Reading the record for H19 from HGNC, NCBI Gene and Ensembl.Still reading. A first read of a gene can take a while; this page waits up to 115 seconds for it, and its scripts then bring in the page, or a line saying what did not arrive.
The full name, the identifiers, the location and the notes from the sources arrive with the record. Nothing is filled in ahead of it.
Order door
The door to order for H19 opens with the record, which decides which product it carries. The order page itself is open now.
Cytogenetic band 11p15.5NCBI: 11:1,995,176-2,001,266 on the minus strand, GRCh38.p14 (GCF_000001405.40), sequence NC_000011.10, annotation GCF_000001405.40-RS_2025_08 of 2025-08-01Ensembl: 11:1,995,165-2,004,552 on the minus strand, GRCh38.p14 (GCA_000001405.29), release 116Coordinates are one-based with both ends included, as each source reports them.
This gene is located in an imprinted region of chromosome 11 near the… UniProt has 0 reviewed entries named H19 in human.
NCBI Gene summary
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Reading NCBI Gene and UniProt.Still reading. A first read of a gene can take a while; this page waits up to 30 seconds for it, and its scripts then bring in the panel, or a line saying what did not arrive.
02 / Transcripts and isoforms
The RNA a design targets
7 RefSeq and 46 Ensembl transcripts on GRCh38.p14; MANE Select NR_002196.3.
NCBI Datasets · Ensembl
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Reading NCBI Datasets and Ensembl.Still reading. A first read of a gene can take a while; this page waits up to 80 seconds for it, and its scripts then bring in the panel, or a line saying what did not arrive.
03 / Expression by tissue
Where H19 is expressed
54 GTEx tissues; the highest median in Muscle - Skeletal, 228 TPM.
GTEx
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04 / Protein
The protein H19 encodes
UniProt did not give one reviewed entry for H19 in human, so InterPro, AlphaFold DB and PDBe were not asked and no protein entry is shown.
UniProt
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05 / Interactions
Proteins STRING associates with H19
STRING did not resolve H19 in human to a protein under this gene's symbol or a name it is known by, so no partner list is shown.
STRING
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06 / Pathways
Where H19 acts, as Reactome curates it
UniProt did not give one reviewed entry for H19 in human, so Reactome was not asked and no pathway list is shown.
UniProt
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07 / Disease associations
Diseases linked to H19
774 Open Targets disease associations; isolated hemihyperplasia first, at 0.37.
Open Targets
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08 / Variants
Classified variants of H19
ClinVar: 118 records for H19, 37 pathogenic or likely pathogenic.
ClinVar
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09 / Constraint
How much variation H19 tolerates
gnomAD holds H19 but its record carries no constraint metrics.
gnomAD
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10 / Orthologs
The same gene in mouse, rat and human
Mouse H19 by 2 of 3 votes; rat H19 by 1 of 3 votes. RGD is not answering, so the ortholog list could not be shown. Try again later. Reference 4972b089-670.
Alliance · NCBI · Ensembl Compara
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11 /MicroRNAs
MicroRNAs hosted within H19
1 microRNA gene overlaps H19 in Ensembl release 116: MIR675.
No annotated long non-coding RNA overlaps H19 in Ensembl release 116, on GRCh38.p14.
Ensembl
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13 / Literature
Papers that mention H19
37,613 PubMed-indexed papers mention H19 at Europe PMC, newest first. Europe PMC ignores letter case, so the count also covers another species' symbol spelled with the same letters.
Europe PMC
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14 / Silencing this gene
From H19 to a sequence that silences it
This is a long non-coding RNA gene. The order page opens with H19 and human filled in, on AUMlnc™ sdASO™, with AUMlnc toASO beside it, and the price on that page. Its long non-coding RNA page sets out the steps that come first, each with the sources it rests on.
For research use only. Not for use in diagnostic or therapeutic procedures.
Gene summary
This gene is located in an imprinted region of chromosome 11 near the insulin-like growth factor 2 (IGF2) gene. This gene is only expressed from the maternally-inherited chromosome, whereas IGF2 is only expressed from the paternally-inherited chromosome. The product of this gene is a long non-coding RNA which functions as a tumor suppressor. Mutations in this gene have been associated with Beckwith-Wiedemann Syndrome and Wilms tumorigenesis. Alternative splicing results in multiple transcript variants.
Provided by RefSeq, Apr 2015, through NCBI Gene. NCBI disclaimer
Protein function
Not available
UniProt has 0 reviewed entries named H19 in human.
NCBI Gene summary · NCBI Gene annotation RS_2025_08 · read · NCBI Gene 283120Data from NCBI, provided as is; NCBI's policies and disclaimers apply.
Placed on GRCh38.p14 (GCF_000001405.40). MANE Select marks the one transcript RefSeq and Ensembl agree is the reference for this gene.
RefSeq 7 transcripts
coding sequence, tall
untranslated region, thin
non-coding exon
intron, fixed width
Genomic strand: minus. Drawn 5' to 3', so exon 1 sits at the left here and at the highest coordinate on the chromosome.
NR_002196.3NR_002196.3MANE Select
NR_185829.1NR_185829.1
NR_131223.2NR_131223.2
NR_185831.1NR_185831.1
NR_185830.1NR_185830.1
NR_185828.1NR_185828.1
NR_131224.2NR_131224.2
scale
Drawn 5' to 3' from each transcript's exons as placed on the reference assembly; exon 1 is the 5' exon on the transcript's own strand. Exon blocks are to scale with each other; introns are drawn at one fixed width whatever their length, so the map is not to scale along the chromosome. Numbers are exon ranks along the strand; a rank is omitted where the exon is too narrow to carry it.
A window on one transcript
One pixel of the map above stands for several bases, and a block too short to see is drawn wider than its own scale, so the map chooses a region and the sequence here chooses the window. Click an exon on a row of the map, or drag across a row; then set the exact start and end below.
These controls are ready in a moment.
No transcript is chosen.
Once a window is chosen this panel shows its length, its G and C count as a percentage of that length, the letters it is made of, the exons it falls in, whether it crosses a junction, and its antisense strand.
Drawn 5' to 3' from each transcript's exons as placed on the reference assembly; exon 1 is the 5' exon on the transcript's own strand. Exon blocks are to scale with each other; introns are drawn at one fixed width whatever their length, so the map is not to scale along the chromosome. Numbers are exon ranks along the strand; a rank is omitted where the exon is too narrow to carry it.
A window on one transcript
One pixel of the map above stands for several bases, and a block too short to see is drawn wider than its own scale, so the map chooses a region and the sequence here chooses the window. Click an exon on a row of the map, or drag across a row; then set the exact start and end below.
These controls are ready in a moment.
No transcript is chosen.
Once a window is chosen this panel shows its length, its G and C count as a percentage of that length, the letters it is made of, the exons it falls in, whether it crosses a junction, and its antisense strand.
Lengths are spliced lengths, as each source states them. Exon ranks follow the strand: on a minus-strand gene exon 1 has the highest genomic coordinate. Reference assembly for human: GRCh38.
