Gene Human Homo sapiens

NAA38

N-alpha-acetyltransferase 38, NatC auxiliary subunit

gene with protein product

Human NAA38MouseRat

Reading the ortholog votes for mouse and rat.

Location: Cytogenetic band 17p13.1NCBI: 17:7,856,685-7,885,420 on the minus strand, GRCh38.p14 (GCF_000001405.40), sequence NC_000017.11, annotation GCF_000001405.40-RS_2025_08 of 2025-08-01Ensembl: 17:7,856,681-7,885,238 on the minus strand, GRCh38.p14 (GCA_000001405.29), release 116Coordinates are one-based with both ends included, as each source reports them.
Also known as: MGC14151, PFAAP2
Previous symbols: LSMD1

Gene identity, from HGNC · HGNC 2026-09-29 · read 2026-10-01 ET · HGNC:28212

Silence this gene

The order page opens with NAA38 and human filled in. The sequences are designed against the transcripts below; the price is on that page.

Order for NAA38

sdASO, toASO or siRNA, chosen on the next page

Bring your own sequence Transcripts

For research use only. Not for use in diagnostic or therapeutic procedures.

Summary
Transcripts
Expression
Protein
Interactions
Pathways
Disease
Variants
Constraint
Orthologs
MicroRNAs
Long non-coding RNAs
Literature
Silencing this gene

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01 Summary and function

What NAA38 does

Predicted to enable RNA binding activity.

NCBI Gene summary

Ready in a moment

02 Transcripts and isoforms

The RNA a design targets

Reading NCBI Datasets and Ensembl.Still reading. A first read of a gene can take a while; this page waits up to 80 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

Ready in a moment

03 Expression by tissue

Where NAA38 is expressed

54 GTEx tissues; the highest median in Testis, 136 TPM.

GTEx

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04 Protein

The protein NAA38 encodes

Reading UniProt, InterPro, AlphaFold DB and PDBe.Still reading. A first read of a gene can take a while; this page waits up to 80 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

Ready in a moment

05 Interactions

Proteins STRING associates with NAA38

The 25 highest-scoring STRING partners at or above a combined score of 0.4, of up to 25 asked for; NAA35, NAA30, NAA15 lead.

STRING v12.0

Ready in a moment

06 Pathways

Where NAA38 acts, as Reactome curates it

Reading UniProt and Reactome.Still reading. A first read of a gene can take a while; this page waits up to 60 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

Ready in a moment

07 Disease associations

Diseases linked to NAA38

44 Open Targets disease associations; hereditary disease first, at 0.19.

Open Targets

Ready in a moment

08 Variants

Classified variants of NAA38

ClinVar: 177 records for NAA38, 24 pathogenic or likely pathogenic.

ClinVar

Ready in a moment

09 Constraint

How much variation NAA38 tolerates

pLI below 0.0001 and LOEUF 1.83 in gnomAD v4 (GRCh38), on ENST00000575771.6.

gnomAD

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10 Orthologs

The same gene in mouse, rat and human

Reading the Alliance, NCBI, Ensembl Compara and RGD.Still reading. A first read of a gene can take a while; this page waits up to 145 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

Ready in a moment

11 MicroRNAs

MicroRNAs hosted within NAA38

Ensembl is not answering, so the non-coding annotation could not be shown. Try again later. Reference a5a7959a-6fb.

Ready in a moment

12 Long non-coding RNAs

Long non-coding RNAs at the NAA38 locus

Ensembl is not answering, so the non-coding annotation could not be shown. Try again later. Reference a5a7959a-6fb.

Ready in a moment

13 Literature

Papers that mention NAA38

Reading Europe PMC.Still reading. A first read of a gene can take a while; this page waits up to 55 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

Ready in a moment

14 Silencing this gene

From NAA38 to a sequence that silences it

The AUMsilence platform designs the sequences against the human transcripts on this page. Six decisions are yours before it does. What is written under each is AUM's guidance; the timings and the concentrations are in the usage guide below.

01
Choose the region
A knockdown oligonucleotide can sit in the 5' untranslated region, the coding sequence or the 3' untranslated region, and all three are used. The coding sequence and the 3' untranslated region are the usual first choices for an RNase H design; the 5' end near the start codon suits a steric block. The map above shows where each region sits on the isoforms it draws.
02
Cover the isoforms you mean
An exon every isoform carries silences the whole gene; an exon only some isoforms carry silences those and spares the rest. Decide which you want before a sequence is chosen, and check the reference transcript (MANE Select in human; RefSeq Select and Ensembl canonical in mouse and rat) is the one your cells express.
03
Think across species early
The orthologs panel says whether mouse and rat carry the same gene. Whether one oligonucleotide can serve two species is a sequence question, settled at design by matching the candidate against each transcript, not by the protein identity shown there.
04
Check expression in your model
A transcript that is not expressed in your cells cannot show knockdown. Confirm the gene is expressed in the cell type and condition you will use, from your own data or a reference atlas, before the order. The expression panel above gives GTEx's median per tissue for a human gene; for mouse and rat it says that no atlas is on this page yet.
05
Run the controls
A scramble control of the same chemistry, a positive control against a gene known to knock down in your cells, untreated cells, and a mock condition where a transfection reagent is used. Read knockdown at the RNA level first, then at the protein; the usage guide gives the timing and the concentrations to start from.
06
Pick the product
AUMsilence sdASO needs no transfection reagent and works in the cells that resist one. AUMsilence toASO is the transfection-optimised version of the same design, and AUMsiRNA is the siRNA route. The selection guide compares them.

