Reading the record for LRCH4 from HGNC, NCBI Gene and Ensembl.Still reading. A first read of a gene can take a while; this page waits up to 115 seconds for it, and its scripts then bring in the page, or a line saying what did not arrive.
The full name, the identifiers, the location and the notes from the sources arrive with the record. Nothing is filled in ahead of it.
Order door
The door to order for LRCH4 opens with the record, which decides which product it carries. The order page itself is open now.
Cytogenetic band 7q22.1NCBI: 7:100,574,011-100,586,129 on the minus strand, GRCh38.p14 (GCF_000001405.40), sequence NC_000007.14, annotation GCF_000001405.40-RS_2025_08 of 2025-08-01Ensembl: 7:100,574,011-100,586,236 on the minus strand, GRCh38.p14 (GCA_000001405.29), release 116Coordinates are one-based with both ends included, as each source reports them.
This gene encodes a protein that contains leucine-rich repeats (LRR) at its…
NCBI Gene summary
Ready in a moment
Reading NCBI Gene and UniProt.Still reading. A first read of a gene can take a while; this page waits up to 30 seconds for it, and its scripts then bring in the panel, or a line saying what did not arrive.
02 / Transcripts and isoforms
The RNA a design targets
Reading NCBI Datasets and Ensembl.Still reading. A first read of a gene can take a while; this page waits up to 80 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.
Ready in a moment
Reading NCBI Datasets and Ensembl.Still reading. A first read of a gene can take a while; this page waits up to 80 seconds for it, and its scripts then bring in the panel, or a line saying what did not arrive.
03 / Expression by tissue
Where LRCH4 is expressed
Reading GTEx and the Human Protein Atlas.Still reading. A first read of a gene can take a while; this page waits up to 80 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.
Ready in a moment
04 / Protein
The protein LRCH4 encodes
Reading UniProt, InterPro, AlphaFold DB and PDBe.Still reading. A first read of a gene can take a while; this page waits up to 80 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.
Ready in a moment
05 / Interactions
Proteins STRING associates with LRCH4
Reading STRING.Still reading. A first read of a gene can take a while; this page waits up to 50 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.
Ready in a moment
06 / Pathways
Where LRCH4 acts, as Reactome curates it
Reading UniProt and Reactome.Still reading. A first read of a gene can take a while; this page waits up to 60 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.
Ready in a moment
07 / Disease associations
Diseases linked to LRCH4
Reading Open Targets and ClinGen.Still reading. A first read of a gene can take a while; this page waits up to 105 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.
Ready in a moment
08 / Variants
Classified variants of LRCH4
Reading ClinVar.Still reading. A first read of a gene can take a while; this page waits up to 60 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.
Ready in a moment
09 / Constraint
How much variation LRCH4 tolerates
Reading gnomAD and Open Targets.Still reading. A first read of a gene can take a while; this page waits up to 45 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.
Ready in a moment
10 / Orthologs
The same gene in mouse, rat and human
Reading the Alliance, NCBI, Ensembl Compara and RGD.Still reading. A first read of a gene can take a while; this page waits up to 145 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.
Ready in a moment
11 /MicroRNAs
MicroRNAs hosted within LRCH4
Reading Ensembl and miRBase.Still reading. A first read of a gene can take a while; this page waits up to 110 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.
Ready in a moment
12 / Long non-coding RNAs
Long non-coding RNAs at the LRCH4 locus
Reading Ensembl.Still reading. A first read of a gene can take a while; this page waits up to 110 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.
Ready in a moment
13 / Literature
Papers that mention LRCH4
Reading Europe PMC.Still reading. A first read of a gene can take a while; this page waits up to 55 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.
Ready in a moment
14 / Silencing this gene
From LRCH4 to a sequence that silences it
The AUMsilence™ platform designs the sequences against the human transcripts on this page. Six decisions are yours before it does. What is written under each is AUM's guidance; the timings and the concentrations are in the usage guide below.
01
Choose the region
A knockdown oligonucleotide can sit in the 5' untranslated region, the coding sequence or the 3' untranslated region, and all three are used. The coding sequence and the 3' untranslated region are the usual first choices for an RNase H design; the 5' end near the start codon suits a steric block. The map above shows where each region sits on the isoforms it draws.
