Gene Human Homo sapiens

LOXL3

lysyl oxidase like 3

gene with protein product

Human LOXL3MouseRat

Reading the ortholog votes for mouse and rat.

Location: Cytogenetic band 2p13.1NCBI: 2:74,532,258-74,555,702 on the minus strand, GRCh38.p14 (GCF_000001405.40), sequence NC_000002.12, annotation GCF_000001405.40-RS_2025_08 of 2025-08-01Ensembl: no location was read.Coordinates are one-based with both ends included, as each source reports them.

Gene identity, from HGNC · HGNC 2026-09-29 · read 2026-10-01 ET · HGNC:13869

Notes from the sources

Ensembl did not answer (upstream error).
Ensembl did not answer (upstream error); the Ensembl location and release are missing

Silence this gene

The order page opens with LOXL3 and human filled in. The sequences are designed against the transcripts below; the price is on that page.

Order for LOXL3

sdASO, toASO or siRNA, chosen on the next page

Bring your own sequence Transcripts

For research use only. Not for use in diagnostic or therapeutic procedures.

Summary
Transcripts
Expression
Protein
Interactions
Pathways
Disease
Variants

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Ready in a moment

01 Summary and function

What LOXL3 does

Ready in a moment

02 Transcripts and isoforms

The RNA a design targets

Reading NCBI Datasets and Ensembl.Still reading. A first read of a gene can take a while; this page waits up to 80 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

Ready in a moment

14 Silencing this gene

From LOXL3 to a sequence that silences it

The AUMsilence platform designs the sequences against the human transcripts on this page. Six decisions are yours before it does. What is written under each is AUM's guidance; the timings and the concentrations are in the usage guide below.

01
Choose the region
A knockdown oligonucleotide can sit in the 5' untranslated region, the coding sequence or the 3' untranslated region, and all three are used. The coding sequence and the 3' untranslated region are the usual first choices for an RNase H design; the 5' end near the start codon suits a steric block. The map above shows where each region sits on the isoforms it draws.
02
Cover the isoforms you mean
An exon every isoform carries silences the whole gene; an exon only some isoforms carry silences those and spares the rest. Decide which you want before a sequence is chosen, and check the reference transcript (MANE Select in human; RefSeq Select and Ensembl canonical in mouse and rat) is the one your cells express.
03
Think across species early
The orthologs panel says whether mouse and rat carry the same gene. Whether one oligonucleotide can serve two species is a sequence question, settled at design by matching the candidate against each transcript, not by the protein identity shown there.
04
Check expression in your model
A transcript that is not expressed in your cells cannot show knockdown. Confirm the gene is expressed in the cell type and condition you will use, from your own data or a reference atlas, before the order. The expression panel above gives GTEx's median per tissue for a human gene; for mouse and rat it says that no atlas is on this page yet.

Gene Human Homo sapiens

LOXL3

Reading the record for LOXL3 from HGNC, NCBI Gene and Ensembl.Still reading. A first read of a gene can take a while; this page waits up to 115 seconds for it, and its scripts then bring in the page, or a line saying what did not arrive.

The full name, the identifiers, the location and the notes from the sources arrive with the record. Nothing is filled in ahead of it.

Order door

The door to order for LOXL3 opens with the record, which decides which product it carries. The order page itself is open now.

Bring your own sequence

For research use only. Not for use in diagnostic or therapeutic procedures.

This page is still reading the record. Its scripts replace this shell with the record when it arrives; with scripts off, it stays at this shell however long you wait.

01 Summary and function

What LOXL3 does

Waiting for the record before reading NCBI Gene and UniProt.

02 Transcripts and isoforms

The RNA a design targets

Waiting for the record before reading NCBI Datasets and Ensembl.

03 Expression by tissue

Where LOXL3 is expressed

Waiting for the record before reading GTEx and the Human Protein Atlas.

04 Protein

The protein LOXL3 encodes

Waiting for the record before reading UniProt, InterPro, AlphaFold DB and PDBe.

05 Interactions

Proteins STRING associates with LOXL3

Waiting for the record before reading STRING.

06 Pathways

Where LOXL3 acts, as Reactome curates it

Waiting for the record before reading UniProt and Reactome.

07 Disease associations

Diseases linked to LOXL3

Waiting for the record before reading Open Targets and ClinGen.

08 Variants

Classified variants of LOXL3

Waiting for the record before reading ClinVar.

09 Constraint

How much variation LOXL3 tolerates

Waiting for the record before reading gnomAD and Open Targets.

10 Orthologs

The same gene in mouse, rat and human

Waiting for the record before reading the Alliance, NCBI, Ensembl Compara and RGD.

11 MicroRNAs

MicroRNAs hosted within LOXL3

Waiting for the record before reading Ensembl and miRBase.

12 Long non-coding RNAs

Long non-coding RNAs at the LOXL3 locus

Waiting for the record before reading Ensembl.

13 Literature

Papers that mention LOXL3

Waiting for the record before reading Europe PMC.

LOXL3

lysyl oxidase like 3

gene with protein product

Human LOXL3MouseRat

Reading the ortholog votes for mouse and rat.

Location

Cytogenetic band 2p13.1NCBI: 2:74,532,258-74,555,702 on the minus strand, GRCh38.p14 (GCF_000001405.40), sequence NC_000002.12, annotation GCF_000001405.40-RS_2025_08 of 2025-08-01Ensembl: no location was read.Coordinates are one-based with both ends included, as each source reports them.

