Gene Human Homo sapiens

NECTIN4

nectin cell adhesion molecule 4

gene with protein product

Human NECTIN4MouseRat

Reading the ortholog votes for mouse and rat.

Location: Cytogenetic band 1q23.3NCBI: 1:161,070,998-161,089,558 on the minus strand, GRCh38.p14 (GCF_000001405.40), sequence NC_000001.11, annotation GCF_000001405.40-RS_2025_08 of 2025-08-01Ensembl: 1:161,070,988-161,090,045 on the minus strand, GRCh38.p14 (GCA_000001405.29), release 116Coordinates are one-based with both ends included, as each source reports them.
Also known as: nectin-4, PRR4, LNIR
Previous symbols: PVRL4

Gene identity, from HGNC · HGNC 2026-09-29 · read 2026-09-30 ET · HGNC:19688

Silence this gene

The order page opens with NECTIN4 and human filled in. The sequences are designed against the transcripts below; the price is on that page.

Order for NECTIN4

sdASO, toASO or siRNA, chosen on the next page

Bring your own sequence Transcripts

For research use only. Not for use in diagnostic or therapeutic procedures.

Summary
Transcripts
Expression
Protein
Interactions
Pathways
Disease
Variants
Constraint
Orthologs
MicroRNAs
Long non-coding RNAs
Literature
Silencing this gene

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Ready in a moment

01 Summary and function

What NECTIN4 does

This gene encodes a member of the nectin family. UniProt answered in a shape this page does not read, so nothing is shown for the protein entry. Reference b5cf9193-112.

NCBI Gene summary

Ready in a moment

02 Transcripts and isoforms

The RNA a design targets

Reading NCBI Datasets and Ensembl.Still reading. A first read of a gene can take a while; this page waits up to 80 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

Ready in a moment

03 Expression by tissue

Where NECTIN4 is expressed

Reading GTEx and the Human Protein Atlas.Still reading. A first read of a gene can take a while; this page waits up to 80 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

Ready in a moment

04 Protein

The protein NECTIN4 encodes

UniProt answered in a shape this page does not read, so nothing is shown for the protein entry. Reference b5cf9193-112.

Ready in a moment

05 Interactions

Proteins STRING associates with NECTIN4

Reading STRING.Still reading. A first read of a gene can take a while; this page waits up to 50 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

Ready in a moment

06 Pathways

Where NECTIN4 acts, as Reactome curates it

UniProt answered in a shape this page does not read, so nothing is shown for the pathway list. Reference b5cf9193-112.

Ready in a moment

07 Disease associations

Diseases linked to NECTIN4

301 Open Targets disease associations; ectodermal dysplasia-syndactyly syndrome first, at 0.78.

Open Targets

Ready in a moment

08 Variants

Classified variants of NECTIN4

Reading ClinVar.Still reading. A first read of a gene can take a while; this page waits up to 60 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

Ready in a moment

09 Constraint

How much variation NECTIN4 tolerates

Reading gnomAD and Open Targets.Still reading. A first read of a gene can take a while; this page waits up to 45 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

Ready in a moment

10 Orthologs

The same gene in mouse, rat and human

Reading the Alliance, NCBI, Ensembl Compara and RGD.Still reading. A first read of a gene can take a while; this page waits up to 145 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

Ready in a moment

11 MicroRNAs

MicroRNAs hosted within NECTIN4

Reading Ensembl and miRBase.Still reading. A first read of a gene can take a while; this page waits up to 110 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

Ready in a moment

12 Long non-coding RNAs

Long non-coding RNAs at the NECTIN4 locus

Reading Ensembl.Still reading. A first read of a gene can take a while; this page waits up to 110 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

Ready in a moment

13 Literature

Papers that mention NECTIN4

Reading Europe PMC.Still reading. A first read of a gene can take a while; this page waits up to 55 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

Ready in a moment

14 Silencing this gene

From NECTIN4 to a sequence that silences it

The AUMsilence platform designs the sequences against the human transcripts on this page. Six decisions are yours before it does. What is written under each is AUM's guidance; the timings and the concentrations are in the usage guide below.

