Cytogenetic band 4q13.3NCBI: 4:70,430,492-70,482,997 on the plus strand, GRCh38.p14 (GCF_000001405.40), sequence NC_000004.12, annotation GCF_000001405.40-RS_2025_08 of 2025-08-01Coordinates are one-based with both ends included, as each source reports them.
Reading NCBI Gene and UniProt.Still reading. A first read of a gene can take a while; this page waits up to 30 seconds for it, and its scripts then bring in the panel, or a line saying what did not arrive.
02 / Transcripts and isoforms
The RNA a design targets
Reading NCBI Datasets and Ensembl.
Ready in a moment
Reading NCBI Datasets and Ensembl.
03 / Expression by tissue
Where MUC7 is expressed
Reading GTEx and the Human Protein Atlas.Still reading. A first read of a gene can take a while; this page waits up to 80 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.
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14 / Silencing this gene
From MUC7 to a sequence that silences it
The AUMsilence™ platform designs the sequences against the human MUC7 transcripts.
01
Choose the region
A knockdown oligonucleotide can sit in the 5' untranslated region, the coding sequence or the 3' untranslated region, and all three are used. The coding sequence and the 3' untranslated region are the usual first choices for an RNase H design; the 5' end near the start codon suits a steric block. The map above shows where each region sits on the isoforms it draws.
02
Cover the isoforms you mean
An exon every isoform carries silences the whole gene; an exon only some isoforms carry silences those and spares the rest. Decide which you want before a sequence is chosen, and check the reference transcript (MANE Select in human; RefSeq Select and Ensembl canonical in mouse and rat) is the one your cells express.
03
Think across species early
The orthologs panel says whether mouse and rat carry the same gene. Whether one oligonucleotide can serve two species is a sequence question, settled at design by matching the candidate against each transcript, not by the protein identity shown there.
04
Check expression in your model
A transcript that is not expressed in your cells cannot show knockdown. Confirm the gene is expressed in the cell type and condition you will use, from your own data or a reference atlas, before the order. The expression panel above gives GTEx's median per tissue for a human gene; for mouse and rat it says that no atlas is on this page yet.
GTEx's medians say how much of this gene's RNA the sampled tissues carried, tissue by tissue, in transcripts per million, and the Human Protein Atlas adds how specific that expression is and where the protein sits in the cell. Read the profile for the tissue your cells come from, then check your own model: a transcript that is not expressed in the cells you will use cannot show knockdown, and a bulk tissue median is not a cell line.
The median is the middle sample of a tissue, so a gene expressed in a few cells of a mixed tissue reads low here and may still be the one your cell type needs. Nothing on this panel is adjusted or averaged across tissues; each figure is the source's own, and a tissue GTEx did not sample is absent from the chart.
04 / Protein
The protein MUC7 encodes
Reading UniProt, InterPro, AlphaFold DB and PDBe.Still reading. A first read of a gene can take a while; this page waits up to 80 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.
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05 / Interactions
Proteins STRING associates with MUC7
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06 / Pathways
Where MUC7 acts, as Reactome curates it
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07 / Disease associations
Diseases linked to MUC7
Reading Open Targets and ClinGen.Still reading. A first read of a gene can take a while; this page waits up to 105 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.
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08 / Variants
Classified variants of MUC7
Reading ClinVar.Still reading. A first read of a gene can take a while; this page waits up to 60 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.
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09 / Constraint
How much variation MUC7 tolerates
Reading gnomAD and Open Targets.Still reading. A first read of a gene can take a while; this page waits up to 45 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.
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10 / Orthologs
The same gene in mouse, rat and human
Reading the Alliance, NCBI, Ensembl Compara and RGD.
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11 /MicroRNAs
MicroRNAs hosted within MUC7
Ready in a moment
12 / Long non-coding RNAs
Long non-coding RNAs at the MUC7 locus
Ready in a moment
13 / Literature
Papers that mention MUC7
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05
Run the controls
A scramble control of the same chemistry, a positive control against a gene known to knock down in your cells, untreated cells, and a mock condition where a transfection reagent is used. Read knockdown at the RNA level first, then at the protein; the usage guide gives the timing and the concentrations to start from.
06
Pick the product
AUMsilence sdASO needs no transfection reagent and works in the cells that resist one. AUMsilence toASO is the transfection-optimised version of the same design, and AUMsiRNA™ is the siRNA route. The selection guide compares them.
Ensembl did not answer (upstream error); the Ensembl location and release are missing
This gene encodes a small salivary mucin, which is thought to play a role in…
NCBI Gene summary
144 Open Targets disease associations; asthma first, at 0.38.
Open Targets
Ensembl is not answering, so the non-coding annotation could not be shown. Try again later. Reference 5a1bca2d-2a4.
Ensembl is not answering, so the non-coding annotation could not be shown. Try again later. Reference 5a1bca2d-2a4.
Gene summary
This gene encodes a small salivary mucin, which is thought to play a role in facilitating the clearance of bacteria in the oral cavity and to aid in mastication, speech, and swallowing. The central domain of this glycoprotein contains tandem repeats, each composed of 23 amino acids. This antimicrobial protein has antibacterial and antifungal activity. The most common allele contains 6 repeats, and some alleles may be associated with susceptibility to asthma. Alternatively spliced transcript variants with different 5' UTR, but encoding the same protein, have been found for this gene.
