Gene Human Homo sapiens

CTSE

cathepsin E

gene with protein product

Human CTSEMouseRat

Reading the ortholog votes for mouse and rat.

Location: Cytogenetic band 1q32.1NCBI: 1:206,009,264-206,023,895 on the minus strand, GRCh38.p14 (GCF_000001405.40), sequence NC_000001.11, annotation GCF_000001405.40-RS_2025_08 of 2025-08-01Ensembl: 1:206,008,535-206,023,917 on the minus strand, GRCh38.p14 (GCA_000001405.29), release 116Coordinates are one-based with both ends included, as each source reports them.

Gene identity, from HGNC · HGNC 2026-09-25 · read 2026-09-25 ET · HGNC:2530

Silence this gene

The order page opens with CTSE and human filled in. The sequences are designed against the transcripts below; the price is on that page.

Order for CTSE

sdASO, toASO or siRNA, chosen on the next page

Bring your own sequence Transcripts

For research use only. Not for use in diagnostic or therapeutic procedures.

Summary
Transcripts
Expression
Protein
Interactions
Pathways
Disease
Variants
Constraint
Orthologs
MicroRNAs
Long non-coding RNAs
Literature
Silencing this gene

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Ready in a moment

01 Summary and function

What CTSE does

This gene encodes a member of the A1 family of peptidases.

NCBI Gene summary

Ready in a moment

02 Transcripts and isoforms

The RNA a design targets

Reading NCBI Datasets and Ensembl.Still reading. A first read of a gene can take a while; this page waits up to 80 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

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03 Expression by tissue

Where CTSE is expressed

Reading GTEx and the Human Protein Atlas.Still reading. A first read of a gene can take a while; this page waits up to 80 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

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04 Protein

The protein CTSE encodes

Reading UniProt, InterPro, AlphaFold DB and PDBe.Still reading. A first read of a gene can take a while; this page waits up to 80 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

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05 Interactions

Proteins STRING associates with CTSE

Reading STRING.Still reading. A first read of a gene can take a while; this page waits up to 50 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

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06 Pathways

Where CTSE acts, as Reactome curates it

Reading UniProt and Reactome.Still reading. A first read of a gene can take a while; this page waits up to 60 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

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07 Disease associations

Diseases linked to CTSE

Reading Open Targets and ClinGen.Still reading. A first read of a gene can take a while; this page waits up to 105 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

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08 Variants

Classified variants of CTSE

Reading ClinVar.Still reading. A first read of a gene can take a while; this page waits up to 60 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

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09 Constraint

How much variation CTSE tolerates

Reading gnomAD and Open Targets.Still reading. A first read of a gene can take a while; this page waits up to 45 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

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10 Orthologs

The same gene in mouse, rat and human

Reading the Alliance, NCBI, Ensembl Compara and RGD.Still reading. A first read of a gene can take a while; this page waits up to 145 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

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11 MicroRNAs

MicroRNAs hosted within CTSE

Reading Ensembl and miRBase.Still reading. A first read of a gene can take a while; this page waits up to 110 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

Ready in a moment

12 Long non-coding RNAs

Long non-coding RNAs at the CTSE locus

Reading Ensembl.Still reading. A first read of a gene can take a while; this page waits up to 110 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

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13 Literature

Papers that mention CTSE

Reading Europe PMC.Still reading. A first read of a gene can take a while; this page waits up to 55 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

Ready in a moment

14 Silencing this gene

From CTSE to a sequence that silences it

The AUMsilence platform designs the sequences against the human transcripts on this page. Six decisions are yours before it does. What is written under each is AUM's guidance; the timings and the concentrations are in the usage guide below.

