Gene Human Homo sapiens

CELF6

CUGBP Elav-like family member 6

gene with protein product

Human CELF6MouseRat

Reading the ortholog votes for mouse and rat.

Location: Cytogenetic band 15q23NCBI: 15:72,284,727-72,320,157 on the minus strand, GRCh38.p14 (GCF_000001405.40), sequence NC_000015.10, annotation GCF_000001405.40-RS_2025_08 of 2025-08-01Ensembl: 15:72,284,727-72,320,622 on the minus strand, GRCh38.p14 (GCA_000001405.29), release 116Coordinates are one-based with both ends included, as each source reports them.
Previous symbols: BRUNOL6

Gene identity, from HGNC · HGNC 2026-10-02 · read 2026-10-03 ET · HGNC:14059

Silence this gene

The order page opens with CELF6 and human filled in. The sequences are designed against the transcripts below; the price is on that page.

Order for CELF6

sdASO, toASO or siRNA

Bring your own sequence Transcripts

For research use only. Not for use in diagnostic or therapeutic procedures.

Summary
Transcripts
Expression
Protein
Interactions
Pathways
Disease
Variants
Constraint
Orthologs
MicroRNAs
Long non-coding RNAs
Literature
Silencing this gene

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Ready in a moment

01 Summary and function

What CELF6 does

Members of the CELF/BRUNOL protein family contain two N-terminal RNA…

NCBI Gene summary

Ready in a moment

02 Transcripts and isoforms

The RNA a design targets

Reading NCBI Datasets and Ensembl.Still reading. A first read of a gene can take a while; this page waits up to 80 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

Ready in a moment

03 Expression by tissue

Where CELF6 is expressed

Reading GTEx and the Human Protein Atlas.Still reading. A first read of a gene can take a while; this page waits up to 80 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

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04 Protein

The protein CELF6 encodes

Reading UniProt, InterPro, AlphaFold DB and PDBe.Still reading. A first read of a gene can take a while; this page waits up to 80 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

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05 Interactions

Proteins STRING associates with CELF6

Reading STRING.Still reading. A first read of a gene can take a while; this page waits up to 50 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

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06 Pathways

Where CELF6 acts, as Reactome curates it

Reading UniProt and Reactome.Still reading. A first read of a gene can take a while; this page waits up to 60 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

Ready in a moment

07 Disease associations

Diseases linked to CELF6

33 Open Targets disease associations; neurodegenerative disease first, at 0.26.

Open Targets

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08 Variants

Classified variants of CELF6

Reading ClinVar.Still reading. A first read of a gene can take a while; this page waits up to 60 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

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09 Constraint

How much variation CELF6 tolerates

Reading gnomAD and Open Targets.Still reading. A first read of a gene can take a while; this page waits up to 45 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

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10 Orthologs

The same gene in mouse, rat and human

Reading the Alliance, NCBI, Ensembl Compara and RGD.Still reading. A first read of a gene can take a while; this page waits up to 145 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

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11 MicroRNAs

MicroRNAs hosted within CELF6

Reading Ensembl and miRBase.Still reading. A first read of a gene can take a while; this page waits up to 110 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

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12 Long non-coding RNAs

Long non-coding RNAs at the CELF6 locus

Reading Ensembl.Still reading. A first read of a gene can take a while; this page waits up to 110 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

Ready in a moment

13 Literature

Papers that mention CELF6

Reading Europe PMC.Still reading. A first read of a gene can take a while; this page waits up to 55 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

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14 Silencing this gene

From CELF6 to a sequence that silences it

The AUMsilence platform designs the sequences against the human transcripts on this page. Six decisions are yours before it does. What is written under each is AUM's guidance; the timings and the concentrations are in the usage guide below.

