Gene Human Homo sapiens

PCDHGB4

protocadherin gamma subfamily B, 4

complex locus constituent

Human PCDHGB4MouseRat

Reading the ortholog votes for mouse and rat.

Location: Cytogenetic band 5q31NCBI: 5:141,387,698-141,512,975 on the plus strand, GRCh38.p14 (GCF_000001405.40), sequence NC_000005.10, annotation GCF_000001405.40-RS_2025_08 of 2025-08-01Ensembl: 5:141,387,698-141,512,977 on the plus strand, GRCh38.p14 (GCA_000001405.29), release 116Coordinates are one-based with both ends included, as each source reports them.
Also known as: FIB2, CDH20, PCDH-GAMMA-B4

Gene identity, from HGNC · HGNC 2026-10-02 · read 2026-10-02 ET · HGNC:8711

Silence this gene

The order page opens with PCDHGB4 and human filled in. The sequences are designed against the transcripts below; the price is on that page.

Order for PCDHGB4

sdASO, toASO or siRNA, chosen on the next page

Bring your own sequence Transcripts

For research use only. Not for use in diagnostic or therapeutic procedures.

Summary
Transcripts
Expression
Protein
Interactions
Pathways
Disease
Variants
Constraint
Orthologs
MicroRNAs
Long non-coding RNAs
Literature
Silencing this gene

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01 Summary and function

What PCDHGB4 does

Ready in a moment

02 Transcripts and isoforms

The RNA a design targets

Reading NCBI Datasets and Ensembl.Still reading. A first read of a gene can take a while; this page waits up to 80 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.

Ready in a moment

14 Silencing this gene

From PCDHGB4 to a sequence that silences it

The AUMsilence platform designs the sequences against the human transcripts on this page. Six decisions are yours before it does. What is written under each is AUM's guidance; the timings and the concentrations are in the usage guide below.

01
Choose the region
A knockdown oligonucleotide can sit in the 5' untranslated region, the coding sequence or the 3' untranslated region, and all three are used. The coding sequence and the 3' untranslated region are the usual first choices for an RNase H design; the 5' end near the start codon suits a steric block. The map above shows where each region sits on the isoforms it draws.
02
Cover the isoforms you mean
An exon every isoform carries silences the whole gene; an exon only some isoforms carry silences those and spares the rest. Decide which you want before a sequence is chosen, and check the reference transcript (MANE Select in human; RefSeq Select and Ensembl canonical in mouse and rat) is the one your cells express.
03
Think across species early
The orthologs panel says whether mouse and rat carry the same gene. Whether one oligonucleotide can serve two species is a sequence question, settled at design by matching the candidate against each transcript, not by the protein identity shown there.
04
Check expression in your model
A transcript that is not expressed in your cells cannot show knockdown. Confirm the gene is expressed in the cell type and condition you will use, from your own data or a reference atlas, before the order. The expression panel above gives GTEx's median per tissue for a human gene; for mouse and rat it says that no atlas is on this page yet.

Gene Human Homo sapiens

PCDHGB4

Reading the record for PCDHGB4 from HGNC, NCBI Gene and Ensembl.Still reading. A first read of a gene can take a while; this page waits up to 115 seconds for it, and its scripts then bring in the page, or a line saying what did not arrive.

The full name, the identifiers, the location and the notes from the sources arrive with the record. Nothing is filled in ahead of it.

Order door

The door to order for PCDHGB4 opens with the record, which decides which product it carries. The order page itself is open now.

Bring your own sequence

For research use only. Not for use in diagnostic or therapeutic procedures.

This page is still reading the record. Its scripts replace this shell with the record when it arrives; with scripts off, it stays at this shell however long you wait.

01 Summary and function

What PCDHGB4 does

Waiting for the record before reading NCBI Gene and UniProt.

02 Transcripts and isoforms

The RNA a design targets

Waiting for the record before reading NCBI Datasets and Ensembl.

03 Expression by tissue

Where PCDHGB4 is expressed

Waiting for the record before reading GTEx and the Human Protein Atlas.

04 Protein

The protein PCDHGB4 encodes

Waiting for the record before reading UniProt, InterPro, AlphaFold DB and PDBe.

05 Interactions

Proteins STRING associates with PCDHGB4

Waiting for the record before reading STRING.

