Gene Human Homo sapiens

LMNTD2

lamin tail domain containing 2

gene with protein product

Human LMNTD2MouseRat

Reading the ortholog votes for mouse and rat.

Location: Cytogenetic band 11p15.5NCBI: 11:554,850-560,738 on the minus strand, GRCh38.p14 (GCF_000001405.40), sequence NC_000011.10, annotation GCF_000001405.40-RS_2025_08 of 2025-08-01Ensembl: 11:554,850-560,743 on the minus strand, GRCh38.p14 (GCA_000001405.29), release 116Coordinates are one-based with both ends included, as each source reports them.
Also known as: MGC35138
Previous symbols: C11orf35

Gene identity, from HGNC · HGNC 2026-10-02 · read 2026-10-02 ET · HGNC:28561

Notes from the sources

NCBI places this gene on more than one sequence of GRCh38.p14 (11 NC_000011.10, 11 NT_187586.1); the coordinates shown are the 11 placement

Silence this gene

The order page opens with LMNTD2 and human filled in. The sequences are designed against the transcripts below; the price is on that page.

Order for LMNTD2

sdASO, toASO or siRNA

Bring your own sequence Transcripts

For research use only. Not for use in diagnostic or therapeutic procedures.

Summary
Transcripts
Expression
Protein
Interactions
Pathways
Disease
Variants
Constraint
Orthologs
MicroRNAs
Long non-coding RNAs
Literature
Silencing this gene

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01 Summary and function

What LMNTD2 does

Predicted to be a structural constituent of chromatin.

NCBI Gene summary

Ready in a moment

02 Transcripts and isoforms

The RNA a design targets

Reading NCBI Datasets and Ensembl.Still reading. A first read of a gene can take a while; this page waits up to 80 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

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03 Expression by tissue

Where LMNTD2 is expressed

Reading GTEx and the Human Protein Atlas.Still reading. A first read of a gene can take a while; this page waits up to 80 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

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04 Protein

The protein LMNTD2 encodes

Reading UniProt, InterPro, AlphaFold DB and PDBe.Still reading. A first read of a gene can take a while; this page waits up to 80 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

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05 Interactions

Proteins STRING associates with LMNTD2

Reading STRING.Still reading. A first read of a gene can take a while; this page waits up to 50 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

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06 Pathways

Where LMNTD2 acts, as Reactome curates it

Reading UniProt and Reactome.Still reading. A first read of a gene can take a while; this page waits up to 60 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

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07 Disease associations

Diseases linked to LMNTD2

37 Open Targets disease associations; systemic lupus erythematosus first, at 0.15.

Open Targets

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08 Variants

Classified variants of LMNTD2

Reading ClinVar.Still reading. A first read of a gene can take a while; this page waits up to 60 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

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09 Constraint

How much variation LMNTD2 tolerates

pLI below 0.0001 and LOEUF 1.42 in gnomAD v4 (GRCh38), on ENST00000329451.8.

gnomAD

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10 Orthologs

The same gene in mouse, rat and human

Reading the Alliance, NCBI, Ensembl Compara and RGD.Still reading. A first read of a gene can take a while; this page waits up to 145 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

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11 MicroRNAs

MicroRNAs hosted within LMNTD2

Reading Ensembl and miRBase.Still reading. A first read of a gene can take a while; this page waits up to 110 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

Ready in a moment

12 Long non-coding RNAs

Long non-coding RNAs at the LMNTD2 locus

Reading Ensembl.Still reading. A first read of a gene can take a while; this page waits up to 110 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

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13 Literature

Papers that mention LMNTD2

Reading Europe PMC.Still reading. A first read of a gene can take a while; this page waits up to 55 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

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14 Silencing this gene

From LMNTD2 to a sequence that silences it

The AUMsilence platform designs the sequences against the human transcripts on this page. Six decisions are yours before it does. What is written under each is AUM's guidance; the timings and the concentrations are in the usage guide below.