01
Choose the region
A knockdown oligonucleotide can sit in the 5' untranslated region, the coding sequence or the 3' untranslated region, and all three are used. The coding sequence and the 3' untranslated region are the usual first choices for an RNase H design; the 5' end near the start codon suits a steric block. The map above shows where each region sits on the isoforms it draws.
02
Cover the isoforms you mean
An exon every isoform carries silences the whole gene; an exon only some isoforms carry silences those and spares the rest. Decide which you want before a sequence is chosen, and check the reference transcript (MANE Select in human; RefSeq Select and Ensembl canonical in mouse and rat) is the one your cells express.
03
Think across species early
The orthologs panel says whether mouse and rat carry the same gene. Whether one oligonucleotide can serve two species is a sequence question, settled at design by matching the candidate against each transcript, not by the protein identity shown there.
04
Check expression in your model
A transcript that is not expressed in your cells cannot show knockdown. Confirm the gene is expressed in the cell type and condition you will use, from your own data or a reference atlas, before the order. The expression panel above gives GTEx's median per tissue for a human gene; for mouse and rat it says that no atlas is on this page yet.
05
Run the controls
A scramble control of the same chemistry, a positive control against a gene known to knock down in your cells, untreated cells, and a mock condition where a transfection reagent is used. Read knockdown at the RNA level first, then at the protein; the usage guide gives the timing and the concentrations to start from.
06
Pick the product
AUMsilence sdASO needs no transfection reagent and works in the cells that resist one. AUMsilence toASO is the transfection-optimised version of the same design, and AUMsiRNA is the siRNA route. The selection guide compares them.

Order for CTSE Bring your own sequence The usage guide Selection guide

For research use only. Not for use in diagnostic or therapeutic procedures.

Gene Human Homo sapiens

CTSE

Reading the record for CTSE from HGNC, NCBI Gene and Ensembl.Still reading. A first read of a gene can take a while; this page waits up to 115 seconds for it, and its scripts then bring in the page, or a line saying what did not arrive.

The full name, the identifiers, the location and the notes from the sources arrive with the record. Nothing is filled in ahead of it.

Order door

The door to order for CTSE opens with the record, which decides which product it carries. The order page itself is open now.

Bring your own sequence

For research use only. Not for use in diagnostic or therapeutic procedures.

This page is still reading the record. Its scripts replace this shell with the record when it arrives; with scripts off, it stays at this shell however long you wait.

01 Summary and function

What CTSE does

Waiting for the record before reading NCBI Gene and UniProt.

02 Transcripts and isoforms

The RNA a design targets

Waiting for the record before reading NCBI Datasets and Ensembl.

03 Expression by tissue

Where CTSE is expressed

Waiting for the record before reading GTEx and the Human Protein Atlas.

04 Protein

The protein CTSE encodes

Waiting for the record before reading UniProt, InterPro, AlphaFold DB and PDBe.

05 Interactions

Proteins STRING associates with CTSE

Waiting for the record before reading STRING.

06 Pathways

Where CTSE acts, as Reactome curates it

Waiting for the record before reading UniProt and Reactome.

07 Disease associations

Diseases linked to CTSE

Waiting for the record before reading Open Targets and ClinGen.

08 Variants

Classified variants of CTSE

Waiting for the record before reading ClinVar.

09 Constraint

How much variation CTSE tolerates

Waiting for the record before reading gnomAD and Open Targets.

10 Orthologs

The same gene in mouse, rat and human

Waiting for the record before reading the Alliance, NCBI, Ensembl Compara and RGD.

11 MicroRNAs

MicroRNAs hosted within CTSE

Waiting for the record before reading Ensembl and miRBase.

12 Long non-coding RNAs

Long non-coding RNAs at the CTSE locus

Waiting for the record before reading Ensembl.

13 Literature

Papers that mention CTSE

Waiting for the record before reading Europe PMC.

Accession	Name	Biotype	Labels	Exons	Spliced length	Protein	Sequence
NM_001910.4matches ENST00000358184.7	transcript variant 1	protein coding	MANE Select	9	2,214 nt	396 aaNP_001901.1	Ready in a moment
XM_011509244.2matches ENST00000360218.4	transcript variant X1	protein coding model	none	9	2,229 nt	401 aaXP_011507546.1	Ready in a moment
XM_011509245.2matches ENST00001024726.1	transcript variant X2	protein coding model	none	8	2,087 nt	368 aaXP_011507547.1	Ready in a moment
NM_148964.3	Ready in a moment