02
Cover the isoforms you mean
An exon every isoform carries silences the whole gene; an exon only some isoforms carry silences those and spares the rest. Decide which you want before a sequence is chosen, and check the reference transcript (MANE Select in human; RefSeq Select and Ensembl canonical in mouse and rat) is the one your cells express.
03
Think across species early
The orthologs panel says whether mouse and rat carry the same gene. Whether one oligonucleotide can serve two species is a sequence question, settled at design by matching the candidate against each transcript, not by the protein identity shown there.
04
Check expression in your model
A transcript that is not expressed in your cells cannot show knockdown. Confirm the gene is expressed in the cell type and condition you will use, from your own data or a reference atlas, before the order. The expression panel above gives GTEx's median per tissue for a human gene; for mouse and rat it says that no atlas is on this page yet.
05
Run the controls
A scramble control of the same chemistry, a positive control against a gene known to knock down in your cells, untreated cells, and a mock condition where a transfection reagent is used. Read knockdown at the RNA level first, then at the protein; the usage guide gives the timing and the concentrations to start from.
06
Pick the product
AUMsilence sdASO needs no transfection reagent and works in the cells that resist one. AUMsilence toASO is the transfection-optimised version of the same design, and AUMsiRNA™ is the siRNA route. The selection guide compares them.
For research use only. Not for use in diagnostic or therapeutic procedures.
Gene summary
This gene encodes a protein that contains leucine-rich repeats (LRR) at its amino terminus and that is known to be involved in ligand binding. The carboxyl terminus may act as a membrane anchor. Identified structural elements suggest that the encoded protein resembles a receptor.
Provided by RefSeq, Jul 2008, through NCBI Gene. NCBI disclaimer
Protein function
Leucine-rich repeat and calponin homology domain-containing protein 4, O75427
Accessory protein that regulates signaling by multiple TLRs, acting as a broad-spanning regulator of the innate immune response. In macrophages, binds LPS and promotes proper docking of LPS in lipid raft membrane. May be required for lipid raft maintenance
NCBI Gene summary · NCBI Gene annotation RS_2025_08 · read · NCBI Gene 4034Data from NCBI, provided as is; NCBI's policies and disclaimers apply.
UniProtKB function · 2026_03 · read · UniProt O75427UniProt data are available under the Creative Commons Attribution 4.0 licence.
384 PubMed-indexed papers mention LRCH4 at Europe PMC, newest first. Europe PMC ignores letter case, so the count also covers another species' symbol spelled with the same letters.
Europe PMC
54 GTEx tissues; the highest median in Testis, 281 TPM.
GTEx
No annotated microRNA lies within LRCH4 in Ensembl release 116, on GRCh38.p14.
Ensembl · miRBase
1 long non-coding RNA gene overlaps LRCH4 in Ensembl release 116, without a symbol.
23 RefSeq and 46 Ensembl transcripts on GRCh38.p14; MANE Select NM_002319.5.
NCBI Datasets · Ensembl
Placed on GRCh38.p14 (GCF_000001405.40). MANE Select marks the one transcript RefSeq and Ensembl agree is the reference for this gene.
RefSeq 23 transcripts
coding sequence, tall
untranslated region, thin
non-coding exon
intron, fixed width
Genomic strand: minus. Drawn 5' to 3', so exon 1 sits at the left here and at the highest coordinate on the chromosome.
NM_002319.5NM_002319.5MANE Select
A window on one transcript
One pixel of the map above stands for several bases, and a block too short to see is drawn wider than its own scale, so the map chooses a region and the sequence here chooses the window. Click an exon on a row of the map, or drag across a row; then set the exact start and end below.
These controls are ready in a moment.
No transcript is chosen.
Once a window is chosen this panel shows its length, its G and C count as a percentage of that length, the letters it is made of, the exons it falls in, whether it crosses a junction, and its antisense strand.
