Gene Human Homo sapiens

HLA-DRB3

major histocompatibility complex, class II, DR beta 3

gene with protein product

Location: Cytogenetic band 6p21.3 alternate reference locusNCBI: 6:3,934,018-3,947,156 on the minus strand, GRCh38.p14 (GCF_000001405.40), sequence NT_113891.3, annotation GCF_000001405.40-RS_2025_08 of 2025-08-01Ensembl: HSCHR6_MHC_QBL_CTG1:3,715,355-3,728,422 on the minus strand, GRCh38.p14 (GCA_000001405.29), release 116Coordinates are one-based with both ends included, as each source reports them.
Previous symbols: HLA-DR3B

Gene identity, from HGNC · HGNC 2026-09-29 · read 2026-10-01 ET · HGNC:4951

Notes from the sources

HGNC lists more than one mouse id for this gene (MGI:95901, MGI:95902); MGI:95901 is used
NCBI places this gene on more than one sequence of GRCh38.p14 (6 NT_113891.3, 6 NT_167244.2, 6 NT_167248.2); the coordinates shown are the 6 placement

Silence this gene

The order page opens with HLA-DRB3 and human filled in. The sequences are designed against the transcripts below; the price is on that page.

Order for HLA-DRB3

sdASO, toASO or siRNA, chosen on the next page

Bring your own sequence Transcripts

For research use only. Not for use in diagnostic or therapeutic procedures.

Summary
Transcripts
Expression
Protein
Interactions
Pathways
Disease
Variants

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01 Summary and function

What HLA-DRB3 does

Ready in a moment

02 Transcripts and isoforms

The RNA a design targets

Ready in a moment

03 Expression by tissue

Where HLA-DRB3 is expressed

Reading GTEx and the Human Protein Atlas.Still reading. A first read of a gene can take a while; this page waits up to 80 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

Ready in a moment

14 Silencing this gene

From HLA-DRB3 to a sequence that silences it

The AUMsilence platform designs the sequences against the human transcripts on this page. Six decisions are yours before it does. What is written under each is AUM's guidance; the timings and the concentrations are in the usage guide below.

01
Choose the region
A knockdown oligonucleotide can sit in the 5' untranslated region, the coding sequence or the 3' untranslated region, and all three are used. The coding sequence and the 3' untranslated region are the usual first choices for an RNase H design; the 5' end near the start codon suits a steric block. The map above shows where each region sits on the isoforms it draws.
02
Cover the isoforms you mean
An exon every isoform carries silences the whole gene; an exon only some isoforms carry silences those and spares the rest. Decide which you want before a sequence is chosen, and check the reference transcript (MANE Select in human; RefSeq Select and Ensembl canonical in mouse and rat) is the one your cells express.
03
Think across species early
The orthologs panel says whether mouse and rat carry the same gene. Whether one oligonucleotide can serve two species is a sequence question, settled at design by matching the candidate against each transcript, not by the protein identity shown there.
04
Check expression in your model
A transcript that is not expressed in your cells cannot show knockdown. Confirm the gene is expressed in the cell type and condition you will use, from your own data or a reference atlas, before the order. The expression panel above gives GTEx's median per tissue for a human gene; for mouse and rat it says that no atlas is on this page yet.

Gene Human Homo sapiens

HLA-DRB3

Reading the record for HLA-DRB3 from HGNC, NCBI Gene and Ensembl.Still reading. A first read of a gene can take a while; this page waits up to 115 seconds for it, and its scripts then bring in the page, or a line saying what did not arrive.

The full name, the identifiers, the location and the notes from the sources arrive with the record. Nothing is filled in ahead of it.

Order door

The door to order for HLA-DRB3 opens with the record, which decides which product it carries. The order page itself is open now.

Bring your own sequence

For research use only. Not for use in diagnostic or therapeutic procedures.

This page is still reading the record. Its scripts replace this shell with the record when it arrives; with scripts off, it stays at this shell however long you wait.

01 Summary and function

What HLA-DRB3 does

Waiting for the record before reading NCBI Gene and UniProt.

02 Transcripts and isoforms

The RNA a design targets

Waiting for the record before reading NCBI Datasets and Ensembl.

03 Expression by tissue

Where HLA-DRB3 is expressed

Waiting for the record before reading GTEx and the Human Protein Atlas.

04 Protein

The protein HLA-DRB3 encodes

Waiting for the record before reading UniProt, InterPro, AlphaFold DB and PDBe.

05 Interactions

Proteins STRING associates with HLA-DRB3

Waiting for the record before reading STRING.

06 Pathways

Where HLA-DRB3 acts, as Reactome curates it

Waiting for the record before reading UniProt and Reactome.

07 Disease associations

Diseases linked to HLA-DRB3

Waiting for the record before reading Open Targets and ClinGen.

08 Variants

Classified variants of HLA-DRB3

Waiting for the record before reading ClinVar.

09 Constraint

How much variation HLA-DRB3 tolerates

Waiting for the record before reading gnomAD and Open Targets.

10 Orthologs

The same gene in mouse, rat and human

Waiting for the record before reading the Alliance, NCBI, Ensembl Compara and RGD.

11 MicroRNAs

MicroRNAs hosted within HLA-DRB3

Waiting for the record before reading Ensembl and miRBase.

12 Long non-coding RNAs

Long non-coding RNAs at the HLA-DRB3 locus

Waiting for the record before reading Ensembl.

13 Literature

Papers that mention HLA-DRB3

Waiting for the record before reading Europe PMC.

HLA-DRB3

What HLA-DRB3 does

The RNA a design targets

Where HLA-DRB3 is expressed

From HLA-DRB3 to a sequence that silences it

Choose the region

Cover the isoforms you mean

Think across species early

Check expression in your model

HLA-DRB3

What HLA-DRB3 does

The RNA a design targets

Where HLA-DRB3 is expressed

The protein HLA-DRB3 encodes

Proteins STRING associates with HLA-DRB3

Where HLA-DRB3 acts, as Reactome curates it

Diseases linked to HLA-DRB3

Classified variants of HLA-DRB3

How much variation HLA-DRB3 tolerates

The same gene in mouse, rat and human

MicroRNAs hosted within HLA-DRB3

Long non-coding RNAs at the HLA-DRB3 locus

Papers that mention HLA-DRB3

HLA-DRB3

What HLA-DRB3 does

Gene summary

Protein function

The RNA a design targets

RefSeq 1 transcript

A window on one transcript

Ensembl 1 transcript

A window on one transcript

Where HLA-DRB3 is expressed

From HLA-DRB3 to a sequence that silences it

Choose the region

Cover the isoforms you mean

Think across species early

Check expression in your model

The protein HLA-DRB3 encodes

Proteins STRING associates with HLA-DRB3

Where HLA-DRB3 acts, as Reactome curates it

Diseases linked to HLA-DRB3

Classified variants of HLA-DRB3

How much variation HLA-DRB3 tolerates

The same gene in mouse, rat and human

MicroRNAs hosted within HLA-DRB3

Long non-coding RNAs at the HLA-DRB3 locus

Papers that mention HLA-DRB3

Run the controls

Pick the product

Gene summary

Protein function

RefSeq 1 transcript

A window on one transcript

Ensembl 1 transcript

A window on one transcript