Gene Human Homo sapiens

NOTCH2NLR

notch 2 N-terminal like R

gene with protein product

Human NOTCH2NLRMouseRat

Reading the ortholog votes for mouse and rat.

Location: Cytogenetic band 1p11.2NCBI: 1:120,723,945-120,794,851 on the plus strand, GRCh38.p14 (GCF_000001405.40), sequence NC_000001.11, annotation GCF_000001405.40-RS_2025_08 of 2025-08-01Ensembl: 1:120,723,912-120,794,851 on the plus strand, GRCh38.p14 (GCA_000001405.29), release 116Coordinates are one-based with both ends included, as each source reports them.

Gene identity, from HGNC · HGNC 2026-10-02 · read 2026-10-05 ET · HGNC:53925

Notes from the sources

NCBI places this gene on more than one sequence of GRCh38.p14 (1 NC_000001.11, 1 NW_025791753.1); the coordinates shown are the 1 placement

Silence this gene

The order page opens with NOTCH2NLR and human filled in. The sequences are designed against the transcripts below; the price is on that page.

Order for NOTCH2NLR

sdASO, toASO or siRNA

Bring your own sequence Transcripts

For research use only. Not for use in diagnostic or therapeutic procedures.

Summary
Transcripts
Expression
Protein
Interactions
Pathways
Disease
Variants
Constraint
Orthologs
MicroRNAs
Long non-coding RNAs
Literature
Silencing this gene

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Ready in a moment

01 Summary and function

What NOTCH2NLR does

Predicted to enable calcium ion binding activity.

NCBI Gene summary

Ready in a moment

02 Transcripts and isoforms

The RNA a design targets

Reading NCBI Datasets and Ensembl.Still reading. A first read of a gene can take a while; this page waits up to 80 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

Ready in a moment

03 Expression by tissue

Where NOTCH2NLR is expressed

Reading GTEx and the Human Protein Atlas.Still reading. A first read of a gene can take a while; this page waits up to 80 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

Ready in a moment

04 Protein

The protein NOTCH2NLR encodes

Reading UniProt, InterPro, AlphaFold DB and PDBe.Still reading. A first read of a gene can take a while; this page waits up to 80 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

Ready in a moment

05 Interactions

Proteins STRING associates with NOTCH2NLR

Reading STRING.Still reading. A first read of a gene can take a while; this page waits up to 50 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

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06 Pathways

Where NOTCH2NLR acts, as Reactome curates it

Reading UniProt and Reactome.Still reading. A first read of a gene can take a while; this page waits up to 60 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

Ready in a moment

07 Disease associations

Diseases linked to NOTCH2NLR

Reading Open Targets and ClinGen.Still reading. A first read of a gene can take a while; this page waits up to 105 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

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08 Variants

Classified variants of NOTCH2NLR

Reading ClinVar.Still reading. A first read of a gene can take a while; this page waits up to 60 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

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09 Constraint

How much variation NOTCH2NLR tolerates

Reading gnomAD and Open Targets.Still reading. A first read of a gene can take a while; this page waits up to 45 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

Ready in a moment

10 Orthologs

The same gene in mouse, rat and human

Reading the Alliance, NCBI, Ensembl Compara and RGD.Still reading. A first read of a gene can take a while; this page waits up to 145 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

Ready in a moment

11 MicroRNAs

MicroRNAs hosted within NOTCH2NLR

Reading Ensembl and miRBase.Still reading. A first read of a gene can take a while; this page waits up to 110 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

Ready in a moment

12 Long non-coding RNAs

Long non-coding RNAs at the NOTCH2NLR locus

Reading Ensembl.Still reading. A first read of a gene can take a while; this page waits up to 110 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

Ready in a moment

13 Literature

Papers that mention NOTCH2NLR

Reading Europe PMC.Still reading. A first read of a gene can take a while; this page waits up to 55 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

Ready in a moment

14 Silencing this gene

From NOTCH2NLR to a sequence that silences it

The AUMsilence platform designs the sequences against the human transcripts on this page. Six decisions are yours before it does. What is written under each is AUM's guidance; the timings and the concentrations are in the usage guide below.

01
Choose the region
A knockdown oligonucleotide can sit in the 5' untranslated region, the coding sequence or the 3' untranslated region, and all three are used. The coding sequence and the 3' untranslated region are the usual first choices for an RNase H design; the 5' end near the start codon suits a steric block. The map above shows where each region sits on the isoforms it draws.
02
Cover the isoforms you mean
An exon every isoform carries silences the whole gene; an exon only some isoforms carry silences those and spares the rest. Decide which you want before a sequence is chosen, and check the reference transcript (MANE Select in human; RefSeq Select and Ensembl canonical in mouse and rat) is the one your cells express.
03
Think across species early
The orthologs panel says whether mouse and rat carry the same gene. Whether one oligonucleotide can serve two species is a sequence question, settled at design by matching the candidate against each transcript, not by the protein identity shown there.
04
Check expression in your model
A transcript that is not expressed in your cells cannot show knockdown. Confirm the gene is expressed in the cell type and condition you will use, from your own data or a reference atlas, before the order. The expression panel above gives GTEx's median per tissue for a human gene; for mouse and rat it says that no atlas is on this page yet.
05
Run the controls
A scramble control of the same chemistry, a positive control against a gene known to knock down in your cells, untreated cells, and a mock condition where a transfection reagent is used. Read knockdown at the RNA level first, then at the protein; the usage guide gives the timing and the concentrations to start from.
06
Pick the product
AUMsilence sdASO needs no transfection reagent and works in the cells that resist one. AUMsilence toASO is the transfection-optimised version of the same design, and AUMsiRNA is the siRNA route. The selection guide compares them.

