Reading the record for NR2C1 from HGNC, NCBI Gene and Ensembl.Still reading. A first read of a gene can take a while; this page waits up to 115 seconds for it, and its scripts then bring in the page, or a line saying what did not arrive.
The full name, the identifiers, the location and the notes from the sources arrive with the record. Nothing is filled in ahead of it.
Order door
The door to order for NR2C1 opens with the record, which decides which product it carries. The order page itself is open now.
Cytogenetic band 12q22NCBI: 12:95,020,229-95,073,618 on the minus strand, GRCh38.p14 (GCF_000001405.40), sequence NC_000012.12, annotation GCF_000001405.40-RS_2025_08 of 2025-08-01Ensembl: 12:95,020,229-95,073,641 on the minus strand, GRCh38.p14 (GCA_000001405.29), release 116Coordinates are one-based with both ends included, as each source reports them.
Reading NCBI Gene and UniProt.Still reading. A first read of a gene can take a while; this page waits up to 30 seconds for it, and its scripts then bring in the panel, or a line saying what did not arrive.
02 / Transcripts and isoforms
The RNA a design targets
Ready in a moment
Reading NCBI Datasets and Ensembl.Still reading. A first read of a gene can take a while; this page waits up to 80 seconds for it, and its scripts then bring in the panel, or a line saying what did not arrive.
03 / Expression by tissue
Where NR2C1 is expressed
Reading GTEx and the Human Protein Atlas.Still reading. A first read of a gene can take a while; this page waits up to 80 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.
Ready in a moment
14 / Silencing this gene
From NR2C1 to a sequence that silences it
The AUMsilence™ platform designs the sequences against the human transcripts on this page. Six decisions are yours before it does. What is written under each is AUM's guidance; the timings and the concentrations are in the usage guide below.
01
Choose the region
A knockdown oligonucleotide can sit in the 5' untranslated region, the coding sequence or the 3' untranslated region, and all three are used. The coding sequence and the 3' untranslated region are the usual first choices for an RNase H design; the 5' end near the start codon suits a steric block. The map above shows where each region sits on the isoforms it draws.
02
Cover the isoforms you mean
An exon every isoform carries silences the whole gene; an exon only some isoforms carry silences those and spares the rest. Decide which you want before a sequence is chosen, and check the reference transcript (MANE Select in human; RefSeq Select and Ensembl canonical in mouse and rat) is the one your cells express.
03
Think across species early
The orthologs panel says whether mouse and rat carry the same gene. Whether one oligonucleotide can serve two species is a sequence question, settled at design by matching the candidate against each transcript, not by the protein identity shown there.
04
Check expression in your model
A transcript that is not expressed in your cells cannot show knockdown. Confirm the gene is expressed in the cell type and condition you will use, from your own data or a reference atlas, before the order. The expression panel above gives GTEx's median per tissue for a human gene; for mouse and rat it says that no atlas is on this page yet.
GTEx's medians say how much of this gene's RNA the sampled tissues carried, tissue by tissue, in transcripts per million, and the Human Protein Atlas adds how specific that expression is and where the protein sits in the cell. Read the profile for the tissue your cells come from, then check your own model: a transcript that is not expressed in the cells you will use cannot show knockdown, and a bulk tissue median is not a cell line.
The median is the middle sample of a tissue, so a gene expressed in a few cells of a mixed tissue reads low here and may still be the one your cell type needs. Nothing on this panel is adjusted or averaged across tissues; each figure is the source's own, and a tissue GTEx did not sample is absent from the chart.
04 / Protein
The protein NR2C1 encodes
Reading UniProt, InterPro, AlphaFold DB and PDBe.Still reading. A first read of a gene can take a while; this page waits up to 80 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.
Ready in a moment
05 / Interactions
Proteins STRING associates with NR2C1
Ready in a moment
06 / Pathways
Where NR2C1 acts, as Reactome curates it
Reading UniProt and Reactome.Still reading. A first read of a gene can take a while; this page waits up to 60 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.
Ready in a moment
07 / Disease associations
Diseases linked to NR2C1
Reading Open Targets and ClinGen.Still reading. A first read of a gene can take a while; this page waits up to 105 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.
