Gene Human Homo sapiens

OLFM2

olfactomedin 2

gene with protein product

Human OLFM2MouseRat

Reading the ortholog votes for mouse and rat.

Location: Cytogenetic band 19p13.2NCBI: 19:9,853,718-9,936,515 on the minus strand, GRCh38.p14 (GCF_000001405.40), sequence NC_000019.10, annotation GCF_000001405.40-RS_2025_08 of 2025-08-01Ensembl: 19:9,853,717-9,936,559 on the minus strand, GRCh38.p14 (GCA_000001405.29), release 116Coordinates are one-based with both ends included, as each source reports them.
Also known as: OlfC, NOE2

Gene identity, from HGNC · HGNC 2026-10-02 · read 2026-10-02 ET · HGNC:17189

Silence this gene

The order page opens with OLFM2 and human filled in. The sequences are designed against the transcripts below; the price is on that page.

Order for OLFM2

sdASO, toASO or siRNA

Bring your own sequence Transcripts

For research use only. Not for use in diagnostic or therapeutic procedures.

Summary
Transcripts
Expression
Protein
Interactions
Pathways
Disease
Variants
Constraint
Orthologs
MicroRNAs
Long non-coding RNAs
Literature
Silencing this gene

A line below that says it is reading needs JavaScript to be replaced: with scripts off, it stays at that line however long you wait. Opening a card also needs JavaScript.

Ready in a moment

01 Summary and function

What OLFM2 does

Involved in positive regulation of smooth muscle cell differentiation.

NCBI Gene summary

Ready in a moment

02 Transcripts and isoforms

The RNA a design targets

Reading NCBI Datasets and Ensembl.Still reading. A first read of a gene can take a while; this page waits up to 80 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

Ready in a moment

03 Expression by tissue

Where OLFM2 is expressed

Reading GTEx and the Human Protein Atlas.Still reading. A first read of a gene can take a while; this page waits up to 80 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

Ready in a moment

04 Protein

The protein OLFM2 encodes

Reading UniProt, InterPro, AlphaFold DB and PDBe.Still reading. A first read of a gene can take a while; this page waits up to 80 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

Ready in a moment

05 Interactions

Proteins STRING associates with OLFM2

The 25 highest-scoring STRING partners at or above a combined score of 0.4, of up to 25 asked for; GRIA1, GRIA4, CNIH2 lead.

STRING v12.0

Ready in a moment

06 Pathways

Where OLFM2 acts, as Reactome curates it

Reading UniProt and Reactome.Still reading. A first read of a gene can take a while; this page waits up to 60 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

Ready in a moment

07 Disease associations

Diseases linked to OLFM2

Reading Open Targets and ClinGen.Still reading. A first read of a gene can take a while; this page waits up to 105 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

Ready in a moment

08 Variants

Classified variants of OLFM2

Reading ClinVar.Still reading. A first read of a gene can take a while; this page waits up to 60 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

Ready in a moment

09 Constraint

How much variation OLFM2 tolerates

Reading gnomAD and Open Targets.Still reading. A first read of a gene can take a while; this page waits up to 45 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

Ready in a moment

10 Orthologs

The same gene in mouse, rat and human

Reading the Alliance, NCBI, Ensembl Compara and RGD.Still reading. A first read of a gene can take a while; this page waits up to 145 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

Ready in a moment

11 MicroRNAs

MicroRNAs hosted within OLFM2

Reading Ensembl and miRBase.Still reading. A first read of a gene can take a while; this page waits up to 110 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

Ready in a moment

12 Long non-coding RNAs

Long non-coding RNAs at the OLFM2 locus

Reading Ensembl.Still reading. A first read of a gene can take a while; this page waits up to 110 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

Ready in a moment

13 Literature

Papers that mention OLFM2

Reading Europe PMC.Still reading. A first read of a gene can take a while; this page waits up to 55 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

Ready in a moment

14 Silencing this gene

From OLFM2 to a sequence that silences it

The AUMsilence platform designs the sequences against the human transcripts on this page. Six decisions are yours before it does. What is written under each is AUM's guidance; the timings and the concentrations are in the usage guide below.