06 Pathways

Where PCDHGB4 acts, as Reactome curates it

Waiting for the record before reading UniProt and Reactome.

07 Disease associations

Diseases linked to PCDHGB4

Waiting for the record before reading Open Targets and ClinGen.

08 Variants

Classified variants of PCDHGB4

Waiting for the record before reading ClinVar.

09 Constraint

How much variation PCDHGB4 tolerates

Waiting for the record before reading gnomAD and Open Targets.

10 Orthologs

The same gene in mouse, rat and human

Waiting for the record before reading the Alliance, NCBI, Ensembl Compara and RGD.

11 MicroRNAs

MicroRNAs hosted within PCDHGB4

Waiting for the record before reading Ensembl and miRBase.

12 Long non-coding RNAs

Long non-coding RNAs at the PCDHGB4 locus

Waiting for the record before reading Ensembl.

13 Literature

Papers that mention PCDHGB4

Waiting for the record before reading Europe PMC.

Accession	Name	Biotype	Labels	Exons	Spliced length	Protein	Sequence
NM_003736.4matches ENST00000519479.2 NCBI's product report carries no genomic placement for this transcript, so its exon coordinates are not available from NCBI	transcript variant 1	protein coding	MANE Select	not placed	4,761 nt	923 aaNP_003727.1	Ready in a moment
NM_032098.1matches ENST00000615384.1	transcript variant 2	protein coding	none	1	2,412 nt	803 aaNP_115269.1	Ready in a moment

Accession	Name	Biotype	Labels	Exons	Spliced length	Protein	Sequence
NM_003736.4matches ENST00000519479.2 NCBI's product report carries no genomic placement for this transcript, so its exon coordinates are not available from NCBI	transcript variant 1	protein coding	MANE Select	not placed	4,761 nt	923 aaNP_003727.1	Ready in a moment
NM_032098.1matches ENST00000615384.1	transcript variant 2	protein coding	none	1	2,412 nt	803 aaNP_115269.1	Ready in a moment

Accession	Name	Biotype	Labels	Exons	Spliced length	Protein	Sequence
ENST00000519479.2matches NM_003736.4	PCDHGB4-201	protein coding	MANE SelectEnsembl canonical	4	4,761 nt	923 aaENSP00000428288.1	Ready in a moment
ENST00001138143.1	PCDHGB4-203	protein coding	none	4	4,763 nt	923 aaENSP00000813640.1	Ready in a moment
ENST00000615384.1	PCDHGB4-202	protein coding	none	1	4,725 nt	803 aaENSP00000484560.1	Ready in a moment

PCDHGB4

What PCDHGB4 does

The RNA a design targets

From PCDHGB4 to a sequence that silences it

Choose the region

Cover the isoforms you mean

Think across species early

Check expression in your model

PCDHGB4

What PCDHGB4 does

The RNA a design targets

Where PCDHGB4 is expressed

The protein PCDHGB4 encodes

Proteins STRING associates with PCDHGB4

Where PCDHGB4 acts, as Reactome curates it

Diseases linked to PCDHGB4

Classified variants of PCDHGB4

How much variation PCDHGB4 tolerates

The same gene in mouse, rat and human

MicroRNAs hosted within PCDHGB4

Long non-coding RNAs at the PCDHGB4 locus

Papers that mention PCDHGB4

PCDHGB4

What PCDHGB4 does

Gene summary

Protein function

The RNA a design targets

RefSeq 2 transcripts

A window on one transcript

Ensembl 3 transcripts

A window on one transcript

From PCDHGB4 to a sequence that silences it

Choose the region

Cover the isoforms you mean

Think across species early

Check expression in your model

Where PCDHGB4 is expressed

The protein PCDHGB4 encodes

Proteins STRING associates with PCDHGB4

Where PCDHGB4 acts, as Reactome curates it

Diseases linked to PCDHGB4

Classified variants of PCDHGB4

How much variation PCDHGB4 tolerates

The same gene in mouse, rat and human

MicroRNAs hosted within PCDHGB4

Long non-coding RNAs at the PCDHGB4 locus

Papers that mention PCDHGB4

Run the controls

Pick the product

Gene summary

Protein function

RefSeq 2 transcripts

A window on one transcript

Ensembl 3 transcripts

A window on one transcript