Gene Human Homo sapiens

KAT2A

lysine acetyltransferase 2A

gene with protein product

Location: Cytogenetic band 17q21.2NCBI: 17:42,113,111-42,121,367 on the minus strand, GRCh38.p14 (GCF_000001405.40), sequence NC_000017.11, annotation GCF_000001405.40-RS_2025_08 of 2025-08-01Ensembl: 17:42,113,109-42,121,382 on the minus strand, GRCh38.p14 (GCA_000001405.29), release 116Coordinates are one-based with both ends included, as each source reports them.
Also known as: GCN5, PCAF-b
Previous symbols: GCN5L2

Gene identity, from HGNC · HGNC 2026-10-02 · read 2026-10-05 ET · HGNC:4201

Silence this gene

The order page opens with KAT2A and human filled in. The sequences are designed against the transcripts below; the price is on that page.

Order for KAT2A

sdASO, toASO or siRNA

Bring your own sequence Transcripts

For research use only. Not for use in diagnostic or therapeutic procedures.

Summary
Transcripts
Expression
Protein
Interactions
Pathways
Disease
Variants
Constraint
Orthologs
MicroRNAs
Long non-coding RNAs
Literature
Silencing this gene

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Ready in a moment

01 Summary and function

What KAT2A does

Ready in a moment

02 Transcripts and isoforms

The RNA a design targets

Ready in a moment

03 Expression by tissue

Where KAT2A is expressed

Ready in a moment

14 Silencing this gene

From KAT2A to a sequence that silences it

The AUMsilence platform designs the sequences against the human transcripts on this page. Six decisions are yours before it does. What is written under each is AUM's guidance; the timings and the concentrations are in the usage guide below.

01
Choose the region
A knockdown oligonucleotide can sit in the 5' untranslated region, the coding sequence or the 3' untranslated region, and all three are used. The coding sequence and the 3' untranslated region are the usual first choices for an RNase H design; the 5' end near the start codon suits a steric block. The map above shows where each region sits on the isoforms it draws.
02
Cover the isoforms you mean
An exon every isoform carries silences the whole gene; an exon only some isoforms carry silences those and spares the rest. Decide which you want before a sequence is chosen, and check the reference transcript (MANE Select in human; RefSeq Select and Ensembl canonical in mouse and rat) is the one your cells express.
03
Think across species early
The orthologs panel says whether mouse and rat carry the same gene. Whether one oligonucleotide can serve two species is a sequence question, settled at design by matching the candidate against each transcript, not by the protein identity shown there.
04
Check expression in your model
A transcript that is not expressed in your cells cannot show knockdown. Confirm the gene is expressed in the cell type and condition you will use, from your own data or a reference atlas, before the order. The expression panel above gives GTEx's median per tissue for a human gene; for mouse and rat it says that no atlas is on this page yet.

Gene Human Homo sapiens

KAT2A

Reading the record for KAT2A from HGNC, NCBI Gene and Ensembl.Still reading. A first read of a gene can take a while; this page waits up to 115 seconds for it, and its scripts then bring in the page, or a line saying what did not arrive.

The full name, the identifiers, the location and the notes from the sources arrive with the record. Nothing is filled in ahead of it.

Order door

The door to order for KAT2A opens with the record, which decides which product it carries. The order page itself is open now.

Bring your own sequence

For research use only. Not for use in diagnostic or therapeutic procedures.

This page is still reading the record. Its scripts replace this shell with the record when it arrives; with scripts off, it stays at this shell however long you wait.

01 Summary and function

What KAT2A does

Waiting for the record before reading NCBI Gene and UniProt.

02 Transcripts and isoforms

The RNA a design targets

Waiting for the record before reading NCBI Datasets and Ensembl.

03 Expression by tissue

Where KAT2A is expressed

Waiting for the record before reading GTEx and the Human Protein Atlas.

04 Protein

The protein KAT2A encodes

Waiting for the record before reading UniProt, InterPro, AlphaFold DB and PDBe.

05 Interactions

Proteins STRING associates with KAT2A

Waiting for the record before reading STRING.

06 Pathways

Where KAT2A acts, as Reactome curates it

Waiting for the record before reading UniProt and Reactome.

07 Disease associations

Diseases linked to KAT2A

Waiting for the record before reading Open Targets and ClinGen.

08 Variants

Classified variants of KAT2A

Waiting for the record before reading ClinVar.

09 Constraint

How much variation KAT2A tolerates

Waiting for the record before reading gnomAD and Open Targets.