Provided by RefSeq, Oct 2014, through NCBI Gene. NCBI disclaimer
May function in a protective capacity by promoting the clearance of bacteria in the oral cavity and aiding in mastication, speech, and swallowing. Binds P.aeruginosa pili
NCBI Gene summary · NCBI Gene annotation RS_2025_08 · read · NCBI Gene 4589Data from NCBI, provided as is; NCBI's policies and disclaimers apply.
UniProtKB function · 2026_04 · read · UniProt Q8TAX7UniProt data are available under the Creative Commons Attribution 4.0 licence.
pLI 0.1085 and LOEUF 2.55 in gnomAD v4 (GRCh38), on ENST00000304887.6.
gnomAD
54 GTEx tissues; the highest median in Minor Salivary Gland, 31,781 TPM.
GTEx
1,908 PubMed-indexed papers mention MUC7 at Europe PMC, newest first. Europe PMC ignores letter case, so the count also covers another species' symbol spelled with the same letters.
Europe PMC
Mouse Prol1 by 1 of 3 votes; rat: no ortholog named by the 3 votes that answered. RGD is not answering, so the ortholog list could not be shown. Try again later. Reference 064dc443-f0a.
Alliance · NCBI · Ensembl Compara
Rat: no ortholog is named for this gene: the Alliance, NCBI and Ensembl Compara answered and named none.
6 curated, 0 inferred Reactome pathways for Q8TAX7 in human, v98.
Reactome
The 25 highest-scoring STRING partners at or above a combined score of 0.4, of up to 25 asked for; MUC5B, MUC2, MUC1 lead.
STRING v12.0
ClinVar: 92 records for MUC7, 23 pathogenic or likely pathogenic.
ClinVar
377 residues, reviewed Q8TAX7; mean pLDDT 55; no experimental structure at PDBe. InterPro is not answering, so the domain entries could not be shown. Try again later. Reference f4a713c5-2d5.
UniProt · AlphaFold DB · PDBe
4 RefSeq and 7 Ensembl transcripts on GRCh38.p14; MANE Select NM_152291.3.
NCBI Datasets · Ensembl
Placed on GRCh38.p14 (GCF_000001405.40). MANE Select marks the one transcript RefSeq and Ensembl agree is the reference for this gene.
RefSeq 4 transcripts
coding sequence, tall
untranslated region, thin
non-coding exon
intron, fixed width
Genomic strand: plus. Drawn 5' to 3', so exon 1 sits at the left here and at the lowest coordinate on the chromosome.
NM_152291.3NM_152291.3MANE Select
NM_001145006.2NM_001145006.2
NM_001145007.2NM_001145007.2
XM_047415723.1XM_047415723.1
scale
Drawn 5' to 3' from each transcript's exons as placed on the reference assembly; exon 1 is the 5' exon on the transcript's own strand. Exon blocks are to scale with each other; introns are drawn at one fixed width whatever their length, so the map is not to scale along the chromosome. Numbers are exon ranks along the strand; a rank is omitted where the exon is too narrow to carry it.
A window on one transcript
One pixel of the map above stands for several bases, and a block too short to see is drawn wider than its own scale, so the map chooses a region and the sequence here chooses the window. Click an exon on a row of the map, or drag across a row; then set the exact start and end below.
These controls are ready in a moment.
No transcript is chosen.
Once a window is chosen this panel shows its length, its G and C count as a percentage of that length, the letters it is made of, the exons it falls in, whether it crosses a junction, and its antisense strand.
Not listed, because the source places them on another assembly only: XM_054350095.1 (not placed on GRCh38.p14).
NCBI Datasets, RefSeq transcripts · NCBI Datasets 18.41.0; GCF_000001405.40-RS_2025_08 · read · NCBI Gene 4589Data from NCBI, provided as is; NCBI's policies and disclaimers apply.
Ensembl 7 transcripts
coding sequence, tall
untranslated region, thin
non-coding exon
intron, fixed width
Genomic strand: plus. Drawn 5' to 3', so exon 1 sits at the left here and at the lowest coordinate on the chromosome.
A window on one transcript
One pixel of the map above stands for several bases, and a block too short to see is drawn wider than its own scale, so the map chooses a region and the sequence here chooses the window. Click an exon on a row of the map, or drag across a row; then set the exact start and end below.
These controls are ready in a moment.
No transcript is chosen.
Once a window is chosen this panel shows its length, its G and C count as a percentage of that length, the letters it is made of, the exons it falls in, whether it crosses a junction, and its antisense strand.
Lengths are spliced lengths, as each source states them. Exon ranks follow the strand: on a minus-strand gene exon 1 has the highest genomic coordinate. Reference assembly for human: GRCh38.
Drawn 5' to 3' from each transcript's exons as placed on the reference assembly; exon 1 is the 5' exon on the transcript's own strand. Exon blocks are to scale with each other; introns are drawn at one fixed width whatever their length, so the map is not to scale along the chromosome. Numbers are exon ranks along the strand; a rank is omitted where the exon is too narrow to carry it.
