Gene Human Homo sapiens

GFOD1

Gfo/Idh/MocA-like oxidoreductase domain containing 1

gene with protein product

Human GFOD1MouseRat

Reading the ortholog votes for mouse and rat.

Location: Cytogenetic band 6p24.1-p23NCBI: 6:13,357,830-13,487,600 on the minus strand, GRCh38.p14 (GCF_000001405.40), sequence NC_000006.12, annotation GCF_000001405.40-RS_2025_08 of 2025-08-01Ensembl: 6:13,357,830-13,487,662 on the minus strand, GRCh38.p14 (GCA_000001405.29), release 116Coordinates are one-based with both ends included, as each source reports them.
Also known as: FLJ20330, ADG-90
Previous symbols: C6orf114

Gene identity, from HGNC · HGNC 2026-09-29 · read 2026-10-01 ET · HGNC:21096

Silence this gene

The order page opens with GFOD1 and human filled in. The sequences are designed against the transcripts below; the price is on that page.

Order for GFOD1

sdASO, toASO or siRNA, chosen on the next page

Bring your own sequence Transcripts

For research use only. Not for use in diagnostic or therapeutic procedures.

Summary
Transcripts
Expression
Protein
Interactions
Pathways
Disease
Variants
Constraint
Orthologs
MicroRNAs
Long non-coding RNAs
Literature
Silencing this gene

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Ready in a moment

01 Summary and function

What GFOD1 does

Enables identical protein binding activity.

NCBI Gene summary

Ready in a moment

02 Transcripts and isoforms

The RNA a design targets

Reading NCBI Datasets and Ensembl.Still reading. A first read of a gene can take a while; this page waits up to 80 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

Ready in a moment

03 Expression by tissue

Where GFOD1 is expressed

Reading GTEx and the Human Protein Atlas.Still reading. A first read of a gene can take a while; this page waits up to 80 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

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04 Protein

The protein GFOD1 encodes

Reading UniProt, InterPro, AlphaFold DB and PDBe.Still reading. A first read of a gene can take a while; this page waits up to 80 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

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05 Interactions

Proteins STRING associates with GFOD1

Reading STRING.Still reading. A first read of a gene can take a while; this page waits up to 50 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

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06 Pathways

Where GFOD1 acts, as Reactome curates it

Reading UniProt and Reactome.Still reading. A first read of a gene can take a while; this page waits up to 60 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

Ready in a moment

07 Disease associations

Diseases linked to GFOD1

77 Open Targets disease associations; gout first, at 0.24.

Open Targets

Ready in a moment

08 Variants

Classified variants of GFOD1

Reading ClinVar.Still reading. A first read of a gene can take a while; this page waits up to 60 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

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09 Constraint

How much variation GFOD1 tolerates

Reading gnomAD and Open Targets.Still reading. A first read of a gene can take a while; this page waits up to 45 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

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10 Orthologs

The same gene in mouse, rat and human

Reading the Alliance, NCBI, Ensembl Compara and RGD.Still reading. A first read of a gene can take a while; this page waits up to 145 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

Ready in a moment

11 MicroRNAs

MicroRNAs hosted within GFOD1

No annotated microRNA lies within GFOD1 in Ensembl release 116, on GRCh38.p14.

Ensembl · miRBase

Ready in a moment

12 Long non-coding RNAs

Long non-coding RNAs at the GFOD1 locus

Reading Ensembl.Still reading. A first read of a gene can take a while; this page waits up to 110 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

Ready in a moment

13 Literature

Papers that mention GFOD1

Reading Europe PMC.Still reading. A first read of a gene can take a while; this page waits up to 55 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

Ready in a moment

14 Silencing this gene

From GFOD1 to a sequence that silences it

The AUMsilence platform designs the sequences against the human transcripts on this page. Six decisions are yours before it does. What is written under each is AUM's guidance; the timings and the concentrations are in the usage guide below.

