Gene Human Homo sapiens

Symbol resolved

You asked for FAM205C; that is a previous symbol, and the current HGNC symbol is SPATA31F3.

SPATA31F3

SPATA31 subfamily F member 3

gene with protein product

Human SPATA31F3MouseRat

Reading the ortholog votes for mouse and rat.

Location: Cytogenetic band 9p13.3NCBI: 9:34,889,066-34,895,764 on the minus strand, GRCh38.p14 (GCF_000001405.40), sequence NC_000009.12, annotation GCF_000001405.40-RS_2025_08 of 2025-08-01Ensembl: 9:34,889,062-34,895,797 on the minus strand, GRCh38.p14 (GCA_000001405.29), release 116Coordinates are one-based with both ends included, as each source reports them.
Previous symbols: FAM205CP, FAM205C

Gene identity, from HGNC · HGNC 2026-10-02 · read 2026-10-02 ET · HGNC:42673

Silence this gene

The order page opens with SPATA31F3 and human filled in. The sequences are designed against the transcripts below; the price is on that page.

Order for SPATA31F3

sdASO, toASO or siRNA, chosen on the next page

Bring your own sequence Transcripts

For research use only. Not for use in diagnostic or therapeutic procedures.

Summary
Transcripts
Expression
Protein
Interactions
Pathways
Disease
Variants
Constraint
Orthologs
MicroRNAs
Long non-coding RNAs
Literature
Silencing this gene

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01 Summary and function

What SPATA31F3 does

Predicted to be located in membrane.

NCBI Gene summary

Ready in a moment

02 Transcripts and isoforms

The RNA a design targets

Reading NCBI Datasets and Ensembl.Still reading. A first read of a gene can take a while; this page waits up to 80 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

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03 Expression by tissue

Where SPATA31F3 is expressed

Reading GTEx and the Human Protein Atlas.Still reading. A first read of a gene can take a while; this page waits up to 80 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

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04 Protein

The protein SPATA31F3 encodes

Reading UniProt, InterPro, AlphaFold DB and PDBe.Still reading. A first read of a gene can take a while; this page waits up to 80 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

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05 Interactions

Proteins STRING associates with SPATA31F3

Reading STRING.Still reading. A first read of a gene can take a while; this page waits up to 50 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

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06 Pathways

Where SPATA31F3 acts, as Reactome curates it

Reading UniProt and Reactome.Still reading. A first read of a gene can take a while; this page waits up to 60 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

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07 Disease associations

Diseases linked to SPATA31F3

57 Open Targets disease associations; ulcerative colitis first, at 0.14.

Open Targets

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08 Variants

Classified variants of SPATA31F3

Reading ClinVar.Still reading. A first read of a gene can take a while; this page waits up to 60 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

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09 Constraint

How much variation SPATA31F3 tolerates

Reading gnomAD and Open Targets.Still reading. A first read of a gene can take a while; this page waits up to 45 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

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10 Orthologs

The same gene in mouse, rat and human

Mouse Spata31f3 by 2 of 2 votes; rat Spata31f3 by 2 of 2 votes. RGD is not answering, so the ortholog list could not be shown. Try again later. Reference 6141814f-451.

Alliance · NCBI

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11 MicroRNAs

MicroRNAs hosted within SPATA31F3

Reading Ensembl and miRBase.Still reading. A first read of a gene can take a while; this page waits up to 110 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

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12 Long non-coding RNAs

Long non-coding RNAs at the SPATA31F3 locus

Reading Ensembl.Still reading. A first read of a gene can take a while; this page waits up to 110 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

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13 Literature

Papers that mention SPATA31F3

Reading Europe PMC.Still reading. A first read of a gene can take a while; this page waits up to 55 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

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14 Silencing this gene

From SPATA31F3 to a sequence that silences it

The AUMsilence platform designs the sequences against the human transcripts on this page. Six decisions are yours before it does. What is written under each is AUM's guidance; the timings and the concentrations are in the usage guide below.

01
Choose the region
A knockdown oligonucleotide can sit in the 5' untranslated region, the coding sequence or the 3' untranslated region, and all three are used. The coding sequence and the 3' untranslated region are the usual first choices for an RNase H design; the 5' end near the start codon suits a steric block. The map above shows where each region sits on the isoforms it draws.
02
Cover the isoforms you mean
An exon every isoform carries silences the whole gene; an exon only some isoforms carry silences those and spares the rest. Decide which you want before a sequence is chosen, and check the reference transcript (MANE Select in human; RefSeq Select and Ensembl canonical in mouse and rat) is the one your cells express.
03
Think across species early
The orthologs panel says whether mouse and rat carry the same gene. Whether one oligonucleotide can serve two species is a sequence question, settled at design by matching the candidate against each transcript, not by the protein identity shown there.
04
Check expression in your model
A transcript that is not expressed in your cells cannot show knockdown. Confirm the gene is expressed in the cell type and condition you will use, from your own data or a reference atlas, before the order. The expression panel above gives GTEx's median per tissue for a human gene; for mouse and rat it says that no atlas is on this page yet.
05
Run the controls
A scramble control of the same chemistry, a positive control against a gene known to knock down in your cells, untreated cells, and a mock condition where a transfection reagent is used. Read knockdown at the RNA level first, then at the protein; the usage guide gives the timing and the concentrations to start from.
06
Pick the product
AUMsilence sdASO needs no transfection reagent and works in the cells that resist one. AUMsilence toASO is the transfection-optimised version of the same design, and AUMsiRNA is the siRNA route. The selection guide compares them.