Order for NOTCH2NLR Bring your own sequence The usage guide Selection guide

For research use only. Not for use in diagnostic or therapeutic procedures.

Gene Human Homo sapiens

NOTCH2NLR

Reading the record for NOTCH2NLR from HGNC, NCBI Gene and Ensembl.Still reading. A first read of a gene can take a while; this page waits up to 115 seconds for it, and its scripts then bring in the page, or a line saying what did not arrive.

The full name, the identifiers, the location and the notes from the sources arrive with the record. Nothing is filled in ahead of it.

Order door

The door to order for NOTCH2NLR opens with the record, which decides which product it carries. The order page itself is open now.

Bring your own sequence

For research use only. Not for use in diagnostic or therapeutic procedures.

This page is still reading the record. Its scripts replace this shell with the record when it arrives; with scripts off, it stays at this shell however long you wait.

01 Summary and function

What NOTCH2NLR does

Waiting for the record before reading NCBI Gene and UniProt.

02 Transcripts and isoforms

The RNA a design targets

Waiting for the record before reading NCBI Datasets and Ensembl.

03 Expression by tissue

Where NOTCH2NLR is expressed

Waiting for the record before reading GTEx and the Human Protein Atlas.

04 Protein

The protein NOTCH2NLR encodes

Waiting for the record before reading UniProt, InterPro, AlphaFold DB and PDBe.

05 Interactions

Proteins STRING associates with NOTCH2NLR

Waiting for the record before reading STRING.

06 Pathways

Where NOTCH2NLR acts, as Reactome curates it

Waiting for the record before reading UniProt and Reactome.

07 Disease associations

Diseases linked to NOTCH2NLR

Waiting for the record before reading Open Targets and ClinGen.

08 Variants

Classified variants of NOTCH2NLR

Waiting for the record before reading ClinVar.

09 Constraint

How much variation NOTCH2NLR tolerates

Waiting for the record before reading gnomAD and Open Targets.

10 Orthologs

The same gene in mouse, rat and human

Waiting for the record before reading the Alliance, NCBI, Ensembl Compara and RGD.

11 MicroRNAs

MicroRNAs hosted within NOTCH2NLR

Waiting for the record before reading Ensembl and miRBase.

12 Long non-coding RNAs

Long non-coding RNAs at the NOTCH2NLR locus

Waiting for the record before reading Ensembl.

13 Literature

Papers that mention NOTCH2NLR

Waiting for the record before reading Europe PMC.

Accession	Name	Biotype	Labels	Exons	Spliced length	Protein	Sequence
ENST00000624419.3matches NM_001396072.1	NOTCH2NLR-201	protein coding	MANE SelectEnsembl canonical	5	2,089 nt	274 aaENSP00000485259.2	Ready in a moment
ENST00001141948.1	NOTCH2NLR-203	protein coding	none	5	2,122 nt	274 aaENSP00000814837.1	Ready in a moment
ENST00000690847.1	NOTCH2NLR-202	protein coding	none	4	1,403 nt	312 aaENSP00000509634.1	Ready in a moment

NOTCH2NLR

What NOTCH2NLR does

The RNA a design targets

Where NOTCH2NLR is expressed

The protein NOTCH2NLR encodes

Proteins STRING associates with NOTCH2NLR

Where NOTCH2NLR acts, as Reactome curates it

Diseases linked to NOTCH2NLR

Classified variants of NOTCH2NLR

How much variation NOTCH2NLR tolerates

The same gene in mouse, rat and human

MicroRNAs hosted within NOTCH2NLR

Long non-coding RNAs at the NOTCH2NLR locus

Papers that mention NOTCH2NLR

From NOTCH2NLR to a sequence that silences it

Choose the region

Cover the isoforms you mean

Think across species early

Check expression in your model

Run the controls

Pick the product

NOTCH2NLR

What NOTCH2NLR does

The RNA a design targets

Where NOTCH2NLR is expressed

The protein NOTCH2NLR encodes

Proteins STRING associates with NOTCH2NLR

Where NOTCH2NLR acts, as Reactome curates it

Diseases linked to NOTCH2NLR

Classified variants of NOTCH2NLR

How much variation NOTCH2NLR tolerates

The same gene in mouse, rat and human

MicroRNAs hosted within NOTCH2NLR

Long non-coding RNAs at the NOTCH2NLR locus

Papers that mention NOTCH2NLR

NOTCH2NLR

What NOTCH2NLR does

Gene summary

Protein function

The RNA a design targets

RefSeq 1 transcript

A window on one transcript

Ensembl 3 transcripts

A window on one transcript

Where NOTCH2NLR is expressed

The protein NOTCH2NLR encodes

Proteins STRING associates with NOTCH2NLR

Where NOTCH2NLR acts, as Reactome curates it

Diseases linked to NOTCH2NLR

Classified variants of NOTCH2NLR

How much variation NOTCH2NLR tolerates

The same gene in mouse, rat and human

MicroRNAs hosted within NOTCH2NLR

Long non-coding RNAs at the NOTCH2NLR locus

Papers that mention NOTCH2NLR

From NOTCH2NLR to a sequence that silences it

Choose the region

Cover the isoforms you mean

Think across species early

Check expression in your model

Run the controls

Pick the product

Gene summary

Protein function

RefSeq 1 transcript

A window on one transcript

Ensembl 3 transcripts

A window on one transcript