01
Choose the region
A knockdown oligonucleotide can sit in the 5' untranslated region, the coding sequence or the 3' untranslated region, and all three are used. The coding sequence and the 3' untranslated region are the usual first choices for an RNase H design; the 5' end near the start codon suits a steric block. The map above shows where each region sits on the isoforms it draws.
02
Cover the isoforms you mean
An exon every isoform carries silences the whole gene; an exon only some isoforms carry silences those and spares the rest. Decide which you want before a sequence is chosen, and check the reference transcript (MANE Select in human; RefSeq Select and Ensembl canonical in mouse and rat) is the one your cells express.
03
Think across species early
The orthologs panel says whether mouse and rat carry the same gene. Whether one oligonucleotide can serve two species is a sequence question, settled at design by matching the candidate against each transcript, not by the protein identity shown there.
04
Check expression in your model
A transcript that is not expressed in your cells cannot show knockdown. Confirm the gene is expressed in the cell type and condition you will use, from your own data or a reference atlas, before the order. The expression panel above gives GTEx's median per tissue for a human gene; for mouse and rat it says that no atlas is on this page yet.
05
Run the controls
A scramble control of the same chemistry, a positive control against a gene known to knock down in your cells, untreated cells, and a mock condition where a transfection reagent is used. Read knockdown at the RNA level first, then at the protein; the usage guide gives the timing and the concentrations to start from.
06
Pick the product
AUMsilence sdASO needs no transfection reagent and works in the cells that resist one. AUMsilence toASO is the transfection-optimised version of the same design, and AUMsiRNA is the siRNA route. The selection guide compares them.

Order for GFOD1 Bring your own sequence The usage guide Selection guide

For research use only. Not for use in diagnostic or therapeutic procedures.

Gene Human Homo sapiens

GFOD1

Reading the record for GFOD1 from HGNC, NCBI Gene and Ensembl.Still reading. A first read of a gene can take a while; this page waits up to 115 seconds for it, and its scripts then bring in the page, or a line saying what did not arrive.

The full name, the identifiers, the location and the notes from the sources arrive with the record. Nothing is filled in ahead of it.

Order door

The door to order for GFOD1 opens with the record, which decides which product it carries. The order page itself is open now.

Bring your own sequence

For research use only. Not for use in diagnostic or therapeutic procedures.

This page is still reading the record. Its scripts replace this shell with the record when it arrives; with scripts off, it stays at this shell however long you wait.

01 Summary and function

What GFOD1 does

Waiting for the record before reading NCBI Gene and UniProt.

02 Transcripts and isoforms

The RNA a design targets

Waiting for the record before reading NCBI Datasets and Ensembl.

03 Expression by tissue

Where GFOD1 is expressed

Waiting for the record before reading GTEx and the Human Protein Atlas.

04 Protein

The protein GFOD1 encodes

Waiting for the record before reading UniProt, InterPro, AlphaFold DB and PDBe.

05 Interactions

Proteins STRING associates with GFOD1

Waiting for the record before reading STRING.

06 Pathways

Where GFOD1 acts, as Reactome curates it

Waiting for the record before reading UniProt and Reactome.

07 Disease associations

Diseases linked to GFOD1

Waiting for the record before reading Open Targets and ClinGen.

08 Variants

Classified variants of GFOD1

Waiting for the record before reading ClinVar.

09 Constraint

How much variation GFOD1 tolerates

Waiting for the record before reading gnomAD and Open Targets.

10 Orthologs

The same gene in mouse, rat and human

Waiting for the record before reading the Alliance, NCBI, Ensembl Compara and RGD.

11 MicroRNAs

MicroRNAs hosted within GFOD1

Waiting for the record before reading Ensembl and miRBase.

12 Long non-coding RNAs

Long non-coding RNAs at the GFOD1 locus

Waiting for the record before reading Ensembl.

13 Literature

Papers that mention GFOD1

Waiting for the record before reading Europe PMC.

Accession	Name	Biotype	Labels	Exons	Spliced length	Protein	Sequence
NM_018988.4matches ENST00000379287.4	transcript variant 1	protein coding	MANE Select	2	8,796 nt	390 aaNP_061861.1	Ready in a moment
NM_001242630.2matches ENST00000379284.1	transcript variant 3	protein coding	none	2	8,061 nt	287 aaNP_001229559.1	Ready in a moment
NM_001242628.2matches ENST00000612338.5	transcript variant 2	protein coding	none	2	7,967 nt	287 aaNP_001229557.1	Ready in a moment
NM_001242629.2	Ready in a moment