Gene identity, from HGNC · HGNC 2026-09-29 · read 2026-10-01 ET · HGNC:13869

Notes from the sources

Ensembl did not answer (upstream error).
Ensembl did not answer (upstream error); the Ensembl location and release are missing

RefSeq transcripts of this gene
Accession	Name	Biotype	Labels	Exons	Spliced length	Protein	Sequence
NM_032603.5matches ENST00000264094.8	transcript variant 1	protein coding	MANE Select	14	3,689 nt	753 aaNP_115992.1	Ready in a moment
XM_024453178.2matches ENST00000853959.2	transcript variant X2	protein coding model	none	14	4,956 nt	753 aaXP_024308946.1	Ready in a moment
XM_024453177.2	transcript variant X3	protein coding model	none	16	3,881 nt	753 aaXP_024308945.1	Ready in a moment
XM_024453176.2matches ENST00000853957.2	Ready in a moment

Accession

Name

Biotype

Labels

Exons

Spliced length

Protein

Sequence

NM_032603.5matches ENST00000264094.8

transcript variant 1

protein coding

MANE Select

3,689 nt

753 aaNP_115992.1

Ready in a moment

XM_024453178.2matches ENST00000853959.2

transcript variant X2

protein coding model

none

4,956 nt

753 aaXP_024308946.1

Ready in a moment

XM_024453177.2

transcript variant X3

protein coding model

none

3,881 nt

753 aaXP_024308945.1

Ready in a moment

XM_024453176.2matches ENST00000853957.2

Ready in a moment

From LOXL3 to a sequence that silences it

Choose the region

A knockdown oligonucleotide can sit in the 5' untranslated region, the coding sequence or the 3' untranslated region, and all three are used. The coding sequence and the 3' untranslated region are the usual first choices for an RNase H design; the 5' end near the start codon suits a steric block. The map above shows where each region sits on the isoforms it draws.

Cover the isoforms you mean

An exon every isoform carries silences the whole gene; an exon only some isoforms carry silences those and spares the rest. Decide which you want before a sequence is chosen, and check the reference transcript (MANE Select in human; RefSeq Select and Ensembl canonical in mouse and rat) is the one your cells express.

Think across species early

The orthologs panel says whether mouse and rat carry the same gene. Whether one oligonucleotide can serve two species is a sequence question, settled at design by matching the candidate against each transcript, not by the protein identity shown there.

Check expression in your model

A transcript that is not expressed in your cells cannot show knockdown. Confirm the gene is expressed in the cell type and condition you will use, from your own data or a reference atlas, before the order. The expression panel above gives GTEx's median per tissue for a human gene; for mouse and rat it says that no atlas is on this page yet.

RefSeq transcripts of this gene
Accession	Name	Biotype	Labels	Exons	Spliced length	Protein	Sequence
NM_032603.5matches ENST00000264094.8	transcript variant 1	protein coding	MANE Select	14	3,689 nt	753 aaNP_115992.1	Ready in a moment
XM_024453178.2matches ENST00000853959.2	transcript variant X2	protein coding model	none	14	4,956 nt	753 aaXP_024308946.1	Ready in a moment
XM_024453177.2	transcript variant X3	protein coding model	none	16	3,881 nt	753 aaXP_024308945.1	Ready in a moment
XM_024453176.2matches ENST00000853957.2	Ready in a moment

Accession

Name

Biotype

Labels

Exons

Spliced length

Protein

Sequence

NM_032603.5matches ENST00000264094.8

transcript variant 1

protein coding

MANE Select

3,689 nt

753 aaNP_115992.1

Ready in a moment

XM_024453178.2matches ENST00000853959.2

transcript variant X2

protein coding model

none

4,956 nt

753 aaXP_024308946.1

Ready in a moment

XM_024453177.2

transcript variant X3

protein coding model

none

3,881 nt

753 aaXP_024308945.1

Ready in a moment

XM_024453176.2matches ENST00000853957.2

Ready in a moment

LOXL3

What LOXL3 does

The RNA a design targets

From LOXL3 to a sequence that silences it

Choose the region

Cover the isoforms you mean

Think across species early

Check expression in your model

LOXL3

What LOXL3 does

The RNA a design targets

Where LOXL3 is expressed

The protein LOXL3 encodes

Proteins STRING associates with LOXL3

Where LOXL3 acts, as Reactome curates it

Diseases linked to LOXL3

Classified variants of LOXL3

How much variation LOXL3 tolerates

The same gene in mouse, rat and human

MicroRNAs hosted within LOXL3

Long non-coding RNAs at the LOXL3 locus

Papers that mention LOXL3

LOXL3

What LOXL3 does

Gene summary

Protein function

The RNA a design targets

RefSeq 7 transcripts

A window on one transcript

Ensembl 0 transcripts

From LOXL3 to a sequence that silences it

Choose the region

Cover the isoforms you mean

Think across species early

Check expression in your model

Where LOXL3 is expressed

The protein LOXL3 encodes

Proteins STRING associates with LOXL3

Where LOXL3 acts, as Reactome curates it

Diseases linked to LOXL3

Classified variants of LOXL3

How much variation LOXL3 tolerates

The same gene in mouse, rat and human

MicroRNAs hosted within LOXL3

Long non-coding RNAs at the LOXL3 locus

Papers that mention LOXL3

Run the controls

Pick the product

Gene summary

Protein function

RefSeq 7 transcripts

A window on one transcript

Ensembl 0 transcripts