10 Orthologs

The same gene in mouse, rat and human

Waiting for the record before reading the Alliance, NCBI, Ensembl Compara and RGD.

11 MicroRNAs

MicroRNAs hosted within KAT2A

Waiting for the record before reading Ensembl and miRBase.

12 Long non-coding RNAs

Long non-coding RNAs at the KAT2A locus

Waiting for the record before reading Ensembl.

13 Literature

Papers that mention KAT2A

Waiting for the record before reading Europe PMC.

Accession	Name	Biotype	Labels	Exons	Spliced length	Protein	Sequence
NM_021078.3matches ENST00000225916.10	transcript variant 1	protein coding	MANE Select	18	3,115 nt	837 aaNP_066564.2	Ready in a moment
NM_001376227.1matches ENST00000873170.2	transcript variant 2	protein coding	none	18	3,118 nt	838 aaNP_001363156.1	Ready in a moment
XM_006721818.5	transcript variant X1	protein coding model	none	13	2,170 nt	477 aaXP_006721881.1	Ready in a moment

Accession	Name	Biotype	Labels	Exons	Spliced length	Protein	Sequence
NM_021078.3matches ENST00000225916.10	transcript variant 1	protein coding	MANE Select	18	3,115 nt	837 aaNP_066564.2	Ready in a moment
NM_001376227.1matches ENST00000873170.2	transcript variant 2	protein coding	none	18	3,118 nt	838 aaNP_001363156.1	Ready in a moment
XM_006721818.5	transcript variant X1	protein coding model	none	13	2,170 nt	477 aaXP_006721881.1	Ready in a moment