01
Choose the region
A knockdown oligonucleotide can sit in the 5' untranslated region, the coding sequence or the 3' untranslated region, and all three are used. The coding sequence and the 3' untranslated region are the usual first choices for an RNase H design; the 5' end near the start codon suits a steric block. The map above shows where each region sits on the isoforms it draws.
02
Cover the isoforms you mean
An exon every isoform carries silences the whole gene; an exon only some isoforms carry silences those and spares the rest. Decide which you want before a sequence is chosen, and check the reference transcript (MANE Select in human; RefSeq Select and Ensembl canonical in mouse and rat) is the one your cells express.
03
Think across species early
The orthologs panel says whether mouse and rat carry the same gene. Whether one oligonucleotide can serve two species is a sequence question, settled at design by matching the candidate against each transcript, not by the protein identity shown there.
04
Check expression in your model
A transcript that is not expressed in your cells cannot show knockdown. Confirm the gene is expressed in the cell type and condition you will use, from your own data or a reference atlas, before the order. The expression panel above gives GTEx's median per tissue for a human gene; for mouse and rat it says that no atlas is on this page yet.
05
Run the controls
A scramble control of the same chemistry, a positive control against a gene known to knock down in your cells, untreated cells, and a mock condition where a transfection reagent is used. Read knockdown at the RNA level first, then at the protein; the usage guide gives the timing and the concentrations to start from.
06
Pick the product
AUMsilence sdASO needs no transfection reagent and works in the cells that resist one. AUMsilence toASO is the transfection-optimised version of the same design, and AUMsiRNA is the siRNA route. The selection guide compares them.

Order for LMNTD2 Bring your own sequence The usage guide Selection guide

For research use only. Not for use in diagnostic or therapeutic procedures.

Gene Human Homo sapiens

LMNTD2

Reading the record for LMNTD2 from HGNC, NCBI Gene and Ensembl.Still reading. A first read of a gene can take a while; this page waits up to 115 seconds for it, and its scripts then bring in the page, or a line saying what did not arrive.

The full name, the identifiers, the location and the notes from the sources arrive with the record. Nothing is filled in ahead of it.

Order door

The door to order for LMNTD2 opens with the record, which decides which product it carries. The order page itself is open now.

Bring your own sequence

For research use only. Not for use in diagnostic or therapeutic procedures.

This page is still reading the record. Its scripts replace this shell with the record when it arrives; with scripts off, it stays at this shell however long you wait.

01 Summary and function

What LMNTD2 does

Waiting for the record before reading NCBI Gene and UniProt.

02 Transcripts and isoforms

The RNA a design targets

Waiting for the record before reading NCBI Datasets and Ensembl.

03 Expression by tissue

Where LMNTD2 is expressed

Waiting for the record before reading GTEx and the Human Protein Atlas.

04 Protein

The protein LMNTD2 encodes

Waiting for the record before reading UniProt, InterPro, AlphaFold DB and PDBe.

05 Interactions

Proteins STRING associates with LMNTD2

Waiting for the record before reading STRING.

06 Pathways

Where LMNTD2 acts, as Reactome curates it

Waiting for the record before reading UniProt and Reactome.

07 Disease associations

Diseases linked to LMNTD2

Waiting for the record before reading Open Targets and ClinGen.

08 Variants

Classified variants of LMNTD2

Waiting for the record before reading ClinVar.

09 Constraint

How much variation LMNTD2 tolerates

Waiting for the record before reading gnomAD and Open Targets.

10 Orthologs

The same gene in mouse, rat and human

Waiting for the record before reading the Alliance, NCBI, Ensembl Compara and RGD.

11 MicroRNAs

MicroRNAs hosted within LMNTD2

Waiting for the record before reading Ensembl and miRBase.

12 Long non-coding RNAs

Long non-coding RNAs at the LMNTD2 locus

Waiting for the record before reading Ensembl.

13 Literature

Papers that mention LMNTD2

Waiting for the record before reading Europe PMC.

Accession	Name	Biotype	Labels	Exons	Spliced length	Protein	Sequence
NM_173573.3matches ENST00000329451.8 NCBI also places this transcript on 11 NT_187586.1 in this annotation, with 14 exons; only the 11 placement is drawn	none given	protein coding	MANE Select	14	2,057 nt	634 aaNP_775844.2	Ready in a moment
XM_011519965.3	transcript variant X1	protein coding model	none	14	3,408 nt	707 aaXP_011518267.2	Ready in a moment
XM_047426712.1	transcript variant X2	protein coding model	none	14	3,393 nt	702 aaXP_047282668.1	Ready in a moment
XM_011519967.3	Ready in a moment