Ready in a moment
08 / Variants
Classified variants of NR2C1
Reading ClinVar.Still reading. A first read of a gene can take a while; this page waits up to 60 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.
Ready in a moment
09 / Constraint
How much variation NR2C1 tolerates
Reading gnomAD and Open Targets.Still reading. A first read of a gene can take a while; this page waits up to 45 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.
Ready in a moment
10 / Orthologs
The same gene in mouse, rat and human
Ready in a moment
11 /MicroRNAs
MicroRNAs hosted within NR2C1
Ready in a moment
12 / Long non-coding RNAs
Long non-coding RNAs at the NR2C1 locus
Ready in a moment
13 / Literature
Papers that mention NR2C1
Reading Europe PMC.Still reading. A first read of a gene can take a while; this page waits up to 55 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.
Ready in a moment
05
Run the controls
A scramble control of the same chemistry, a positive control against a gene known to knock down in your cells, untreated cells, and a mock condition where a transfection reagent is used. Read knockdown at the RNA level first, then at the protein; the usage guide gives the timing and the concentrations to start from.
06
Pick the product
AUMsilence sdASO needs no transfection reagent and works in the cells that resist one. AUMsilence toASO is the transfection-optimised version of the same design, and AUMsiRNA™ is the siRNA route. The selection guide compares them.
For research use only. Not for use in diagnostic or therapeutic procedures.
This gene encodes a nuclear hormone receptor characterized by a highly…
NCBI Gene summary
13 RefSeq and 48 Ensembl transcripts on GRCh38.p14; MANE Select NM_003297.4.
NCBI Datasets · Ensembl
The 25 highest-scoring STRING partners at or above a combined score of 0.4, of up to 25 asked for; NRIP1, HDAC3, NR2C2 lead.
STRING v12.0
Mouse Nr2c1 by 3 of 3 votes; rat Nr2c1 by 3 of 3 votes. RGD is not answering, so the ortholog list could not be shown. Try again later. Reference 983f95f7-9f0.
Alliance · NCBI · Ensembl Compara
No annotated microRNA lies within NR2C1 in Ensembl release 116, on GRCh38.p14.
Ensembl · miRBase
No annotated long non-coding RNA overlaps NR2C1 in Ensembl release 116, on GRCh38.p14.
Ensembl
Gene summary
This gene encodes a nuclear hormone receptor characterized by a highly conserved DNA binding domain (DBD), a variable hinge region, and a carboxy-terminal ligand binding domain (LBD) that is typical for all members of the steroid/thyroid hormone receptor superfamily. This protein also belongs to a large family of ligand-inducible transcription factors that regulate gene expression by binding to specific DNA sequences within promoters of target genes. Multiple alternatively spliced transcript variants have been described, but the full-length nature of some of these variants has not been determined.
Provided by RefSeq, Jul 2008, through NCBI Gene. NCBI disclaimer
Protein function
Nuclear receptor subfamily 2 group C member 1, P13056
Orphan nuclear receptor. Binds the IR7 element in the promoter of its own gene in an autoregulatory negative feedback mechanism. Primarily repressor of a broad range of genes. Binds to hormone response elements (HREs) consisting of two 5'-AGGTCA-3' half site direct repeat consensus sequences. Together with NR2C2, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription. Also activator of OCT4 gene expression. May be involved in stem cell proliferation and differentiation. Mediator of retinoic acid-regulated preadipocyte proliferation
NCBI Gene summary · NCBI Gene annotation RS_2025_08 · read · NCBI Gene 7181Data from NCBI, provided as is; NCBI's policies and disclaimers apply.
UniProtKB function · 2026_03 · read · UniProt P13056UniProt data are available under the Creative Commons Attribution 4.0 licence.
Placed on GRCh38.p14 (GCF_000001405.40). MANE Select marks the one transcript RefSeq and Ensembl agree is the reference for this gene.
RefSeq 13 transcripts
coding sequence, tall
untranslated region, thin
non-coding exon
intron, fixed width
Genomic strand: minus. Drawn 5' to 3', so exon 1 sits at the left here and at the highest coordinate on the chromosome.