01
Choose the region
A knockdown oligonucleotide can sit in the 5' untranslated region, the coding sequence or the 3' untranslated region, and all three are used. The coding sequence and the 3' untranslated region are the usual first choices for an RNase H design; the 5' end near the start codon suits a steric block. The map above shows where each region sits on the isoforms it draws.
02
Cover the isoforms you mean
An exon every isoform carries silences the whole gene; an exon only some isoforms carry silences those and spares the rest. Decide which you want before a sequence is chosen, and check the reference transcript (MANE Select in human; RefSeq Select and Ensembl canonical in mouse and rat) is the one your cells express.
03
Think across species early
The orthologs panel says whether mouse and rat carry the same gene. Whether one oligonucleotide can serve two species is a sequence question, settled at design by matching the candidate against each transcript, not by the protein identity shown there.
04
Check expression in your model
A transcript that is not expressed in your cells cannot show knockdown. Confirm the gene is expressed in the cell type and condition you will use, from your own data or a reference atlas, before the order. The expression panel above gives GTEx's median per tissue for a human gene; for mouse and rat it says that no atlas is on this page yet.
05
Run the controls
A scramble control of the same chemistry, a positive control against a gene known to knock down in your cells, untreated cells, and a mock condition where a transfection reagent is used. Read knockdown at the RNA level first, then at the protein; the usage guide gives the timing and the concentrations to start from.
06
Pick the product
AUMsilence sdASO needs no transfection reagent and works in the cells that resist one. AUMsilence toASO is the transfection-optimised version of the same design, and AUMsiRNA is the siRNA route. The selection guide compares them.

Order for OLFM2 Bring your own sequence The usage guide Selection guide

For research use only. Not for use in diagnostic or therapeutic procedures.

Gene Human Homo sapiens

OLFM2

Reading the record for OLFM2 from HGNC, NCBI Gene and Ensembl.Still reading. A first read of a gene can take a while; this page waits up to 115 seconds for it, and its scripts then bring in the page, or a line saying what did not arrive.

The full name, the identifiers, the location and the notes from the sources arrive with the record. Nothing is filled in ahead of it.

Order door

The door to order for OLFM2 opens with the record, which decides which product it carries. The order page itself is open now.

Bring your own sequence

For research use only. Not for use in diagnostic or therapeutic procedures.

This page is still reading the record. Its scripts replace this shell with the record when it arrives; with scripts off, it stays at this shell however long you wait.

01 Summary and function

What OLFM2 does

Waiting for the record before reading NCBI Gene and UniProt.

02 Transcripts and isoforms

The RNA a design targets

Waiting for the record before reading NCBI Datasets and Ensembl.

03 Expression by tissue

Where OLFM2 is expressed

Waiting for the record before reading GTEx and the Human Protein Atlas.

04 Protein

The protein OLFM2 encodes

Waiting for the record before reading UniProt, InterPro, AlphaFold DB and PDBe.

05 Interactions

Proteins STRING associates with OLFM2

Waiting for the record before reading STRING.

06 Pathways

Where OLFM2 acts, as Reactome curates it

Waiting for the record before reading UniProt and Reactome.

07 Disease associations

Diseases linked to OLFM2

Waiting for the record before reading Open Targets and ClinGen.

08 Variants

Classified variants of OLFM2

Waiting for the record before reading ClinVar.

09 Constraint

How much variation OLFM2 tolerates

Waiting for the record before reading gnomAD and Open Targets.

10 Orthologs

The same gene in mouse, rat and human

Waiting for the record before reading the Alliance, NCBI, Ensembl Compara and RGD.

11 MicroRNAs

MicroRNAs hosted within OLFM2

Waiting for the record before reading Ensembl and miRBase.

12 Long non-coding RNAs

Long non-coding RNAs at the OLFM2 locus

Waiting for the record before reading Ensembl.

13 Literature

Papers that mention OLFM2

Waiting for the record before reading Europe PMC.

Accession	Name	Biotype	Labels	Exons	Spliced length	Protein	Sequence
NM_058164.4matches ENST00000264833.9	transcript variant 2	protein coding	MANE Select	6	1,982 nt	454 aaNP_477512.1	Ready in a moment
NM_001304347.2matches ENST00000593091.2	transcript variant 1	protein coding	none	6	2,089 nt	478 aaNP_001291276.1	Ready in a moment
XM_047439713.1	transcript variant X1	protein coding model	none	6	1,913 nt	386 aaXP_047295669.1	Ready in a moment
NM_001304348.2matches ENST00000590841.6	Ready in a moment