Not listed, because the source places them on another assembly only: XM_054358231.1 (not placed on GRCh38.p14); XM_054358232.1 (not placed on GRCh38.p14); XM_054358233.1 (not placed on GRCh38.p14); XM_054358234.1 (not placed on GRCh38.p14); XM_054358235.1 (not placed on GRCh38.p14); XM_054358236.1 (not placed on GRCh38.p14); XM_054358237.1 (not placed on GRCh38.p14); XM_054358238.1 (not placed on GRCh38.p14); XM_054358239.1 (not placed on GRCh38.p14); XM_054358240.1 (not placed on GRCh38.p14); XM_054358241.1 (not placed on GRCh38.p14); XM_054358242.1 (not placed on GRCh38.p14); XM_054358243.1 (not placed on GRCh38.p14); XM_054358244.1 (not placed on GRCh38.p14); XM_054358245.1 (not placed on GRCh38.p14); XM_054358246.1 (not placed on GRCh38.p14); XM_054358247.1 (not placed on GRCh38.p14); XM_054358248.1 (not placed on GRCh38.p14); XM_054358249.1 (not placed on GRCh38.p14); XM_054358250.1 (not placed on GRCh38.p14); XM_054358251.1 (not placed on GRCh38.p14); XR_008487616.1 (not placed on GRCh38.p14).
NCBI Datasets, RefSeq transcripts · NCBI Datasets 18.37.0; GCF_000001405.40-RS_2025_08 · read · NCBI Gene 4034Data from NCBI, provided as is; NCBI's policies and disclaimers apply.
Ensembl 46 transcripts
A window on one transcript
One pixel of the map above stands for several bases, and a block too short to see is drawn wider than its own scale, so the map chooses a region and the sequence here chooses the window. Click an exon on a row of the map, or drag across a row; then set the exact start and end below.
These controls are ready in a moment.
No transcript is chosen.
Once a window is chosen this panel shows its length, its G and C count as a percentage of that length, the letters it is made of, the exons it falls in, whether it crosses a junction, and its antisense strand.
Lengths are spliced lengths, as each source states them. Exon ranks follow the strand: on a minus-strand gene exon 1 has the highest genomic coordinate. Reference assembly for human: GRCh38.
XM_047420384.1XM_047420384.1
XM_047420387.1XM_047420387.1
XM_047420388.1XM_047420388.1
XM_047420389.1XM_047420389.1
XM_047420390.1XM_047420390.1
XM_047420378.1XM_047420378.1
XM_047420379.1XM_047420379.1
XM_047420383.1XM_047420383.1
NM_001289934.2NM_001289934.2
XM_047420380.1XM_047420380.1
XM_047420381.1XM_047420381.1
XM_047420382.1XM_047420382.1
XM_047420385.1XM_047420385.1
XM_047420391.1XM_047420391.1
XM_047420392.1XM_047420392.1
XM_047420393.1XM_047420393.1
XM_047420395.1XM_047420395.1
XM_047420394.1XM_047420394.1
XM_047420396.1XM_047420396.1
XM_047420397.1XM_047420397.1
XM_047420398.1XM_047420398.1
XR_007060035.1XR_007060035.1
scale
Drawn 5' to 3' from each transcript's exons as placed on the reference assembly; exon 1 is the 5' exon on the transcript's own strand. Exon blocks are to scale with each other; introns are drawn at one fixed width whatever their length, so the map is not to scale along the chromosome. Numbers are exon ranks along the strand; a rank is omitted where the exon is too narrow to carry it.
Drawn 5' to 3' from each transcript's exons as placed on the reference assembly; exon 1 is the 5' exon on the transcript's own strand. Exon blocks are to scale with each other; introns are drawn at one fixed width whatever their length, so the map is not to scale along the chromosome. Numbers are exon ranks along the strand; a rank is omitted where the exon is too narrow to carry it.
39 Open Targets disease associations; ankylosing spondylitis first, at 0.05.
Open Targets
The 25 highest-scoring STRING partners at or above a combined score of 0.4, of up to 25 asked for; DOCK8, LRCH3, LRCH1 lead.
STRING v12.0
pLI below 0.0001 and LOEUF 0.862 in gnomAD v4 (GRCh38), on ENST00000310300.11.
gnomAD
683 residues, reviewed O75427; 14 entries from the member databases this page shows along the chain; mean pLDDT 64.19; no experimental structure at PDBe.
UniProt · InterPro · AlphaFold DB · PDBe
ClinVar: 197 records for LRCH4, 23 pathogenic or likely pathogenic.
ClinVar
Mouse Lrch4 by 3 of 3 votes; rat Lrch4 by 3 of 3 votes. RGD is not answering, so the ortholog list could not be shown. Try again later. Reference 61cf1618-2ae.
