Gene Human Homo sapiens

CDYL2

chromodomain Y like 2

gene with protein product

Human CDYL2MouseRat

Reading the ortholog votes for mouse and rat.

Location: Cytogenetic band 16q23.2NCBI: 16:80,597,907-80,805,037 on the minus strand, GRCh38.p14 (GCF_000001405.40), sequence NC_000016.10, annotation GCF_000001405.40-RS_2025_08 of 2025-08-01Ensembl: 16:80,597,907-80,804,611 on the minus strand, GRCh38.p14 (GCA_000001405.29), release 116Coordinates are one-based with both ends included, as each source reports them.
Also known as: FLJ38866

Gene identity, from HGNC · HGNC 2026-10-02 · read 2026-10-02 ET · HGNC:23030

Silence this gene

The order page opens with CDYL2 and human filled in. The sequences are designed against the transcripts below; the price is on that page.

Order for CDYL2

sdASO, toASO or siRNA

Bring your own sequence Transcripts

For research use only. Not for use in diagnostic or therapeutic procedures.

Summary
Transcripts
Expression
Protein
Interactions
Pathways
Disease
Variants
Constraint
Orthologs
MicroRNAs
Long non-coding RNAs
Literature
Silencing this gene

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01 Summary and function

What CDYL2 does

Predicted to enable transcription corepressor activity.

NCBI Gene summary

Ready in a moment

02 Transcripts and isoforms

The RNA a design targets

Reading NCBI Datasets and Ensembl.Still reading. A first read of a gene can take a while; this page waits up to 80 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

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03 Expression by tissue

Where CDYL2 is expressed

54 GTEx tissues; the highest median in Brain - Cerebellar Hemisphere, 28.1 TPM.

GTEx

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04 Protein

The protein CDYL2 encodes

Reading UniProt, InterPro, AlphaFold DB and PDBe.Still reading. A first read of a gene can take a while; this page waits up to 80 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

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05 Interactions

Proteins STRING associates with CDYL2

Reading STRING.Still reading. A first read of a gene can take a while; this page waits up to 50 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

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06 Pathways

Where CDYL2 acts, as Reactome curates it

Reading UniProt and Reactome.Still reading. A first read of a gene can take a while; this page waits up to 60 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

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07 Disease associations

Diseases linked to CDYL2

89 Open Targets disease associations; inflammatory bowel disease first, at 0.43.

Open Targets

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08 Variants

Classified variants of CDYL2

Reading ClinVar.Still reading. A first read of a gene can take a while; this page waits up to 60 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

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09 Constraint

How much variation CDYL2 tolerates

pLI 0.01435 and LOEUF 0.660 in gnomAD v4 (GRCh38), on ENST00000570137.7.

gnomAD

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10 Orthologs

The same gene in mouse, rat and human

Reading the Alliance, NCBI, Ensembl Compara and RGD.Still reading. A first read of a gene can take a while; this page waits up to 145 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

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11 MicroRNAs

MicroRNAs hosted within CDYL2

No annotated microRNA lies within CDYL2 in Ensembl release 116, on GRCh38.p14.

Ensembl · miRBase

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12 Long non-coding RNAs

Long non-coding RNAs at the CDYL2 locus

2 long non-coding RNA genes overlap CDYL2 in Ensembl release 116, 1 antisense, none with a symbol.

Ensembl

Order against a long non-coding RNA

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13 Literature

Papers that mention CDYL2

Reading Europe PMC.Still reading. A first read of a gene can take a while; this page waits up to 55 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

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14 Silencing this gene

From CDYL2 to a sequence that silences it

The AUMsilence platform designs the sequences against the human transcripts on this page. Six decisions are yours before it does. What is written under each is AUM's guidance; the timings and the concentrations are in the usage guide below.