Accession	Name	Biotype	Labels	Exons	Spliced length	Protein	Sequence
NM_173573.3matches ENST00000329451.8 NCBI also places this transcript on 11 NT_187586.1 in this annotation, with 14 exons; only the 11 placement is drawn	none given	protein coding	MANE Select	14	2,057 nt	634 aaNP_775844.2	Ready in a moment
XM_011519965.3	transcript variant X1	protein coding model	none	14	3,408 nt	707 aaXP_011518267.2	Ready in a moment
XM_047426712.1	transcript variant X2	protein coding model	none	14	3,393 nt	702 aaXP_047282668.1	Ready in a moment
XM_011519967.3	Ready in a moment

Accession	Name	Biotype	Labels	Exons	Spliced length	Protein	Sequence
ENST00000329451.8matches NM_173573.3	LMNTD2-201	protein coding	MANE SelectEnsembl canonical	14	2,057 nt	634 aaENSP00000331167.3	Ready in a moment
ENST00000886189.2	LMNTD2-206	protein coding	none	14	2,077 nt	639 aaENSP00000556248.1	Ready in a moment
ENST00001144541.1	LMNTD2-211	protein coding	none	14	2,062 nt	634 aaENSP00000807289.1	Ready in a moment
ENST00000886190.2	LMNTD2-207	protein coding	none	14	2,023 nt	621 aaENSP00000556249.1	Ready in a moment
ENST00001041307.1	LMNTD2-210	nonsense mediated decay	none	14	2,021 nt	557 aaENSP00000711124.1	Ready in a moment
ENST00000989473.1	LMNTD2-209	protein coding	none	14	1,916 nt	550 aaENSP00000659290.1	Ready in a moment
ENST00000441853.5	LMNTD2-202	protein coding	none	9	1,051 nt	302 aaENSP00000393529.1	Ready in a moment
ENST00000486629.1	LMNTD2-204	protein coding	none	7	798 nt	247 aaENSP00000435529.1	Ready in a moment
ENST00000973068.1	LMNTD2-208	retained intron	none	11	4,316 nt	none	Ready in a moment
ENST00000469990.1	LMNTD2-203	retained intron	none	4	1,232 nt	none	Ready in a moment
ENST00000492515.1	LMNTD2-205	retained intron	none	3	608 nt	none	Ready in a moment

LMNTD2

What LMNTD2 does

The RNA a design targets

Where LMNTD2 is expressed

The protein LMNTD2 encodes

Proteins STRING associates with LMNTD2

Where LMNTD2 acts, as Reactome curates it

Diseases linked to LMNTD2

Classified variants of LMNTD2

How much variation LMNTD2 tolerates

The same gene in mouse, rat and human

MicroRNAs hosted within LMNTD2

Long non-coding RNAs at the LMNTD2 locus

Papers that mention LMNTD2

From LMNTD2 to a sequence that silences it

Choose the region

Cover the isoforms you mean

Think across species early

Check expression in your model

Run the controls

Pick the product

LMNTD2

What LMNTD2 does

The RNA a design targets

Where LMNTD2 is expressed

The protein LMNTD2 encodes

Proteins STRING associates with LMNTD2

Where LMNTD2 acts, as Reactome curates it

Diseases linked to LMNTD2

Classified variants of LMNTD2

How much variation LMNTD2 tolerates

The same gene in mouse, rat and human

MicroRNAs hosted within LMNTD2

Long non-coding RNAs at the LMNTD2 locus

Papers that mention LMNTD2

LMNTD2

What LMNTD2 does

Gene summary

Protein function

The RNA a design targets

RefSeq 16 transcripts

A window on one transcript

Ensembl 11 transcripts

A window on one transcript

Where LMNTD2 is expressed

The protein LMNTD2 encodes

Proteins STRING associates with LMNTD2

Where LMNTD2 acts, as Reactome curates it

Diseases linked to LMNTD2

Classified variants of LMNTD2

How much variation LMNTD2 tolerates

The same gene in mouse, rat and human

MicroRNAs hosted within LMNTD2

Long non-coding RNAs at the LMNTD2 locus

Papers that mention LMNTD2

From LMNTD2 to a sequence that silences it

Choose the region

Cover the isoforms you mean

Think across species early

Check expression in your model

Run the controls

Pick the product

Gene summary

Protein function

RefSeq 16 transcripts

A window on one transcript

Ensembl 11 transcripts

A window on one transcript