Gene Human Homo sapiens

CXCL17

C-X-C motif chemokine ligand 17

gene with protein product

Human CXCL17MouseRat

Reading the ortholog votes for mouse and rat.

Location: Cytogenetic band 19q13.2NCBI: 19:42,428,278-42,442,946 on the minus strand, GRCh38.p14 (GCF_000001405.40), sequence NC_000019.10, annotation GCF_000001405.40-RS_2025_08 of 2025-08-01Ensembl: 19:42,427,995-42,443,029 on the minus strand, GRCh38.p14 (GCA_000001405.29), release 116Coordinates are one-based with both ends included, as each source reports them.
Also known as: Dcip1, UNQ473, DMC, VCC1

Gene identity, from HGNC · HGNC 2026-09-18 · read 2026-09-23 ET · HGNC:19232

Silence this gene

The order page opens with CXCL17 and human filled in. The sequences are designed against the transcripts below; the price is on that page.

Order for CXCL17

sdASO, toASO or siRNA, chosen on the next page

Bring your own sequence Transcripts

For research use only. Not for use in diagnostic or therapeutic procedures.

Summary
Transcripts
Expression
Protein
Interactions
Pathways
Disease
Variants
Constraint
Orthologs
MicroRNAs
Long non-coding RNAs
Literature
Silencing this gene

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01 Summary and function

What CXCL17 does

The protein encoded by this gene is a mucosal chemokine that attracts…

NCBI Gene summary

Ready in a moment

02 Transcripts and isoforms

The RNA a design targets

Reading NCBI Datasets and Ensembl.Still reading. A first read of a gene can take a while; this page waits up to 80 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

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03 Expression by tissue

Where CXCL17 is expressed

54 GTEx tissues; the highest median in Stomach, 346 TPM.

GTEx

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04 Protein

The protein CXCL17 encodes

119 residues, reviewed Q6UXB2; 3 entries from the member databases this page shows along the chain; mean pLDDT 59.66; no experimental structure at PDBe.

UniProt · InterPro · AlphaFold DB · PDBe

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05 Interactions

Proteins STRING associates with CXCL17

Reading STRING.Still reading. A first read of a gene can take a while; this page waits up to 50 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

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06 Pathways

Where CXCL17 acts, as Reactome curates it

Reading UniProt and Reactome.Still reading. A first read of a gene can take a while; this page waits up to 60 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

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07 Disease associations

Diseases linked to CXCL17

199 Open Targets disease associations; neoplasm first, at 0.11.

Open Targets

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08 Variants

Classified variants of CXCL17

Reading ClinVar.Still reading. A first read of a gene can take a while; this page waits up to 60 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

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09 Constraint

How much variation CXCL17 tolerates

pLI 0.01773 and LOEUF 1.01 in gnomAD v4 (GRCh38), on ENST00000601181.6.

gnomAD

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10 Orthologs

The same gene in mouse, rat and human

Reading the Alliance, NCBI, Ensembl Compara and RGD.Still reading. A first read of a gene can take a while; this page waits up to 145 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

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11 MicroRNAs

MicroRNAs hosted within CXCL17

No annotated microRNA lies within CXCL17 in Ensembl release 116, on GRCh38.p14.

Ensembl · miRBase

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12 Long non-coding RNAs

Long non-coding RNAs at the CXCL17 locus

Reading Ensembl.Still reading. A first read of a gene can take a while; this page waits up to 110 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

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13 Literature

Papers that mention CXCL17

Reading Europe PMC.Still reading. A first read of a gene can take a while; this page waits up to 55 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

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14 Silencing this gene

From CXCL17 to a sequence that silences it

The AUMsilence platform designs the sequences against the human transcripts on this page. Six decisions are yours before it does. What is written under each is AUM's guidance; the timings and the concentrations are in the usage guide below.

01
Choose the region
A knockdown oligonucleotide can sit in the 5' untranslated region, the coding sequence or the 3' untranslated region, and all three are used. The coding sequence and the 3' untranslated region are the usual first choices for an RNase H design; the 5' end near the start codon suits a steric block. The map above shows where each region sits on the isoforms it draws.
02
Cover the isoforms you mean
An exon every isoform carries silences the whole gene; an exon only some isoforms carry silences those and spares the rest. Decide which you want before a sequence is chosen, and check the reference transcript (MANE Select in human; RefSeq Select and Ensembl canonical in mouse and rat) is the one your cells express.
03
Think across species early
The orthologs panel says whether mouse and rat carry the same gene. Whether one oligonucleotide can serve two species is a sequence question, settled at design by matching the candidate against each transcript, not by the protein identity shown there.
04
Check expression in your model
A transcript that is not expressed in your cells cannot show knockdown. Confirm the gene is expressed in the cell type and condition you will use, from your own data or a reference atlas, before the order. The expression panel above gives GTEx's median per tissue for a human gene; for mouse and rat it says that no atlas is on this page yet.
05
Run the controls
A scramble control of the same chemistry, a positive control against a gene known to knock down in your cells, untreated cells, and a mock condition where a transfection reagent is used. Read knockdown at the RNA level first, then at the protein; the usage guide gives the timing and the concentrations to start from.
06
Pick the product
AUMsilence sdASO needs no transfection reagent and works in the cells that resist one. AUMsilence toASO is the transfection-optimised version of the same design, and AUMsiRNA is the siRNA route. The selection guide compares them.

Order for CXCL17 Bring your own sequence The usage guide Selection guide

For research use only. Not for use in diagnostic or therapeutic procedures.

