Reading the record for PPIA from HGNC, NCBI Gene and Ensembl.Still reading. A first read of a gene can take a while; this page waits up to 115 seconds for it, and its scripts then bring in the page, or a line saying what did not arrive.
The full name, the identifiers, the location and the notes from the sources arrive with the record. Nothing is filled in ahead of it.
Order door
The door to order for PPIA opens with the record, which decides which product it carries. The order page itself is open now.
Cytogenetic band 7p13NCBI: 7:44,796,681-44,803,117 on the plus strand, GRCh38.p14 (GCF_000001405.40), sequence NC_000007.14, annotation GCF_000001405.40-RS_2025_08 of 2025-08-01Ensembl: 7:44,796,620-44,824,564 on the plus strand, GRCh38.p14 (GCA_000001405.29), release 116Coordinates are one-based with both ends included, as each source reports them.
This gene encodes a member of the peptidyl-prolyl cis-trans isomerase… UniProt did not answer in time, so the protein entry could not be shown. Try again in a minute. Reference 398e33d2-3ef.
NCBI Gene summary
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Reading NCBI Gene and UniProt.Still reading. A first read of a gene can take a while; this page waits up to 30 seconds for it, and its scripts then bring in the panel, or a line saying what did not arrive.
02 / Transcripts and isoforms
The RNA a design targets
4 RefSeq and 47 Ensembl transcripts on GRCh38.p14; MANE Select NM_021130.5.
NCBI Datasets · Ensembl
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Reading NCBI Datasets and Ensembl.Still reading. A first read of a gene can take a while; this page waits up to 80 seconds for it, and its scripts then bring in the panel, or a line saying what did not arrive.
03 / Expression by tissue
Where PPIA is expressed
54 GTEx tissues; the highest median in Cells - EBV-transformed lymphocytes, 561 TPM.
GTEx
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04 / Protein
The protein PPIA encodes
UniProt did not answer in time, so the protein entry could not be shown. Try again in a minute. Reference 398e33d2-3ef.
Ready in a moment
05 / Interactions
Proteins STRING associates with PPIA
The 25 highest-scoring STRING partners at or above a combined score of 0.4, of up to 25 asked for; BSG, PPP3R1, PPP3CA lead.
STRING v12.0
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06 / Pathways
Where PPIA acts, as Reactome curates it
UniProt did not answer in time, so the pathway list could not be shown. Try again in a minute. Reference 398e33d2-3ef.
Ready in a moment
07 / Disease associations
Diseases linked to PPIA
1,056 Open Targets disease associations; HIV infectious disease first, at 0.62.
Open Targets
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08 / Variants
Classified variants of PPIA
Reading ClinVar.Still reading. A first read of a gene can take a while; this page waits up to 60 seconds for it, and its scripts then bring in this line, or a line saying what did not arrive.
Ready in a moment
09 / Constraint
How much variation PPIA tolerates
pLI 0.9894 and LOEUF 0.411 in gnomAD v4 (GRCh38), on ENST00000468812.6.
gnomAD
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10 / Orthologs
The same gene in mouse, rat and human
Mouse Ppia by 2 of 3 votes; rat: 3 candidates named (Ppia, LOC100911252, Ppial4d) and the votes differ. RGD is not answering, so the ortholog list could not be shown. Try again later. Reference fe4a7ed6-d90.
Alliance · NCBI · Ensembl Compara
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11 /MicroRNAs
MicroRNAs hosted within PPIA
No annotated microRNA lies within PPIA in Ensembl release 116, on GRCh38.p14.
Ensembl · miRBase
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12 / Long non-coding RNAs
Long non-coding RNAs at the PPIA locus
No annotated long non-coding RNA overlaps PPIA in Ensembl release 116, on GRCh38.p14.
Ensembl
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13 / Literature
Papers that mention PPIA
17,276 PubMed-indexed papers mention PPIA at Europe PMC, newest first. Europe PMC ignores letter case, so the count also covers another species' symbol spelled with the same letters.
Europe PMC
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14 / Silencing this gene
From PPIA to a sequence that silences it
The AUMsilence™ platform designs the sequences against the human transcripts on this page. Six decisions are yours before it does. What is written under each is AUM's guidance; the timings and the concentrations are in the usage guide below.
01
Choose the region
A knockdown oligonucleotide can sit in the 5' untranslated region, the coding sequence or the 3' untranslated region, and all three are used. The coding sequence and the 3' untranslated region are the usual first choices for an RNase H design; the 5' end near the start codon suits a steric block. The map above shows where each region sits on the isoforms it draws.
