Gene Human Homo sapiens

CEACAM4

CEA cell adhesion molecule 4

gene with protein product

Human CEACAM4MouseRat

Reading the ortholog votes for mouse and rat.

Location: Cytogenetic band 19q13.2NCBI: 19:41,613,436-41,627,074 on the minus strand, GRCh38.p14 (GCF_000001405.40), sequence NC_000019.10, annotation GCF_000001405.40-RS_2025_08 of 2025-08-01Ensembl: 19:41,619,014-41,627,082 on the minus strand, GRCh38.p14 (GCA_000001405.29), release 116Coordinates are one-based with both ends included, as each source reports them.
Previous symbols: CGM7

Gene identity, from HGNC · HGNC 2026-09-18 · read 2026-09-23 ET · HGNC:1816

Notes from the sources

HGNC lists more than one mouse id for this gene (MGI:1347248, MGI:1347251, MGI:1891354, MGI:1891361, MGI:1914246, MGI:1914334, MGI:1914565, MGI:1917035); MGI:1347248 is used
NCBI places this gene on more than one sequence of GRCh38.p14 (19 NC_000019.10, 19 NT_187620.1); the coordinates shown are the 19 placement

Silence this gene

The order page opens with CEACAM4 and human filled in. The sequences are designed against the transcripts below; the price is on that page.

Order for CEACAM4

sdASO, toASO or siRNA, chosen on the next page

Bring your own sequence Transcripts

For research use only. Not for use in diagnostic or therapeutic procedures.

Summary
Transcripts
Expression
Protein
Interactions
Pathways
Disease
Variants
Constraint
Orthologs
MicroRNAs
Long non-coding RNAs
Literature
Silencing this gene

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01 Summary and function

What CEACAM4 does

NCBI Gene asked this site to slow down, so the gene summary could not be read. Try again in a minute. Reference ead3472e-37c.

Ready in a moment

02 Transcripts and isoforms

The RNA a design targets

Reading NCBI Datasets and Ensembl.Still reading. A first read of a gene can take a while; this page waits up to 80 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

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03 Expression by tissue

Where CEACAM4 is expressed

54 GTEx tissues; the highest median in Whole Blood, 99.8 TPM.

GTEx

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04 Protein

The protein CEACAM4 encodes

244 residues, reviewed O75871; 10 entries from the member databases this page shows along the chain; mean pLDDT 77.25; no experimental structure at PDBe.

UniProt · InterPro · AlphaFold DB · PDBe

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05 Interactions

Proteins STRING associates with CEACAM4

Reading STRING.Still reading. A first read of a gene can take a while; this page waits up to 50 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

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06 Pathways

Where CEACAM4 acts, as Reactome curates it

Reactome v97 maps no pathway to O75871 in human.

Reactome

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07 Disease associations

Diseases linked to CEACAM4

Reading Open Targets and ClinGen.Still reading. A first read of a gene can take a while; this page waits up to 105 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

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08 Variants

Classified variants of CEACAM4

Reading ClinVar.Still reading. A first read of a gene can take a while; this page waits up to 60 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

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09 Constraint

How much variation CEACAM4 tolerates

pLI below 0.0001 and LOEUF 1.42 in gnomAD v4 (GRCh38), on ENST00000221954.7.

gnomAD

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10 Orthologs

The same gene in mouse, rat and human

Reading the Alliance, NCBI, Ensembl Compara and RGD.Still reading. A first read of a gene can take a while; this page waits up to 145 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

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11 MicroRNAs

MicroRNAs hosted within CEACAM4

Reading Ensembl and miRBase.Still reading. A first read of a gene can take a while; this page waits up to 110 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

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12 Long non-coding RNAs

Long non-coding RNAs at the CEACAM4 locus

Reading Ensembl.Still reading. A first read of a gene can take a while; this page waits up to 110 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

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13 Literature

Papers that mention CEACAM4

Reading Europe PMC.Still reading. A first read of a gene can take a while; this page waits up to 55 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

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14 Silencing this gene

From CEACAM4 to a sequence that silences it

The AUMsilence platform designs the sequences against the human transcripts on this page. Six decisions are yours before it does. What is written under each is AUM's guidance; the timings and the concentrations are in the usage guide below.

01
Choose the region
A knockdown oligonucleotide can sit in the 5' untranslated region, the coding sequence or the 3' untranslated region, and all three are used. The coding sequence and the 3' untranslated region are the usual first choices for an RNase H design; the 5' end near the start codon suits a steric block. The map above shows where each region sits on the isoforms it draws.
02
Cover the isoforms you mean
An exon every isoform carries silences the whole gene; an exon only some isoforms carry silences those and spares the rest. Decide which you want before a sequence is chosen, and check the reference transcript (MANE Select in human; RefSeq Select and Ensembl canonical in mouse and rat) is the one your cells express.
03
Think across species early
The orthologs panel says whether mouse and rat carry the same gene. Whether one oligonucleotide can serve two species is a sequence question, settled at design by matching the candidate against each transcript, not by the protein identity shown there.
04
Check expression in your model
A transcript that is not expressed in your cells cannot show knockdown. Confirm the gene is expressed in the cell type and condition you will use, from your own data or a reference atlas, before the order. The expression panel above gives GTEx's median per tissue for a human gene; for mouse and rat it says that no atlas is on this page yet.
05
Run the controls
A scramble control of the same chemistry, a positive control against a gene known to knock down in your cells, untreated cells, and a mock condition where a transfection reagent is used. Read knockdown at the RNA level first, then at the protein; the usage guide gives the timing and the concentrations to start from.
06
Pick the product
AUMsilence sdASO needs no transfection reagent and works in the cells that resist one. AUMsilence toASO is the transfection-optimised version of the same design, and AUMsiRNA is the siRNA route. The selection guide compares them.