01
Choose the region
A knockdown oligonucleotide can sit in the 5' untranslated region, the coding sequence or the 3' untranslated region, and all three are used. The coding sequence and the 3' untranslated region are the usual first choices for an RNase H design; the 5' end near the start codon suits a steric block. The map above shows where each region sits on the isoforms it draws.
02
Cover the isoforms you mean
An exon every isoform carries silences the whole gene; an exon only some isoforms carry silences those and spares the rest. Decide which you want before a sequence is chosen, and check the reference transcript (MANE Select in human; RefSeq Select and Ensembl canonical in mouse and rat) is the one your cells express.
03
Think across species early
The orthologs panel says whether mouse and rat carry the same gene. Whether one oligonucleotide can serve two species is a sequence question, settled at design by matching the candidate against each transcript, not by the protein identity shown there.
04
Check expression in your model
A transcript that is not expressed in your cells cannot show knockdown. Confirm the gene is expressed in the cell type and condition you will use, from your own data or a reference atlas, before the order. The expression panel above gives GTEx's median per tissue for a human gene; for mouse and rat it says that no atlas is on this page yet.
05
Run the controls
A scramble control of the same chemistry, a positive control against a gene known to knock down in your cells, untreated cells, and a mock condition where a transfection reagent is used. Read knockdown at the RNA level first, then at the protein; the usage guide gives the timing and the concentrations to start from.
06
Pick the product
AUMsilence sdASO needs no transfection reagent and works in the cells that resist one. AUMsilence toASO is the transfection-optimised version of the same design, and AUMsiRNA is the siRNA route. The selection guide compares them.

Order for NECTIN4 Bring your own sequence The usage guide Selection guide

For research use only. Not for use in diagnostic or therapeutic procedures.

Gene Human Homo sapiens

NECTIN4

Reading the record for NECTIN4 from HGNC, NCBI Gene and Ensembl.Still reading. A first read of a gene can take a while; this page waits up to 115 seconds for it, and its scripts then bring in the page, or a line saying what did not arrive.

The full name, the identifiers, the location and the notes from the sources arrive with the record. Nothing is filled in ahead of it.

Order door

The door to order for NECTIN4 opens with the record, which decides which product it carries. The order page itself is open now.

Bring your own sequence

For research use only. Not for use in diagnostic or therapeutic procedures.

This page is still reading the record. Its scripts replace this shell with the record when it arrives; with scripts off, it stays at this shell however long you wait.

01 Summary and function

What NECTIN4 does

Waiting for the record before reading NCBI Gene and UniProt.

02 Transcripts and isoforms

The RNA a design targets

Waiting for the record before reading NCBI Datasets and Ensembl.

03 Expression by tissue

Where NECTIN4 is expressed

Waiting for the record before reading GTEx and the Human Protein Atlas.

04 Protein

The protein NECTIN4 encodes

Waiting for the record before reading UniProt, InterPro, AlphaFold DB and PDBe.

05 Interactions

Proteins STRING associates with NECTIN4

Waiting for the record before reading STRING.

06 Pathways

Where NECTIN4 acts, as Reactome curates it

Waiting for the record before reading UniProt and Reactome.

07 Disease associations

Diseases linked to NECTIN4

Waiting for the record before reading Open Targets and ClinGen.

08 Variants

Classified variants of NECTIN4

Waiting for the record before reading ClinVar.

09 Constraint

How much variation NECTIN4 tolerates

Waiting for the record before reading gnomAD and Open Targets.

10 Orthologs

The same gene in mouse, rat and human

Waiting for the record before reading the Alliance, NCBI, Ensembl Compara and RGD.

11 MicroRNAs

MicroRNAs hosted within NECTIN4

Waiting for the record before reading Ensembl and miRBase.

12 Long non-coding RNAs

Long non-coding RNAs at the NECTIN4 locus

Waiting for the record before reading Ensembl.

13 Literature

Papers that mention NECTIN4

Waiting for the record before reading Europe PMC.