01
Choose the region
A knockdown oligonucleotide can sit in the 5' untranslated region, the coding sequence or the 3' untranslated region, and all three are used. The coding sequence and the 3' untranslated region are the usual first choices for an RNase H design; the 5' end near the start codon suits a steric block. The map above shows where each region sits on the isoforms it draws.
02
Cover the isoforms you mean
An exon every isoform carries silences the whole gene; an exon only some isoforms carry silences those and spares the rest. Decide which you want before a sequence is chosen, and check the reference transcript (MANE Select in human; RefSeq Select and Ensembl canonical in mouse and rat) is the one your cells express.
03
Think across species early
The orthologs panel says whether mouse and rat carry the same gene. Whether one oligonucleotide can serve two species is a sequence question, settled at design by matching the candidate against each transcript, not by the protein identity shown there.
04
Check expression in your model
A transcript that is not expressed in your cells cannot show knockdown. Confirm the gene is expressed in the cell type and condition you will use, from your own data or a reference atlas, before the order. The expression panel above gives GTEx's median per tissue for a human gene; for mouse and rat it says that no atlas is on this page yet.
05
Run the controls
A scramble control of the same chemistry, a positive control against a gene known to knock down in your cells, untreated cells, and a mock condition where a transfection reagent is used. Read knockdown at the RNA level first, then at the protein; the usage guide gives the timing and the concentrations to start from.
06
Pick the product
AUMsilence sdASO needs no transfection reagent and works in the cells that resist one. AUMsilence toASO is the transfection-optimised version of the same design, and AUMsiRNA is the siRNA route. The selection guide compares them.

Order for CDYL2 Bring your own sequence The usage guide Selection guide

For research use only. Not for use in diagnostic or therapeutic procedures.

Gene Human Homo sapiens

CDYL2

Reading the record for CDYL2 from HGNC, NCBI Gene and Ensembl.Still reading. A first read of a gene can take a while; this page waits up to 115 seconds for it, and its scripts then bring in the page, or a line saying what did not arrive.

The full name, the identifiers, the location and the notes from the sources arrive with the record. Nothing is filled in ahead of it.

Order door

The door to order for CDYL2 opens with the record, which decides which product it carries. The order page itself is open now.

Bring your own sequence

For research use only. Not for use in diagnostic or therapeutic procedures.

This page is still reading the record. Its scripts replace this shell with the record when it arrives; with scripts off, it stays at this shell however long you wait.

01 Summary and function

What CDYL2 does

Waiting for the record before reading NCBI Gene and UniProt.

02 Transcripts and isoforms

The RNA a design targets

Waiting for the record before reading NCBI Datasets and Ensembl.

03 Expression by tissue

Where CDYL2 is expressed

Waiting for the record before reading GTEx and the Human Protein Atlas.

04 Protein

The protein CDYL2 encodes

Waiting for the record before reading UniProt, InterPro, AlphaFold DB and PDBe.

05 Interactions

Proteins STRING associates with CDYL2

Waiting for the record before reading STRING.

06 Pathways

Where CDYL2 acts, as Reactome curates it

Waiting for the record before reading UniProt and Reactome.

07 Disease associations

Diseases linked to CDYL2

Waiting for the record before reading Open Targets and ClinGen.

08 Variants

Classified variants of CDYL2

Waiting for the record before reading ClinVar.

09 Constraint

How much variation CDYL2 tolerates

Waiting for the record before reading gnomAD and Open Targets.

10 Orthologs

The same gene in mouse, rat and human

Waiting for the record before reading the Alliance, NCBI, Ensembl Compara and RGD.

11 MicroRNAs

MicroRNAs hosted within CDYL2

Waiting for the record before reading Ensembl and miRBase.

12 Long non-coding RNAs

Long non-coding RNAs at the CDYL2 locus

Waiting for the record before reading Ensembl.

13 Literature

Papers that mention CDYL2

Waiting for the record before reading Europe PMC.

