Gene Human Homo sapiens

CPNE7

copine 7

gene with protein product

Human CPNE7MouseRat

Reading the ortholog votes for mouse and rat.

Location: Cytogenetic band 16q24.3NCBI: 16:89,575,758-89,597,246 on the plus strand, GRCh38.p14 (GCF_000001405.40), sequence NC_000016.10, annotation GCF_000001405.40-RS_2025_08 of 2025-08-01Ensembl: 16:89,575,730-89,597,247 on the plus strand, GRCh38.p14 (GCA_000001405.29), release 116Coordinates are one-based with both ends included, as each source reports them.

Gene identity, from HGNC · HGNC 2026-10-02 · read 2026-10-02 ET · HGNC:2320

Silence this gene

The order page opens with CPNE7 and human filled in. The sequences are designed against the transcripts below; the price is on that page.

Order for CPNE7

sdASO, toASO or siRNA

Bring your own sequence Transcripts

For research use only. Not for use in diagnostic or therapeutic procedures.

Summary
Transcripts
Expression
Protein
Interactions
Pathways
Disease
Variants
Constraint
Orthologs
MicroRNAs
Long non-coding RNAs
Literature
Silencing this gene

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01 Summary and function

What CPNE7 does

This gene encodes a member of the copine family, which is composed of…

NCBI Gene summary

Ready in a moment

02 Transcripts and isoforms

The RNA a design targets

Reading NCBI Datasets and Ensembl.Still reading. A first read of a gene can take a while; this page waits up to 80 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

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03 Expression by tissue

Where CPNE7 is expressed

Reading GTEx and the Human Protein Atlas.Still reading. A first read of a gene can take a while; this page waits up to 80 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

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04 Protein

The protein CPNE7 encodes

Reading UniProt, InterPro, AlphaFold DB and PDBe.Still reading. A first read of a gene can take a while; this page waits up to 80 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

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05 Interactions

Proteins STRING associates with CPNE7

Reading STRING.Still reading. A first read of a gene can take a while; this page waits up to 50 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

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06 Pathways

Where CPNE7 acts, as Reactome curates it

Reading UniProt and Reactome.Still reading. A first read of a gene can take a while; this page waits up to 60 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

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07 Disease associations

Diseases linked to CPNE7

Reading Open Targets and ClinGen.Still reading. A first read of a gene can take a while; this page waits up to 105 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

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08 Variants

Classified variants of CPNE7

Reading ClinVar.Still reading. A first read of a gene can take a while; this page waits up to 60 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

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09 Constraint

How much variation CPNE7 tolerates

Reading gnomAD and Open Targets.Still reading. A first read of a gene can take a while; this page waits up to 45 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

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10 Orthologs

The same gene in mouse, rat and human

Reading the Alliance, NCBI, Ensembl Compara and RGD.Still reading. A first read of a gene can take a while; this page waits up to 145 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

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11 MicroRNAs

MicroRNAs hosted within CPNE7

Reading Ensembl and miRBase.Still reading. A first read of a gene can take a while; this page waits up to 110 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

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12 Long non-coding RNAs

Long non-coding RNAs at the CPNE7 locus

Reading Ensembl.Still reading. A first read of a gene can take a while; this page waits up to 110 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

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13 Literature

Papers that mention CPNE7

Reading Europe PMC.Still reading. A first read of a gene can take a while; this page waits up to 55 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

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14 Silencing this gene

From CPNE7 to a sequence that silences it

The AUMsilence platform designs the sequences against the human transcripts on this page. Six decisions are yours before it does. What is written under each is AUM's guidance; the timings and the concentrations are in the usage guide below.

01
Choose the region
A knockdown oligonucleotide can sit in the 5' untranslated region, the coding sequence or the 3' untranslated region, and all three are used. The coding sequence and the 3' untranslated region are the usual first choices for an RNase H design; the 5' end near the start codon suits a steric block. The map above shows where each region sits on the isoforms it draws.
02
Cover the isoforms you mean
An exon every isoform carries silences the whole gene; an exon only some isoforms carry silences those and spares the rest. Decide which you want before a sequence is chosen, and check the reference transcript (MANE Select in human; RefSeq Select and Ensembl canonical in mouse and rat) is the one your cells express.
03
Think across species early
The orthologs panel says whether mouse and rat carry the same gene. Whether one oligonucleotide can serve two species is a sequence question, settled at design by matching the candidate against each transcript, not by the protein identity shown there.
04
Check expression in your model
A transcript that is not expressed in your cells cannot show knockdown. Confirm the gene is expressed in the cell type and condition you will use, from your own data or a reference atlas, before the order. The expression panel above gives GTEx's median per tissue for a human gene; for mouse and rat it says that no atlas is on this page yet.
05
Run the controls
A scramble control of the same chemistry, a positive control against a gene known to knock down in your cells, untreated cells, and a mock condition where a transfection reagent is used. Read knockdown at the RNA level first, then at the protein; the usage guide gives the timing and the concentrations to start from.
06
Pick the product
AUMsilence sdASO needs no transfection reagent and works in the cells that resist one. AUMsilence toASO is the transfection-optimised version of the same design, and AUMsiRNA is the siRNA route. The selection guide compares them.