Gene Human Homo sapiens

CXCL17

Reading the record for CXCL17 from HGNC, NCBI Gene and Ensembl.Still reading. A first read of a gene can take a while; this page waits up to 115 seconds for it, and its scripts then bring in the page, or a line saying what did not arrive.

The full name, the identifiers, the location and the notes from the sources arrive with the record. Nothing is filled in ahead of it.

Order door

The door to order for CXCL17 opens with the record, which decides which product it carries. The order page itself is open now.

Bring your own sequence

For research use only. Not for use in diagnostic or therapeutic procedures.

This page is still reading the record. Its scripts replace this shell with the record when it arrives; with scripts off, it stays at this shell however long you wait.

01 Summary and function

What CXCL17 does

Waiting for the record before reading NCBI Gene and UniProt.

02 Transcripts and isoforms

The RNA a design targets

Waiting for the record before reading NCBI Datasets and Ensembl.

03 Expression by tissue

Where CXCL17 is expressed

Waiting for the record before reading GTEx and the Human Protein Atlas.

04 Protein

The protein CXCL17 encodes

Waiting for the record before reading UniProt, InterPro, AlphaFold DB and PDBe.

05 Interactions

Proteins STRING associates with CXCL17

Waiting for the record before reading STRING.

06 Pathways

Where CXCL17 acts, as Reactome curates it

Waiting for the record before reading UniProt and Reactome.

07 Disease associations

Diseases linked to CXCL17

Waiting for the record before reading Open Targets and ClinGen.

08 Variants

Classified variants of CXCL17

Waiting for the record before reading ClinVar.

09 Constraint

How much variation CXCL17 tolerates

Waiting for the record before reading gnomAD and Open Targets.

10 Orthologs

The same gene in mouse, rat and human

Waiting for the record before reading the Alliance, NCBI, Ensembl Compara and RGD.

11 MicroRNAs

MicroRNAs hosted within CXCL17

Waiting for the record before reading Ensembl and miRBase.

12 Long non-coding RNAs

Long non-coding RNAs at the CXCL17 locus

Waiting for the record before reading Ensembl.

13 Literature

Papers that mention CXCL17

Waiting for the record before reading Europe PMC.

Accession	Name	Biotype	Labels	Exons	Spliced length	Protein	Sequence
NM_198477.3matches ENST00000601181.6	transcript variant 1	protein coding	MANE Select	4	1,080 nt	119 aaNP_940879.1	Ready in a moment
NR_133910.2	transcript variant 2	non coding	none	4	1,097 nt	none	Ready in a moment

Accession	Name	Biotype	Labels	Exons	Spliced length	Protein	Sequence
NM_198477.3matches ENST00000601181.6	transcript variant 1	protein coding	MANE Select	4	1,080 nt	119 aaNP_940879.1	Ready in a moment
NR_133910.2	transcript variant 2	non coding	none	4	1,097 nt	none	Ready in a moment

Accession	Name	Biotype	Labels	Exons	Spliced length	Protein	Sequence
ENST00000601181.6matches NM_198477.3	CXCL17-202	protein coding	MANE SelectEnsembl canonical	4	1,080 nt	119 aaENSP00000472467.1	Ready in a moment
ENST00001140738.1	CXCL17-204	protein coding	none	4	1,446 nt	119 aaENSP00000814481.1	Ready in a moment
ENST00000869328.2	CXCL17-203	protein coding	none	4	1,434 nt	115 aaENSP00000539387.1	Ready in a moment
ENST00000341918.4	CXCL17-201	nonsense mediated decay	none	4	748 nt	62 aaENSP00000345317.4	Ready in a moment

CXCL17

What CXCL17 does

The RNA a design targets

Where CXCL17 is expressed

The protein CXCL17 encodes

Proteins STRING associates with CXCL17

Where CXCL17 acts, as Reactome curates it

Diseases linked to CXCL17

Classified variants of CXCL17

How much variation CXCL17 tolerates

The same gene in mouse, rat and human

MicroRNAs hosted within CXCL17

Long non-coding RNAs at the CXCL17 locus

Papers that mention CXCL17

From CXCL17 to a sequence that silences it

Choose the region

Cover the isoforms you mean

Think across species early

Check expression in your model

Run the controls

Pick the product

CXCL17

What CXCL17 does

The RNA a design targets

Where CXCL17 is expressed

The protein CXCL17 encodes

Proteins STRING associates with CXCL17

Where CXCL17 acts, as Reactome curates it

Diseases linked to CXCL17

Classified variants of CXCL17

How much variation CXCL17 tolerates

The same gene in mouse, rat and human

MicroRNAs hosted within CXCL17

Long non-coding RNAs at the CXCL17 locus

Papers that mention CXCL17

CXCL17

What CXCL17 does

Gene summary

Protein function

The RNA a design targets

RefSeq 2 transcripts

A window on one transcript

Ensembl 4 transcripts

A window on one transcript

Where CXCL17 is expressed

The protein CXCL17 encodes

Proteins STRING associates with CXCL17

Where CXCL17 acts, as Reactome curates it

Diseases linked to CXCL17

Classified variants of CXCL17

How much variation CXCL17 tolerates

The same gene in mouse, rat and human

MicroRNAs hosted within CXCL17

Long non-coding RNAs at the CXCL17 locus

Papers that mention CXCL17

From CXCL17 to a sequence that silences it

Choose the region

Cover the isoforms you mean

Think across species early

Check expression in your model

Run the controls

Pick the product

Gene summary

Protein function

RefSeq 2 transcripts

A window on one transcript

Ensembl 4 transcripts

A window on one transcript