Accession	Name	Biotype	Labels	Exons	Spliced length	Protein	Sequence
NM_152342.4matches ENST00000570137.7	none given	protein coding	MANE Select	7	8,427 nt	506 aaNP_689555.2	Ready in a moment
XM_011522867.3	transcript variant X2	protein coding model	none	7	8,664 nt	503 aaXP_011521169.1	Ready in a moment
XM_024450151.2	transcript variant X3	protein coding model	none	7	8,197 nt	447 aaXP_024305919.1	Ready in a moment
XM_011522866.2	transcript variant X1	protein coding model	none	Ready in a moment

Accession	Name	Biotype	Labels	Exons	Spliced length	Protein	Sequence
NM_152342.4matches ENST00000570137.7	none given	protein coding	MANE Select	7	8,427 nt	506 aaNP_689555.2	Ready in a moment
XM_011522867.3	transcript variant X2	protein coding model	none	7	8,664 nt	503 aaXP_011521169.1	Ready in a moment
XM_024450151.2	transcript variant X3	protein coding model	none	7	8,197 nt	447 aaXP_024305919.1	Ready in a moment
XM_011522866.2	transcript variant X1	protein coding model	none	Ready in a moment

Accession	Name	Biotype	Labels	Exons	Spliced length	Protein	Sequence
ENST00000570137.7matches NM_152342.4	CDYL2-207	protein coding	MANE SelectEnsembl canonical	7	8,427 nt	506 aaENSP00000476295.1	Ready in a moment
ENST00000562812.6	CDYL2-203	protein coding	none	8	8,443 nt	507 aaENSP00000454546.1	Ready in a moment
ENST00000563890.6	CDYL2-204	protein coding	none	8	8,443 nt	507 aaENSP00000455111.1	Ready in a moment
ENST00000566173.4	CDYL2-205	protein coding	none	8	8,443 nt	507 aaENSP00000456934.1	Ready in a moment
ENST00001135577.1	CDYL2-209	protein coding	none	7	8,440 nt	506 aaENSP00000814538.1	Ready in a moment
ENST00000919359.2	CDYL2-208	protein coding	none	6	8,296 nt	458 aaENSP00000589418.1	Ready in a moment
ENST00000561616.2	CDYL2-201	protein coding cds not defined	none	4	655 nt	none	Ready in a moment
ENST00000562753.1	CDYL2-202	protein coding cds not defined	none	2	557 nt	none	Ready in a moment
ENST00000567924.1	CDYL2-206	protein coding cds not defined	none	2	453 nt	none	Ready in a moment

CDYL2

What CDYL2 does

The RNA a design targets

Where CDYL2 is expressed

The protein CDYL2 encodes

Proteins STRING associates with CDYL2

Where CDYL2 acts, as Reactome curates it

Diseases linked to CDYL2

Classified variants of CDYL2

How much variation CDYL2 tolerates

The same gene in mouse, rat and human

MicroRNAs hosted within CDYL2

Long non-coding RNAs at the CDYL2 locus

Papers that mention CDYL2

From CDYL2 to a sequence that silences it

Choose the region

Cover the isoforms you mean

Think across species early

Check expression in your model

Run the controls

Pick the product

CDYL2

What CDYL2 does

The RNA a design targets

Where CDYL2 is expressed

The protein CDYL2 encodes

Proteins STRING associates with CDYL2

Where CDYL2 acts, as Reactome curates it

Diseases linked to CDYL2

Classified variants of CDYL2

How much variation CDYL2 tolerates

The same gene in mouse, rat and human

MicroRNAs hosted within CDYL2

Long non-coding RNAs at the CDYL2 locus

Papers that mention CDYL2

CDYL2

What CDYL2 does

Gene summary

Protein function

The RNA a design targets

RefSeq 4 transcripts

A window on one transcript

Ensembl 9 transcripts

A window on one transcript

Where CDYL2 is expressed

The protein CDYL2 encodes

Proteins STRING associates with CDYL2

Where CDYL2 acts, as Reactome curates it

Diseases linked to CDYL2

Classified variants of CDYL2

How much variation CDYL2 tolerates

The same gene in mouse, rat and human

MicroRNAs hosted within CDYL2

Long non-coding RNAs at the CDYL2 locus

Papers that mention CDYL2

From CDYL2 to a sequence that silences it

Choose the region

Cover the isoforms you mean

Think across species early

Check expression in your model

Run the controls

Pick the product

Gene summary

Protein function

RefSeq 4 transcripts

A window on one transcript

Ensembl 9 transcripts

A window on one transcript