01
Choose the region
A knockdown oligonucleotide can sit in the 5' untranslated region, the coding sequence or the 3' untranslated region, and all three are used. The coding sequence and the 3' untranslated region are the usual first choices for an RNase H design; the 5' end near the start codon suits a steric block. The map above shows where each region sits on the isoforms it draws.
02
Cover the isoforms you mean
An exon every isoform carries silences the whole gene; an exon only some isoforms carry silences those and spares the rest. Decide which you want before a sequence is chosen, and check the reference transcript (MANE Select in human; RefSeq Select and Ensembl canonical in mouse and rat) is the one your cells express.
03
Think across species early
The orthologs panel says whether mouse and rat carry the same gene. Whether one oligonucleotide can serve two species is a sequence question, settled at design by matching the candidate against each transcript, not by the protein identity shown there.
04
Check expression in your model
A transcript that is not expressed in your cells cannot show knockdown. Confirm the gene is expressed in the cell type and condition you will use, from your own data or a reference atlas, before the order. The expression panel above gives GTEx's median per tissue for a human gene; for mouse and rat it says that no atlas is on this page yet.
05
Run the controls
A scramble control of the same chemistry, a positive control against a gene known to knock down in your cells, untreated cells, and a mock condition where a transfection reagent is used. Read knockdown at the RNA level first, then at the protein; the usage guide gives the timing and the concentrations to start from.
06
Pick the product
AUMsilence sdASO needs no transfection reagent and works in the cells that resist one. AUMsilence toASO is the transfection-optimised version of the same design, and AUMsiRNA is the siRNA route. The selection guide compares them.

Order for CELF6 Bring your own sequence The usage guide Selection guide

For research use only. Not for use in diagnostic or therapeutic procedures.

Gene Human Homo sapiens

CELF6

Reading the record for CELF6 from HGNC, NCBI Gene and Ensembl.Still reading. A first read of a gene can take a while; this page waits up to 115 seconds for it, and its scripts then bring in the page, or a line saying what did not arrive.

The full name, the identifiers, the location and the notes from the sources arrive with the record. Nothing is filled in ahead of it.

Order door

The door to order for CELF6 opens with the record, which decides which product it carries. The order page itself is open now.

Bring your own sequence

For research use only. Not for use in diagnostic or therapeutic procedures.

This page is still reading the record. Its scripts replace this shell with the record when it arrives; with scripts off, it stays at this shell however long you wait.

01 Summary and function

What CELF6 does

Waiting for the record before reading NCBI Gene and UniProt.

02 Transcripts and isoforms

The RNA a design targets

Waiting for the record before reading NCBI Datasets and Ensembl.

03 Expression by tissue

Where CELF6 is expressed

Waiting for the record before reading GTEx and the Human Protein Atlas.

04 Protein

The protein CELF6 encodes

Waiting for the record before reading UniProt, InterPro, AlphaFold DB and PDBe.

05 Interactions

Proteins STRING associates with CELF6

Waiting for the record before reading STRING.

06 Pathways

Where CELF6 acts, as Reactome curates it

Waiting for the record before reading UniProt and Reactome.

07 Disease associations

Diseases linked to CELF6

Waiting for the record before reading Open Targets and ClinGen.

08 Variants

Classified variants of CELF6

Waiting for the record before reading ClinVar.

09 Constraint

How much variation CELF6 tolerates

Waiting for the record before reading gnomAD and Open Targets.

10 Orthologs

The same gene in mouse, rat and human

Waiting for the record before reading the Alliance, NCBI, Ensembl Compara and RGD.

11 MicroRNAs

MicroRNAs hosted within CELF6

Waiting for the record before reading Ensembl and miRBase.

12 Long non-coding RNAs

Long non-coding RNAs at the CELF6 locus

Waiting for the record before reading Ensembl.

13 Literature

Papers that mention CELF6

Waiting for the record before reading Europe PMC.

Accession	Name	Biotype	Labels	Exons	Spliced length	Protein	Sequence
NM_052840.5matches ENST00000287202.10	transcript variant 1	protein coding	MANE Select	13	3,373 nt	481 aaNP_443072.3	Ready in a moment
NM_001172684.2matches ENST00000567083.3	transcript variant 2	protein coding	none	12	3,292 nt	454 aaNP_001166155.1	Ready in a moment
NM_001172685.2matches ENST00000543764.7	transcript variant 3	protein coding	none	11	2,883 nt	344 aaNP_001166156.1	Ready in a moment

Accession	Name	Biotype	Labels	Exons	Spliced length	Protein	Sequence
NM_052840.5matches ENST00000287202.10	transcript variant 1	protein coding	MANE Select	13	3,373 nt	481 aaNP_443072.3	Ready in a moment
NM_001172684.2matches ENST00000567083.3	transcript variant 2	protein coding	none	12	3,292 nt	454 aaNP_001166155.1	Ready in a moment
NM_001172685.2matches ENST00000543764.7	transcript variant 3	protein coding	none	11	2,883 nt	344 aaNP_001166156.1	Ready in a moment

