Gene Human Homo sapiens

EFCAB5

EF-hand calcium binding domain 5

gene with protein product

Human EFCAB5MouseRat

Reading the ortholog votes for mouse and rat.

Location: Cytogenetic band 17q11.2NCBI: 17:29,929,903-30,108,452 on the plus strand, GRCh38.p14 (GCF_000001405.40), sequence NC_000017.11, annotation GCF_000001405.40-RS_2025_08 of 2025-08-01Ensembl: 17:29,929,200-30,108,452 on the plus strand, GRCh38.p14 (GCA_000001405.29), release 116Coordinates are one-based with both ends included, as each source reports them.
Also known as: FLJ46247

Gene identity, from HGNC · HGNC 2026-09-29 · read 2026-10-01 ET · HGNC:24801

Silence this gene

The order page opens with EFCAB5 and human filled in. The sequences are designed against the transcripts below; the price is on that page.

Order for EFCAB5

sdASO, toASO or siRNA, chosen on the next page

Bring your own sequence Transcripts

For research use only. Not for use in diagnostic or therapeutic procedures.

Summary
Transcripts
Expression
Protein
Interactions
Pathways
Disease
Variants
Constraint
Orthologs
MicroRNAs
Long non-coding RNAs
Literature
Silencing this gene

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Ready in a moment

01 Summary and function

What EFCAB5 does

Predicted to enable calcium ion binding activity.

NCBI Gene summary

Ready in a moment

02 Transcripts and isoforms

The RNA a design targets

Reading NCBI Datasets and Ensembl.Still reading. A first read of a gene can take a while; this page waits up to 80 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

Ready in a moment

03 Expression by tissue

Where EFCAB5 is expressed

Reading GTEx and the Human Protein Atlas.Still reading. A first read of a gene can take a while; this page waits up to 80 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

Ready in a moment

04 Protein

The protein EFCAB5 encodes

Reading UniProt, InterPro, AlphaFold DB and PDBe.Still reading. A first read of a gene can take a while; this page waits up to 80 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

Ready in a moment

05 Interactions

Proteins STRING associates with EFCAB5

Reading STRING.Still reading. A first read of a gene can take a while; this page waits up to 50 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

Ready in a moment

06 Pathways

Where EFCAB5 acts, as Reactome curates it

Reading UniProt and Reactome.Still reading. A first read of a gene can take a while; this page waits up to 60 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

Ready in a moment

07 Disease associations

Diseases linked to EFCAB5

90 Open Targets disease associations; intracranial hemorrhage first, at 0.27.

Open Targets

Ready in a moment

08 Variants

Classified variants of EFCAB5

Reading ClinVar.Still reading. A first read of a gene can take a while; this page waits up to 60 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

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09 Constraint

How much variation EFCAB5 tolerates

Reading gnomAD and Open Targets.Still reading. A first read of a gene can take a while; this page waits up to 45 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

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10 Orthologs

The same gene in mouse, rat and human

Reading the Alliance, NCBI, Ensembl Compara and RGD.Still reading. A first read of a gene can take a while; this page waits up to 145 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

Ready in a moment

11 MicroRNAs

MicroRNAs hosted within EFCAB5

Reading Ensembl and miRBase.Still reading. A first read of a gene can take a while; this page waits up to 110 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

Ready in a moment

12 Long non-coding RNAs

Long non-coding RNAs at the EFCAB5 locus

Reading Ensembl.Still reading. A first read of a gene can take a while; this page waits up to 110 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

Ready in a moment

13 Literature

Papers that mention EFCAB5

Reading Europe PMC.Still reading. A first read of a gene can take a while; this page waits up to 55 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

Ready in a moment

14 Silencing this gene

From EFCAB5 to a sequence that silences it

The AUMsilence platform designs the sequences against the human transcripts on this page. Six decisions are yours before it does. What is written under each is AUM's guidance; the timings and the concentrations are in the usage guide below.