Order for CEACAM4 Bring your own sequence The usage guide Selection guide

For research use only. Not for use in diagnostic or therapeutic procedures.

Gene Human Homo sapiens

CEACAM4

Reading the record for CEACAM4 from HGNC, NCBI Gene and Ensembl.Still reading. A first read of a gene can take a while; this page waits up to 115 seconds for it, and its scripts then bring in the page, or a line saying what did not arrive.

The full name, the identifiers, the location and the notes from the sources arrive with the record. Nothing is filled in ahead of it.

Order door

The door to order for CEACAM4 opens with the record, which decides which product it carries. The order page itself is open now.

Bring your own sequence

For research use only. Not for use in diagnostic or therapeutic procedures.

This page is still reading the record. Its scripts replace this shell with the record when it arrives; with scripts off, it stays at this shell however long you wait.

01 Summary and function

What CEACAM4 does

Waiting for the record before reading NCBI Gene and UniProt.

02 Transcripts and isoforms

The RNA a design targets

Waiting for the record before reading NCBI Datasets and Ensembl.

03 Expression by tissue

Where CEACAM4 is expressed

Waiting for the record before reading GTEx and the Human Protein Atlas.

04 Protein

The protein CEACAM4 encodes

Waiting for the record before reading UniProt, InterPro, AlphaFold DB and PDBe.

05 Interactions

Proteins STRING associates with CEACAM4

Waiting for the record before reading STRING.

06 Pathways

Where CEACAM4 acts, as Reactome curates it

Waiting for the record before reading UniProt and Reactome.

07 Disease associations

Diseases linked to CEACAM4

Waiting for the record before reading Open Targets and ClinGen.

08 Variants

Classified variants of CEACAM4

Waiting for the record before reading ClinVar.

09 Constraint

How much variation CEACAM4 tolerates

Waiting for the record before reading gnomAD and Open Targets.

10 Orthologs

The same gene in mouse, rat and human

Waiting for the record before reading the Alliance, NCBI, Ensembl Compara and RGD.

11 MicroRNAs

MicroRNAs hosted within CEACAM4

Waiting for the record before reading Ensembl and miRBase.

12 Long non-coding RNAs

Long non-coding RNAs at the CEACAM4 locus

Waiting for the record before reading Ensembl.

13 Literature

Papers that mention CEACAM4

Waiting for the record before reading Europe PMC.

Accession	Name	Biotype	Labels	Exons	Spliced length	Protein	Sequence
ENST00000221954.7matches NM_001817.4	CEACAM4-201	protein coding	MANE SelectEnsembl canonical	7	1,161 nt	244 aaENSP00000221954.2	Ready in a moment
ENST00001093481.1	CEACAM4-207	protein coding	none	7	1,224 nt	262 aaENSP00000763287.1	Ready in a moment
ENST00001143378.1	CEACAM4-208	protein coding	none	7	1,170 nt	244 aaENSP00000801748.1	Ready in a moment
ENST00001028485.1	CEACAM4-205	protein coding	none	6	1,052 nt	239 aaENSP00000698302.1	Ready in a moment
ENST00000600925.2	CEACAM4-203	protein coding	none	6	907 nt	254 aaENSP00000473018.1	Ready in a moment
ENST00001093480.1	CEACAM4-206	protein coding	none	6	864 nt	142 aaENSP00000763286.1	Ready in a moment
ENST00000902906.2	CEACAM4-204	protein coding	none	6	810 nt	124 aaENSP00000572965.1	Ready in a moment
ENST00000472081.1	CEACAM4-202	retained intron	none	2	569 nt	none	Ready in a moment

CEACAM4

What CEACAM4 does

The RNA a design targets

Where CEACAM4 is expressed

The protein CEACAM4 encodes

Proteins STRING associates with CEACAM4

Where CEACAM4 acts, as Reactome curates it

Diseases linked to CEACAM4

Classified variants of CEACAM4

How much variation CEACAM4 tolerates

The same gene in mouse, rat and human

MicroRNAs hosted within CEACAM4

Long non-coding RNAs at the CEACAM4 locus

Papers that mention CEACAM4

From CEACAM4 to a sequence that silences it

Choose the region

Cover the isoforms you mean

Think across species early

Check expression in your model

Run the controls

Pick the product

CEACAM4

What CEACAM4 does

The RNA a design targets

Where CEACAM4 is expressed

The protein CEACAM4 encodes

Proteins STRING associates with CEACAM4

Where CEACAM4 acts, as Reactome curates it

Diseases linked to CEACAM4

Classified variants of CEACAM4

How much variation CEACAM4 tolerates

The same gene in mouse, rat and human

MicroRNAs hosted within CEACAM4

Long non-coding RNAs at the CEACAM4 locus

Papers that mention CEACAM4

CEACAM4

What CEACAM4 does

Gene summary

Protein function

The RNA a design targets

RefSeq 65 transcripts

A window on one transcript

Ensembl 8 transcripts

A window on one transcript

Where CEACAM4 is expressed

The protein CEACAM4 encodes

Proteins STRING associates with CEACAM4

Where CEACAM4 acts, as Reactome curates it

Diseases linked to CEACAM4

Classified variants of CEACAM4

How much variation CEACAM4 tolerates

The same gene in mouse, rat and human

MicroRNAs hosted within CEACAM4

Long non-coding RNAs at the CEACAM4 locus

Papers that mention CEACAM4

From CEACAM4 to a sequence that silences it

Choose the region

Cover the isoforms you mean

Think across species early

Check expression in your model

Run the controls

Pick the product

Gene summary

Protein function

RefSeq 65 transcripts

A window on one transcript

Ensembl 8 transcripts

A window on one transcript