Gene Human Homo sapiens

FCN2

ficolin 2

gene with protein product

Human FCN2MouseRat

Reading the ortholog votes for mouse and rat.

Location: Cytogenetic band 9q34.3NCBI: 9:134,864,144-134,887,523 on the plus strand, GRCh38.p14 (GCF_000001405.40), sequence NC_000009.12, annotation GCF_000001405.40-RS_2025_08 of 2025-08-01Ensembl: no location was read.Coordinates are one-based with both ends included, as each source reports them.
Also known as: P35, FCNL, EBP-37, ficolin-2

Gene identity, from HGNC · HGNC 2026-10-02 · read 2026-10-05 ET · HGNC:3624

Notes from the sources

Ensembl did not answer (upstream error).
Ensembl did not answer (upstream error); the Ensembl location and release are missing

Silence this gene

The order page opens with FCN2 and human filled in. The sequences are designed against the transcripts below; the price is on that page.

Order for FCN2

sdASO, toASO or siRNA

Bring your own sequence Transcripts

For research use only. Not for use in diagnostic or therapeutic procedures.

Summary
Transcripts
Expression
Protein
Interactions
Pathways
Disease
Variants
Constraint
Orthologs
MicroRNAs
Long non-coding RNAs
Literature
Silencing this gene

A line below that says it is reading needs JavaScript to be replaced: with scripts off, it stays at that line however long you wait. Opening a card also needs JavaScript.

Ready in a moment

01 Summary and function

What FCN2 does

The product of this gene belongs to the ficolin family of proteins.

NCBI Gene summary

Ready in a moment

02 Transcripts and isoforms

The RNA a design targets

4 RefSeq transcripts on GRCh38.p14; MANE Select NM_004108.3. Ensembl is not answering, so the Ensembl transcripts could not be shown. Try again later. Reference 629f15f7-1bf.

NCBI Datasets

Ready in a moment

03 Expression by tissue

Where FCN2 is expressed

54 GTEx tissues; the highest median in Liver, 36.4 TPM.

GTEx

Ready in a moment

04 Protein

The protein FCN2 encodes

Reading UniProt, InterPro, AlphaFold DB and PDBe.Still reading. A first read of a gene can take a while; this page waits up to 80 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

Ready in a moment

05 Interactions

Proteins STRING associates with FCN2

Reading STRING.Still reading. A first read of a gene can take a while; this page waits up to 50 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

Ready in a moment

06 Pathways

Where FCN2 acts, as Reactome curates it

Reading UniProt and Reactome.Still reading. A first read of a gene can take a while; this page waits up to 60 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

Ready in a moment

07 Disease associations

Diseases linked to FCN2

257 Open Targets disease associations; hypopituitarism first, at 0.19.

Open Targets

Ready in a moment

08 Variants

Classified variants of FCN2

Reading ClinVar.Still reading. A first read of a gene can take a while; this page waits up to 60 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

Ready in a moment

09 Constraint

How much variation FCN2 tolerates

pLI below 0.0001 and LOEUF 1.29 in gnomAD v4 (GRCh38), on ENST00000291744.11.

gnomAD

Ready in a moment

10 Orthologs

The same gene in mouse, rat and human

Mouse: 2 candidates named (Fcna, Fcnb) and the votes differ; rat Fcnb by 1 of 2 votes. RGD is not answering, so the ortholog list could not be shown. Try again later. Reference fae9ea1c-a6b.

Alliance · NCBI

Ready in a moment

11 MicroRNAs

MicroRNAs hosted within FCN2

Ensembl is not answering, so the non-coding annotation could not be shown. Try again later. Reference 63d8b8d6-022.

Ready in a moment

12 Long non-coding RNAs

Long non-coding RNAs at the FCN2 locus

Ensembl is not answering, so the non-coding annotation could not be shown. Try again later. Reference 63d8b8d6-022.

Ready in a moment

13 Literature

Papers that mention FCN2

Reading Europe PMC.Still reading. A first read of a gene can take a while; this page waits up to 55 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

Ready in a moment

14 Silencing this gene

From FCN2 to a sequence that silences it

The AUMsilence platform designs the sequences against the human transcripts on this page. Six decisions are yours before it does. What is written under each is AUM's guidance; the timings and the concentrations are in the usage guide below.

01
Choose the region
A knockdown oligonucleotide can sit in the 5' untranslated region, the coding sequence or the 3' untranslated region, and all three are used. The coding sequence and the 3' untranslated region are the usual first choices for an RNase H design; the 5' end near the start codon suits a steric block. The map above shows where each region sits on the isoforms it draws.
02
Cover the isoforms you mean
An exon every isoform carries silences the whole gene; an exon only some isoforms carry silences those and spares the rest. Decide which you want before a sequence is chosen, and check the reference transcript (MANE Select in human; RefSeq Select and Ensembl canonical in mouse and rat) is the one your cells express.
03
Think across species early
The orthologs panel says whether mouse and rat carry the same gene. Whether one oligonucleotide can serve two species is a sequence question, settled at design by matching the candidate against each transcript, not by the protein identity shown there.
04
Check expression in your model
A transcript that is not expressed in your cells cannot show knockdown. Confirm the gene is expressed in the cell type and condition you will use, from your own data or a reference atlas, before the order. The expression panel above gives GTEx's median per tissue for a human gene; for mouse and rat it says that no atlas is on this page yet.
05
Run the controls
A scramble control of the same chemistry, a positive control against a gene known to knock down in your cells, untreated cells, and a mock condition where a transfection reagent is used. Read knockdown at the RNA level first, then at the protein; the usage guide gives the timing and the concentrations to start from.
06
Pick the product
AUMsilence sdASO needs no transfection reagent and works in the cells that resist one. AUMsilence toASO is the transfection-optimised version of the same design, and AUMsiRNA is the siRNA route. The selection guide compares them.

