Gene Human Homo sapiens

OXCT1

3-oxoacid CoA-transferase 1

gene with protein product

Human OXCT1MouseRat

Reading the ortholog votes for mouse and rat.

Location: Cytogenetic band 5p13.1NCBI: 5:41,730,065-41,870,425 on the minus strand, GRCh38.p14 (GCF_000001405.40), sequence NC_000005.10, annotation GCF_000001405.40-RS_2025_08 of 2025-08-01Ensembl: 5:41,729,460-41,870,590 on the minus strand, GRCh38.p14 (GCA_000001405.29), release 116Coordinates are one-based with both ends included, as each source reports them.
Also known as: SCOT
Previous symbols: OXCT

Gene identity, from HGNC · HGNC 2026-09-18 · read 2026-09-24 ET · HGNC:8527

Silence this gene

The order page opens with OXCT1 and human filled in. The sequences are designed against the transcripts below; the price is on that page.

Order for OXCT1

sdASO, toASO or siRNA, chosen on the next page

Bring your own sequence Transcripts

For research use only. Not for use in diagnostic or therapeutic procedures.

Summary
Transcripts
Expression
Protein
Interactions
Pathways
Disease
Variants

A line below that says it is reading needs JavaScript to be replaced: with scripts off, it stays at that line however long you wait. Opening a card also needs JavaScript.

Ready in a moment

01 Summary and function

What OXCT1 does

Ready in a moment

02 Transcripts and isoforms

The RNA a design targets

Reading NCBI Datasets and Ensembl.Still reading. A first read of a gene can take a while; this page waits up to 80 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

Ready in a moment

14 Silencing this gene

From OXCT1 to a sequence that silences it

The AUMsilence platform designs the sequences against the human transcripts on this page. Six decisions are yours before it does. What is written under each is AUM's guidance; the timings and the concentrations are in the usage guide below.

01
Choose the region
A knockdown oligonucleotide can sit in the 5' untranslated region, the coding sequence or the 3' untranslated region, and all three are used. The coding sequence and the 3' untranslated region are the usual first choices for an RNase H design; the 5' end near the start codon suits a steric block. The map above shows where each region sits on the isoforms it draws.
02
Cover the isoforms you mean
An exon every isoform carries silences the whole gene; an exon only some isoforms carry silences those and spares the rest. Decide which you want before a sequence is chosen, and check the reference transcript (MANE Select in human; RefSeq Select and Ensembl canonical in mouse and rat) is the one your cells express.
03
Think across species early
The orthologs panel says whether mouse and rat carry the same gene. Whether one oligonucleotide can serve two species is a sequence question, settled at design by matching the candidate against each transcript, not by the protein identity shown there.
04
Check expression in your model
A transcript that is not expressed in your cells cannot show knockdown. Confirm the gene is expressed in the cell type and condition you will use, from your own data or a reference atlas, before the order. The expression panel above gives GTEx's median per tissue for a human gene; for mouse and rat it says that no atlas is on this page yet.

Gene Human Homo sapiens

OXCT1

Reading the record for OXCT1 from HGNC, NCBI Gene and Ensembl.Still reading. A first read of a gene can take a while; this page waits up to 115 seconds for it, and its scripts then bring in the page, or a line saying what did not arrive.

The full name, the identifiers, the location and the notes from the sources arrive with the record. Nothing is filled in ahead of it.

Order door

The door to order for OXCT1 opens with the record, which decides which product it carries. The order page itself is open now.

Bring your own sequence

For research use only. Not for use in diagnostic or therapeutic procedures.

This page is still reading the record. Its scripts replace this shell with the record when it arrives; with scripts off, it stays at this shell however long you wait.

01 Summary and function

What OXCT1 does

Waiting for the record before reading NCBI Gene and UniProt.

02 Transcripts and isoforms

The RNA a design targets

Waiting for the record before reading NCBI Datasets and Ensembl.

03 Expression by tissue

Where OXCT1 is expressed

Waiting for the record before reading GTEx and the Human Protein Atlas.

