Reading the record for HDAC7 from HGNC, NCBI Gene and Ensembl.Still reading. A first read of a gene can take a while; this page waits up to 115 seconds for it, and its scripts then bring in the page, or a line saying what did not arrive.
The full name, the identifiers, the location and the notes from the sources arrive with the record. Nothing is filled in ahead of it.
Order door
The door to order for HDAC7 opens with the record, which decides which product it carries. The order page itself is open now.
Cytogenetic band 12q13.11NCBI: 12:47,782,722-47,821,344 on the minus strand, GRCh38.p14 (GCF_000001405.40), sequence NC_000012.12, annotation GCF_000001405.40-RS_2025_08 of 2025-08-01Ensembl: 12:47,782,722-47,833,132 on the minus strand, GRCh38.p14 (GCA_000001405.29), release 116Coordinates are one-based with both ends included, as each source reports them.
Histones play a critical role in transcriptional regulation, cell cycle…
NCBI Gene summary
Ready in a moment
Reading NCBI Gene and UniProt.Still reading. A first read of a gene can take a while; this page waits up to 30 seconds for it, and its scripts then bring in the panel, or a line saying what did not arrive.
02 / Transcripts and isoforms
The RNA a design targets
17 RefSeq and 45 Ensembl transcripts on GRCh38.p14; MANE Select NM_015401.5.
NCBI Datasets · Ensembl
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Reading NCBI Datasets and Ensembl.Still reading. A first read of a gene can take a while; this page waits up to 80 seconds for it, and its scripts then bring in the panel, or a line saying what did not arrive.
03 / Expression by tissue
Where HDAC7 is expressed
54 GTEx tissues; the highest median in Uterus, 128 TPM.
GTEx
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04 / Protein
The protein HDAC7 encodes
Reading UniProt, InterPro, AlphaFold DB and PDBe.Still reading. A first read of a gene can take a while; this page waits up to 80 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.
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05 / Interactions
Proteins STRING associates with HDAC7
The 25 highest-scoring STRING partners at or above a combined score of 0.4, of up to 25 asked for; KAT5, FOXA1, MEF2A lead.
STRING v12.0
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06 / Pathways
Where HDAC7 acts, as Reactome curates it
7 curated, 0 inferred Reactome pathways for Q8WUI4 in human, v97.
Reactome
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07 / Disease associations
Diseases linked to HDAC7
482 Open Targets disease associations; neoplasm first, at 0.56.
Open Targets
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08 / Variants
Classified variants of HDAC7
Reading ClinVar.Still reading. A first read of a gene can take a while; this page waits up to 60 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.
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09 / Constraint
How much variation HDAC7 tolerates
pLI above 0.9999 and LOEUF 0.312 in gnomAD v4 (GRCh38), on ENST00000080059.12.
gnomAD
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10 / Orthologs
The same gene in mouse, rat and human
Reading the Alliance, NCBI, Ensembl Compara and RGD.Still reading. A first read of a gene can take a while; this page waits up to 145 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.
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11 /MicroRNAs
MicroRNAs hosted within HDAC7
No annotated microRNA lies within HDAC7 in Ensembl release 116, on GRCh38.p14.
Ensembl · miRBase
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12 / Long non-coding RNAs
Long non-coding RNAs at the HDAC7 locus
Reading Ensembl.Still reading. A first read of a gene can take a while; this page waits up to 110 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.
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13 / Literature
Papers that mention HDAC7
Reading Europe PMC.Still reading. A first read of a gene can take a while; this page waits up to 55 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.
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14 / Silencing this gene
From HDAC7 to a sequence that silences it
The AUMsilence™ platform designs the sequences against the human transcripts on this page. Six decisions are yours before it does. What is written under each is AUM's guidance; the timings and the concentrations are in the usage guide below.
01
Choose the region
A knockdown oligonucleotide can sit in the 5' untranslated region, the coding sequence or the 3' untranslated region, and all three are used. The coding sequence and the 3' untranslated region are the usual first choices for an RNase H design; the 5' end near the start codon suits a steric block. The map above shows where each region sits on the isoforms it draws.