Order for NAA38 Bring your own sequence The usage guide Selection guide

For research use only. Not for use in diagnostic or therapeutic procedures.

Gene Human Homo sapiens

NAA38

Reading the record for NAA38 from HGNC, NCBI Gene and Ensembl.Still reading. A first read of a gene can take a while; this page waits up to 115 seconds for it, and its scripts then bring in the page, or a line saying what did not arrive.

The full name, the identifiers, the location and the notes from the sources arrive with the record. Nothing is filled in ahead of it.

Order door

The door to order for NAA38 opens with the record, which decides which product it carries. The order page itself is open now.

Bring your own sequence

For research use only. Not for use in diagnostic or therapeutic procedures.

This page is still reading the record. Its scripts replace this shell with the record when it arrives; with scripts off, it stays at this shell however long you wait.

01 Summary and function

What NAA38 does

Waiting for the record before reading NCBI Gene and UniProt.

02 Transcripts and isoforms

The RNA a design targets

Waiting for the record before reading NCBI Datasets and Ensembl.

03 Expression by tissue

Where NAA38 is expressed

Waiting for the record before reading GTEx and the Human Protein Atlas.

04 Protein

The protein NAA38 encodes

Waiting for the record before reading UniProt, InterPro, AlphaFold DB and PDBe.

05 Interactions

Proteins STRING associates with NAA38

Waiting for the record before reading STRING.

06 Pathways

Where NAA38 acts, as Reactome curates it

Waiting for the record before reading UniProt and Reactome.

07 Disease associations

Diseases linked to NAA38

Waiting for the record before reading Open Targets and ClinGen.

08 Variants

Classified variants of NAA38

Waiting for the record before reading ClinVar.

09 Constraint

How much variation NAA38 tolerates

Waiting for the record before reading gnomAD and Open Targets.

10 Orthologs

The same gene in mouse, rat and human

Waiting for the record before reading the Alliance, NCBI, Ensembl Compara and RGD.

11 MicroRNAs

MicroRNAs hosted within NAA38

Waiting for the record before reading Ensembl and miRBase.

12 Long non-coding RNAs

Long non-coding RNAs at the NAA38 locus

Waiting for the record before reading Ensembl.

13 Literature

Papers that mention NAA38

Waiting for the record before reading Europe PMC.

NAA38

N-alpha-acetyltransferase 38, NatC auxiliary subunit

gene with protein product

Human NAA38MouseRat

Reading the ortholog votes for mouse and rat.

Location

Cytogenetic band 17p13.1NCBI: 17:7,856,685-7,885,420 on the minus strand, GRCh38.p14 (GCF_000001405.40), sequence NC_000017.11, annotation GCF_000001405.40-RS_2025_08 of 2025-08-01Ensembl: 17:7,856,681-7,885,238 on the minus strand, GRCh38.p14 (GCA_000001405.29), release 116Coordinates are one-based with both ends included, as each source reports them.

Also known as

MGC14151, PFAAP2

Previous symbols

LSMD1

Gene identity, from HGNC · HGNC 2026-09-29 · read 2026-10-01 ET · HGNC:28212

RefSeq transcripts of this gene
Accession	Name	Biotype	Labels	Exons	Spliced length	Protein	Sequence
NM_001320925.4matches ENST00000575771.6	transcript variant 3	protein coding	MANE Select	3	520 nt	125 aaNP_001307854.1	Ready in a moment
NM_001330111.2matches ENST00000576861.6	transcript variant 4	protein coding	none	5	768 nt	99 aaNP_001317040.1	Ready in a moment
NM_032356.6matches ENST00000333775.10	transcript variant 1	protein coding	none	2	704 nt	173 aaNP_115732.2	Ready in a moment
NM_001320924.3	Ready in a moment

Accession

Name

Biotype

Labels

Exons

Spliced length

Protein

Sequence

NM_001320925.4matches ENST00000575771.6

transcript variant 3

protein coding

MANE Select

520 nt

125 aaNP_001307854.1

Ready in a moment

NM_001330111.2matches ENST00000576861.6

transcript variant 4

protein coding

none

768 nt

99 aaNP_001317040.1

Ready in a moment

NM_032356.6matches ENST00000333775.10

transcript variant 1

protein coding

none

704 nt

173 aaNP_115732.2

Ready in a moment

NM_001320924.3

Ready in a moment

From NAA38 to a sequence that silences it

Choose the region

A knockdown oligonucleotide can sit in the 5' untranslated region, the coding sequence or the 3' untranslated region, and all three are used. The coding sequence and the 3' untranslated region are the usual first choices for an RNase H design; the 5' end near the start codon suits a steric block. The map above shows where each region sits on the isoforms it draws.

