Gene Human Homo sapiens

GOLGA8O

golgin A8 family member O

gene with protein product

Rat: several candidates are named (Golga2, Golga2l1), none marked the best match. The orthologs panel below shows every vote.

Location: Cytogenetic band 15q13.3NCBI: 15:32,441,914-32,461,984 on the minus strand, GRCh38.p14 (GCF_000001405.40), sequence NC_000015.10, annotation GCF_000001405.40-RS_2025_08 of 2025-08-01Ensembl: 15:32,441,914-32,455,634 on the minus strand, GRCh38.p14 (GCA_000001405.29), release 116Coordinates are one-based with both ends included, as each source reports them.

Gene identity, from HGNC · HGNC 2026-10-02 · read 2026-10-04 ET · HGNC:44406

Notes from the sources

NCBI places this gene on more than one sequence of GRCh38.p14 (15 NC_000015.10, 15 NW_012132920.1); the coordinates shown are the 15 placement

Silence this gene

The order page opens with GOLGA8O and human filled in. The sequences are designed against the transcripts below; the price is on that page.

Order for GOLGA8O

sdASO, toASO or siRNA

Bring your own sequence Transcripts

For research use only. Not for use in diagnostic or therapeutic procedures.

Summary
Transcripts
Expression
Protein
Interactions
Pathways
Disease
Variants
Constraint
Orthologs
MicroRNAs
Long non-coding RNAs
Literature
Silencing this gene

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Ready in a moment

01 Summary and function

What GOLGA8O does

Ready in a moment

02 Transcripts and isoforms

The RNA a design targets

Ready in a moment

03 Expression by tissue

Where GOLGA8O is expressed

Ready in a moment

14 Silencing this gene

From GOLGA8O to a sequence that silences it

The AUMsilence platform designs the sequences against the human transcripts on this page. Six decisions are yours before it does. What is written under each is AUM's guidance; the timings and the concentrations are in the usage guide below.

01
Choose the region
A knockdown oligonucleotide can sit in the 5' untranslated region, the coding sequence or the 3' untranslated region, and all three are used. The coding sequence and the 3' untranslated region are the usual first choices for an RNase H design; the 5' end near the start codon suits a steric block. The map above shows where each region sits on the isoforms it draws.
02
Cover the isoforms you mean
An exon every isoform carries silences the whole gene; an exon only some isoforms carry silences those and spares the rest. Decide which you want before a sequence is chosen, and check the reference transcript (MANE Select in human; RefSeq Select and Ensembl canonical in mouse and rat) is the one your cells express.
03
Think across species early
The orthologs panel says whether mouse and rat carry the same gene. Whether one oligonucleotide can serve two species is a sequence question, settled at design by matching the candidate against each transcript, not by the protein identity shown there.
04
Check expression in your model
A transcript that is not expressed in your cells cannot show knockdown. Confirm the gene is expressed in the cell type and condition you will use, from your own data or a reference atlas, before the order. The expression panel above gives GTEx's median per tissue for a human gene; for mouse and rat it says that no atlas is on this page yet.

Gene Human Homo sapiens

GOLGA8O

Reading the record for GOLGA8O from HGNC, NCBI Gene and Ensembl.Still reading. A first read of a gene can take a while; this page waits up to 115 seconds for it, and its scripts then bring in the page, or a line saying what did not arrive.

The full name, the identifiers, the location and the notes from the sources arrive with the record. Nothing is filled in ahead of it.

Order door

The door to order for GOLGA8O opens with the record, which decides which product it carries. The order page itself is open now.

Bring your own sequence

For research use only. Not for use in diagnostic or therapeutic procedures.

This page is still reading the record. Its scripts replace this shell with the record when it arrives; with scripts off, it stays at this shell however long you wait.

01 Summary and function

What GOLGA8O does

Waiting for the record before reading NCBI Gene and UniProt.

02 Transcripts and isoforms

The RNA a design targets

Waiting for the record before reading NCBI Datasets and Ensembl.

03 Expression by tissue

Where GOLGA8O is expressed

Waiting for the record before reading GTEx and the Human Protein Atlas.

