Reading the record for HLA-G from HGNC, NCBI Gene and Ensembl.Still reading. A first read of a gene can take a while; this page waits up to 115 seconds for it, and its scripts then bring in the page, or a line saying what did not arrive.
The full name, the identifiers, the location and the notes from the sources arrive with the record. Nothing is filled in ahead of it.
Order door
The door to order for HLA-G opens with the record, which decides which product it carries. The order page itself is open now.
Cytogenetic band 6p22.1NCBI: 6:29,826,474-29,831,021 on the plus strand, GRCh38.p14 (GCF_000001405.40), sequence NC_000006.12, annotation GCF_000001405.40-RS_2025_08 of 2025-08-01Ensembl: 6:29,826,967-29,831,130 on the plus strand, GRCh38.p14 (GCA_000001405.29), release 116Coordinates are one-based with both ends included, as each source reports them.
HGNC lists more than one mouse id for this gene (MGI:95896, MGI:95904, MGI:95912, MGI:95928, MGI:95929, MGI:95931, MGI:95933, MGI:95935, MGI:95936, MGI:95937, MGI:95957); MGI:95896 is used
NCBI places this gene on more than one sequence of GRCh38.p14 (6 NC_000006.12, 6 NT_113891.3, 6 NT_167244.2, 6 NT_167245.2, 6 NT_167246.2, 6 NT_167247.2, 6 NT_167248.2, 6 NT_167249.2); the coordinates shown are the 6 placement
Silence this gene
The order page opens with HLA-G and human filled in. The sequences are designed against the transcripts below; the price is on that page.
HLA-G belongs to the HLA class I heavy chain paralogues. UniProt answered in a shape this page does not read, so nothing is shown for the protein entry. Reference 35137bd9-360.
NCBI Gene summary
Ready in a moment
Reading NCBI Gene and UniProt.Still reading. A first read of a gene can take a while; this page waits up to 30 seconds for it, and its scripts then bring in the panel, or a line saying what did not arrive.
02 / Transcripts and isoforms
The RNA a design targets
35 RefSeq and 11 Ensembl transcripts on GRCh38.p14; MANE Select NM_001384290.1.
NCBI Datasets · Ensembl
Ready in a moment
Reading NCBI Datasets and Ensembl.Still reading. A first read of a gene can take a while; this page waits up to 80 seconds for it, and its scripts then bring in the panel, or a line saying what did not arrive.
03 / Expression by tissue
Where HLA-G is expressed
54 GTEx tissues; the highest median in Pituitary, 26.5 TPM.
GTEx
Ready in a moment
04 / Protein
The protein HLA-G encodes
UniProt answered in a shape this page does not read, so nothing is shown for the protein entry. Reference 35137bd9-360.
Ready in a moment
05 / Interactions
Proteins STRING associates with HLA-G
The 25 highest-scoring STRING partners at or above a combined score of 0.4, of up to 25 asked for; LILRB2, LILRB1, B2M lead.
STRING v12.0
Ready in a moment
06 / Pathways
Where HLA-G acts, as Reactome curates it
UniProt answered in a shape this page does not read, so nothing is shown for the pathway list. Reference 35137bd9-360.
Ready in a moment
07 / Disease associations
Diseases linked to HLA-G
1,035 Open Targets disease associations; COVID-19 first, at 0.49.
Open Targets
Ready in a moment
08 / Variants
Classified variants of HLA-G
Reading ClinVar.Still reading. A first read of a gene can take a while; this page waits up to 60 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.
Ready in a moment
09 / Constraint
How much variation HLA-G tolerates
pLI below 0.0001 and LOEUF 1.15 in gnomAD v4 (GRCh38), on ENST00000360323.11.
gnomAD
Ready in a moment
10 / Orthologs
The same gene in mouse, rat and human
Reading the Alliance, NCBI, Ensembl Compara and RGD.Still reading. A first read of a gene can take a while; this page waits up to 145 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.
Ready in a moment
11 /MicroRNAs
MicroRNAs hosted within HLA-G
No annotated microRNA lies within HLA-G in Ensembl release 116, on GRCh38.p14.
Ensembl · miRBase
Ready in a moment
12 / Long non-coding RNAs
Long non-coding RNAs at the HLA-G locus
Reading Ensembl.Still reading. A first read of a gene can take a while; this page waits up to 110 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.