Accession	Name	Biotype	Labels	Exons	Spliced length	Protein	Sequence
NM_058164.4matches ENST00000264833.9	transcript variant 2	protein coding	MANE Select	6	1,982 nt	454 aaNP_477512.1	Ready in a moment
NM_001304347.2matches ENST00000593091.2	transcript variant 1	protein coding	none	6	2,089 nt	478 aaNP_001291276.1	Ready in a moment
XM_047439713.1	transcript variant X1	protein coding model	none	6	1,913 nt	386 aaXP_047295669.1	Ready in a moment
NM_001304348.2matches ENST00000590841.6	Ready in a moment

Accession	Name	Biotype	Labels	Exons	Spliced length	Protein	Sequence
ENST00000264833.9matches NM_058164.4	OLFM2-201	protein coding	MANE SelectEnsembl canonical	6	1,982 nt	454 aaENSP00000264833.3	Ready in a moment
ENST00000593091.2	OLFM2-205	protein coding	none	6	2,124 nt	478 aaENSP00000465809.2	Ready in a moment
ENST00001077063.1	OLFM2-211	protein coding	none	6	2,041 nt	459 aaENSP00000746869.1	Ready in a moment
ENST00001142664.1	OLFM2-213	protein coding	none	6	2,026 nt	454 aaENSP00000803663.1	Ready in a moment
ENST00000983299.1	OLFM2-209	protein coding	none	6	2,020 nt	452 aaENSP00000653116.1	Ready in a moment
ENST00000971550.2	OLFM2-208	protein coding	none	6	2,017 nt	451 aaENSP00000641609.1	Ready in a moment
ENST00000882493.2	OLFM2-206	protein coding	none	5	1,879 nt	405 aaENSP00000552552.1	Ready in a moment
ENST00001122306.1	OLFM2-212	protein coding	none	5	1,876 nt	404 aaENSP00000792111.1	Ready in a moment
ENST00001041544.1	OLFM2-210	nonsense mediated decay	none	6	1,857 nt	156 aaENSP00000711361.1	Ready in a moment
ENST00000590841.6	OLFM2-203	protein coding	none	5	1,692 nt	376 aaENSP00000464877.1	Ready in a moment
ENST00000923214.2	OLFM2-207	protein coding	none	3	1,552 nt	296 aaENSP00000593273.1	Ready in a moment
ENST00000592448.1	OLFM2-204	nonsense mediated decay	none	5	713 nt	78 aaENSP00000466018.1	Ready in a moment
ENST00000590410.1	OLFM2-202	retained intron	none	4	593 nt	none	Ready in a moment

OLFM2

What OLFM2 does

The RNA a design targets

Where OLFM2 is expressed

The protein OLFM2 encodes

Proteins STRING associates with OLFM2

Where OLFM2 acts, as Reactome curates it

Diseases linked to OLFM2

Classified variants of OLFM2

How much variation OLFM2 tolerates

The same gene in mouse, rat and human

MicroRNAs hosted within OLFM2

Long non-coding RNAs at the OLFM2 locus

Papers that mention OLFM2

From OLFM2 to a sequence that silences it

Choose the region

Cover the isoforms you mean

Think across species early

Check expression in your model

Run the controls

Pick the product

OLFM2

What OLFM2 does

The RNA a design targets

Where OLFM2 is expressed

The protein OLFM2 encodes

Proteins STRING associates with OLFM2

Where OLFM2 acts, as Reactome curates it

Diseases linked to OLFM2

Classified variants of OLFM2

How much variation OLFM2 tolerates

The same gene in mouse, rat and human

MicroRNAs hosted within OLFM2

Long non-coding RNAs at the OLFM2 locus

Papers that mention OLFM2

OLFM2

What OLFM2 does

Gene summary

Protein function

The RNA a design targets

RefSeq 4 transcripts

A window on one transcript

Ensembl 13 transcripts

A window on one transcript

Where OLFM2 is expressed

The protein OLFM2 encodes

Proteins STRING associates with OLFM2

Where OLFM2 acts, as Reactome curates it

Diseases linked to OLFM2

Classified variants of OLFM2

How much variation OLFM2 tolerates

The same gene in mouse, rat and human

MicroRNAs hosted within OLFM2

Long non-coding RNAs at the OLFM2 locus

Papers that mention OLFM2

From OLFM2 to a sequence that silences it

Choose the region

Cover the isoforms you mean

Think across species early

Check expression in your model

Run the controls

Pick the product

Gene summary

Protein function

RefSeq 4 transcripts

A window on one transcript

Ensembl 13 transcripts

A window on one transcript