Gene Human Homo sapiens

CDKL3

cyclin dependent kinase like 3

gene with protein product

Human CDKL3MouseRat

Reading the ortholog votes for mouse and rat.

Location: Cytogenetic band 5q31.1NCBI: 5:134,283,345-134,371,624 on the minus strand, GRCh38.p14 (GCF_000001405.40), sequence NC_000005.10, annotation GCF_000001405.40-RS_2025_08 of 2025-08-01Ensembl: 5:134,286,350-134,371,047 on the minus strand, GRCh38.p14 (GCA_000001405.29), release 116Coordinates are one-based with both ends included, as each source reports them.
Also known as: NKIAMRE

Gene identity, from HGNC · HGNC 2026-09-29 · read 2026-10-02 ET · HGNC:15483

Silence this gene

The order page opens with CDKL3 and human filled in. The sequences are designed against the transcripts below; the price is on that page.

Order for CDKL3

sdASO, toASO or siRNA, chosen on the next page

Bring your own sequence Transcripts

For research use only. Not for use in diagnostic or therapeutic procedures.

Summary
Transcripts
Expression
Protein
Interactions
Pathways
Disease
Variants
Constraint
Orthologs
MicroRNAs
Long non-coding RNAs
Literature
Silencing this gene

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Ready in a moment

01 Summary and function

What CDKL3 does

The protein encoded by this gene is a member of cyclin-dependent protein…

NCBI Gene summary

Ready in a moment

02 Transcripts and isoforms

The RNA a design targets

Reading NCBI Datasets and Ensembl.Still reading. A first read of a gene can take a while; this page waits up to 80 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

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03 Expression by tissue

Where CDKL3 is expressed

Reading GTEx and the Human Protein Atlas.Still reading. A first read of a gene can take a while; this page waits up to 80 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

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04 Protein

The protein CDKL3 encodes

Reading UniProt, InterPro, AlphaFold DB and PDBe.Still reading. A first read of a gene can take a while; this page waits up to 80 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

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05 Interactions

Proteins STRING associates with CDKL3

Reading STRING.Still reading. A first read of a gene can take a while; this page waits up to 50 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

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06 Pathways

Where CDKL3 acts, as Reactome curates it

Reading UniProt and Reactome.Still reading. A first read of a gene can take a while; this page waits up to 60 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

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07 Disease associations

Diseases linked to CDKL3

Reading Open Targets and ClinGen.Still reading. A first read of a gene can take a while; this page waits up to 105 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

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08 Variants

Classified variants of CDKL3

Reading ClinVar.Still reading. A first read of a gene can take a while; this page waits up to 60 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

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09 Constraint

How much variation CDKL3 tolerates

Reading gnomAD and Open Targets.Still reading. A first read of a gene can take a while; this page waits up to 45 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

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10 Orthologs

The same gene in mouse, rat and human

Reading the Alliance, NCBI, Ensembl Compara and RGD.Still reading. A first read of a gene can take a while; this page waits up to 145 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

Ready in a moment

11 MicroRNAs

MicroRNAs hosted within CDKL3

Reading Ensembl and miRBase.Still reading. A first read of a gene can take a while; this page waits up to 110 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

Ready in a moment

12 Long non-coding RNAs

Long non-coding RNAs at the CDKL3 locus

Reading Ensembl.Still reading. A first read of a gene can take a while; this page waits up to 110 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

Ready in a moment

13 Literature

Papers that mention CDKL3

Reading Europe PMC.Still reading. A first read of a gene can take a while; this page waits up to 55 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

Ready in a moment

14 Silencing this gene

From CDKL3 to a sequence that silences it

The AUMsilence platform designs the sequences against the human transcripts on this page. Six decisions are yours before it does. What is written under each is AUM's guidance; the timings and the concentrations are in the usage guide below.