04 Protein

The protein GOLGA8O encodes

Waiting for the record before reading UniProt, InterPro, AlphaFold DB and PDBe.

05 Interactions

Proteins STRING associates with GOLGA8O

Waiting for the record before reading STRING.

06 Pathways

Where GOLGA8O acts, as Reactome curates it

Waiting for the record before reading UniProt and Reactome.

07 Disease associations

Diseases linked to GOLGA8O

Waiting for the record before reading Open Targets and ClinGen.

08 Variants

Classified variants of GOLGA8O

Waiting for the record before reading ClinVar.

09 Constraint

How much variation GOLGA8O tolerates

Waiting for the record before reading gnomAD and Open Targets.

10 Orthologs

The same gene in mouse, rat and human

Waiting for the record before reading the Alliance, NCBI, Ensembl Compara and RGD.

11 MicroRNAs

MicroRNAs hosted within GOLGA8O

Waiting for the record before reading Ensembl and miRBase.

12 Long non-coding RNAs

Long non-coding RNAs at the GOLGA8O locus

Waiting for the record before reading Ensembl.

13 Literature

Papers that mention GOLGA8O

Waiting for the record before reading Europe PMC.

GOLGA8O

golgin A8 family member O

gene with protein product

Rat: several candidates are named (Golga2, Golga2l1), none marked the best match. The orthologs panel below shows every vote.

Location

Cytogenetic band 15q13.3NCBI: 15:32,441,914-32,461,984 on the minus strand, GRCh38.p14 (GCF_000001405.40), sequence NC_000015.10, annotation GCF_000001405.40-RS_2025_08 of 2025-08-01Ensembl: 15:32,441,914-32,455,634 on the minus strand, GRCh38.p14 (GCA_000001405.29), release 116Coordinates are one-based with both ends included, as each source reports them.

Gene identity, from HGNC · HGNC 2026-10-02 · read 2026-10-04 ET · HGNC:44406

Notes from the sources

NCBI places this gene on more than one sequence of GRCh38.p14 (15 NC_000015.10, 15 NW_012132920.1); the coordinates shown are the 15 placement

RefSeq transcripts of this gene
Accession	Name	Biotype	Labels	Exons	Spliced length	Protein	Sequence
NM_001277308.1matches ENST00000509311.7 NCBI also places this transcript on 15 NW_012132920.1 in this annotation, with 19 exons; only the 15 placement is drawn	none given	protein coding	MANE Select	19	5,189 nt	632 aaNP_001264237.1	Ready in a moment
XM_024450042.2	transcript variant X3	protein coding model	none	19	5,373 nt	481 aaXP_024305810.1	Ready in a moment
XM_047433006.1	transcript variant X1	protein coding model	none	19	5,213 nt	619 aaXP_047288962.1	Ready in a moment
XM_054331873.1	Ready in a moment

Accession

Name

Biotype

Labels

Exons

Spliced length

Protein

Sequence

NM_001277308.1matches ENST00000509311.7

NCBI also places this transcript on 15 NW_012132920.1 in this annotation, with 19 exons; only the 15 placement is drawn

none given

protein coding

MANE Select

5,189 nt

632 aaNP_001264237.1

Ready in a moment

XM_024450042.2

transcript variant X3

protein coding model

none

5,373 nt

481 aaXP_024305810.1

Ready in a moment

XM_047433006.1

transcript variant X1

protein coding model

none

5,213 nt

619 aaXP_047288962.1

Ready in a moment

XM_054331873.1

Ready in a moment

From GOLGA8O to a sequence that silences it

Choose the region

A knockdown oligonucleotide can sit in the 5' untranslated region, the coding sequence or the 3' untranslated region, and all three are used. The coding sequence and the 3' untranslated region are the usual first choices for an RNase H design; the 5' end near the start codon suits a steric block. The map above shows where each region sits on the isoforms it draws.

Cover the isoforms you mean

An exon every isoform carries silences the whole gene; an exon only some isoforms carry silences those and spares the rest. Decide which you want before a sequence is chosen, and check the reference transcript (MANE Select in human; RefSeq Select and Ensembl canonical in mouse and rat) is the one your cells express.