Accession	Name	Biotype	Labels	Exons	Spliced length	Protein	Sequence
ENST00000287202.10matches NM_052840.5	CELF6-201	protein coding	MANE SelectEnsembl canonical	13	3,373 nt	481 aaENSP00000287202.5	Ready in a moment
ENST00001050431.1	CELF6-211	nonsense mediated decay	none	13	3,743 nt	394 aaENSP00000720248.1	Ready in a moment
ENST00001050430.1	CELF6-210	nonsense mediated decay	none	11	3,693 nt	255 aaENSP00000720247.1	Ready in a moment
ENST00001132593.1	CELF6-214	protein coding	none	13	3,664 nt	481 aaENSP00000804653.1	Ready in a moment
ENST00000962371.2	CELF6-208	protein coding	none	12	3,601 nt	460 aaENSP00000632430.1	Ready in a moment
ENST00000567083.3	CELF6-205	protein coding	none	12	3,583 nt	454 aaENSP00000457863.1	Ready in a moment
ENST00000870866.2	CELF6-206	protein coding	none	11	3,532 nt	437 aaENSP00000540925.1	Ready in a moment
ENST00000962372.2	CELF6-209	protein coding	none	10	3,451 nt	410 aaENSP00000632431.1	Ready in a moment
ENST00001050432.1	CELF6-212	nonsense mediated decay	none	12	3,316 nt	255 aaENSP00000720249.1	Ready in a moment
ENST00001124492.1	CELF6-213	nonsense mediated decay	none	11	2,994 nt	99 aaENSP00000794297.1	Ready in a moment
ENST00000395258.8	CELF6-202	protein coding	none	13	2,965 nt	368 aaENSP00000378677.2	Ready in a moment
ENST00000543764.7	CELF6-204	protein coding	none	11	2,854 nt	344 aaENSP00000439956.2	Ready in a moment
ENST00000437872.7	CELF6-203	nonsense mediated decay	none	12	2,497 nt	133 aaENSP00000400439.3	Ready in a moment
ENST00000870867.2	CELF6-207	protein coding	none	11	1,982 nt	459 aaENSP00000540926.1	Ready in a moment

CELF6

What CELF6 does

The RNA a design targets

Where CELF6 is expressed

The protein CELF6 encodes

Proteins STRING associates with CELF6

Where CELF6 acts, as Reactome curates it

Diseases linked to CELF6

Classified variants of CELF6

How much variation CELF6 tolerates

The same gene in mouse, rat and human

MicroRNAs hosted within CELF6

Long non-coding RNAs at the CELF6 locus

Papers that mention CELF6

From CELF6 to a sequence that silences it

Choose the region

Cover the isoforms you mean

Think across species early

Check expression in your model

Run the controls

Pick the product

CELF6

What CELF6 does

The RNA a design targets

Where CELF6 is expressed

The protein CELF6 encodes

Proteins STRING associates with CELF6

Where CELF6 acts, as Reactome curates it

Diseases linked to CELF6

Classified variants of CELF6

How much variation CELF6 tolerates

The same gene in mouse, rat and human

MicroRNAs hosted within CELF6

Long non-coding RNAs at the CELF6 locus

Papers that mention CELF6

CELF6

What CELF6 does

Gene summary

Protein function

The RNA a design targets

RefSeq 3 transcripts

A window on one transcript

Ensembl 14 transcripts

A window on one transcript

Where CELF6 is expressed

The protein CELF6 encodes

Proteins STRING associates with CELF6

Where CELF6 acts, as Reactome curates it

Diseases linked to CELF6

Classified variants of CELF6

How much variation CELF6 tolerates

The same gene in mouse, rat and human

MicroRNAs hosted within CELF6

Long non-coding RNAs at the CELF6 locus

Papers that mention CELF6

From CELF6 to a sequence that silences it

Choose the region

Cover the isoforms you mean

Think across species early

Check expression in your model

Run the controls

Pick the product

Gene summary

Protein function

RefSeq 3 transcripts

A window on one transcript

Ensembl 14 transcripts

A window on one transcript