Order for SPATA31F3 Bring your own sequence The usage guide Selection guide

For research use only. Not for use in diagnostic or therapeutic procedures.

Gene Human Homo sapiens

FAM205C

Reading the record for FAM205C from HGNC, NCBI Gene and Ensembl.Still reading. A first read of a gene can take a while; this page waits up to 115 seconds for it, and its scripts then bring in the page, or a line saying what did not arrive.

The full name, the identifiers, the location and the notes from the sources arrive with the record. Nothing is filled in ahead of it.

Order door

The door to order for FAM205C opens with the record, which decides which product it carries. The order page itself is open now.

Bring your own sequence

For research use only. Not for use in diagnostic or therapeutic procedures.

This page is still reading the record. Its scripts replace this shell with the record when it arrives; with scripts off, it stays at this shell however long you wait.

01 Summary and function

What FAM205C does

Waiting for the record before reading NCBI Gene and UniProt.

02 Transcripts and isoforms

The RNA a design targets

Waiting for the record before reading NCBI Datasets and Ensembl.

03 Expression by tissue

Where FAM205C is expressed

Waiting for the record before reading GTEx and the Human Protein Atlas.

04 Protein

The protein FAM205C encodes

Waiting for the record before reading UniProt, InterPro, AlphaFold DB and PDBe.

05 Interactions

Proteins STRING associates with FAM205C

Waiting for the record before reading STRING.

06 Pathways

Where FAM205C acts, as Reactome curates it

Waiting for the record before reading UniProt and Reactome.

07 Disease associations

Diseases linked to FAM205C

Waiting for the record before reading Open Targets and ClinGen.

08 Variants

Classified variants of FAM205C

Waiting for the record before reading ClinVar.

09 Constraint

How much variation FAM205C tolerates

Waiting for the record before reading gnomAD and Open Targets.

10 Orthologs

The same gene in mouse, rat and human

Waiting for the record before reading the Alliance, NCBI, Ensembl Compara and RGD.

11 MicroRNAs

MicroRNAs hosted within FAM205C

Waiting for the record before reading Ensembl and miRBase.

12 Long non-coding RNAs

Long non-coding RNAs at the FAM205C locus

Waiting for the record before reading Ensembl.

13 Literature

Papers that mention FAM205C

Waiting for the record before reading Europe PMC.

Accession	Name	Biotype	Labels	Exons	Spliced length	Protein	Sequence
NM_001309427.2matches ENST00000340783.11	transcript variant 2	protein coding	MANE Select	5	967 nt	208 aaNP_001296356.1	Ready in a moment
NM_001309426.2matches ENST00000603640.6	transcript variant 1	protein coding	none	5	1,357 nt	338 aaNP_001296355.1	Ready in a moment
NM_001375894.1matches ENST00001103774.1	transcript variant 3	protein coding	none	5	970 nt	209 aaNP_001362823.1	Ready in a moment
NR_164743.1	Ready in a moment

Accession	Name	Biotype	Labels	Exons	Spliced length	Protein	Sequence
NM_001309427.2matches ENST00000340783.11	transcript variant 2	protein coding	MANE Select	5	967 nt	208 aaNP_001296356.1	Ready in a moment
NM_001309426.2matches ENST00000603640.6	transcript variant 1	protein coding	none	5	1,357 nt	338 aaNP_001296355.1	Ready in a moment
NM_001375894.1matches ENST00001103774.1	transcript variant 3	protein coding	none	5	970 nt	209 aaNP_001362823.1	Ready in a moment
NR_164743.1	Ready in a moment

SPATA31F3

What SPATA31F3 does

The RNA a design targets

Where SPATA31F3 is expressed

The protein SPATA31F3 encodes

Proteins STRING associates with SPATA31F3

Where SPATA31F3 acts, as Reactome curates it

Diseases linked to SPATA31F3

Classified variants of SPATA31F3

How much variation SPATA31F3 tolerates

The same gene in mouse, rat and human

MicroRNAs hosted within SPATA31F3

Long non-coding RNAs at the SPATA31F3 locus

Papers that mention SPATA31F3

From SPATA31F3 to a sequence that silences it

Choose the region

Cover the isoforms you mean

Think across species early

Check expression in your model

Run the controls

Pick the product

FAM205C

What FAM205C does

The RNA a design targets

Where FAM205C is expressed

The protein FAM205C encodes

Proteins STRING associates with FAM205C

Where FAM205C acts, as Reactome curates it

Diseases linked to FAM205C

Classified variants of FAM205C

How much variation FAM205C tolerates

The same gene in mouse, rat and human

MicroRNAs hosted within FAM205C

Long non-coding RNAs at the FAM205C locus

Papers that mention FAM205C

SPATA31F3

What SPATA31F3 does

Gene summary

Protein function

The RNA a design targets

RefSeq 4 transcripts

A window on one transcript

Ensembl 0 transcripts

Where SPATA31F3 is expressed

The protein SPATA31F3 encodes

Proteins STRING associates with SPATA31F3

Where SPATA31F3 acts, as Reactome curates it

Diseases linked to SPATA31F3

Classified variants of SPATA31F3

How much variation SPATA31F3 tolerates

The same gene in mouse, rat and human

MicroRNAs hosted within SPATA31F3

Long non-coding RNAs at the SPATA31F3 locus

Papers that mention SPATA31F3

From SPATA31F3 to a sequence that silences it

Choose the region

Cover the isoforms you mean

Think across species early

Check expression in your model

Run the controls

Pick the product

Gene summary

Protein function

RefSeq 4 transcripts

A window on one transcript

Ensembl 0 transcripts