02
Cover the isoforms you mean
An exon every isoform carries silences the whole gene; an exon only some isoforms carry silences those and spares the rest. Decide which you want before a sequence is chosen, and check the reference transcript (MANE Select in human; RefSeq Select and Ensembl canonical in mouse and rat) is the one your cells express.
03
Think across species early
The orthologs panel says whether mouse and rat carry the same gene. Whether one oligonucleotide can serve two species is a sequence question, settled at design by matching the candidate against each transcript, not by the protein identity shown there.
04
Check expression in your model
A transcript that is not expressed in your cells cannot show knockdown. Confirm the gene is expressed in the cell type and condition you will use, from your own data or a reference atlas, before the order. The expression panel above gives GTEx's median per tissue for a human gene; for mouse and rat it says that no atlas is on this page yet.
05
Run the controls
A scramble control of the same chemistry, a positive control against a gene known to knock down in your cells, untreated cells, and a mock condition where a transfection reagent is used. Read knockdown at the RNA level first, then at the protein; the usage guide gives the timing and the concentrations to start from.
06
Pick the product
AUMsilence sdASO needs no transfection reagent and works in the cells that resist one. AUMsilence toASO is the transfection-optimised version of the same design, and AUMsiRNA™ is the siRNA route. The selection guide compares them.
For research use only. Not for use in diagnostic or therapeutic procedures.
Gene summary
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene has sequence homology to members of the histone deacetylase family. This gene is orthologous to mouse HDAC7 gene whose protein promotes repression mediated via the transcriptional corepressor SMRT. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Provided by RefSeq, Jul 2008, through NCBI Gene. NCBI disclaimer
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) (By similarity). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (By similarity). Histone deacetylases act via the formation of large multiprotein complexes (By similarity). Involved in muscle maturation by repressing transcription of myocyte enhancer factors such as MEF2A, MEF2B and MEF2C (By similarity). During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors (By similarity). May be involved in Epstein-Barr virus (EBV) latency, possibly by repressing the viral BZLF1 gene (PubMed:12239305). Positively regulates the transcriptional repressor activity of FOXP3 (PubMed:17360565). Serves as a corepressor of RARA, causing its deacetylation and inhibition of RARE DNA element binding (PubMed:28167758). In association with RARA, plays a role in the repression of microRNA-10a and thereby in the inflammatory response (PubMed:28167758). Also acetylates non-histone proteins, such as ALKBH5 (PubMed:37369679)
NCBI Gene summary · NCBI Gene annotation RS_2025_08 · read · NCBI Gene 51564Data from NCBI, provided as is; NCBI's policies and disclaimers apply.
UniProtKB function · 2026_03 · read · UniProt Q8WUI4UniProt data are available under the Creative Commons Attribution 4.0 licence.
Placed on GRCh38.p14 (GCF_000001405.40). MANE Select marks the one transcript RefSeq and Ensembl agree is the reference for this gene.
RefSeq 17 transcripts
coding sequence, tall
untranslated region, thin
non-coding exon
intron, fixed width
Genomic strand: minus. Drawn 5' to 3', so exon 1 sits at the left here and at the highest coordinate on the chromosome.
NM_015401.5NM_015401.5MANE Select
XM_047428978.1XM_047428978.1
XM_024449018.2XM_024449018.2
XM_047428981.1XM_047428981.1
NM_001368046.1NM_001368046.1
XM_011538481.2XM_011538481.2
NM_001308090.2NM_001308090.2
XM_011538480.1XM_011538480.1
XM_047428979.1XM_047428979.1
NM_001098416.4NM_001098416.4
XM_047428982.1XM_047428982.1
XM_047428984.1XM_047428984.1
XM_047428980.1XM_047428980.1
XM_047428983.1XM_047428983.1
XM_011538483.1XM_011538483.1
NR_160436.1NR_160436.1
NR_160435.1NR_160435.1
scale
Drawn 5' to 3' from each transcript's exons as placed on the reference assembly; exon 1 is the 5' exon on the transcript's own strand. Exon blocks are to scale with each other, except 6 blocks too short to see, widened to a fixed few pixels; introns are drawn at one fixed width whatever their length, so the map is not to scale along the chromosome. Numbers are exon ranks along the strand; a rank is omitted where the exon is too narrow to carry it.