01
Choose the region
A knockdown oligonucleotide can sit in the 5' untranslated region, the coding sequence or the 3' untranslated region, and all three are used. The coding sequence and the 3' untranslated region are the usual first choices for an RNase H design; the 5' end near the start codon suits a steric block. The map above shows where each region sits on the isoforms it draws.
02
Cover the isoforms you mean
An exon every isoform carries silences the whole gene; an exon only some isoforms carry silences those and spares the rest. Decide which you want before a sequence is chosen, and check the reference transcript (MANE Select in human; RefSeq Select and Ensembl canonical in mouse and rat) is the one your cells express.
03
Think across species early
The orthologs panel says whether mouse and rat carry the same gene. Whether one oligonucleotide can serve two species is a sequence question, settled at design by matching the candidate against each transcript, not by the protein identity shown there.
04
Check expression in your model
A transcript that is not expressed in your cells cannot show knockdown. Confirm the gene is expressed in the cell type and condition you will use, from your own data or a reference atlas, before the order. The expression panel above gives GTEx's median per tissue for a human gene; for mouse and rat it says that no atlas is on this page yet.
05
Run the controls
A scramble control of the same chemistry, a positive control against a gene known to knock down in your cells, untreated cells, and a mock condition where a transfection reagent is used. Read knockdown at the RNA level first, then at the protein; the usage guide gives the timing and the concentrations to start from.
06
Pick the product
AUMsilence sdASO needs no transfection reagent and works in the cells that resist one. AUMsilence toASO is the transfection-optimised version of the same design, and AUMsiRNA is the siRNA route. The selection guide compares them.

Order for CDKL3 Bring your own sequence The usage guide Selection guide

For research use only. Not for use in diagnostic or therapeutic procedures.

Gene Human Homo sapiens

CDKL3

Reading the record for CDKL3 from HGNC, NCBI Gene and Ensembl.Still reading. A first read of a gene can take a while; this page waits up to 115 seconds for it, and its scripts then bring in the page, or a line saying what did not arrive.

The full name, the identifiers, the location and the notes from the sources arrive with the record. Nothing is filled in ahead of it.

Order door

The door to order for CDKL3 opens with the record, which decides which product it carries. The order page itself is open now.

Bring your own sequence

For research use only. Not for use in diagnostic or therapeutic procedures.

This page is still reading the record. Its scripts replace this shell with the record when it arrives; with scripts off, it stays at this shell however long you wait.

01 Summary and function

What CDKL3 does

Waiting for the record before reading NCBI Gene and UniProt.

02 Transcripts and isoforms

The RNA a design targets

Waiting for the record before reading NCBI Datasets and Ensembl.

03 Expression by tissue

Where CDKL3 is expressed

Waiting for the record before reading GTEx and the Human Protein Atlas.

04 Protein

The protein CDKL3 encodes

Waiting for the record before reading UniProt, InterPro, AlphaFold DB and PDBe.

05 Interactions

Proteins STRING associates with CDKL3

Waiting for the record before reading STRING.

06 Pathways

Where CDKL3 acts, as Reactome curates it

Waiting for the record before reading UniProt and Reactome.

07 Disease associations

Diseases linked to CDKL3

Waiting for the record before reading Open Targets and ClinGen.

08 Variants

Classified variants of CDKL3

Waiting for the record before reading ClinVar.

09 Constraint

How much variation CDKL3 tolerates

Waiting for the record before reading gnomAD and Open Targets.

10 Orthologs

The same gene in mouse, rat and human

Waiting for the record before reading the Alliance, NCBI, Ensembl Compara and RGD.

11 MicroRNAs

MicroRNAs hosted within CDKL3

Waiting for the record before reading Ensembl and miRBase.

12 Long non-coding RNAs

Long non-coding RNAs at the CDKL3 locus

Waiting for the record before reading Ensembl.

13 Literature

Papers that mention CDKL3

Waiting for the record before reading Europe PMC.

Accession	Name	Biotype	Labels	Exons	Spliced length	Protein	Sequence
NM_001113575.2matches ENST00000265334.9	transcript variant 1	protein coding	MANE Select	13	2,222 nt	592 aaNP_001107047.1	Ready in a moment
XM_024446091.2	transcript variant X11	protein coding model	none	12	5,618 nt	598 aaXP_024301859.1	Ready in a moment
XM_017009534.2	transcript variant X9	protein coding model	none	13	2,785 nt	602 aaXP_016865023.1	Ready in a moment
XM_047417267.1	transcript variant X1	protein coding model	none	Ready in a moment