Order for CPNE7 Bring your own sequence The usage guide Selection guide

For research use only. Not for use in diagnostic or therapeutic procedures.

Gene Human Homo sapiens

CPNE7

Reading the record for CPNE7 from HGNC, NCBI Gene and Ensembl.Still reading. A first read of a gene can take a while; this page waits up to 115 seconds for it, and its scripts then bring in the page, or a line saying what did not arrive.

The full name, the identifiers, the location and the notes from the sources arrive with the record. Nothing is filled in ahead of it.

Order door

The door to order for CPNE7 opens with the record, which decides which product it carries. The order page itself is open now.

Bring your own sequence

For research use only. Not for use in diagnostic or therapeutic procedures.

This page is still reading the record. Its scripts replace this shell with the record when it arrives; with scripts off, it stays at this shell however long you wait.

01 Summary and function

What CPNE7 does

Waiting for the record before reading NCBI Gene and UniProt.

02 Transcripts and isoforms

The RNA a design targets

Waiting for the record before reading NCBI Datasets and Ensembl.

03 Expression by tissue

Where CPNE7 is expressed

Waiting for the record before reading GTEx and the Human Protein Atlas.

04 Protein

The protein CPNE7 encodes

Waiting for the record before reading UniProt, InterPro, AlphaFold DB and PDBe.

05 Interactions

Proteins STRING associates with CPNE7

Waiting for the record before reading STRING.

06 Pathways

Where CPNE7 acts, as Reactome curates it

Waiting for the record before reading UniProt and Reactome.

07 Disease associations

Diseases linked to CPNE7

Waiting for the record before reading Open Targets and ClinGen.

08 Variants

Classified variants of CPNE7

Waiting for the record before reading ClinVar.

09 Constraint

How much variation CPNE7 tolerates

Waiting for the record before reading gnomAD and Open Targets.

10 Orthologs

The same gene in mouse, rat and human

Waiting for the record before reading the Alliance, NCBI, Ensembl Compara and RGD.

11 MicroRNAs

MicroRNAs hosted within CPNE7

Waiting for the record before reading Ensembl and miRBase.

12 Long non-coding RNAs

Long non-coding RNAs at the CPNE7 locus

Waiting for the record before reading Ensembl.

13 Literature

Papers that mention CPNE7

Waiting for the record before reading Europe PMC.

Accession	Name	Biotype	Labels	Exons	Spliced length	Protein	Sequence
NM_153636.3matches ENST00000319518.13	transcript variant 1	protein coding	MANE Select	15	2,442 nt	558 aaNP_705900.1	Ready in a moment
XM_047433906.1	transcript variant X9	protein coding model	none	14	3,209 nt	434 aaXP_047289862.1	Ready in a moment
XM_017023138.3	transcript variant X1	protein coding model	none	18	2,761 nt	670 aaXP_016878627.1	Ready in a moment
XM_017023139.3	transcript variant X2	protein coding model	none	Ready in a moment

Accession	Name	Biotype	Labels	Exons	Spliced length	Protein	Sequence
NM_153636.3matches ENST00000319518.13	transcript variant 1	protein coding	MANE Select	15	2,442 nt	558 aaNP_705900.1	Ready in a moment
XM_047433906.1	transcript variant X9	protein coding model	none	14	3,209 nt	434 aaXP_047289862.1	Ready in a moment
XM_017023138.3	transcript variant X1	protein coding model	none	18	2,761 nt	670 aaXP_016878627.1	Ready in a moment
XM_017023139.3	transcript variant X2	protein coding model	none	Ready in a moment