04 Protein

The protein OXCT1 encodes

Waiting for the record before reading UniProt, InterPro, AlphaFold DB and PDBe.

05 Interactions

Proteins STRING associates with OXCT1

Waiting for the record before reading STRING.

06 Pathways

Where OXCT1 acts, as Reactome curates it

Waiting for the record before reading UniProt and Reactome.

07 Disease associations

Diseases linked to OXCT1

Waiting for the record before reading Open Targets and ClinGen.

08 Variants

Classified variants of OXCT1

Waiting for the record before reading ClinVar.

09 Constraint

How much variation OXCT1 tolerates

Waiting for the record before reading gnomAD and Open Targets.

10 Orthologs

The same gene in mouse, rat and human

Waiting for the record before reading the Alliance, NCBI, Ensembl Compara and RGD.

11 MicroRNAs

MicroRNAs hosted within OXCT1

Waiting for the record before reading Ensembl and miRBase.

12 Long non-coding RNAs

Long non-coding RNAs at the OXCT1 locus

Waiting for the record before reading Ensembl.

13 Literature

Papers that mention OXCT1

Waiting for the record before reading Europe PMC.

Accession	Name	Biotype	Labels	Exons	Spliced length	Protein	Sequence
NM_000436.4matches ENST00000196371.10	transcript variant 3	protein coding	MANE Select	17	3,294 nt	520 aaNP_000427.1	Ready in a moment
NM_001364300.2	transcript variant 2	protein coding	none	17	3,930 nt	527 aaNP_001351229.1	Ready in a moment
NM_001364299.2matches ENST00000997981.1	transcript variant 1	protein coding	none	18	3,315 nt	527 aaNP_001351228.1	Ready in a moment
NM_001364301.2	transcript variant 4	Ready in a moment

Accession	Name	Biotype	Labels	Exons	Spliced length	Protein	Sequence
NM_000436.4matches ENST00000196371.10	transcript variant 3	protein coding	MANE Select	17	3,294 nt	520 aaNP_000427.1	Ready in a moment
NM_001364300.2	transcript variant 2	protein coding	none	17	3,930 nt	527 aaNP_001351229.1	Ready in a moment
NM_001364299.2matches ENST00000997981.1	transcript variant 1	protein coding	none	18	3,315 nt	527 aaNP_001351228.1	Ready in a moment
NM_001364301.2	transcript variant 4	Ready in a moment

OXCT1

What OXCT1 does

The RNA a design targets

From OXCT1 to a sequence that silences it

Choose the region

Cover the isoforms you mean

Think across species early

Check expression in your model

OXCT1

What OXCT1 does

The RNA a design targets

Where OXCT1 is expressed

The protein OXCT1 encodes

Proteins STRING associates with OXCT1

Where OXCT1 acts, as Reactome curates it

Diseases linked to OXCT1

Classified variants of OXCT1

How much variation OXCT1 tolerates

The same gene in mouse, rat and human

MicroRNAs hosted within OXCT1

Long non-coding RNAs at the OXCT1 locus

Papers that mention OXCT1

OXCT1

What OXCT1 does

Gene summary

Protein function

The RNA a design targets

RefSeq 7 transcripts

A window on one transcript

Ensembl 0 transcripts

From OXCT1 to a sequence that silences it

Choose the region

Cover the isoforms you mean

Think across species early

Check expression in your model

Where OXCT1 is expressed

The protein OXCT1 encodes

Proteins STRING associates with OXCT1

Where OXCT1 acts, as Reactome curates it

Diseases linked to OXCT1

Classified variants of OXCT1

How much variation OXCT1 tolerates

The same gene in mouse, rat and human

MicroRNAs hosted within OXCT1

Long non-coding RNAs at the OXCT1 locus

Papers that mention OXCT1

Run the controls

Pick the product

Gene summary

Protein function

RefSeq 7 transcripts

A window on one transcript

Ensembl 0 transcripts