Accession	Name	Biotype	Labels	Exons	Spliced length	Protein	Sequence
NM_001113575.2matches ENST00000265334.9	transcript variant 1	protein coding	MANE Select	13	2,222 nt	592 aaNP_001107047.1	Ready in a moment
XM_024446091.2	transcript variant X11	protein coding model	none	12	5,618 nt	598 aaXP_024301859.1	Ready in a moment
XM_017009534.2	transcript variant X9	protein coding model	none	13	2,785 nt	602 aaXP_016865023.1	Ready in a moment
XM_047417267.1	transcript variant X1	protein coding model	none	Ready in a moment

Accession	Name	Biotype	Labels	Exons	Spliced length	Protein	Sequence
ENST00000265334.9matches NM_001113575.2	CDKL3-201	protein coding	MANE SelectEnsembl canonical	13	2,222 nt	592 aaENSP00000265334.4	Ready in a moment
ENST00001137320.1	CDKL3-211	protein coding	none	13	3,229 nt	592 aaENSP00000803741.1	Ready in a moment
ENST00000521118.6	CDKL3-206	protein coding	none	13	2,289 nt	590 aaENSP00000428689.1	Ready in a moment
ENST00000523054.5	CDKL3-209	protein coding	none	13	1,775 nt	401 aaENSP00000428500.1	Ready in a moment
ENST00000523832.1	CDKL3-210	protein coding	none	8	1,501 nt	455 aaENSP00000430496.1	Ready in a moment
ENST00000520693.5	CDKL3-205	nonsense mediated decay	none	10	1,417 nt	82 aaENSP00000430777.1	Ready in a moment
ENST00000519312.5	CDKL3-203	nonsense mediated decay	none	9	1,198 nt	106 aaENSP00000427738.1	Ready in a moment
ENST00000520592.1	CDKL3-204	nonsense mediated decay	none	3	652 nt	18 aaENSP00000428498.1	Ready in a moment
ENST00000521755.1	CDKL3-207	protein coding	none	3	586 nt	44 aaENSP00000427964.1	Ready in a moment
ENST00000518990.5	CDKL3-202	protein coding	none	4	466 nt	73 aaENSP00000427836.1	Ready in a moment
ENST00000522501.1	CDKL3-208	protein coding cds not defined	none	4	432 nt	none	Ready in a moment

CDKL3

What CDKL3 does

The RNA a design targets

Where CDKL3 is expressed

The protein CDKL3 encodes

Proteins STRING associates with CDKL3

Where CDKL3 acts, as Reactome curates it

Diseases linked to CDKL3

Classified variants of CDKL3

How much variation CDKL3 tolerates

The same gene in mouse, rat and human

MicroRNAs hosted within CDKL3

Long non-coding RNAs at the CDKL3 locus

Papers that mention CDKL3

From CDKL3 to a sequence that silences it

Choose the region

Cover the isoforms you mean

Think across species early

Check expression in your model

Run the controls

Pick the product

CDKL3

What CDKL3 does

The RNA a design targets

Where CDKL3 is expressed

The protein CDKL3 encodes

Proteins STRING associates with CDKL3

Where CDKL3 acts, as Reactome curates it

Diseases linked to CDKL3

Classified variants of CDKL3

How much variation CDKL3 tolerates

The same gene in mouse, rat and human

MicroRNAs hosted within CDKL3

Long non-coding RNAs at the CDKL3 locus

Papers that mention CDKL3

CDKL3

What CDKL3 does

Gene summary

Protein function

The RNA a design targets

RefSeq 30 transcripts

A window on one transcript

Ensembl 11 transcripts

A window on one transcript

Where CDKL3 is expressed

The protein CDKL3 encodes

Proteins STRING associates with CDKL3

Where CDKL3 acts, as Reactome curates it

Diseases linked to CDKL3

Classified variants of CDKL3

How much variation CDKL3 tolerates

The same gene in mouse, rat and human

MicroRNAs hosted within CDKL3

Long non-coding RNAs at the CDKL3 locus

Papers that mention CDKL3

From CDKL3 to a sequence that silences it

Choose the region

Cover the isoforms you mean

Think across species early

Check expression in your model

Run the controls

Pick the product

Gene summary

Protein function

RefSeq 30 transcripts

A window on one transcript

Ensembl 11 transcripts

A window on one transcript