02
Cover the isoforms you mean
An exon every isoform carries silences the whole gene; an exon only some isoforms carry silences those and spares the rest. Decide which you want before a sequence is chosen, and check the reference transcript (MANE Select in human; RefSeq Select and Ensembl canonical in mouse and rat) is the one your cells express.
03
Think across species early
The orthologs panel says whether mouse and rat carry the same gene. Whether one oligonucleotide can serve two species is a sequence question, settled at design by matching the candidate against each transcript, not by the protein identity shown there.
04
Check expression in your model
A transcript that is not expressed in your cells cannot show knockdown. Confirm the gene is expressed in the cell type and condition you will use, from your own data or a reference atlas, before the order. The expression panel above gives GTEx's median per tissue for a human gene; for mouse and rat it says that no atlas is on this page yet.
05
Run the controls
A scramble control of the same chemistry, a positive control against a gene known to knock down in your cells, untreated cells, and a mock condition where a transfection reagent is used. Read knockdown at the RNA level first, then at the protein; the usage guide gives the timing and the concentrations to start from.
06
Pick the product
AUMsilence sdASO needs no transfection reagent and works in the cells that resist one. AUMsilence toASO is the transfection-optimised version of the same design, and AUMsiRNA™ is the siRNA route. The selection guide compares them.
For research use only. Not for use in diagnostic or therapeutic procedures.
Gene summary
This gene encodes a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. The encoded protein is a cyclosporin binding-protein and may play a role in cyclosporin A-mediated immunosuppression. The protein can also interact with several HIV proteins, including p55 gag, Vpr, and capsid protein, and has been shown to be necessary for the formation of infectious HIV virions. Multiple pseudogenes that map to different chromosomes have been reported.
Provided by RefSeq, Jul 2008, through NCBI Gene. NCBI disclaimer
Protein function
Not read
UniProt did not answer in time, so the protein entry could not be shown. Try again in a minute.
Reference 398e33d2-3ef
NCBI Gene summary · NCBI Gene annotation RS_2025_08 · read · NCBI Gene 5478Data from NCBI, provided as is; NCBI's policies and disclaimers apply.
Placed on GRCh38.p14 (GCF_000001405.40). MANE Select marks the one transcript RefSeq and Ensembl agree is the reference for this gene.
RefSeq 4 transcripts
coding sequence, tall
untranslated region, thin
non-coding exon
intron, fixed width
Genomic strand: plus. Drawn 5' to 3', so exon 1 sits at the left here and at the lowest coordinate on the chromosome.
NM_021130.5NM_021130.5MANE Select
XM_047420536.1XM_047420536.1
XM_047420537.1XM_047420537.1
NM_001300981.2NM_001300981.2
scale
Drawn 5' to 3' from each transcript's exons as placed on the reference assembly; exon 1 is the 5' exon on the transcript's own strand. Exon blocks are to scale with each other; introns are drawn at one fixed width whatever their length, so the map is not to scale along the chromosome. Numbers are exon ranks along the strand; a rank is omitted where the exon is too narrow to carry it.
A window on one transcript
One pixel of the map above stands for several bases, and a block too short to see is drawn wider than its own scale, so the map chooses a region and the sequence here chooses the window. Click an exon on a row of the map, or drag across a row; then set the exact start and end below.
These controls are ready in a moment.
No transcript is chosen.
Once a window is chosen this panel shows its length, its G and C count as a percentage of that length, the letters it is made of, the exons it falls in, whether it crosses a junction, and its antisense strand.
Drawn 5' to 3' from each transcript's exons as placed on the reference assembly; exon 1 is the 5' exon on the transcript's own strand. Exon blocks are to scale with each other; introns are drawn at one fixed width whatever their length, so the map is not to scale along the chromosome. Numbers are exon ranks along the strand; a rank is omitted where the exon is too narrow to carry it.
A window on one transcript
One pixel of the map above stands for several bases, and a block too short to see is drawn wider than its own scale, so the map chooses a region and the sequence here chooses the window. Click an exon on a row of the map, or drag across a row; then set the exact start and end below.
These controls are ready in a moment.
No transcript is chosen.
Once a window is chosen this panel shows its length, its G and C count as a percentage of that length, the letters it is made of, the exons it falls in, whether it crosses a junction, and its antisense strand.
Lengths are spliced lengths, as each source states them. Exon ranks follow the strand: on a minus-strand gene exon 1 has the highest genomic coordinate. Reference assembly for human: GRCh38.
ClinVar: 41 records for PPIA, 24 pathogenic or likely pathogenic.