Cover the isoforms you mean

An exon every isoform carries silences the whole gene; an exon only some isoforms carry silences those and spares the rest. Decide which you want before a sequence is chosen, and check the reference transcript (MANE Select in human; RefSeq Select and Ensembl canonical in mouse and rat) is the one your cells express.

Think across species early

The orthologs panel says whether mouse and rat carry the same gene. Whether one oligonucleotide can serve two species is a sequence question, settled at design by matching the candidate against each transcript, not by the protein identity shown there.

Check expression in your model

A transcript that is not expressed in your cells cannot show knockdown. Confirm the gene is expressed in the cell type and condition you will use, from your own data or a reference atlas, before the order. The expression panel above gives GTEx's median per tissue for a human gene; for mouse and rat it says that no atlas is on this page yet.

Run the controls

A scramble control of the same chemistry, a positive control against a gene known to knock down in your cells, untreated cells, and a mock condition where a transfection reagent is used. Read knockdown at the RNA level first, then at the protein; the usage guide gives the timing and the concentrations to start from.

Pick the product

AUMsilence sdASO needs no transfection reagent and works in the cells that resist one. AUMsilence toASO is the transfection-optimised version of the same design, and AUMsiRNA is the siRNA route. The selection guide compares them.

For research use only. Not for use in diagnostic or therapeutic procedures.

RefSeq transcripts of this gene
Accession	Name	Biotype	Labels	Exons	Spliced length	Protein	Sequence
NM_001320925.4matches ENST00000575771.6	transcript variant 3	protein coding	MANE Select	3	520 nt	125 aaNP_001307854.1	Ready in a moment
NM_001330111.2matches ENST00000576861.6	transcript variant 4	protein coding	none	5	768 nt	99 aaNP_001317040.1	Ready in a moment
NM_032356.6matches ENST00000333775.10	transcript variant 1	protein coding	none	2	704 nt	173 aaNP_115732.2	Ready in a moment
NM_001320924.3	Ready in a moment

Accession

Name

Biotype

Labels

Exons

Spliced length

Protein

Sequence

NM_001320925.4matches ENST00000575771.6

transcript variant 3

protein coding

MANE Select

520 nt

125 aaNP_001307854.1

Ready in a moment

NM_001330111.2matches ENST00000576861.6

transcript variant 4

protein coding

none

768 nt

99 aaNP_001317040.1

Ready in a moment

NM_032356.6matches ENST00000333775.10

transcript variant 1

protein coding

none

704 nt

173 aaNP_115732.2

Ready in a moment

NM_001320924.3

Ready in a moment

NAA38

What NAA38 does

The RNA a design targets

Where NAA38 is expressed

The protein NAA38 encodes

Proteins STRING associates with NAA38

Where NAA38 acts, as Reactome curates it

Diseases linked to NAA38

Classified variants of NAA38

How much variation NAA38 tolerates

The same gene in mouse, rat and human

MicroRNAs hosted within NAA38

Long non-coding RNAs at the NAA38 locus

Papers that mention NAA38

From NAA38 to a sequence that silences it

Choose the region

Cover the isoforms you mean

Think across species early

Check expression in your model

Run the controls

Pick the product

NAA38

What NAA38 does

The RNA a design targets

Where NAA38 is expressed

The protein NAA38 encodes

Proteins STRING associates with NAA38

Where NAA38 acts, as Reactome curates it

Diseases linked to NAA38

Classified variants of NAA38

How much variation NAA38 tolerates

The same gene in mouse, rat and human

MicroRNAs hosted within NAA38

Long non-coding RNAs at the NAA38 locus

Papers that mention NAA38

NAA38

What NAA38 does

Gene summary

Protein function

The RNA a design targets

RefSeq 4 transcripts

A window on one transcript

Ensembl 0 transcripts

Where NAA38 is expressed

The protein NAA38 encodes

Proteins STRING associates with NAA38

Where NAA38 acts, as Reactome curates it

Diseases linked to NAA38

Classified variants of NAA38

How much variation NAA38 tolerates

The same gene in mouse, rat and human

MicroRNAs hosted within NAA38

Long non-coding RNAs at the NAA38 locus

Papers that mention NAA38

From NAA38 to a sequence that silences it

Choose the region

Cover the isoforms you mean

Think across species early

Check expression in your model

Run the controls

Pick the product

Gene summary

Protein function

RefSeq 4 transcripts

A window on one transcript

Ensembl 0 transcripts