Gene Human Homo sapiens

Symbol resolved

You asked for BVES; that is a previous symbol, and the current HGNC symbol is POPDC1.

POPDC1

popeye domain cAMP effector 1

gene with protein product

Human POPDC1MouseRat

Reading the ortholog votes for mouse and rat.

Location: Cytogenetic band 6q21NCBI: 6:105,096,822-105,137,157 on the minus strand, GRCh38.p14 (GCF_000001405.40), sequence NC_000006.12, annotation GCF_000001405.40-RS_2025_08 of 2025-08-01Ensembl: 6:105,096,822-105,137,237 on the minus strand, GRCh38.p14 (GCA_000001405.29), release 116Coordinates are one-based with both ends included, as each source reports them.
Also known as: POP1, HBVES
Previous symbols: BVES

Gene identity, from HGNC · HGNC 2026-10-02 · read 2026-10-02 ET · HGNC:1152

Silence this gene

The order page opens with POPDC1 and human filled in. The sequences are designed against the transcripts below; the price is on that page.

Order for POPDC1

sdASO, toASO or siRNA

Bring your own sequence Transcripts

For research use only. Not for use in diagnostic or therapeutic procedures.

Summary
Transcripts
Expression
Protein
Interactions
Pathways
Disease
Variants
Constraint
Orthologs
MicroRNAs
Long non-coding RNAs
Literature
Silencing this gene

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Ready in a moment

01 Summary and function

What POPDC1 does

Ready in a moment

02 Transcripts and isoforms

The RNA a design targets

Reading NCBI Datasets and Ensembl.Still reading. A first read of a gene can take a while; this page waits up to 80 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

Ready in a moment

14 Silencing this gene

From POPDC1 to a sequence that silences it

The AUMsilence platform designs the sequences against the human transcripts on this page. Six decisions are yours before it does. What is written under each is AUM's guidance; the timings and the concentrations are in the usage guide below.

01
Choose the region
A knockdown oligonucleotide can sit in the 5' untranslated region, the coding sequence or the 3' untranslated region, and all three are used. The coding sequence and the 3' untranslated region are the usual first choices for an RNase H design; the 5' end near the start codon suits a steric block. The map above shows where each region sits on the isoforms it draws.
02
Cover the isoforms you mean
An exon every isoform carries silences the whole gene; an exon only some isoforms carry silences those and spares the rest. Decide which you want before a sequence is chosen, and check the reference transcript (MANE Select in human; RefSeq Select and Ensembl canonical in mouse and rat) is the one your cells express.
03
Think across species early
The orthologs panel says whether mouse and rat carry the same gene. Whether one oligonucleotide can serve two species is a sequence question, settled at design by matching the candidate against each transcript, not by the protein identity shown there.
04
Check expression in your model
A transcript that is not expressed in your cells cannot show knockdown. Confirm the gene is expressed in the cell type and condition you will use, from your own data or a reference atlas, before the order. The expression panel above gives GTEx's median per tissue for a human gene; for mouse and rat it says that no atlas is on this page yet.

Gene Human Homo sapiens

BVES

Reading the record for BVES from HGNC, NCBI Gene and Ensembl.Still reading. A first read of a gene can take a while; this page waits up to 115 seconds for it, and its scripts then bring in the page, or a line saying what did not arrive.

The full name, the identifiers, the location and the notes from the sources arrive with the record. Nothing is filled in ahead of it.

Order door

The door to order for BVES opens with the record, which decides which product it carries. The order page itself is open now.

Bring your own sequence

For research use only. Not for use in diagnostic or therapeutic procedures.

This page is still reading the record. Its scripts replace this shell with the record when it arrives; with scripts off, it stays at this shell however long you wait.

01 Summary and function

What BVES does

Waiting for the record before reading NCBI Gene and UniProt.

02 Transcripts and isoforms

The RNA a design targets

Waiting for the record before reading NCBI Datasets and Ensembl.

03 Expression by tissue

Where BVES is expressed

Waiting for the record before reading GTEx and the Human Protein Atlas.

04 Protein

The protein BVES encodes

Waiting for the record before reading UniProt, InterPro, AlphaFold DB and PDBe.

05 Interactions

Proteins STRING associates with BVES

Waiting for the record before reading STRING.

06 Pathways

Where BVES acts, as Reactome curates it

Waiting for the record before reading UniProt and Reactome.