01
Choose the region
A knockdown oligonucleotide can sit in the 5' untranslated region, the coding sequence or the 3' untranslated region, and all three are used. The coding sequence and the 3' untranslated region are the usual first choices for an RNase H design; the 5' end near the start codon suits a steric block. The map above shows where each region sits on the isoforms it draws.
02
Cover the isoforms you mean
An exon every isoform carries silences the whole gene; an exon only some isoforms carry silences those and spares the rest. Decide which you want before a sequence is chosen, and check the reference transcript (MANE Select in human; RefSeq Select and Ensembl canonical in mouse and rat) is the one your cells express.
03
Think across species early
The orthologs panel says whether mouse and rat carry the same gene. Whether one oligonucleotide can serve two species is a sequence question, settled at design by matching the candidate against each transcript, not by the protein identity shown there.
04
Check expression in your model
A transcript that is not expressed in your cells cannot show knockdown. Confirm the gene is expressed in the cell type and condition you will use, from your own data or a reference atlas, before the order. The expression panel above gives GTEx's median per tissue for a human gene; for mouse and rat it says that no atlas is on this page yet.
05
Run the controls
A scramble control of the same chemistry, a positive control against a gene known to knock down in your cells, untreated cells, and a mock condition where a transfection reagent is used. Read knockdown at the RNA level first, then at the protein; the usage guide gives the timing and the concentrations to start from.
06
Pick the product
AUMsilence sdASO needs no transfection reagent and works in the cells that resist one. AUMsilence toASO is the transfection-optimised version of the same design, and AUMsiRNA is the siRNA route. The selection guide compares them.

Order for EFCAB5 Bring your own sequence The usage guide Selection guide

For research use only. Not for use in diagnostic or therapeutic procedures.

Gene Human Homo sapiens

EFCAB5

Reading the record for EFCAB5 from HGNC, NCBI Gene and Ensembl.Still reading. A first read of a gene can take a while; this page waits up to 115 seconds for it, and its scripts then bring in the page, or a line saying what did not arrive.

The full name, the identifiers, the location and the notes from the sources arrive with the record. Nothing is filled in ahead of it.

Order door

The door to order for EFCAB5 opens with the record, which decides which product it carries. The order page itself is open now.

Bring your own sequence

For research use only. Not for use in diagnostic or therapeutic procedures.

This page is still reading the record. Its scripts replace this shell with the record when it arrives; with scripts off, it stays at this shell however long you wait.

01 Summary and function

What EFCAB5 does

Waiting for the record before reading NCBI Gene and UniProt.

02 Transcripts and isoforms

The RNA a design targets

Waiting for the record before reading NCBI Datasets and Ensembl.

03 Expression by tissue

Where EFCAB5 is expressed

Waiting for the record before reading GTEx and the Human Protein Atlas.

04 Protein

The protein EFCAB5 encodes

Waiting for the record before reading UniProt, InterPro, AlphaFold DB and PDBe.

05 Interactions

Proteins STRING associates with EFCAB5

Waiting for the record before reading STRING.

06 Pathways

Where EFCAB5 acts, as Reactome curates it

Waiting for the record before reading UniProt and Reactome.

07 Disease associations

Diseases linked to EFCAB5

Waiting for the record before reading Open Targets and ClinGen.

08 Variants

Classified variants of EFCAB5

Waiting for the record before reading ClinVar.

09 Constraint

How much variation EFCAB5 tolerates

Waiting for the record before reading gnomAD and Open Targets.

10 Orthologs

The same gene in mouse, rat and human

Waiting for the record before reading the Alliance, NCBI, Ensembl Compara and RGD.

11 MicroRNAs

MicroRNAs hosted within EFCAB5

Waiting for the record before reading Ensembl and miRBase.

12 Long non-coding RNAs

Long non-coding RNAs at the EFCAB5 locus

Waiting for the record before reading Ensembl.

13 Literature

Papers that mention EFCAB5

Waiting for the record before reading Europe PMC.

Accession	Name	Biotype	Labels	Exons	Spliced length	Protein	Sequence
NM_198529.4matches ENST00000394835.8	transcript variant 1	protein coding	MANE Select	23	5,103 nt	1,503 aaNP_940931.3	Ready in a moment
XM_011524763.3	transcript variant X2	protein coding model	none	23	5,214 nt	1,458 aaXP_011523065.1	Ready in a moment
XM_011524759.2	transcript variant X1	protein coding model	none	23	5,109 nt	1,505 aaXP_011523061.1	Ready in a moment
XM_024450742.1	transcript variant X11	protein coding model	none	Ready in a moment