Accession	Name	Biotype	Labels	Exons	Spliced length	Protein	Sequence
ENST00000225916.10matches NM_021078.3	KAT2A-201	protein coding	MANE SelectEnsembl canonical	18	3,115 nt	837 aaENSP00000225916.5	Ready in a moment
ENST00000979332.1	KAT2A-222	nonsense mediated decay	none	16	4,276 nt	358 aaENSP00000649149.1	Ready in a moment
ENST00001052611.1	KAT2A-231	nonsense mediated decay	none	16	4,091 nt	358 aaENSP00000722428.1	Ready in a moment
ENST00000979329.1	KAT2A-219	nonsense mediated decay	none	17	3,993 nt	358 aaENSP00000649146.1	Ready in a moment
ENST00000979328.1	KAT2A-218	nonsense mediated decay	none	17	3,597 nt	358 aaENSP00000649145.1	Ready in a moment
ENST00000979331.1	KAT2A-221	nonsense mediated decay	none	17	3,438 nt	358 aaENSP00000649148.1	Ready in a moment
ENST00001052608.1	KAT2A-228	nonsense mediated decay	none	17	3,352 nt	358 aaENSP00000722425.1	Ready in a moment
ENST00000979330.1	KAT2A-220	nonsense mediated decay	none	18	3,302 nt	358 aaENSP00000649147.1	Ready in a moment
ENST00000979334.1	KAT2A-224	nonsense mediated decay	none	18	3,299 nt	358 aaENSP00000649151.1	Ready in a moment
ENST00000979333.1	KAT2A-223	nonsense mediated decay	none	18	3,287 nt	300 aaENSP00000649150.1	Ready in a moment
ENST00001052609.1	KAT2A-229	nonsense mediated decay	none	18	3,287 nt	358 aaENSP00000722426.1	Ready in a moment
ENST00000979336.1	KAT2A-225	nonsense mediated decay	none	18	3,279 nt	358 aaENSP00000649153.1	Ready in a moment
ENST00001052607.1	KAT2A-227	nonsense mediated decay	none	19	3,232 nt	390 aaENSP00000722424.1	Ready in a moment
ENST00001084992.1	KAT2A-233	nonsense mediated decay	none	19	3,208 nt	478 aaENSP00000754798.1	Ready in a moment
ENST00001052606.1	KAT2A-226	nonsense mediated decay	none	17	3,185 nt	314 aaENSP00000722423.1	Ready in a moment
ENST00001119508.1	KAT2A-238	nonsense mediated decay	none	17	3,182 nt	127 aaENSP00000789313.1	Ready in a moment
ENST00001052610.1	KAT2A-230	nonsense mediated decay	none	17	3,164 nt	358 aaENSP00000722427.1	Ready in a moment
ENST00000873177.2	KAT2A-214	protein coding	none	18	3,151 nt	844 aaENSP00000543236.1	Ready in a moment
ENST00000873169.2	KAT2A-206	protein coding	none	18	3,142 nt	841 aaENSP00000543228.1	Ready in a moment
ENST00000873170.2	KAT2A-207	protein coding	none	18	3,133 nt	838 aaENSP00000543229.1	Ready in a moment
ENST00001133908.1	KAT2A-239	protein coding	none	18	3,130 nt	837 aaENSP00000801872.1	Ready in a moment
ENST00000963388.2	KAT2A-217	protein coding	none	18	3,124 nt	835 aaENSP00000633447.1	Ready in a moment
ENST00000873176.2	KAT2A-213	protein coding	none	18	3,121 nt	834 aaENSP00000543235.1	Ready in a moment
ENST00000963387.2	KAT2A-216	protein coding	none	18	3,115 nt	832 aaENSP00000633446.1	Ready in a moment
ENST00000873173.2	KAT2A-210	protein coding	none	18	3,106 nt	829 aaENSP00000543232.1	Ready in a moment
ENST00000873175.2	KAT2A-212	protein coding	none	18	3,097 nt	826 aaENSP00000543234.1	Ready in a moment
ENST00001084993.1	KAT2A-234	nonsense mediated decay	none	18	3,077 nt	640 aaENSP00000754799.1	Ready in a moment
ENST00001084991.1	KAT2A-232	nonsense mediated decay	none	18	3,058 nt	326 aaENSP00000754797.1	Ready in a moment
ENST00000915289.2	KAT2A-215	protein coding	none	18	3,052 nt	811 aaENSP00000585348.1	Ready in a moment
ENST00000873172.2	KAT2A-209	protein coding	none	17	3,040 nt	807 aaENSP00000543231.1	Ready in a moment
ENST00000873174.2	KAT2A-211	protein coding	none	17	3,019 nt	800 aaENSP00000543233.1	Ready in a moment
ENST00001084994.1	KAT2A-235	nonsense mediated decay	none	18	3,016 nt	423 aaENSP00000754800.1	Ready in a moment
ENST00001084995.1	KAT2A-236	nonsense mediated decay	none	18	3,016 nt	326 aaENSP00000754801.1	Ready in a moment
ENST00000465682.5	KAT2A-202	nonsense mediated decay	none	18	2,990 nt	276 aaENSP00000468390.1	Ready in a moment
ENST00000873171.2	KAT2A-208	protein coding	none	18	2,977 nt	788 aaENSP00000543230.1	Ready in a moment
ENST00001113127.1	KAT2A-237	protein coding	none	11	2,785 nt	603 aaENSP00000782932.1	Ready in a moment
ENST00000588759.1	KAT2A-204	nonsense mediated decay	none	5	404 nt	70 aaENSP00000467324.1	Ready in a moment
ENST00000586972.1	KAT2A-203	retained intron	none	2	852 nt	none	Ready in a moment
ENST00000592310.1	KAT2A-205	retained intron	none	2	596 nt	none	Ready in a moment

KAT2A

What KAT2A does

The RNA a design targets

Where KAT2A is expressed

From KAT2A to a sequence that silences it

Choose the region

Cover the isoforms you mean

Think across species early

Check expression in your model

KAT2A

What KAT2A does

The RNA a design targets

Where KAT2A is expressed

The protein KAT2A encodes

Proteins STRING associates with KAT2A

Where KAT2A acts, as Reactome curates it

Diseases linked to KAT2A

Classified variants of KAT2A

How much variation KAT2A tolerates

The same gene in mouse, rat and human

MicroRNAs hosted within KAT2A

Long non-coding RNAs at the KAT2A locus

Papers that mention KAT2A

KAT2A

What KAT2A does

Gene summary

Protein function

The RNA a design targets

RefSeq 3 transcripts

A window on one transcript

Ensembl 39 transcripts

A window on one transcript

Where KAT2A is expressed

From KAT2A to a sequence that silences it

Choose the region

Cover the isoforms you mean

Think across species early

Check expression in your model

The protein KAT2A encodes

Proteins STRING associates with KAT2A

Where KAT2A acts, as Reactome curates it

Diseases linked to KAT2A

Classified variants of KAT2A

How much variation KAT2A tolerates

The same gene in mouse, rat and human

MicroRNAs hosted within KAT2A

Long non-coding RNAs at the KAT2A locus

Papers that mention KAT2A

Run the controls

Pick the product

Gene summary

Protein function

RefSeq 3 transcripts

A window on one transcript

Ensembl 39 transcripts

A window on one transcript