NM_003297.4NM_003297.4MANE Select
A window on one transcript
One pixel of the map above stands for several bases, and a block too short to see is drawn wider than its own scale, so the map chooses a region and the sequence here chooses the window. Click an exon on a row of the map, or drag across a row; then set the exact start and end below.
These controls are ready in a moment.
No transcript is chosen.
Once a window is chosen this panel shows its length, its G and C count as a percentage of that length, the letters it is made of, the exons it falls in, whether it crosses a junction, and its antisense strand.
Not listed, because the source places them on another assembly only: XM_054373118.1 (not placed on GRCh38.p14); XM_054373119.1 (not placed on GRCh38.p14); XM_054373120.1 (not placed on GRCh38.p14); XM_054373121.1 (not placed on GRCh38.p14); XM_054373122.1 (not placed on GRCh38.p14); XM_054373123.1 (not placed on GRCh38.p14); XM_054373124.1 (not placed on GRCh38.p14); XM_054373125.1 (not placed on GRCh38.p14); XM_054373126.1 (not placed on GRCh38.p14); XM_054373127.1 (not placed on GRCh38.p14).
NCBI Datasets, RefSeq transcripts · NCBI Datasets 18.38.0; GCF_000001405.40-RS_2025_08 · read · NCBI Gene 7181Data from NCBI, provided as is; NCBI's policies and disclaimers apply.
Ensembl 48 transcripts
A window on one transcript
One pixel of the map above stands for several bases, and a block too short to see is drawn wider than its own scale, so the map chooses a region and the sequence here chooses the window. Click an exon on a row of the map, or drag across a row; then set the exact start and end below.
These controls are ready in a moment.
No transcript is chosen.
Once a window is chosen this panel shows its length, its G and C count as a percentage of that length, the letters it is made of, the exons it falls in, whether it crosses a junction, and its antisense strand.
Lengths are spliced lengths, as each source states them. Exon ranks follow the strand: on a minus-strand gene exon 1 has the highest genomic coordinate. Reference assembly for human: GRCh38.
XM_006719585.3XM_006719585.3
XM_005269133.3XM_005269133.3
XM_011538716.3XM_011538716.3
XM_047429494.1XM_047429494.1
XM_006719584.3XM_006719584.3
XM_011538717.3XM_011538717.3
XM_047429495.1XM_047429495.1
NM_001127362.2NM_001127362.2
NM_001032287.3NM_001032287.3
XM_047429496.1XM_047429496.1
XM_047429497.1XM_047429497.1
XM_047429499.1XM_047429499.1
scale
Drawn 5' to 3' from each transcript's exons as placed on the reference assembly; exon 1 is the 5' exon on the transcript's own strand. Exon blocks are to scale with each other; introns are drawn at one fixed width whatever their length, so the map is not to scale along the chromosome. Numbers are exon ranks along the strand; a rank is omitted where the exon is too narrow to carry it.
Drawn 5' to 3' from each transcript's exons as placed on the reference assembly; exon 1 is the 5' exon on the transcript's own strand. Exon blocks are to scale with each other, except 2 blocks too short to see, widened to a fixed few pixels; introns are drawn at one fixed width whatever their length, so the map is not to scale along the chromosome. Numbers are exon ranks along the strand; a rank is omitted where the exon is too narrow to carry it.
pLI 0.02115 and LOEUF 0.590 in gnomAD v4 (GRCh38), on ENST00000333003.10.
gnomAD
603 residues, reviewed P13056; 19 entries from the member databases this page shows along the chain; mean pLDDT 64.38; no experimental structure at PDBe.
UniProt · InterPro · AlphaFold DB · PDBe
54 GTEx tissues; the highest median in Brain - Cerebellar Hemisphere, 43.1 TPM.
GTEx
776 PubMed-indexed papers mention NR2C1 at Europe PMC, newest first. Europe PMC ignores letter case, so the count also covers another species' symbol spelled with the same letters.
Europe PMC
2 curated, 0 inferred Reactome pathways for P13056 in human, v97.
Reactome
77 Open Targets disease associations; Flexion contracture first, at 0.26.
Open Targets
ClinVar: 100 records for NR2C1, 6 pathogenic or likely pathogenic.