Accession	Name	Biotype	Labels	Exons	Spliced length	Protein	Sequence
NM_198529.4matches ENST00000394835.8	transcript variant 1	protein coding	MANE Select	23	5,103 nt	1,503 aaNP_940931.3	Ready in a moment
XM_011524763.3	transcript variant X2	protein coding model	none	23	5,214 nt	1,458 aaXP_011523065.1	Ready in a moment
XM_011524759.2	transcript variant X1	protein coding model	none	23	5,109 nt	1,505 aaXP_011523061.1	Ready in a moment
XM_024450742.1	transcript variant X11	protein coding model	none	Ready in a moment

Accession	Name	Biotype	Labels	Exons	Spliced length	Protein	Sequence
ENST00000394835.8matches NM_198529.4	EFCAB5-201	protein coding	MANE SelectEnsembl canonical	23	5,103 nt	1,503 aaENSP00000378312.3	Ready in a moment
ENST00000419434.5	EFCAB5-202	protein coding	none	18	3,986 nt	1,185 aaENSP00000417009.1	Ready in a moment
ENST00000440741.7	EFCAB5-205	nonsense mediated decay	none	16	3,965 nt	926 aaENSP00000393095.2	Ready in a moment
ENST00000536908.6	EFCAB5-208	protein coding	none	15	2,826 nt	856 aaENSP00000440619.2	Ready in a moment
ENST00000588978.1	EFCAB5-212	protein coding	none	12	2,605 nt	774 aaENSP00000465109.1	Ready in a moment
ENST00000423598.6	EFCAB5-204	nonsense mediated decay	none	14	2,454 nt	56 aaENSP00000392831.2	Ready in a moment
ENST00000448319.5	EFCAB5-206	protein coding	none	4	566 nt	103 aaENSP00000400023.1	Ready in a moment
ENST00000638539.1	EFCAB5-213	protein coding	none	4	168 nt	56 aaENSP00000492792.1	Ready in a moment
ENST00000581617.1	EFCAB5-209	retained intron	none	4	718 nt	none	Ready in a moment
ENST00000534836.6	EFCAB5-207	protein coding cds not defined	none	6	544 nt	none	Ready in a moment
ENST00000421238.2	EFCAB5-203	protein coding cds not defined	none	5	534 nt	none	Ready in a moment
ENST00000584826.1	EFCAB5-211	protein coding cds not defined	none	4	507 nt	none	Ready in a moment
ENST00000582953.1	EFCAB5-210	protein coding cds not defined	none	2	314 nt	none	Ready in a moment

EFCAB5

What EFCAB5 does

The RNA a design targets

Where EFCAB5 is expressed

The protein EFCAB5 encodes

Proteins STRING associates with EFCAB5

Where EFCAB5 acts, as Reactome curates it

Diseases linked to EFCAB5

Classified variants of EFCAB5

How much variation EFCAB5 tolerates

The same gene in mouse, rat and human

MicroRNAs hosted within EFCAB5

Long non-coding RNAs at the EFCAB5 locus

Papers that mention EFCAB5

From EFCAB5 to a sequence that silences it

Choose the region

Cover the isoforms you mean

Think across species early

Check expression in your model

Run the controls

Pick the product

EFCAB5

What EFCAB5 does

The RNA a design targets

Where EFCAB5 is expressed

The protein EFCAB5 encodes

Proteins STRING associates with EFCAB5

Where EFCAB5 acts, as Reactome curates it

Diseases linked to EFCAB5

Classified variants of EFCAB5

How much variation EFCAB5 tolerates

The same gene in mouse, rat and human

MicroRNAs hosted within EFCAB5

Long non-coding RNAs at the EFCAB5 locus

Papers that mention EFCAB5

EFCAB5

What EFCAB5 does

Gene summary

Protein function

The RNA a design targets

RefSeq 16 transcripts

A window on one transcript

Ensembl 13 transcripts

A window on one transcript

Where EFCAB5 is expressed

The protein EFCAB5 encodes

Proteins STRING associates with EFCAB5

Where EFCAB5 acts, as Reactome curates it

Diseases linked to EFCAB5

Classified variants of EFCAB5

How much variation EFCAB5 tolerates

The same gene in mouse, rat and human

MicroRNAs hosted within EFCAB5

Long non-coding RNAs at the EFCAB5 locus

Papers that mention EFCAB5

From EFCAB5 to a sequence that silences it

Choose the region

Cover the isoforms you mean

Think across species early

Check expression in your model

Run the controls

Pick the product

Gene summary

Protein function

RefSeq 16 transcripts

A window on one transcript

Ensembl 13 transcripts

A window on one transcript