate. Reference assembly for human: GRCh38.
596 PubMed-indexed papers mention BRSK2 at Europe PMC, newest first. Europe PMC ignores letter case, so the count also covers another species' symbol spelled with the same letters.
Europe PMC
736 residues, reviewed Q8IWQ3; 14 entries from the member databases this page shows along the chain; mean pLDDT 67.12; no experimental structure at PDBe.