07 Disease associations

Diseases linked to BVES

Waiting for the record before reading Open Targets and ClinGen.

08 Variants

Classified variants of BVES

Waiting for the record before reading ClinVar.

09 Constraint

How much variation BVES tolerates

Waiting for the record before reading gnomAD and Open Targets.

10 Orthologs

The same gene in mouse, rat and human

Waiting for the record before reading the Alliance, NCBI, Ensembl Compara and RGD.

11 MicroRNAs

MicroRNAs hosted within BVES

Waiting for the record before reading Ensembl and miRBase.

12 Long non-coding RNAs

Long non-coding RNAs at the BVES locus

Waiting for the record before reading Ensembl.

13 Literature

Papers that mention BVES

Waiting for the record before reading Europe PMC.

Accession	Name	Biotype	Labels	Exons	Spliced length	Protein	Sequence
NM_001199563.2matches ENST00000314641.10	transcript variant C	protein coding	MANE Select	8	5,550 nt	360 aaNP_001186492.1	Ready in a moment
NM_147147.4matches ENST00000446408.3	transcript variant B	protein coding	none	8	5,509 nt	360 aaNP_671488.1	Ready in a moment
NM_007073.4matches ENST00000336775.10	transcript variant A	protein coding	none	8	5,469 ntexons sum to 5,437 nt; the record carries 32 nt beyond them	360 aaNP_009004.2	Ready in a moment

Accession	Name	Biotype	Labels	Exons	Spliced length	Protein	Sequence
NM_001199563.2matches ENST00000314641.10	transcript variant C	protein coding	MANE Select	8	5,550 nt	360 aaNP_001186492.1	Ready in a moment
NM_147147.4matches ENST00000446408.3	transcript variant B	protein coding	none	8	5,509 nt	360 aaNP_671488.1	Ready in a moment
NM_007073.4matches ENST00000336775.10	transcript variant A	protein coding	none	8	5,469 ntexons sum to 5,437 nt; the record carries 32 nt beyond them	360 aaNP_009004.2	Ready in a moment

Accession	Name	Biotype	Labels	Exons	Spliced length	Protein	Sequence
ENST00000314641.10matches NM_001199563.2	POPDC1-201	protein coding	MANE SelectEnsembl canonical	8	5,550 nt	360 aaENSP00000313172.5	Ready in a moment
ENST00000336775.10	POPDC1-202	protein coding	none	8	5,907 nt	360 aaENSP00000337259.5	Ready in a moment
ENST00001137420.1	POPDC1-205	protein coding	none	8	5,630 nt	360 aaENSP00000806323.1	Ready in a moment
ENST00000446408.3	POPDC1-203	protein coding	none	8	5,509 nt	360 aaENSP00000397310.2	Ready in a moment
ENST00000932335.2	POPDC1-204	protein coding	none	7	5,420 nt	290 aaENSP00000602394.1	Ready in a moment

POPDC1

What POPDC1 does

The RNA a design targets

From POPDC1 to a sequence that silences it

Choose the region

Cover the isoforms you mean

Think across species early

Check expression in your model

BVES

What BVES does

The RNA a design targets

Where BVES is expressed

The protein BVES encodes

Proteins STRING associates with BVES

Where BVES acts, as Reactome curates it

Diseases linked to BVES

Classified variants of BVES

How much variation BVES tolerates

The same gene in mouse, rat and human

MicroRNAs hosted within BVES

Long non-coding RNAs at the BVES locus

Papers that mention BVES

POPDC1

What POPDC1 does

Gene summary

Protein function

The RNA a design targets

RefSeq 3 transcripts

A window on one transcript

Ensembl 5 transcripts

A window on one transcript

From POPDC1 to a sequence that silences it

Choose the region

Cover the isoforms you mean

Think across species early

Check expression in your model

Where POPDC1 is expressed

The protein POPDC1 encodes

Proteins STRING associates with POPDC1

Where POPDC1 acts, as Reactome curates it

Diseases linked to POPDC1

Classified variants of POPDC1

How much variation POPDC1 tolerates

The same gene in mouse, rat and human

MicroRNAs hosted within POPDC1

Long non-coding RNAs at the POPDC1 locus

Papers that mention POPDC1

Run the controls

Pick the product

Gene summary

Protein function

RefSeq 3 transcripts

A window on one transcript

Ensembl 5 transcripts

A window on one transcript