Accession	Name	Biotype	Labels	Exons	Spliced length	Protein	Sequence
NM_001910.4matches ENST00000358184.7	transcript variant 1	protein coding	MANE Select	9	2,214 nt	396 aaNP_001901.1	Ready in a moment
XM_011509244.2matches ENST00000360218.4	transcript variant X1	protein coding model	none	9	2,229 nt	401 aaXP_011507546.1	Ready in a moment
XM_011509245.2matches ENST00001024726.1	transcript variant X2	protein coding model	none	8	2,087 nt	368 aaXP_011507547.1	Ready in a moment
NM_148964.3	Ready in a moment

Accession	Name	Biotype	Labels	Exons	Spliced length	Protein	Sequence
ENST00000358184.7matches NM_001910.4	CTSE-201	protein coding	MANE SelectEnsembl canonical	9	2,214 nt	396 aaENSP00000350911.2	Ready in a moment
ENST00000360218.4	CTSE-202	protein coding	none	9	2,980 nt	401 aaENSP00000353350.3	Ready in a moment
ENST00001145681.1	CTSE-213	protein coding	none	9	2,965 nt	396 aaENSP00000808630.1	Ready in a moment
ENST00001024725.1	CTSE-211	protein coding	none	9	2,928 nt	398 aaENSP00000694542.1	Ready in a moment
ENST00000678712.2	CTSE-209	protein coding	none	8	2,866 nt	363 aaENSP00000503796.1	Ready in a moment
ENST00001024726.1	CTSE-212	protein coding	none	8	2,838 nt	368 aaENSP00000694543.1	Ready in a moment
ENST00000678498.2	CTSE-208	protein coding	none	8	2,823 nt	363 aaENSP00000504305.1	Ready in a moment
ENST00000966017.2	CTSE-210	protein coding	none	7	2,689 nt	304 aaENSP00000636076.1	Ready in a moment
ENST00000678285.1	CTSE-207	nonsense mediated decay	none	7	1,036 nt	247 aaENSP00000504037.1	Ready in a moment
ENST00000677924.1	CTSE-206	protein coding	none	6	847 nt	266 aaENSP00000504853.1	Ready in a moment
ENST00000677780.1	CTSE-205	nonsense mediated decay	none	5	701 nt	105 aaENSP00000503890.1	Ready in a moment
ENST00000468617.2	CTSE-203	retained intron	none	5	836 nt	none	Ready in a moment
ENST00000486757.1	CTSE-204	retained intron	none	2	435 nt	none	Ready in a moment

CTSE

What CTSE does

The RNA a design targets

Where CTSE is expressed

The protein CTSE encodes

Proteins STRING associates with CTSE

Where CTSE acts, as Reactome curates it

Diseases linked to CTSE

Classified variants of CTSE

How much variation CTSE tolerates

The same gene in mouse, rat and human

MicroRNAs hosted within CTSE

Long non-coding RNAs at the CTSE locus

Papers that mention CTSE

From CTSE to a sequence that silences it

Choose the region

Cover the isoforms you mean

Think across species early

Check expression in your model

Run the controls

Pick the product

CTSE

What CTSE does

The RNA a design targets

Where CTSE is expressed

The protein CTSE encodes

Proteins STRING associates with CTSE

Where CTSE acts, as Reactome curates it

Diseases linked to CTSE

Classified variants of CTSE

How much variation CTSE tolerates

The same gene in mouse, rat and human

MicroRNAs hosted within CTSE

Long non-coding RNAs at the CTSE locus

Papers that mention CTSE

CTSE

What CTSE does

Gene summary

Protein function

The RNA a design targets

RefSeq 5 transcripts

A window on one transcript

Ensembl 13 transcripts

A window on one transcript

Where CTSE is expressed

The protein CTSE encodes

Proteins STRING associates with CTSE

Where CTSE acts, as Reactome curates it

Diseases linked to CTSE

Classified variants of CTSE

How much variation CTSE tolerates

The same gene in mouse, rat and human

MicroRNAs hosted within CTSE

Long non-coding RNAs at the CTSE locus

Papers that mention CTSE

From CTSE to a sequence that silences it

Choose the region

Cover the isoforms you mean

Think across species early

Check expression in your model

Run the controls

Pick the product

Gene summary

Protein function

RefSeq 5 transcripts

A window on one transcript

Ensembl 13 transcripts

A window on one transcript