Reading the record for KIR2DL3 from HGNC, NCBI Gene and Ensembl.Still reading. A first read of a gene can take a while; this page waits up to 115 seconds for it, and its scripts then bring in the page, or a line saying what did not arrive.
The full name, the identifiers, the location and the notes from the sources arrive with the record. Nothing is filled in ahead of it.
Order door
The door to order for KIR2DL3 opens with the record, which decides which product it carries. The order page itself is open now.
Cytogenetic band 19q13.42NCBI: 19:54,738,513-54,753,052 on the plus strand, GRCh38.p14 (GCF_000001405.40), sequence NC_000019.10, annotation GCF_000001405.40-RS_2025_08 of 2025-08-01Ensembl: 19:54,738,505-54,753,061 on the plus strand, GRCh38.p14 (GCA_000001405.29), release 116Coordinates are one-based with both ends included, as each source reports them.
Killer cell immunoglobulin-like receptors (KIRs) are transmembrane…
NCBI Gene summary
Ready in a moment
Reading NCBI Gene and UniProt.Still reading. A first read of a gene can take a while; this page waits up to 30 seconds for it, and its scripts then bring in the panel, or a line saying what did not arrive.
02 / Transcripts and isoforms
The RNA a design targets
Reading NCBI Datasets and Ensembl.Still reading. A first read of a gene can take a while; this page waits up to 80 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.
Ready in a moment
Reading NCBI Datasets and Ensembl.Still reading. A first read of a gene can take a while; this page waits up to 80 seconds for it, and its scripts then bring in the panel, or a line saying what did not arrive.
03 / Expression by tissue
Where KIR2DL3 is expressed
54 GTEx tissues; the highest median in Whole Blood, 3.75 TPM.
GTEx
Ready in a moment
04 / Protein
The protein KIR2DL3 encodes
Reading UniProt, InterPro, AlphaFold DB and PDBe.Still reading. A first read of a gene can take a while; this page waits up to 80 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.
Ready in a moment
05 / Interactions
Proteins STRING associates with KIR2DL3
The 25 highest-scoring STRING partners at or above a combined score of 0.4, of up to 25 asked for; KIR2DL1, KIR3DL3, KIR2DL4 lead.
STRING v12.0
Ready in a moment
06 / Pathways
Where KIR2DL3 acts, as Reactome curates it
Reading UniProt and Reactome.Still reading. A first read of a gene can take a while; this page waits up to 60 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.
Ready in a moment
07 / Disease associations
Diseases linked to KIR2DL3
189 Open Targets disease associations; acute myeloid leukemia first, at 0.11.
Open Targets
Ready in a moment
08 / Variants
Classified variants of KIR2DL3
ClinVar: 104 records for KIR2DL3, 16 pathogenic or likely pathogenic.
ClinVar
Ready in a moment
09 / Constraint
How much variation KIR2DL3 tolerates
pLI below 0.0001 and LOEUF 1.51 in gnomAD v4 (GRCh38), on ENST00000342376.4.
gnomAD
Ready in a moment
10 / Orthologs
The same gene in mouse, rat and human
Reading the Alliance, NCBI, Ensembl Compara and RGD.Still reading. A first read of a gene can take a while; this page waits up to 145 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.
Ready in a moment
11 /MicroRNAs
MicroRNAs hosted within KIR2DL3
Reading Ensembl and miRBase.Still reading. A first read of a gene can take a while; this page waits up to 110 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.
Ready in a moment
12 / Long non-coding RNAs
Long non-coding RNAs at the KIR2DL3 locus
Reading Ensembl.Still reading. A first read of a gene can take a while; this page waits up to 110 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.
Ready in a moment
13 / Literature
Papers that mention KIR2DL3
Reading Europe PMC.Still reading. A first read of a gene can take a while; this page waits up to 55 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.
Ready in a moment
14 / Silencing this gene
From KIR2DL3 to a sequence that silences it
The AUMsilence™ platform designs the sequences against the human transcripts on this page. Six decisions are yours before it does. What is written under each is AUM's guidance; the timings and the concentrations are in the usage guide below.
01
Choose the region
A knockdown oligonucleotide can sit in the 5' untranslated region, the coding sequence or the 3' untranslated region, and all three are used. The coding sequence and the 3' untranslated region are the usual first choices for an RNase H design; the 5' end near the start codon suits a steric block. The map above shows where each region sits on the isoforms it draws.
02
Cover the isoforms you mean
An exon every isoform carries silences the whole gene; an exon only some isoforms carry silences those and spares the rest. Decide which you want before a sequence is chosen, and check the reference transcript (MANE Select in human; RefSeq Select and Ensembl canonical in mouse and rat) is the one your cells express.
03
Think across species early
The orthologs panel says whether mouse and rat carry the same gene. Whether one oligonucleotide can serve two species is a sequence question, settled at design by matching the candidate against each transcript, not by the protein identity shown there.
04
Check expression in your model
A transcript that is not expressed in your cells cannot show knockdown. Confirm the gene is expressed in the cell type and condition you will use, from your own data or a reference atlas, before the order. The expression panel above gives GTEx's median per tissue for a human gene; for mouse and rat it says that no atlas is on this page yet.
