Gene Human Homo sapiens

KY

kyphoscoliosis peptidase

gene with protein product

Human KYMouseRat

Reading the ortholog votes for mouse and rat.

Location: Cytogenetic band 3q22.2NCBI: 3:134,599,923-134,651,022 on the minus strand, GRCh38.p14 (GCF_000001405.40), sequence NC_000003.12, annotation GCF_000001405.40-RS_2025_08 of 2025-08-01Ensembl: 3:134,599,923-134,651,677 on the minus strand, GRCh38.p14 (GCA_000001405.29), release 116Coordinates are one-based with both ends included, as each source reports them.
Also known as: FLJ33207

Gene identity, from HGNC · HGNC 2026-10-02 · read 2026-10-05 ET · HGNC:26576

Silence this gene

The order page opens with KY and human filled in. The sequences are designed against the transcripts below; the price is on that page.

Order for KY

sdASO, toASO or siRNA

Bring your own sequence Transcripts

For research use only. Not for use in diagnostic or therapeutic procedures.

Summary
Transcripts
Expression
Protein
Interactions
Pathways
Disease
Variants
Constraint
Orthologs
MicroRNAs
Long non-coding RNAs
Literature
Silencing this gene

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Ready in a moment

01 Summary and function

What KY does

The protein encoded by this gene belongs to the transglutaminase-like…

NCBI Gene summary

Ready in a moment

02 Transcripts and isoforms

The RNA a design targets

Reading NCBI Datasets and Ensembl.Still reading. A first read of a gene can take a while; this page waits up to 80 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

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03 Expression by tissue

Where KY is expressed

Reading GTEx and the Human Protein Atlas.Still reading. A first read of a gene can take a while; this page waits up to 80 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

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04 Protein

The protein KY encodes

Reading UniProt, InterPro, AlphaFold DB and PDBe.Still reading. A first read of a gene can take a while; this page waits up to 80 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

Ready in a moment

05 Interactions

Proteins STRING associates with KY

Reading STRING.Still reading. A first read of a gene can take a while; this page waits up to 50 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

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06 Pathways

Where KY acts, as Reactome curates it

Reading UniProt and Reactome.Still reading. A first read of a gene can take a while; this page waits up to 60 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

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07 Disease associations

Diseases linked to KY

Reading Open Targets and ClinGen.Still reading. A first read of a gene can take a while; this page waits up to 105 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

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08 Variants

Classified variants of KY

Reading ClinVar.Still reading. A first read of a gene can take a while; this page waits up to 60 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

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09 Constraint

How much variation KY tolerates

Reading gnomAD and Open Targets.Still reading. A first read of a gene can take a while; this page waits up to 45 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

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10 Orthologs

The same gene in mouse, rat and human

Reading the Alliance, NCBI, Ensembl Compara and RGD.Still reading. A first read of a gene can take a while; this page waits up to 145 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

Ready in a moment

11 MicroRNAs

MicroRNAs hosted within KY

Reading Ensembl and miRBase.Still reading. A first read of a gene can take a while; this page waits up to 110 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

Ready in a moment

12 Long non-coding RNAs

Long non-coding RNAs at the KY locus

Reading Ensembl.Still reading. A first read of a gene can take a while; this page waits up to 110 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

Ready in a moment

13 Literature

Papers that mention KY

Reading Europe PMC.Still reading. A first read of a gene can take a while; this page waits up to 55 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

Ready in a moment

14 Silencing this gene

From KY to a sequence that silences it

The AUMsilence platform designs the sequences against the human transcripts on this page. Six decisions are yours before it does. What is written under each is AUM's guidance; the timings and the concentrations are in the usage guide below.

