Gene Human Homo sapiens

MLANA

melan-A

gene with protein product

Location: Cytogenetic band 9p24.1NCBI: 9:5,890,889-5,910,606 on the plus strand, GRCh38.p14 (GCF_000001405.40), sequence NC_000009.12, annotation GCF_000001405.40-RS_2025_08 of 2025-08-01Ensembl: 9:5,890,873-5,910,606 on the plus strand, GRCh38.p14 (GCA_000001405.29), release 116Coordinates are one-based with both ends included, as each source reports them.
Also known as: MART1, MART-1

Gene identity, from HGNC · HGNC 2026-09-29 · read 2026-10-01 ET · HGNC:7124

Silence this gene

The order page opens with MLANA and human filled in. The sequences are designed against the transcripts below; the price is on that page.

Order for MLANA

sdASO, toASO or siRNA, chosen on the next page

Bring your own sequence Transcripts

For research use only. Not for use in diagnostic or therapeutic procedures.

Summary
Transcripts
Expression
Protein
Interactions
Pathways
Disease
Variants

A line below that says it is reading needs JavaScript to be replaced: with scripts off, it stays at that line however long you wait. Opening a card also needs JavaScript.

Ready in a moment

01 Summary and function

What MLANA does

Ready in a moment

02 Transcripts and isoforms

The RNA a design targets

Ready in a moment

03 Expression by tissue

Where MLANA is expressed

Ready in a moment

14 Silencing this gene

From MLANA to a sequence that silences it

The AUMsilence platform designs the sequences against the human transcripts on this page. Six decisions are yours before it does. What is written under each is AUM's guidance; the timings and the concentrations are in the usage guide below.

01
Choose the region
A knockdown oligonucleotide can sit in the 5' untranslated region, the coding sequence or the 3' untranslated region, and all three are used. The coding sequence and the 3' untranslated region are the usual first choices for an RNase H design; the 5' end near the start codon suits a steric block. The map above shows where each region sits on the isoforms it draws.
02
Cover the isoforms you mean
An exon every isoform carries silences the whole gene; an exon only some isoforms carry silences those and spares the rest. Decide which you want before a sequence is chosen, and check the reference transcript (MANE Select in human; RefSeq Select and Ensembl canonical in mouse and rat) is the one your cells express.
03
Think across species early
The orthologs panel says whether mouse and rat carry the same gene. Whether one oligonucleotide can serve two species is a sequence question, settled at design by matching the candidate against each transcript, not by the protein identity shown there.
04
Check expression in your model
A transcript that is not expressed in your cells cannot show knockdown. Confirm the gene is expressed in the cell type and condition you will use, from your own data or a reference atlas, before the order. The expression panel above gives GTEx's median per tissue for a human gene; for mouse and rat it says that no atlas is on this page yet.

Gene Human Homo sapiens

MLANA

Reading the record for MLANA from HGNC, NCBI Gene and Ensembl.Still reading. A first read of a gene can take a while; this page waits up to 115 seconds for it, and its scripts then bring in the page, or a line saying what did not arrive.

The full name, the identifiers, the location and the notes from the sources arrive with the record. Nothing is filled in ahead of it.

Order door

The door to order for MLANA opens with the record, which decides which product it carries. The order page itself is open now.

Bring your own sequence

For research use only. Not for use in diagnostic or therapeutic procedures.

This page is still reading the record. Its scripts replace this shell with the record when it arrives; with scripts off, it stays at this shell however long you wait.

01 Summary and function

What MLANA does

Waiting for the record before reading NCBI Gene and UniProt.

02 Transcripts and isoforms

The RNA a design targets

Waiting for the record before reading NCBI Datasets and Ensembl.

03 Expression by tissue

Where MLANA is expressed

Waiting for the record before reading GTEx and the Human Protein Atlas.

04 Protein

The protein MLANA encodes

Waiting for the record before reading UniProt, InterPro, AlphaFold DB and PDBe.

05 Interactions

Proteins STRING associates with MLANA

Waiting for the record before reading STRING.

06 Pathways

Where MLANA acts, as Reactome curates it

Waiting for the record before reading UniProt and Reactome.

07 Disease associations

Diseases linked to MLANA

Waiting for the record before reading Open Targets and ClinGen.

08 Variants

Classified variants of MLANA

Waiting for the record before reading ClinVar.

09 Constraint

How much variation MLANA tolerates

Waiting for the record before reading gnomAD and Open Targets.

10 Orthologs

The same gene in mouse, rat and human

Waiting for the record before reading the Alliance, NCBI, Ensembl Compara and RGD.

11 MicroRNAs

MicroRNAs hosted within MLANA

Waiting for the record before reading Ensembl and miRBase.

12 Long non-coding RNAs

Long non-coding RNAs at the MLANA locus

Waiting for the record before reading Ensembl.

13 Literature

Papers that mention MLANA

Waiting for the record before reading Europe PMC.