Accession	Name	Biotype	Labels	Exons	Spliced length	Protein	Sequence
NM_030916.3matches ENST00000368012.4	none given	protein coding	MANE Select	9	3,458 nt	510 aaNP_112178.2	Ready in a moment
XM_047431288.1	transcript variant X4	protein coding model	none	9	3,525 nt	459 aaXP_047287244.1	Ready in a moment
XM_011510021.3matches ENST00000891630.2	transcript variant X1	protein coding model	none	9	3,461 nt	511 aaXP_011508323.1	Ready in a moment
XM_011510022.3	Ready in a moment

Accession	Name	Biotype	Labels	Exons	Spliced length	Protein	Sequence
NM_030916.3matches ENST00000368012.4	none given	protein coding	MANE Select	9	3,458 nt	510 aaNP_112178.2	Ready in a moment
XM_047431288.1	transcript variant X4	protein coding model	none	9	3,525 nt	459 aaXP_047287244.1	Ready in a moment
XM_011510021.3matches ENST00000891630.2	transcript variant X1	protein coding model	none	9	3,461 nt	511 aaXP_011508323.1	Ready in a moment
XM_011510022.3	Ready in a moment

Accession	Name	Biotype	Labels	Exons	Spliced length	Protein	Sequence
ENST00000368012.4matches NM_030916.3	NECTIN4-201	protein coding	MANE SelectEnsembl canonical	9	3,458 nt	510 aaENSP00000356991.3	Ready in a moment
ENST00000891630.2	NECTIN4-203	protein coding	none	9	3,515 nt	511 aaENSP00000561689.1	Ready in a moment
ENST00001142179.1	NECTIN4-205	protein coding	none	9	3,512 nt	510 aaENSP00000809339.1	Ready in a moment
ENST00000968999.2	NECTIN4-204	protein coding	none	10	3,440 nt	510 aaENSP00000639058.1	Ready in a moment
ENST00000486694.1	NECTIN4-202	protein coding cds not defined	none	3	864 nt	none	Ready in a moment

NECTIN4

What NECTIN4 does

The RNA a design targets

Where NECTIN4 is expressed

The protein NECTIN4 encodes

Proteins STRING associates with NECTIN4

Where NECTIN4 acts, as Reactome curates it

Diseases linked to NECTIN4

Classified variants of NECTIN4

How much variation NECTIN4 tolerates

The same gene in mouse, rat and human

MicroRNAs hosted within NECTIN4

Long non-coding RNAs at the NECTIN4 locus

Papers that mention NECTIN4

From NECTIN4 to a sequence that silences it

Choose the region

Cover the isoforms you mean

Think across species early

Check expression in your model

Run the controls

Pick the product

NECTIN4

What NECTIN4 does

The RNA a design targets

Where NECTIN4 is expressed

The protein NECTIN4 encodes

Proteins STRING associates with NECTIN4

Where NECTIN4 acts, as Reactome curates it

Diseases linked to NECTIN4

Classified variants of NECTIN4

How much variation NECTIN4 tolerates

The same gene in mouse, rat and human

MicroRNAs hosted within NECTIN4

Long non-coding RNAs at the NECTIN4 locus

Papers that mention NECTIN4

NECTIN4

What NECTIN4 does

Gene summary

Protein function

The RNA a design targets

RefSeq 5 transcripts

A window on one transcript

Ensembl 5 transcripts

A window on one transcript

Where NECTIN4 is expressed

The protein NECTIN4 encodes

Proteins STRING associates with NECTIN4

Where NECTIN4 acts, as Reactome curates it

Diseases linked to NECTIN4

Classified variants of NECTIN4

How much variation NECTIN4 tolerates

The same gene in mouse, rat and human

MicroRNAs hosted within NECTIN4

Long non-coding RNAs at the NECTIN4 locus

Papers that mention NECTIN4

From NECTIN4 to a sequence that silences it

Choose the region

Cover the isoforms you mean

Think across species early

Check expression in your model

Run the controls

Pick the product

Gene summary

Protein function

RefSeq 5 transcripts

A window on one transcript

Ensembl 5 transcripts

A window on one transcript