Accession	Name	Biotype	Labels	Exons	Spliced length	Protein	Sequence
NM_018988.4matches ENST00000379287.4	transcript variant 1	protein coding	MANE Select	2	8,796 nt	390 aaNP_061861.1	Ready in a moment
NM_001242630.2matches ENST00000379284.1	transcript variant 3	protein coding	none	2	8,061 nt	287 aaNP_001229559.1	Ready in a moment
NM_001242628.2matches ENST00000612338.5	transcript variant 2	protein coding	none	2	7,967 nt	287 aaNP_001229557.1	Ready in a moment
NM_001242629.2	Ready in a moment

Accession	Name	Biotype	Labels	Exons	Spliced length	Protein	Sequence
ENST00000379287.4matches NM_018988.4	GFOD1-203	protein coding	MANE SelectEnsembl canonical	2	8,796 nt	390 aaENSP00000368589.3	Ready in a moment
ENST00001124108.1	GFOD1-210	protein coding	none	3	8,951 nt	421 aaENSP00000793913.1	Ready in a moment
ENST00001135205.1	GFOD1-211	protein coding	none	2	8,858 nt	390 aaENSP00000810984.1	Ready in a moment
ENST00000379284.1	GFOD1-202	protein coding	none	2	8,061 nt	287 aaENSP00000368586.1	Ready in a moment
ENST00000612338.5	GFOD1-206	protein coding	none	2	8,006 nt	287 aaENSP00000479493.1	Ready in a moment
ENST00001120709.1	GFOD1-207	nonsense mediated decay	none	3	4,073 nt	189 aaENSP00000790514.1	Ready in a moment
ENST00001120710.1	GFOD1-208	protein coding	none	2	3,807 nt	189 aaENSP00000790515.1	Ready in a moment
ENST00000603223.1	GFOD1-204	protein coding	none	2	2,388 nt	148 aaENSP00000473812.1	Ready in a moment
ENST00001120711.1	GFOD1-209	nonsense mediated decay	none	3	1,280 nt	88 aaENSP00000790516.1	Ready in a moment
ENST00000379278.3	GFOD1-201	protein coding cds not defined	none	2	1,529 nt	none	Ready in a moment
ENST00000605067.1	GFOD1-205	protein coding cds not defined	none	2	1,427 nt	none	Ready in a moment

GFOD1

What GFOD1 does

The RNA a design targets

Where GFOD1 is expressed

The protein GFOD1 encodes

Proteins STRING associates with GFOD1

Where GFOD1 acts, as Reactome curates it

Diseases linked to GFOD1

Classified variants of GFOD1

How much variation GFOD1 tolerates

The same gene in mouse, rat and human

MicroRNAs hosted within GFOD1

Long non-coding RNAs at the GFOD1 locus

Papers that mention GFOD1

From GFOD1 to a sequence that silences it

Choose the region

Cover the isoforms you mean

Think across species early

Check expression in your model

Run the controls

Pick the product

GFOD1

What GFOD1 does

The RNA a design targets

Where GFOD1 is expressed

The protein GFOD1 encodes

Proteins STRING associates with GFOD1

Where GFOD1 acts, as Reactome curates it

Diseases linked to GFOD1

Classified variants of GFOD1

How much variation GFOD1 tolerates

The same gene in mouse, rat and human

MicroRNAs hosted within GFOD1

Long non-coding RNAs at the GFOD1 locus

Papers that mention GFOD1

GFOD1

What GFOD1 does

Gene summary

Protein function

The RNA a design targets

RefSeq 5 transcripts

A window on one transcript

Ensembl 11 transcripts

A window on one transcript

Where GFOD1 is expressed

The protein GFOD1 encodes

Proteins STRING associates with GFOD1

Where GFOD1 acts, as Reactome curates it

Diseases linked to GFOD1

Classified variants of GFOD1

How much variation GFOD1 tolerates

The same gene in mouse, rat and human

MicroRNAs hosted within GFOD1

Long non-coding RNAs at the GFOD1 locus

Papers that mention GFOD1

From GFOD1 to a sequence that silences it

Choose the region

Cover the isoforms you mean

Think across species early

Check expression in your model

Run the controls

Pick the product

Gene summary

Protein function

RefSeq 5 transcripts

A window on one transcript

Ensembl 11 transcripts

A window on one transcript