Think across species early

The orthologs panel says whether mouse and rat carry the same gene. Whether one oligonucleotide can serve two species is a sequence question, settled at design by matching the candidate against each transcript, not by the protein identity shown there.

Check expression in your model

A transcript that is not expressed in your cells cannot show knockdown. Confirm the gene is expressed in the cell type and condition you will use, from your own data or a reference atlas, before the order. The expression panel above gives GTEx's median per tissue for a human gene; for mouse and rat it says that no atlas is on this page yet.

RefSeq transcripts of this gene
Accession	Name	Biotype	Labels	Exons	Spliced length	Protein	Sequence
NM_001277308.1matches ENST00000509311.7 NCBI also places this transcript on 15 NW_012132920.1 in this annotation, with 19 exons; only the 15 placement is drawn	none given	protein coding	MANE Select	19	5,189 nt	632 aaNP_001264237.1	Ready in a moment
XM_024450042.2	transcript variant X3	protein coding model	none	19	5,373 nt	481 aaXP_024305810.1	Ready in a moment
XM_047433006.1	transcript variant X1	protein coding model	none	19	5,213 nt	619 aaXP_047288962.1	Ready in a moment
XM_054331873.1	Ready in a moment

Accession

Name

Biotype

Labels

Exons

Spliced length

Protein

Sequence

NM_001277308.1matches ENST00000509311.7

NCBI also places this transcript on 15 NW_012132920.1 in this annotation, with 19 exons; only the 15 placement is drawn

none given

protein coding

MANE Select

5,189 nt

632 aaNP_001264237.1

Ready in a moment

XM_024450042.2

transcript variant X3

protein coding model

none

5,373 nt

481 aaXP_024305810.1

Ready in a moment

XM_047433006.1

transcript variant X1

protein coding model

none

5,213 nt

619 aaXP_047288962.1

Ready in a moment

XM_054331873.1

Ready in a moment

Accession	Name	Biotype	Labels	Exons	Spliced length	Protein	Sequence
ENST00000509311.7matches NM_001277308.1	GOLGA8O-201	protein coding	MANE SelectEnsembl canonical	19	5,189 nt	632 aaENSP00000423159.2	Ready in a moment
ENST00000562377.1	GOLGA8O-202	protein coding	none	7	555 nt	131 aaENSP00000456713.1	Ready in a moment

GOLGA8O

What GOLGA8O does

The RNA a design targets

Where GOLGA8O is expressed

From GOLGA8O to a sequence that silences it

Choose the region

Cover the isoforms you mean

Think across species early

Check expression in your model

GOLGA8O

What GOLGA8O does

The RNA a design targets

Where GOLGA8O is expressed

The protein GOLGA8O encodes

Proteins STRING associates with GOLGA8O

Where GOLGA8O acts, as Reactome curates it

Diseases linked to GOLGA8O

Classified variants of GOLGA8O

How much variation GOLGA8O tolerates

The same gene in mouse, rat and human

MicroRNAs hosted within GOLGA8O

Long non-coding RNAs at the GOLGA8O locus

Papers that mention GOLGA8O

GOLGA8O

What GOLGA8O does

Gene summary

Protein function

The RNA a design targets

RefSeq 9 transcripts

A window on one transcript

Ensembl 2 transcripts

A window on one transcript

Where GOLGA8O is expressed

From GOLGA8O to a sequence that silences it

Choose the region

Cover the isoforms you mean

Think across species early

Check expression in your model

The protein GOLGA8O encodes

Proteins STRING associates with GOLGA8O

Where GOLGA8O acts, as Reactome curates it

Diseases linked to GOLGA8O

Classified variants of GOLGA8O

How much variation GOLGA8O tolerates

The same gene in mouse, rat and human

MicroRNAs hosted within GOLGA8O

Long non-coding RNAs at the GOLGA8O locus

Papers that mention GOLGA8O

Run the controls

Pick the product

Gene summary

Protein function

RefSeq 9 transcripts

A window on one transcript

Ensembl 2 transcripts

A window on one transcript