05
Run the controls
A scramble control of the same chemistry, a positive control against a gene known to knock down in your cells, untreated cells, and a mock condition where a transfection reagent is used. Read knockdown at the RNA level first, then at the protein; the usage guide gives the timing and the concentrations to start from.
06
Pick the product
AUMsilence sdASO needs no transfection reagent and works in the cells that resist one. AUMsilence toASO is the transfection-optimised version of the same design, and AUMsiRNA™ is the siRNA route. The selection guide compares them.
For research use only. Not for use in diagnostic or therapeutic procedures.
Gene summary
Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response.
Provided by RefSeq, Jul 2008, through NCBI Gene. NCBI disclaimer
2,625 PubMed-indexed papers mention KIR2DL3 at Europe PMC, newest first. Europe PMC ignores letter case, so the count also covers another species' symbol spelled with the same letters.
Europe PMC
1 RefSeq and 3 Ensembl transcripts on GRCh38.p14; MANE Select NM_015868.3.
NCBI Datasets · Ensembl
Placed on GRCh38.p14 (GCF_000001405.40). MANE Select marks the one transcript RefSeq and Ensembl agree is the reference for this gene.
RefSeq 1 transcript
coding sequence, tall
untranslated region, thin
non-coding exon
intron, fixed width
Genomic strand: plus. Drawn 5' to 3', so exon 1 sits at the left here and at the lowest coordinate on the chromosome.
NM_015868.3NM_015868.3MANE Select
scale
Drawn 5' to 3' from each transcript's exons as placed on the reference assembly; exon 1 is the 5' exon on the transcript's own strand. Exon blocks are to scale with each other; introns are drawn at one fixed width whatever their length, so the map is not to scale along the chromosome. Numbers are exon ranks along the strand; a rank is omitted where the exon is too narrow to carry it.
A window on one transcript
One pixel of the map above stands for several bases, and a block too short to see is drawn wider than its own scale, so the map chooses a region and the sequence here chooses the window. Click an exon on a row of the map, or drag across a row; then set the exact start and end below.
These controls are ready in a moment.
No transcript is chosen.
Once a window is chosen this panel shows its length, its G and C count as a percentage of that length, the letters it is made of, the exons it falls in, whether it crosses a junction, and its antisense strand.
One pixel of the map above stands for several bases, and a block too short to see is drawn wider than its own scale, so the map chooses a region and the sequence here chooses the window. Click an exon on a row of the map, or drag across a row; then set the exact start and end below.
These controls are ready in a moment.
No transcript is chosen.
Once a window is chosen this panel shows its length, its G and C count as a percentage of that length, the letters it is made of, the exons it falls in, whether it crosses a junction, and its antisense strand.
Lengths are spliced lengths, as each source states them. Exon ranks follow the strand: on a minus-strand gene exon 1 has the highest genomic coordinate. Reference assembly for human: GRCh38.
NCBI also places this transcript on 19 NT_187643.1 in this annotation, with 8 exons; only the 19 placement is drawn
NCBI also places this transcript on 19 NT_187645.1 in this annotation, with 8 exons; only the 19 placement is drawn
NCBI also places this transcript on 19 NT_187669.1 in this annotation, with 8 exons; only the 19 placement is drawn
NCBI also places this transcript on 19 NT_187671.1 in this annotation, with 8 exons; only the 19 placement is drawn
NCBI also places this transcript on 19 NT_187672.1 in this annotation, with 8 exons; only the 19 placement is drawn
NCBI also places this transcript on 19 NT_187673.1 in this annotation, with 8 exons; only the 19 placement is drawn
NCBI also places this transcript on 19 NT_187674.1 in this annotation, with 8 exons; only the 19 placement is drawn
NCBI also places this transcript on 19 NT_187676.1 in this annotation, with 8 exons; only the 19 placement is drawn
NCBI also places this transcript on 19 NT_187683.1 in this annotation, with 8 exons; only the 19 placement is drawn
NCBI also places this transcript on 19 NT_187684.1 in this annotation, with 8 exons; only the 19 placement is drawn
NCBI also places this transcript on 19 NT_187685.1 in this annotation, with 8 exons; only the 19 placement is drawn
NCBI also places this transcript on 19 NT_187687.1 in this annotation, with 8 exons; only the 19 placement is drawn
Drawn 5' to 3' from each transcript's exons as placed on the reference assembly; exon 1 is the 5' exon on the transcript's own strand. Exon blocks are to scale with each other; introns are drawn at one fixed width whatever their length, so the map is not to scale along the chromosome. Numbers are exon ranks along the strand; a rank is omitted where the exon is too narrow to carry it.
Mouse: several candidates are named (Kir3dl1, Kir3dl2), each marked the best match. The orthologs panel below shows every vote.
Mouse: 2 candidates named (Kir3dl1, Kir3dl2) and the votes differ; rat Kir3dl1 by 2 of 3 votes. RGD is not answering, so the ortholog list could not be shown. Try again later. Reference ffc0fbdf-2fc.