MLANA

melan-A

gene with protein product

Location

Cytogenetic band 9p24.1NCBI: 9:5,890,889-5,910,606 on the plus strand, GRCh38.p14 (GCF_000001405.40), sequence NC_000009.12, annotation GCF_000001405.40-RS_2025_08 of 2025-08-01Ensembl: 9:5,890,873-5,910,606 on the plus strand, GRCh38.p14 (GCA_000001405.29), release 116Coordinates are one-based with both ends included, as each source reports them.

Also known as

MART1, MART-1

Gene identity, from HGNC · HGNC 2026-09-29 · read 2026-10-01 ET · HGNC:7124

RefSeq transcripts of this gene
Accession	Name	Biotype	Labels	Exons	Spliced length	Protein	Sequence
NM_005511.2matches ENST00000381477.8	none given	protein coding	MANE Select	5	2,328 nt	118 aaNP_005502.1	Ready in a moment

Accession

Name

Biotype

Labels

Exons

Spliced length

Protein

Sequence

NM_005511.2matches ENST00000381477.8

none given

protein coding

MANE Select

2,328 nt

118 aaNP_005502.1

Ready in a moment

From MLANA to a sequence that silences it

Choose the region

A knockdown oligonucleotide can sit in the 5' untranslated region, the coding sequence or the 3' untranslated region, and all three are used. The coding sequence and the 3' untranslated region are the usual first choices for an RNase H design; the 5' end near the start codon suits a steric block. The map above shows where each region sits on the isoforms it draws.

Cover the isoforms you mean

An exon every isoform carries silences the whole gene; an exon only some isoforms carry silences those and spares the rest. Decide which you want before a sequence is chosen, and check the reference transcript (MANE Select in human; RefSeq Select and Ensembl canonical in mouse and rat) is the one your cells express.

Think across species early

The orthologs panel says whether mouse and rat carry the same gene. Whether one oligonucleotide can serve two species is a sequence question, settled at design by matching the candidate against each transcript, not by the protein identity shown there.

Check expression in your model

A transcript that is not expressed in your cells cannot show knockdown. Confirm the gene is expressed in the cell type and condition you will use, from your own data or a reference atlas, before the order. The expression panel above gives GTEx's median per tissue for a human gene; for mouse and rat it says that no atlas is on this page yet.

RefSeq transcripts of this gene
Accession	Name	Biotype	Labels	Exons	Spliced length	Protein	Sequence
NM_005511.2matches ENST00000381477.8	none given	protein coding	MANE Select	5	2,328 nt	118 aaNP_005502.1	Ready in a moment

Accession

Name

Biotype

Labels

Exons

Spliced length

Protein

Sequence

NM_005511.2matches ENST00000381477.8

none given

protein coding

MANE Select

2,328 nt

118 aaNP_005502.1

Ready in a moment

Accession	Name	Biotype	Labels	Exons	Spliced length	Protein	Sequence
ENST00000381477.8matches NM_005511.2	MLANA-203	protein coding	MANE SelectEnsembl canonical	5	2,328 nt	118 aaENSP00000370886.3	Ready in a moment
ENST00000381471.2	MLANA-201	protein coding	none	5	2,661 nt	118 aaENSP00000370880.1	Ready in a moment
ENST00000381476.6	MLANA-202	protein coding	none	6	2,489 nt	118 aaENSP00000370885.1	Ready in a moment
ENST00001134943.1	MLANA-206	protein coding	none	5	2,344 nt	118 aaENSP00000811239.1	Ready in a moment
ENST00000490518.1	MLANA-205	protein coding cds not defined	none	3	501 nt	none	Ready in a moment
ENST00000482341.1	MLANA-204	protein coding cds not defined	none	3	448 nt	none	Ready in a moment

MLANA

What MLANA does

The RNA a design targets

Where MLANA is expressed

From MLANA to a sequence that silences it

Choose the region

Cover the isoforms you mean

Think across species early

Check expression in your model

MLANA

What MLANA does

The RNA a design targets

Where MLANA is expressed

The protein MLANA encodes

Proteins STRING associates with MLANA

Where MLANA acts, as Reactome curates it

Diseases linked to MLANA

Classified variants of MLANA

How much variation MLANA tolerates

The same gene in mouse, rat and human

MicroRNAs hosted within MLANA

Long non-coding RNAs at the MLANA locus

Papers that mention MLANA

MLANA

What MLANA does

Gene summary

Protein function

The RNA a design targets

RefSeq 1 transcript

A window on one transcript

Ensembl 6 transcripts

A window on one transcript

Where MLANA is expressed

From MLANA to a sequence that silences it

Choose the region

Cover the isoforms you mean

Think across species early

Check expression in your model

The protein MLANA encodes

Proteins STRING associates with MLANA

Where MLANA acts, as Reactome curates it

Diseases linked to MLANA

Classified variants of MLANA

How much variation MLANA tolerates

The same gene in mouse, rat and human

MicroRNAs hosted within MLANA

Long non-coding RNAs at the MLANA locus

Papers that mention MLANA

Run the controls

Pick the product

Gene summary

Protein function

RefSeq 1 transcript

A window on one transcript

Ensembl 6 transcripts

A window on one transcript