Accession	Name	Biotype	Labels	Exons	Spliced length	Protein	Sequence
ENST00000319518.13matches NM_153636.3	CPNE7-202	protein coding	MANE SelectEnsembl canonical	15	2,442 nt	558 aaENSP00000317374.8	Ready in a moment
ENST00001063512.1	CPNE7-215	nonsense mediated decay	none	14	3,406 nt	357 aaENSP00000733318.1	Ready in a moment
ENST00001063513.1	CPNE7-216	nonsense mediated decay	none	14	3,327 nt	309 aaENSP00000733319.1	Ready in a moment
ENST00000268720.10	CPNE7-201	protein coding	none	17	2,694 nt	633 aaENSP00000268720.5	Ready in a moment
ENST00001063514.1	CPNE7-217	protein coding	none	16	2,560 nt	594 aaENSP00000733320.1	Ready in a moment
ENST00000936168.2	CPNE7-211	protein coding	none	15	2,517 nt	574 aaENSP00000606227.1	Ready in a moment
ENST00000857691.1	CPNE7-210	protein coding	none	15	2,481 nt	562 aaENSP00000527750.1	Ready in a moment
ENST00001137606.1	CPNE7-219	protein coding	none	15	2,469 nt	558 aaENSP00000806537.1	Ready in a moment
ENST00000954262.2	CPNE7-214	protein coding	none	15	2,463 nt	556 aaENSP00000624321.1	Ready in a moment
ENST00000936170.2	CPNE7-213	protein coding	none	14	2,409 nt	538 aaENSP00000606229.1	Ready in a moment
ENST00000936169.2	CPNE7-212	protein coding	none	12	2,283 nt	496 aaENSP00000606228.1	Ready in a moment
ENST00001115369.1	CPNE7-218	protein coding	none	2	697 nt	170 aaENSP00000785174.1	Ready in a moment
ENST00000568977.1	CPNE7-209	nonsense mediated decay	none	5	682 nt	98 aaENSP00000455086.1	Ready in a moment
ENST00000525982.5	CPNE7-203	nonsense mediated decay	none	4	576 nt	120 aaENSP00000431863.1	Ready in a moment
ENST00000529800.5	CPNE7-205	protein coding	none	7	519 nt	173 aaENSP00000435876.1	Ready in a moment
ENST00000526232.1	CPNE7-204	protein coding	none	3	488 nt	92 aaENSP00000434886.1	Ready in a moment
ENST00000566398.1	CPNE7-208	protein coding cds not defined	none	3	672 nt	none	Ready in a moment
ENST00000532500.1	CPNE7-206	retained intron	none	6	550 nt	none	Ready in a moment
ENST00000564421.1	CPNE7-207	protein coding cds not defined	none	2	517 nt	none	Ready in a moment

CPNE7

What CPNE7 does

The RNA a design targets

Where CPNE7 is expressed

The protein CPNE7 encodes

Proteins STRING associates with CPNE7

Where CPNE7 acts, as Reactome curates it

Diseases linked to CPNE7

Classified variants of CPNE7

How much variation CPNE7 tolerates

The same gene in mouse, rat and human

MicroRNAs hosted within CPNE7

Long non-coding RNAs at the CPNE7 locus

Papers that mention CPNE7

From CPNE7 to a sequence that silences it

Choose the region

Cover the isoforms you mean

Think across species early

Check expression in your model

Run the controls

Pick the product

CPNE7

What CPNE7 does

The RNA a design targets

Where CPNE7 is expressed

The protein CPNE7 encodes

Proteins STRING associates with CPNE7

Where CPNE7 acts, as Reactome curates it

Diseases linked to CPNE7

Classified variants of CPNE7

How much variation CPNE7 tolerates

The same gene in mouse, rat and human

MicroRNAs hosted within CPNE7

Long non-coding RNAs at the CPNE7 locus

Papers that mention CPNE7

CPNE7

What CPNE7 does

Gene summary

Protein function

The RNA a design targets

RefSeq 13 transcripts

A window on one transcript

Ensembl 19 transcripts

A window on one transcript

Where CPNE7 is expressed

The protein CPNE7 encodes

Proteins STRING associates with CPNE7

Where CPNE7 acts, as Reactome curates it

Diseases linked to CPNE7

Classified variants of CPNE7

How much variation CPNE7 tolerates

The same gene in mouse, rat and human

MicroRNAs hosted within CPNE7

Long non-coding RNAs at the CPNE7 locus

Papers that mention CPNE7

From CPNE7 to a sequence that silences it

Choose the region

Cover the isoforms you mean

Think across species early

Check expression in your model

Run the controls

Pick the product

Gene summary

Protein function

RefSeq 13 transcripts

A window on one transcript

Ensembl 19 transcripts

A window on one transcript