Order for FCN2 Bring your own sequence The usage guide Selection guide

For research use only. Not for use in diagnostic or therapeutic procedures.

Gene Human Homo sapiens

FCN2

Reading the record for FCN2 from HGNC, NCBI Gene and Ensembl.Still reading. A first read of a gene can take a while; this page waits up to 115 seconds for it, and its scripts then bring in the page, or a line saying what did not arrive.

The full name, the identifiers, the location and the notes from the sources arrive with the record. Nothing is filled in ahead of it.

Order door

The door to order for FCN2 opens with the record, which decides which product it carries. The order page itself is open now.

Bring your own sequence

For research use only. Not for use in diagnostic or therapeutic procedures.

This page is still reading the record. Its scripts replace this shell with the record when it arrives; with scripts off, it stays at this shell however long you wait.

01 Summary and function

What FCN2 does

Waiting for the record before reading NCBI Gene and UniProt.

02 Transcripts and isoforms

The RNA a design targets

Waiting for the record before reading NCBI Datasets and Ensembl.

03 Expression by tissue

Where FCN2 is expressed

Waiting for the record before reading GTEx and the Human Protein Atlas.

04 Protein

The protein FCN2 encodes

Waiting for the record before reading UniProt, InterPro, AlphaFold DB and PDBe.

05 Interactions

Proteins STRING associates with FCN2

Waiting for the record before reading STRING.

06 Pathways

Where FCN2 acts, as Reactome curates it

Waiting for the record before reading UniProt and Reactome.

07 Disease associations

Diseases linked to FCN2

Waiting for the record before reading Open Targets and ClinGen.

08 Variants

Classified variants of FCN2

Waiting for the record before reading ClinVar.

09 Constraint

How much variation FCN2 tolerates

Waiting for the record before reading gnomAD and Open Targets.

10 Orthologs

The same gene in mouse, rat and human

Waiting for the record before reading the Alliance, NCBI, Ensembl Compara and RGD.

11 MicroRNAs

MicroRNAs hosted within FCN2

Waiting for the record before reading Ensembl and miRBase.

12 Long non-coding RNAs

Long non-coding RNAs at the FCN2 locus

Waiting for the record before reading Ensembl.

13 Literature

Papers that mention FCN2

Waiting for the record before reading Europe PMC.

FCN2

ficolin 2

gene with protein product

Human FCN2MouseRat

Reading the ortholog votes for mouse and rat.

Location

Cytogenetic band 9q34.3NCBI: 9:134,864,144-134,887,523 on the plus strand, GRCh38.p14 (GCF_000001405.40), sequence NC_000009.12, annotation GCF_000001405.40-RS_2025_08 of 2025-08-01Ensembl: no location was read.Coordinates are one-based with both ends included, as each source reports them.

Also known as

P35, FCNL, EBP-37, ficolin-2

Gene identity, from HGNC · HGNC 2026-10-02 · read 2026-10-05 ET · HGNC:3624

Notes from the sources

Ensembl did not answer (upstream error).
Ensembl did not answer (upstream error); the Ensembl location and release are missing

RefSeq transcripts of this gene
Accession	Name	Biotype	Labels	Exons	Spliced length	Protein	Sequence
NM_004108.3matches ENST00000291744.11	transcript variant SV0	protein coding	MANE Select	8	1,062 nt	313 aaNP_004099.2	Ready in a moment
XM_011518392.4	transcript variant X1	protein coding model	none	8	1,470 nt	302 aaXP_011516694.1	Ready in a moment
XM_006717015.5	transcript variant X2	protein coding model	none	7	1,355 nt	264 aaXP_006717078.1	Ready in a moment
NM_015837.3matches ENST00000350339.4	transcript variant SV1	protein coding	none	7	948 nt	275 aaNP_056652.1	Ready in a moment

Accession

Name

Biotype

Labels

Exons

Spliced length

Protein

Sequence

NM_004108.3matches ENST00000291744.11

transcript variant SV0

protein coding

MANE Select

1,062 nt

313 aaNP_004099.2

Ready in a moment

XM_011518392.4

transcript variant X1

protein coding model

none

1,470 nt

302 aaXP_011516694.1

Ready in a moment

XM_006717015.5

transcript variant X2

protein coding model

none

1,355 nt

264 aaXP_006717078.1

Ready in a moment

NM_015837.3matches ENST00000350339.4

transcript variant SV1

protein coding

none

948 nt

275 aaNP_056652.1

Ready in a moment

From FCN2 to a sequence that silences it

Choose the region

A knockdown oligonucleotide can sit in the 5' untranslated region, the coding sequence or the 3' untranslated region, and all three are used. The coding sequence and the 3' untranslated region are the usual first choices for an RNase H design; the 5' end near the start codon suits a steric block. The map above shows where each region sits on the isoforms it draws.