A window on one transcript
One pixel of the map above stands for several bases, and a block too short to see is drawn wider than its own scale, so the map chooses a region and the sequence here chooses the window. Click an exon on a row of the map, or drag across a row; then set the exact start and end below.
These controls are ready in a moment.
No transcript is chosen.
Once a window is chosen this panel shows its length, its G and C count as a percentage of that length, the letters it is made of, the exons it falls in, whether it crosses a junction, and its antisense strand.
Not listed, because the source places them on another assembly only: XM_054372244.1 (not placed on GRCh38.p14); XM_054372245.1 (not placed on GRCh38.p14); XM_054372246.1 (not placed on GRCh38.p14); XM_054372247.1 (not placed on GRCh38.p14); XM_054372248.1 (not placed on GRCh38.p14); XM_054372249.1 (not placed on GRCh38.p14); XM_054372250.1 (not placed on GRCh38.p14); XM_054372251.1 (not placed on GRCh38.p14); XM_054372252.1 (not placed on GRCh38.p14); XM_054372253.1 (not placed on GRCh38.p14); XM_054372254.1 (not placed on GRCh38.p14).
NCBI Datasets, RefSeq transcripts · NCBI Datasets 18.37.0; GCF_000001405.40-RS_2025_08 · read · NCBI Gene 51564Data from NCBI, provided as is; NCBI's policies and disclaimers apply.
Ensembl 45 transcripts
coding sequence, tall
untranslated region, thin
non-coding exon
intron, fixed width
Genomic strand: minus. Drawn 5' to 3', so exon 1 sits at the left here and at the highest coordinate on the chromosome.
Drawn 5' to 3' from each transcript's exons as placed on the reference assembly; exon 1 is the 5' exon on the transcript's own strand. Exon blocks are to scale with each other, except 2 blocks too short to see, widened to a fixed few pixels; introns are drawn at one fixed width whatever their length, so the map is not to scale along the chromosome. Numbers are exon ranks along the strand; a rank is omitted where the exon is too narrow to carry it.
A window on one transcript
One pixel of the map above stands for several bases, and a block too short to see is drawn wider than its own scale, so the map chooses a region and the sequence here chooses the window. Click an exon on a row of the map, or drag across a row; then set the exact start and end below.
These controls are ready in a moment.
No transcript is chosen.
Once a window is chosen this panel shows its length, its G and C count as a percentage of that length, the letters it is made of, the exons it falls in, whether it crosses a junction, and its antisense strand.
Lengths are spliced lengths, as each source states them. Exon ranks follow the strand: on a minus-strand gene exon 1 has the highest genomic coordinate. Reference assembly for human: GRCh38.
5 long non-coding RNA genes overlap HDAC7 in Ensembl release 116, 4 antisense: LINC02354 and 4 without a symbol.
952 residues, reviewed Q8WUI4; 11 entries from the member databases this page shows along the chain; mean pLDDT 62.88; 6 PDB entries.
UniProt · InterPro · AlphaFold DB · PDBe
Mouse Hdac7 by 3 of 3 votes; rat Hdac7 by 3 of 3 votes. RGD is not answering, so the ortholog list could not be shown. Try again later. Reference f84d2175-71a.
Alliance · NCBI · Ensembl Compara
4,365 PubMed-indexed papers mention HDAC7 at Europe PMC, newest first. Europe PMC ignores letter case, so the count also covers another species' symbol spelled with the same letters.
Europe PMC
ClinVar asked this site to slow down, so the variant counts could not be read. Try again in a minute. Reference 0d6afe17-7aa.