Ready in a moment
13 / Literature
Papers that mention HLA-G
10,647 PubMed-indexed papers mention HLA-G at Europe PMC, newest first. Europe PMC ignores letter case, so the count also covers another species' symbol spelled with the same letters.
Europe PMC
Ready in a moment
14 / Silencing this gene
From HLA-G to a sequence that silences it
The AUMsilence™ platform designs the sequences against the human transcripts on this page. Six decisions are yours before it does. What is written under each is AUM's guidance; the timings and the concentrations are in the usage guide below.
01
Choose the region
A knockdown oligonucleotide can sit in the 5' untranslated region, the coding sequence or the 3' untranslated region, and all three are used. The coding sequence and the 3' untranslated region are the usual first choices for an RNase H design; the 5' end near the start codon suits a steric block. The map above shows where each region sits on the isoforms it draws.
02
Cover the isoforms you mean
An exon every isoform carries silences the whole gene; an exon only some isoforms carry silences those and spares the rest. Decide which you want before a sequence is chosen, and check the reference transcript (MANE Select in human; RefSeq Select and Ensembl canonical in mouse and rat) is the one your cells express.
03
Think across species early
The orthologs panel says whether mouse and rat carry the same gene. Whether one oligonucleotide can serve two species is a sequence question, settled at design by matching the candidate against each transcript, not by the protein identity shown there.
04
Check expression in your model
A transcript that is not expressed in your cells cannot show knockdown. Confirm the gene is expressed in the cell type and condition you will use, from your own data or a reference atlas, before the order. The expression panel above gives GTEx's median per tissue for a human gene; for mouse and rat it says that no atlas is on this page yet.
05
Run the controls
A scramble control of the same chemistry, a positive control against a gene known to knock down in your cells, untreated cells, and a mock condition where a transfection reagent is used. Read knockdown at the RNA level first, then at the protein; the usage guide gives the timing and the concentrations to start from.
06
Pick the product
AUMsilence sdASO needs no transfection reagent and works in the cells that resist one. AUMsilence toASO is the transfection-optimised version of the same design, and AUMsiRNA™ is the siRNA route. The selection guide compares them.
For research use only. Not for use in diagnostic or therapeutic procedures.
Mouse: several candidates are named (H2-Q10, H2-Q6, H2-D1, H2-L, H2-Q4, H2-Q8, H2-Q1, H2-Q7, H2-T23, H2-K1, H2-Q2), each marked the best match. The orthologs panel below shows every vote.
Rat: several candidates are named (RT1-A1, RT1-CE11, RT1-CE16, RT1-CE2, RT1-A2, RT1-CE1), each marked the best match. The orthologs panel below shows every vote.
Gene summary
HLA-G belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-G is expressed on fetal derived placental cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exon 6 encodes the cytoplasmic tail.
Provided by RefSeq, Jul 2008, through NCBI Gene. NCBI disclaimer
Protein function
Not read
UniProt answered in a shape this page does not read, so nothing is shown for the protein entry.
UniProt entry did not have the shape this code expects
Reference 35137bd9-360
NCBI Gene summary · NCBI Gene annotation RS_2025_08 · read · NCBI Gene 3135Data from NCBI, provided as is; NCBI's policies and disclaimers apply.
Placed on GRCh38.p14 (GCF_000001405.40). MANE Select marks the one transcript RefSeq and Ensembl agree is the reference for this gene.
RefSeq 35 transcripts
coding sequence, tall
untranslated region, thin
non-coding exon
intron, fixed width
Genomic strand: plus. Drawn 5' to 3', so exon 1 sits at the left here and at the lowest coordinate on the chromosome.