01
Choose the region
A knockdown oligonucleotide can sit in the 5' untranslated region, the coding sequence or the 3' untranslated region, and all three are used. The coding sequence and the 3' untranslated region are the usual first choices for an RNase H design; the 5' end near the start codon suits a steric block. The map above shows where each region sits on the isoforms it draws.
02
Cover the isoforms you mean
An exon every isoform carries silences the whole gene; an exon only some isoforms carry silences those and spares the rest. Decide which you want before a sequence is chosen, and check the reference transcript (MANE Select in human; RefSeq Select and Ensembl canonical in mouse and rat) is the one your cells express.
03
Think across species early
The orthologs panel says whether mouse and rat carry the same gene. Whether one oligonucleotide can serve two species is a sequence question, settled at design by matching the candidate against each transcript, not by the protein identity shown there.
04
Check expression in your model
A transcript that is not expressed in your cells cannot show knockdown. Confirm the gene is expressed in the cell type and condition you will use, from your own data or a reference atlas, before the order. The expression panel above gives GTEx's median per tissue for a human gene; for mouse and rat it says that no atlas is on this page yet.
05
Run the controls
A scramble control of the same chemistry, a positive control against a gene known to knock down in your cells, untreated cells, and a mock condition where a transfection reagent is used. Read knockdown at the RNA level first, then at the protein; the usage guide gives the timing and the concentrations to start from.
06
Pick the product
AUMsilence sdASO needs no transfection reagent and works in the cells that resist one. AUMsilence toASO is the transfection-optimised version of the same design, and AUMsiRNA is the siRNA route. The selection guide compares them.

Order for KY Bring your own sequence The usage guide Selection guide

For research use only. Not for use in diagnostic or therapeutic procedures.

Gene Human Homo sapiens

KY

Reading the record for KY from HGNC, NCBI Gene and Ensembl.Still reading. A first read of a gene can take a while; this page waits up to 115 seconds for it, and its scripts then bring in the page, or a line saying what did not arrive.

The full name, the identifiers, the location and the notes from the sources arrive with the record. Nothing is filled in ahead of it.

Order door

The door to order for KY opens with the record, which decides which product it carries. The order page itself is open now.

Bring your own sequence

For research use only. Not for use in diagnostic or therapeutic procedures.

This page is still reading the record. Its scripts replace this shell with the record when it arrives; with scripts off, it stays at this shell however long you wait.

01 Summary and function

What KY does

Waiting for the record before reading NCBI Gene and UniProt.

02 Transcripts and isoforms

The RNA a design targets

Waiting for the record before reading NCBI Datasets and Ensembl.

03 Expression by tissue

Where KY is expressed

Waiting for the record before reading GTEx and the Human Protein Atlas.

04 Protein

The protein KY encodes

Waiting for the record before reading UniProt, InterPro, AlphaFold DB and PDBe.

05 Interactions

Proteins STRING associates with KY

Waiting for the record before reading STRING.

06 Pathways

Where KY acts, as Reactome curates it

Waiting for the record before reading UniProt and Reactome.

07 Disease associations

Diseases linked to KY

Waiting for the record before reading Open Targets and ClinGen.

08 Variants

Classified variants of KY

Waiting for the record before reading ClinVar.

09 Constraint

How much variation KY tolerates

Waiting for the record before reading gnomAD and Open Targets.

10 Orthologs

The same gene in mouse, rat and human

Waiting for the record before reading the Alliance, NCBI, Ensembl Compara and RGD.

11 MicroRNAs

MicroRNAs hosted within KY

Waiting for the record before reading Ensembl and miRBase.

12 Long non-coding RNAs

Long non-coding RNAs at the KY locus

Waiting for the record before reading Ensembl.

13 Literature

Papers that mention KY

Waiting for the record before reading Europe PMC.

Accession	Name	Biotype	Labels	Exons	Spliced length	Protein	Sequence
NM_178554.6matches ENST00000423778.7	transcript variant 1	protein coding	MANE Select	11	5,704 nt	661 aaNP_848649.3	Ready in a moment
NM_001350859.2	transcript variant 2	protein coding	none	10	5,656 nt	645 aaNP_001337788.1	Ready in a moment
NM_001366276.1matches ENST00000508956.6	transcript variant 4	protein coding	none	10	5,637 nt	640 aaNP_001353205.1	Ready in a moment
NM_001366277.2	transcript variant 5	Ready in a moment