Cover the isoforms you mean

An exon every isoform carries silences the whole gene; an exon only some isoforms carry silences those and spares the rest. Decide which you want before a sequence is chosen, and check the reference transcript (MANE Select in human; RefSeq Select and Ensembl canonical in mouse and rat) is the one your cells express.

Think across species early

The orthologs panel says whether mouse and rat carry the same gene. Whether one oligonucleotide can serve two species is a sequence question, settled at design by matching the candidate against each transcript, not by the protein identity shown there.

Check expression in your model

A transcript that is not expressed in your cells cannot show knockdown. Confirm the gene is expressed in the cell type and condition you will use, from your own data or a reference atlas, before the order. The expression panel above gives GTEx's median per tissue for a human gene; for mouse and rat it says that no atlas is on this page yet.

Run the controls

A scramble control of the same chemistry, a positive control against a gene known to knock down in your cells, untreated cells, and a mock condition where a transfection reagent is used. Read knockdown at the RNA level first, then at the protein; the usage guide gives the timing and the concentrations to start from.

Pick the product

AUMsilence sdASO needs no transfection reagent and works in the cells that resist one. AUMsilence toASO is the transfection-optimised version of the same design, and AUMsiRNA is the siRNA route. The selection guide compares them.

For research use only. Not for use in diagnostic or therapeutic procedures.

RefSeq transcripts of this gene
Accession	Name	Biotype	Labels	Exons	Spliced length	Protein	Sequence
NM_004108.3matches ENST00000291744.11	transcript variant SV0	protein coding	MANE Select	8	1,062 nt	313 aaNP_004099.2	Ready in a moment
XM_011518392.4	transcript variant X1	protein coding model	none	8	1,470 nt	302 aaXP_011516694.1	Ready in a moment
XM_006717015.5	transcript variant X2	protein coding model	none	7	1,355 nt	264 aaXP_006717078.1	Ready in a moment
NM_015837.3matches ENST00000350339.4	transcript variant SV1	protein coding	none	7	948 nt	275 aaNP_056652.1	Ready in a moment

Accession

Name

Biotype

Labels

Exons

Spliced length

Protein

Sequence

NM_004108.3matches ENST00000291744.11

transcript variant SV0

protein coding

MANE Select

1,062 nt

313 aaNP_004099.2

Ready in a moment

XM_011518392.4

transcript variant X1

protein coding model

none

1,470 nt

302 aaXP_011516694.1

Ready in a moment

XM_006717015.5

transcript variant X2

protein coding model

none

1,355 nt

264 aaXP_006717078.1

Ready in a moment

NM_015837.3matches ENST00000350339.4

transcript variant SV1

protein coding

none

948 nt

275 aaNP_056652.1

Ready in a moment

FCN2

What FCN2 does

The RNA a design targets

Where FCN2 is expressed

The protein FCN2 encodes

Proteins STRING associates with FCN2

Where FCN2 acts, as Reactome curates it

Diseases linked to FCN2

Classified variants of FCN2

How much variation FCN2 tolerates

The same gene in mouse, rat and human

MicroRNAs hosted within FCN2

Long non-coding RNAs at the FCN2 locus

Papers that mention FCN2

From FCN2 to a sequence that silences it

Choose the region

Cover the isoforms you mean

Think across species early

Check expression in your model

Run the controls

Pick the product

FCN2

What FCN2 does

The RNA a design targets

Where FCN2 is expressed

The protein FCN2 encodes

Proteins STRING associates with FCN2

Where FCN2 acts, as Reactome curates it

Diseases linked to FCN2

Classified variants of FCN2

How much variation FCN2 tolerates

The same gene in mouse, rat and human

MicroRNAs hosted within FCN2

Long non-coding RNAs at the FCN2 locus

Papers that mention FCN2

FCN2

What FCN2 does

Gene summary

Protein function

The RNA a design targets

RefSeq 4 transcripts

A window on one transcript

Ensembl 0 transcripts

Where FCN2 is expressed

The protein FCN2 encodes

Proteins STRING associates with FCN2

Where FCN2 acts, as Reactome curates it

Diseases linked to FCN2

Classified variants of FCN2

How much variation FCN2 tolerates

The same gene in mouse, rat and human

MicroRNAs hosted within FCN2

Long non-coding RNAs at the FCN2 locus

Papers that mention FCN2

From FCN2 to a sequence that silences it

Choose the region

Cover the isoforms you mean

Think across species early

Check expression in your model

Run the controls

Pick the product

Gene summary

Protein function

RefSeq 4 transcripts

A window on one transcript

Ensembl 0 transcripts