NM_001384290.1NM_001384290.1MANE Select
NM_002127.6NM_002127.6
XM_054328500.1XM_054328500.1
XM_054329820.1XM_054329820.1
XM_054331074.1XM_054331074.1
XM_054331339.1XM_054331339.1
NM_001384280.1NM_001384280.1
NM_001363567.2NM_001363567.2
XM_054328499.1XM_054328499.1
XM_054329819.1XM_054329819.1
XM_054331073.1XM_054331073.1
XM_054331338.1XM_054331338.1
XM_054331072.1XM_054331072.1
XM_024446420.2XM_024446420.2
XM_054328501.1XM_054328501.1
XM_054329821.1XM_054329821.1
XM_054330305.1XM_054330305.1
XM_054330601.1XM_054330601.1
XM_054330820.1XM_054330820.1
XM_054331075.1XM_054331075.1
XM_054331340.1XM_054331340.1
XM_054330600.1XM_054330600.1
XM_054330819.1XM_054330819.1
XM_047418722.1XM_047418722.1
XM_054330306.1XM_054330306.1
XM_054330602.1XM_054330602.1
XM_054330821.1XM_054330821.1
XM_054328502.1XM_054328502.1
XM_054329822.1XM_054329822.1
XM_054331076.1XM_054331076.1
XM_054331341.1XM_054331341.1
XM_017010818.2XM_017010818.2
XM_054330307.1XM_054330307.1
XM_054330603.1XM_054330603.1
XM_054330822.1XM_054330822.1
scale
Drawn 5' to 3' from each transcript's exons as placed on the reference assembly; exon 1 is the 5' exon on the transcript's own strand. Exon blocks are to scale with each other, except 20 blocks too short to see, widened to a fixed few pixels; introns are drawn at one fixed width whatever their length, so the map is not to scale along the chromosome. Numbers are exon ranks along the strand; a rank is omitted where the exon is too narrow to carry it.
A window on one transcript
One pixel of the map above stands for several bases, and a block too short to see is drawn wider than its own scale, so the map chooses a region and the sequence here chooses the window. Click an exon on a row of the map, or drag across a row; then set the exact start and end below.
These controls are ready in a moment.
No transcript is chosen.
Once a window is chosen this panel shows its length, its G and C count as a percentage of that length, the letters it is made of, the exons it falls in, whether it crosses a junction, and its antisense strand.
Not listed, because the source places them on another assembly only: XM_054355310.1 (not placed on GRCh38.p14); XM_054355311.1 (not placed on GRCh38.p14); XM_054355312.1 (not placed on GRCh38.p14); XM_054355313.1 (not placed on GRCh38.p14); XM_054355314.1 (not placed on GRCh38.p14).
NCBI Datasets, RefSeq transcripts · NCBI Datasets 18.38.0; GCF_000001405.40-RS_2025_08 · read · NCBI Gene 3135Data from NCBI, provided as is; NCBI's policies and disclaimers apply.
Ensembl 11 transcripts
coding sequence, tall
untranslated region, thin
non-coding exon
intron, fixed width
Genomic strand: plus. Drawn 5' to 3', so exon 1 sits at the left here and at the lowest coordinate on the chromosome.
Drawn 5' to 3' from each transcript's exons as placed on the reference assembly; exon 1 is the 5' exon on the transcript's own strand. Exon blocks are to scale with each other; introns are drawn at one fixed width whatever their length, so the map is not to scale along the chromosome. Numbers are exon ranks along the strand; a rank is omitted where the exon is too narrow to carry it.
A window on one transcript
One pixel of the map above stands for several bases, and a block too short to see is drawn wider than its own scale, so the map chooses a region and the sequence here chooses the window. Click an exon on a row of the map, or drag across a row; then set the exact start and end below.
These controls are ready in a moment.
No transcript is chosen.
Once a window is chosen this panel shows its length, its G and C count as a percentage of that length, the letters it is made of, the exons it falls in, whether it crosses a junction, and its antisense strand.
Lengths are spliced lengths, as each source states them. Exon ranks follow the strand: on a minus-strand gene exon 1 has the highest genomic coordinate. Reference assembly for human: GRCh38.
Mouse: 12 candidates named (H2-Q10, H2-Q6, H2-D1, H2-L, H2-Q4, H2-Q8, H2-Q1, H2-Q7, H2-T23, H2-K1, H2-Q2, H2-Q5) and the votes differ; rat: 7 candidates named (RT1-A1, RT1-CE11, RT1-M3-1, RT1-CE16, RT1-CE2, RT1-A2, RT1-CE1) and the votes differ. RGD is not answering, so the ortholog list could not be shown. Try again later. Reference 3c19e938-205.
Alliance · NCBI · Ensembl Compara
1 long non-coding RNA gene overlaps HLA-G in Ensembl release 116, antisense: HLA-F-AS1.