Accession	Name	Biotype	Labels	Exons	Spliced length	Protein	Sequence
NM_178554.6matches ENST00000423778.7	transcript variant 1	protein coding	MANE Select	11	5,704 nt	661 aaNP_848649.3	Ready in a moment
NM_001350859.2	transcript variant 2	protein coding	none	10	5,656 nt	645 aaNP_001337788.1	Ready in a moment
NM_001366276.1matches ENST00000508956.6	transcript variant 4	protein coding	none	10	5,637 nt	640 aaNP_001353205.1	Ready in a moment
NM_001366277.2	transcript variant 5	Ready in a moment

Accession	Name	Biotype	Labels	Exons	Spliced length	Protein	Sequence
ENST00000423778.7matches NM_178554.6	KY-201	protein coding	MANE SelectEnsembl canonical	11	5,704 nt	661 aaENSP00000397598.2	Ready in a moment
ENST00001143875.1	KY-213	protein coding	none	11	6,359 nt	661 aaENSP00000812756.1	Ready in a moment
ENST00000508956.6	KY-205	protein coding	none	10	6,296 nt	640 aaENSP00000421297.1	Ready in a moment
ENST00000503669.2	KY-202	protein coding	none	10	6,168 nt	308 aaENSP00000426777.1	Ready in a moment
ENST00000864999.2	KY-206	protein coding	none	11	5,693 nt	643 aaENSP00000535058.1	Ready in a moment
ENST00001112839.1	KY-208	protein coding	none	2	2,789 nt	92 aaENSP00000782644.1	Ready in a moment
ENST00001001735.1	KY-207	nonsense mediated decay	none	13	2,593 nt	112 aaENSP00000671552.1	Ready in a moment
ENST00001130022.1	KY-209	protein coding	none	9	1,457 nt	241 aaENSP00000799827.1	Ready in a moment
ENST00001130025.1	KY-212	protein coding	none	2	1,289 nt	61 aaENSP00000799830.1	Ready in a moment
ENST00001130024.1	KY-211	protein coding	none	3	1,035 nt	76 aaENSP00000799829.1	Ready in a moment
ENST00001130023.1	KY-210	protein coding	none	3	369 nt	58 aaENSP00000799828.1	Ready in a moment
ENST00000506319.5	KY-203	retained intron	none	14	4,043 nt	none	Ready in a moment
ENST00000508041.1	KY-204	protein coding cds not defined	none	6	725 nt	none	Ready in a moment

KY

What KY does

The RNA a design targets

Where KY is expressed

The protein KY encodes

Proteins STRING associates with KY

Where KY acts, as Reactome curates it

Diseases linked to KY

Classified variants of KY

How much variation KY tolerates

The same gene in mouse, rat and human

MicroRNAs hosted within KY

Long non-coding RNAs at the KY locus

Papers that mention KY

From KY to a sequence that silences it

Choose the region

Cover the isoforms you mean

Think across species early

Check expression in your model

Run the controls

Pick the product

KY

What KY does

The RNA a design targets

Where KY is expressed

The protein KY encodes

Proteins STRING associates with KY

Where KY acts, as Reactome curates it

Diseases linked to KY

Classified variants of KY

How much variation KY tolerates

The same gene in mouse, rat and human

MicroRNAs hosted within KY

Long non-coding RNAs at the KY locus

Papers that mention KY

KY

What KY does

Gene summary

Protein function

The RNA a design targets

RefSeq 5 transcripts

A window on one transcript

Ensembl 13 transcripts

A window on one transcript

Where KY is expressed

The protein KY encodes

Proteins STRING associates with KY

Where KY acts, as Reactome curates it

Diseases linked to KY

Classified variants of KY

How much variation KY tolerates

The same gene in mouse, rat and human

MicroRNAs hosted within KY

Long non-coding RNAs at the KY locus

Papers that mention KY

From KY to a sequence that silences it

Choose the region

Cover the isoforms you mean

Think across species early

Check expression in your model

Run the controls

Pick the product

Gene summary

Protein function

RefSeq 5 transcripts

A window on one transcript

Ensembl 13 transcripts

A window on one transcript